Abstract：
BACKGROUND:In this study, to clarify whether Helicobacter pylori eradication alters the course of the development of gastric mucosal changes in the stomach, we examined the long-term effects of H. pylori eradication on H. pylori-inoculated gerbils. METHODS:A total of 40 H. pylori-inoculated gerbils were randomized and subjected, at 22 months after inoculation, to eradication treatment with dual therapy of omeprazole plus clarithromycin, or with therapy with a novel quinolone compound, Y-34867, alone. The animals were killed at the start of administration (control group) or at 8 months after the completion of therapy (vehicle or eradication-treatment groups). RESULTS:Severe histopathological changes in the gastric mucosa were observed in all H. pylori-inoculated gerbils at the start of administration. At 8 months after completion of therapy, the frequency of gastritis, erosion, intestinal metaplasia, and gastric carcinoid in the eradication therapy groups was markedly reduced compared with that in the control and vehicle groups. Values for anti- H. pylori IgG titer, bacterial counts, and gastrin also decreased significantly. CONCLUSIONS:These results suggest that H. pylori eradication may have had a therapeutic effect not only on gastritis, erosion, and gastric ulcer but also on glandular atrophy, intestinal metaplasia, and gastric carcinoid.
journal_name
J Gastroenteroljournal_title
Journal of gastroenterologyauthors
Hirayama F,Takagi S,Yokoyama Y,Yamamoto K,Iwao E,Haga Kdoi
10.1007/s005350200130subject
Has Abstractpub_date
2002-01-01 00:00:00pages
779-84issue
10eissn
0944-1174issn
1435-5922journal_volume
37pub_type
杂志文章abstract：:A rare case of benign diaphragmatic schwannoma in a 38-year-old female is reported. Precontrast computed tomography (CT) showed an encapsulated well-defined round homogeneous tumor with central calcification, measuring approximately 5 cm in diameter, arising from the left diaphragm. Contrast-enhanced CT and gadolinium...
journal_title：Journal of gastroenterology
pub_type： 杂志文章,评审
doi：10.1007/BF02389529
更新日期：1996-04-01 00:00:00
abstract：:Depletion of goblet cells (the main mucin-producing cells in the colon) is one of the most reliable histological characteristics of ulcerative colitis, whereas a major symptom of this disease is bloody diarrhea containing a large amount of mucus. The discrepancy between these phenomena was investigated in a time-cours...
journal_title：Journal of gastroenterology
pub_type： 杂志文章
doi：10.1007/s005350050245
更新日期：1999-04-01 00:00:00
abstract：:We report a case of squamous cell carcinoma (SCC) of the gastric cardia showing submucosal progression with direct invasion of the liver. A 71-year-old man was admitted with dysphagia. Esophagogastroscopy showed a protruding tumor covered with normal gastric mucosa in the anterior wall of the gastric cardia, although ...
journal_title：Journal of gastroenterology
pub_type： 杂志文章
doi：10.1007/s005350170113
更新日期：2001-04-01 00:00:00
abstract：BACKGROUND:Corticosteroid therapy has been commonly administered to patients with acute liver injury (ALI)/acute liver failure (ALF) in Japan to prevent the development of hepatic encephalopathy, but the appropriate timing to start corticosteroid therapy has not been determined and optimal response evaluation of the th...
journal_title：Journal of gastroenterology
pub_type： 杂志文章
doi：10.1007/s00535-017-1306-5
更新日期：2017-08-01 00:00:00
abstract：:Inflammatory bowel disease (IBD) could be curable by "immune rest" and correction of the genetic predisposition inherent in allogeneic hematopoietic stem cell transplantation. However, balancing risks against benefits remains challenging. The application of mesenchymal stem cells (MSCs) serving as a site-regulated "dr...
journal_title：Journal of gastroenterology
pub_type： 杂志文章,评审
doi：10.1007/s00535-015-1040-9
更新日期：2015-03-01 00:00:00
abstract：:We report a case of Cruveihier-Baumgarten syndrome associated with portal vein thrombosis that developed, slowly during a 2-year period after endoscopic variceal sclerotherapy. The thrombosis led to the disappearance of the venous hum and the dilated abdominal wall veins characteristic of this syndrome. A 73-year-old ...
journal_title：Journal of gastroenterology
pub_type： 杂志文章
doi：10.1007/BF02355069
更新日期：1996-08-01 00:00:00
abstract：:We report the coexistence of symptomatic viral, bacterial, and fungal infection of the upper gastrointestinal tract in a heart transplant recipient. Endoscopic findings were normal at all levels but, because of severe symptoms and recent conversion to positive serology for Cytomegalovirus, biopsies were taken. These s...
journal_title：Journal of gastroenterology
pub_type： 杂志文章
doi：10.1007/BF02358613
更新日期：1996-12-01 00:00:00
abstract：BACKGROUND:Adiponectin has been shown to have suppressive effects on tumor development, but the expression of adiponectin receptors in tumor tissue has not been fully elucidated. The purpose of this study was to quantitatively evaluate the expression of two adiponectin receptors, AdipoR1 and AdipoR2, in gastric cancer ...
journal_title：Journal of gastroenterology
pub_type： 杂志文章
doi：10.1007/s00535-010-0228-2
更新日期：2010-09-01 00:00:00
abstract：BACKGROUND:DNA microarray technology has enabled genomewide analysis of gene transcript levels, yielding insight into the molecular nature of liver disease. METHODS:We compared gene expression of liver biopsy specimens in 16 patients with different stages of chronic hepatitis B, five with autoimmune hepatitis (AIH), f...
journal_title：Journal of gastroenterology
pub_type： 杂志文章
doi：10.1007/s00535-008-2237-y
更新日期：2008-01-01 00:00:00
abstract：:Focal nodular hyperplasia (FNH) is a benign lesion of the liver which usually presents with one or two localizations. We report a patient with history of resection of a biliary cyst, and who had been taking oral contraceptives for the past 18 years, who had multiple localizations of FNH (more than 30 lesions). The lar...
journal_title：Journal of gastroenterology
pub_type： 杂志文章
doi：10.1007/s005350050198
更新日期：1998-12-01 00:00:00
abstract：:A case of granular cell tumor occurring in the sigmoid colon is reported. The patient, a 56-year-old man, visited our hospital for further evaluation of occult blood in his stool. Endoscopic examination revealed a yellowish, hemispheric submucosal tumor (SMT) with redness, about 6 mm in diameter, in the sigmoid colon....
journal_title：Journal of gastroenterology
pub_type： 杂志文章,评审
doi：10.1007/s005350300068
更新日期：2003-01-01 00:00:00
abstract：BACKGROUND:Liver cirrhosis affects the results of many of the traditional techniques currently used to evaluate nutritional status. Our aim was to compare the traditional two-compartment model (subjective global assessment and anthropometry and blood tests) of nutritional assessment with a multicompartmental model (bod...
journal_title：Journal of gastroenterology
pub_type： 评论,杂志文章
doi：10.1007/s00535-006-1794-1
更新日期：2006-05-01 00:00:00
abstract：BACKGROUND:Although colorectal cancer (CRC) is one of the most common causes of cancer mortality, early-stage detection improves survival rates dramatically. Because cancer impacts important metabolic pathways, the alteration of metabolite levels as a potential biomarker of early-stage cancer has been the focus of many...
journal_title：Journal of gastroenterology
pub_type： 杂志文章
doi：10.1007/s00535-016-1261-6
更新日期：2017-06-01 00:00:00
abstract：:Although esophageal candidiasis is the most common form of Candida infection in the gastro-intestinal tract, little attention has been directed toward determining the mechanism of its infection. We have already clarified the existence of four modes of adherence of Candida albicans to the esophagus; attachment, subepit...
journal_title：Journal of gastroenterology
pub_type： 杂志文章
doi：10.1007/BF01229065
更新日期：1994-02-01 00:00:00
abstract：:A 69-year-old woman was admitted to Hokuso Shiroi Hospital because of recurrent pain in the lower right side of the abdomen. Small-intestinal cancer was strongly suspected after fluoroscopy of the small intestine. Laparotomy showed advanced cancer of the ileum, of complete annular constrictive type, 9.5 x 5cm in size....
journal_title：Journal of gastroenterology
pub_type： 杂志文章
doi：10.1007/s005350050102
更新日期：1998-06-01 00:00:00
abstract：:The proliferative activity of serrated adenomas of the large intestine was determined by examining proliferating cell nuclear antigen (PCNA). The PCNA labeling index, determined by visual inspection, and the PCNA area rate, determined with the newly developed image processor for analytical pathology (IPAP), of serrate...
journal_title：Journal of gastroenterology
pub_type： 杂志文章
doi：10.1007/BF02389519
更新日期：1996-04-01 00:00:00
abstract：BACKGROUND:Depth of submucosal invasion (SM depth) in submucosal invasive colorectal carcinoma (SICC) is considered an important predictive factor for lymph node metastasis. However, no nationwide reports have clarified the relationship between SM depth and rate of lymph node metastasis. Our aim was to investigate the ...
journal_title：Journal of gastroenterology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00535-004-1339-4
更新日期：2004-06-01 00:00:00
abstract：BACKGROUND:Linked color imaging (LCI) increases the visibility of early gastric cancers, which may be associated with characteristic findings including background purple mucosae. These lesions are found in areas of chronic gastritis and surrounding mucosa. The aim of this study is to objectively characterize these lesi...
journal_title：Journal of gastroenterology
pub_type： 杂志文章
doi：10.1007/s00535-018-1515-6
更新日期：2019-05-01 00:00:00
abstract：BACKGROUND:Catechin, a polyphenol contained in tea (a cup of tea contains approximately 0.1% [w/v] catechin), has various physiological effects. The aim of this study was to investigate the mechanism of the inhibitory effect of catechin on gastric mucosal lesions. METHODS:We studied the effect of catechin on gastric m...
journal_title：Journal of gastroenterology
pub_type： 杂志文章
doi：10.1007/s005350200004
更新日期：2002-01-01 00:00:00
abstract：BACKGROUND:The aim of this study was to determine whether leptin and insulin resistance (IR) showed differences between steatotic patients with and without elevated serum transaminases. METHODS:The study included 32 patients with fatty liver and high serum transaminase level (group I), 31 patients with fatty liver and...
journal_title：Journal of gastroenterology
pub_type： 杂志文章
doi：10.1007/s00535-002-1084-5
更新日期：2003-01-01 00:00:00
abstract：:A 21-year-old man with diarrhea and edema was admitted to our hospital and diagnosed with protein-losing enteropathy caused by primary intestinal lymphangiectasia. He was placed, in turn, on a low-fat diet, an elemental diet, and, subsequently, fasting therapy with total parenteral nutrition (TPN) support. However, hi...
journal_title：Journal of gastroenterology
pub_type： 杂志文章
doi：10.1007/s005350170142
更新日期：2001-02-01 00:00:00
abstract：BACKGROUND:To further clarify the clinico-epidemiological features of autoimmune pancreatitis (AIP) in Japan, we conducted the fourth nationwide epidemiological survey. METHODS:This study consisted of two stage surveys; the number of AIP patients was estimated by the first survey and their clinical features were asses...
journal_title：Journal of gastroenterology
pub_type： 杂志文章
doi：10.1007/s00535-019-01658-7
更新日期：2020-04-01 00:00:00
abstract：BACKGROUND:Peristaltic reflex does not fully explain the polarity of peristalsis. In the distal colon, we propose that the balance of circular muscle contraction proximal and distal to the pellet is a local reflex that predicts polarity of peristalsis. METHODS:Guinea pig distal colon segments were harvested, and fecal...
journal_title：Journal of gastroenterology
pub_type： 杂志文章
doi：10.1007/s00535-013-0842-x
更新日期：2014-05-01 00:00:00
abstract：:Asia has intermediate-to-high prevalence and high morbidity of hepatitis B virus (HBV) infection. The use of guideline-recommended nucleos(t)ide analogs with high barrier to resistance, such as entecavir (ETV), tenofovir disoproxil fumarate (TDF), and tenofovir alafenamide (TAF), is one of the key interventions for cu...
journal_title：Journal of gastroenterology
pub_type： 杂志文章,评审
doi：10.1007/s00535-020-01698-4
更新日期：2020-09-01 00:00:00
abstract：BACKGROUND AND AIM:Mac-2 Binding Protein Glycosylation Isomer (M2BPGi) is a novel fibrosis marker. We examined the ability of M2BPGi to predict liver fibrosis in patients with biliary atresia. METHODS:Sixty-four patients who underwent living donor liver transplantation (LDLT) were included [median age, 1.1 years (rang...
journal_title：Journal of gastroenterology
pub_type： 杂志文章
doi：10.1007/s00535-016-1235-8
更新日期：2017-02-01 00:00:00
abstract：:An expert meeting was organized by the Swedish and Norwegian Medical Products Agencies in September 1995 in order to review the current literature and opinions on detection and treatment of Helicobacter pylori. Ten people from these Agencies and 23 experts participated in the workshop and all were involved in the fina...
journal_title：Journal of gastroenterology
pub_type：
doi：
更新日期：1998-01-01 00:00:00
abstract：PURPOSE:In patients chronically infected with hepatitis B virus, interferon has been used for the purpose of viral suppression by loss of hepatitis B e antigen (HBeAg) with or without seroconversion to antibody to HBeAg (anti-HBe). However, discussion about the effect of interferon on the development of hepatocellular ...
journal_title：Journal of gastroenterology
pub_type： 杂志文章,meta分析
doi：10.1007/s00535-009-0024-z
更新日期：2009-01-01 00:00:00
abstract：:This study aimed to investigate sex differences in relation to hepatitis B e antigen (HBeAg) and serum alanine aminotransferase (ALT) levels in chronic asymptomatic hepatitis B virus (HBV) infection. HBeAg and ALT level were determined in 636 asymptomatic hepatitis B surface antigen carriers. There was no significant ...
journal_title：Journal of gastroenterology
pub_type： 杂志文章
doi：10.1007/s005350070048
更新日期：2000-01-01 00:00:00
abstract：:We report a patient who survived total colonic type ulcerative colitis (UC) complicated by toxic megacolon (TM), disseminated intravascular coagulation (DIC), methicillin-resistant Staphylococcus aureus infection, and phlebothrombosis. A 69-year-old man was treated for about 4 months under the diagnosis of ischemic co...
journal_title：Journal of gastroenterology
pub_type： 杂志文章,评审
doi：10.1007/s005350050282
更新日期：1999-06-01 00:00:00
abstract：BACKGROUND:Aberrant methylation of some cancer-related genes has been reported to correlate with sensitivity to chemotherapeutic agents. The present study was designed to determine whether DNA methylation in six cancer-related genes affects recurrence of gastric cancer in patients who received 5-fluorouracil-based adju...
journal_title：Journal of gastroenterology
pub_type： 临床试验,杂志文章
doi：10.1007/s00535-007-2113-1
更新日期：2007-11-01 00:00:00
