Nitric oxide regulates polarity of guinea pig distal colon pellet propagation and circular muscle motor response.

abstract：BACKGROUND:Although previous studies have indicated that serum pepsinogen I levels, as well as the pepsinogen I/II ratio, were positively correlated with maximal gastric output, the relationship may be different between Helicobacter pylori-negative and -positive subjects. The aim of this study was to investigate the re...

journal_title：Journal of gastroenterology

authors： Iijima K,Sekine H,Koike T,Imatani A,Ohara S,Shimosegawa T

更新日期：2005-10-01 00:00:00

abstract：BACKGROUND:DNA microarray technology has enabled genomewide analysis of gene transcript levels, yielding insight into the molecular nature of liver disease. METHODS:We compared gene expression of liver biopsy specimens in 16 patients with different stages of chronic hepatitis B, five with autoimmune hepatitis (AIH), f...

journal_title：Journal of gastroenterology

authors： Furuta K,Sato S,Yamauchi T,Ozawa T,Harada M,Kakumu S

更新日期：2008-01-01 00:00:00

abstract：:To determine the role of endogenous substance P in ethanol-induced mucosal damage, two experiments were performed. In the first experiment, the stomachs of anesthetized rats were doubly cannulated and gastric damage was induced with 5ml of 30% ethanol in the gastric lumen. The damage was ameliorated by pretreatment wi...

journal_title：Journal of gastroenterology

authors： Hayashi H,Nishiyama K,Majima M,Katori M,Saigenji K

更新日期：1996-06-01 00:00:00

abstract：BACKGROUND:The levels of serum HER2 extracellular domain (ECD) are highly correlated with tissue HER2 status in metastatic gastric cancer (AGC). We sought to explore whether serum HER2 ECD could predict the efficacy of trastuzumab-treated HER2-positive AGC. MATERIALS AND METHODS:From 2011 to 2013, trastuzumab-treated ...

journal_title：Journal of gastroenterology

authors： Zhou J,Peng Z,Liu Y,Gong J,Zhang X,Lu M,Gao J,Li Y,Li Y,Shen L

更新日期：2015-09-01 00:00:00

abstract：:We report the coexistence of symptomatic viral, bacterial, and fungal infection of the upper gastrointestinal tract in a heart transplant recipient. Endoscopic findings were normal at all levels but, because of severe symptoms and recent conversion to positive serology for Cytomegalovirus, biopsies were taken. These s...

journal_title：Journal of gastroenterology

authors： Huwez FU,McPhaden AR,Belcher PR,Naik SK,Wheatley DJ

更新日期：1996-12-01 00:00:00

abstract：:We report a case of gastrojejunal fistula caused by benign gastric ulcer, a very rare condition. The patient was an 81-year-old-woman who had had multiple recurrences of gastric ulcer. She also had diabetes mellitus. She was admitted to our hospital because of a left femoral head fracture, necessitating a mechanical b...

journal_title：Journal of gastroenterology

authors： Matsuoka M,Yoshida Y,Hayakawa K,Fukuchi S

更新日期：1998-04-01 00:00:00

abstract：:Both reflex and sensory mechanisms control the function of the stomach, and disturbances in these mechanisms may explain the pathophysiology of disorders of gastric function. The objective of this report is to perform a literature-based critical analysis of new, relevant or conflicting information on gastric sensitivi...

journal_title：Journal of gastroenterology

authors： Azpiroz F,Feinle-Bisset C,Grundy D,Tack J

更新日期：2014-02-01 00:00:00

abstract：:The localization and distribution of gamma delta T cell receptor (TCR)-positive cells (gamma delta T cells) in hepatocellular carcinoma capsules was investigated immunohistochemically at both light and electron microscopic levels. Most of the mononuclear cells infiltrating the tumor capsules were CD3-positive. Togethe...

journal_title：Journal of gastroenterology

authors： Chin K,Morise K,Kanayama K,Nagura H

更新日期：1995-06-01 00:00:00

abstract：BACKGROUND:Fatty liver is an important clinical feature not only in alcoholic and non-alcoholic fatty liver diseases, but in other chronic liver diseases as well. Our aim was to elucidate the effect and relationship between habitual alcohol intake and obesity in the development of fatty liver disease. METHODS:We enrol...

journal_title：Journal of gastroenterology

authors： Takahashi H,Ono M,Hyogo H,Tsuji C,Kitajima Y,Ono N,Eguchi T,Fujimoto K,Chayama K,Saibara T,Anzai K,Eguchi Y

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:Vaniprevir is a potent macrocyclic hepatitis C virus (HCV) nonstructural protein 3/4A protease inhibitor. This phase III study evaluated the safety and efficacy of vaniprevir in combination with peginterferon alfa-2b and ribavirin (PR) for 24 weeks compared with PR alone for 48 weeks in treatment-naive Japan...

journal_title：Journal of gastroenterology

authors： Hayashi N,Nakamuta M,Takehara T,Kumada H,Takase A,Howe AY,Ludmerer SW,Mobashery N

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:White adipose tissue (WAT) is important for the maintenance of metabolic homeostasis, and metabolic syndrome is sometimes associated with WAT dysfunction in humans and animals. WAT reportedly plays a key, beneficial role in the maintenance of glucose and lipid homeostasis during de novo lipogenesis (DNL). Pu...

journal_title：Journal of gastroenterology

authors： Cai X,Hayashi S,Fang C,Hao S,Wang X,Nishiguchi S,Tsutsui H,Sheng J

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Interferon (IFN)-based therapy has been reported to reduce the liver-related mortality rate in patients with chronic hepatitis C virus (HCV) infection. However, predictors of survival and causes of death, including non-liver-related causes, have not been sufficiently investigated in chronic HCV patients who ...

journal_title：Journal of gastroenterology

authors： Tada T,Kumada T,Toyoda H,Kiriyama S,Tanikawa M,Hisanaga Y,Kanamori A,Kitabatake S,Yama T,Tanaka J

更新日期：2016-04-01 00:00:00

abstract：:To evaluate the diagnostic utility of blood biochemical parameters in assessing degree of hepatic fibrosis, serum levels of aminoterminal type III procollagen peptide (P III P), type IV collagen (IV-collagen), 7S domain of type IV collagen (7S-collagen), and hyaluronan (HA) were measured in 54 patients with chronic vi...

journal_title：Journal of gastroenterology

authors： Takamatsu S,Nakabayashi H,Okamoto Y,Nakano H

更新日期：1997-06-01 00:00:00

abstract：BACKGROUND:Only a few studies have longitudinally evaluated whether fatty pancreas increases the risk of type-2 diabetes (T2D), and their results were inconsistent. Fatty pancreas is closely linked to overweight and obesity, but previous studies did not exclude overweight or obese individuals. Therefore, in this cohort...

journal_title：Journal of gastroenterology

authors： Yamazaki H,Tauchi S,Wang J,Dohke M,Hanawa N,Kodama Y,Katanuma A,Saisho Y,Kamitani T,Fukuhara S,Yamamoto Y

更新日期：2020-07-01 00:00:00

abstract：:In our hospital, 83 patients with colorectal cancer underwent the immunologic fecal occult blood test (IFOBT). The positive rate for IFOBT in all patients was 87%. Colon cancers more proximal than the transverse colon were 100% positive. Carcinomas of the ulcerative type showed a significantly higher positive rate tha...

journal_title：Journal of gastroenterology

authors： Iida Y,Munemoto Y,Miura S,Kasahara Y,Saito H,Mitsui T,Asada Y,Fukuoka K,Toya D,Tanaka N

更新日期：1995-04-01 00:00:00

abstract：:An association between Crohn's disease and gastric cancer has not been clearly defined. A 34-year-old man was referred to our hospital for the evaluation of a gastric lesion and treatment of small-bowel Crohn's disease. We diagnosed the gastric lesion as adenocarcinoma, using endoscopy and histological studies. The pa...

journal_title：Journal of gastroenterology

authors： Ikeuchi H,Kusunoki M,Yamamura T,Nishigami T

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Drug resistance in colorectal cancers is assumed to be mediated by changes in the expression of microRNAs, but the specific identities and roles of microRNAs are largely unclear. We examined the effect of 5-fluorouracil (5-FU) resistance on microRNA expression. METHODS:Two types of 5-FU-resistant colon canc...

journal_title：Journal of gastroenterology

authors： Kurokawa K,Tanahashi T,Iima T,Yamamoto Y,Akaike Y,Nishida K,Masuda K,Kuwano Y,Murakami Y,Fukushima M,Rokutan K

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:Pancreatic cancer is obstinate and resistant to gemcitabine, a standard chemotherapeutic agent for the disease. We previously showed a therapeutic effect of glycogen synthase kinase-3β (GSK3β) inhibition against gastrointestinal cancer and glioblastoma. Here, we investigated the effect of GSK3β inhibition on...

journal_title：Journal of gastroenterology

authors： Shimasaki T,Ishigaki Y,Nakamura Y,Takata T,Nakaya N,Nakajima H,Sato I,Zhao X,Kitano A,Kawakami K,Tanaka T,Takegami T,Tomosugi N,Minamoto T,Motoo Y

更新日期：2012-03-01 00:00:00

abstract：:An extremely rare case of malignant schwannoma of the esophagus with lymph node metastasis is reported. A 49-year-old woman was found to have an abnormal shadow on a chest X-ray film taken during an annual checkup. Upper gastrointestinal series showed extrinsic pressure on the middle thoracic esophagus, without a muco...

journal_title：Journal of gastroenterology

authors： Murase K,Hino A,Ozeki Y,Karagiri Y,Onitsuka A,Sugie S

更新日期：2001-11-01 00:00:00

abstract：:The relationship between sphincter of Oddi pressure and the morphological structure of the sphincter was studied in eight dogs prepared with a duodenal cannula. Sphincter of Oddi manometry was performed in awake animals in three directions, ventral, left dorsal, and right dorsal, using a catheter with three radial sid...

journal_title：Journal of gastroenterology

authors： Takeda T,Tohma H,Yoshida J,Naritomi G,Konomi H,Deng ZL,Kinukawa N,Tanaka M

更新日期：1998-12-01 00:00:00

abstract：BACKGROUND:Insufflation with carbon dioxide (CO(2)) in colonoscopy has not been widely adopted and, consequently, limited data are available on insufflated gas volume and blood pCO(2). The aim of this study was to compare CO(2) and air as an insufflation agent in patients undergoing colonoscopy without sedation in term...

journal_title：Journal of gastroenterology

authors： Yamano HO,Yoshikawa K,Kimura T,Yamamoto E,Harada E,Kudou T,Katou R,Hayashi Y,Satou K

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:Although colorectal cancer (CRC) is one of the most common causes of cancer mortality, early-stage detection improves survival rates dramatically. Because cancer impacts important metabolic pathways, the alteration of metabolite levels as a potential biomarker of early-stage cancer has been the focus of many...

journal_title：Journal of gastroenterology

authors： Uchiyama K,Yagi N,Mizushima K,Higashimura Y,Hirai Y,Okayama T,Yoshida N,Katada K,Kamada K,Handa O,Ishikawa T,Takagi T,Konishi H,Kuriu Y,Nakanishi M,Otsuji E,Itoh Y,Naito Y

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:Among the factors influencing variceal relapse after endoscopic treatment, portal hemodynamic changes, especially in portal systemic shunts, could be the most important factor because hemodynamics are directly related to the development of esophageal varices. We aimed to clarify the influence of endoscopic t...

journal_title：Journal of gastroenterology

authors： Ito K,Matsutani S,Maruyama H,Akiike T,Nomoto H,Suzuki T,Fukuzawa T,Mizumoto H,Saisho H

更新日期：2006-02-01 00:00:00

abstract：BACKGROUND:This study examined the association of cholelithiasis post-cholecystectomy with subsequent cancers and evaluated the risk of cancer in patients with both cholelithiasis and cholecystectomy. METHODS:The Taiwanese National Health Insurance Research Database was used to identify 15545 newly diagnosed cholelith...

journal_title：Journal of gastroenterology

authors： Chen YK,Yeh JH,Lin CL,Peng CL,Sung FC,Hwang IM,Kao CH

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:Vedolizumab is a gut-selective humanized antibody that binds the α4β7 integrin. We evaluated efficacy and safety of vedolizumab in Japanese patients with moderate-to-severe Crohn's disease (CD). METHODS:In this Phase 3, double-blind study (NCT02038920), 157 patients were randomized to receive intravenous ve...

journal_title：Journal of gastroenterology

authors： Watanabe K,Motoya S,Ogata H,Kanai T,Matsui T,Suzuki Y,Shikamura M,Sugiura K,Oda K,Hori T,Araki T,Watanabe M,Hibi T

更新日期：2020-03-01 00:00:00

abstract：:An expert meeting was organized by the Swedish and Norwegian Medical Products Agencies in September 1995 in order to review the current literature and opinions on detection and treatment of Helicobacter pylori. Ten people from these Agencies and 23 experts participated in the workshop and all were involved in the fina...

journal_title：Journal of gastroenterology

authors： Unge P

更新日期：1998-01-01 00:00:00

abstract：:We report a 27-year-old male with Crohn's disease (CD) of the small and large intestine, whose peripheral blood lymphocytes (PBL) showed increased cell-mediated cytotoxicity (CTL). Autologous and allogeneic effector cells from PBL and intestinal lymph nodes (LN) were isolated on a Ficoll-Hypaque gradient. Colonic cell...

journal_title：Journal of gastroenterology

authors： Okazaki K,Yokoyama Y,Yamamoto Y,Kobayashi M,Araki K,Ogata T

更新日期：1994-08-01 00:00:00

abstract：:We report a case of pancreas head carcinoma associated with fat replacement of the body and tail. A 68-year-old man presented with obstructive jaundice and was admitted to our hospital. Ultrasonography and computed tomography showed pancreas head tumor with a neighboring cystic lesion and fatty replacement of parenchy...

journal_title：Journal of gastroenterology

authors： Toyama N,Kamiyama H,Suminaga Y,Namai K,Ota M,Konishi F

更新日期：2004-01-01 00:00:00

abstract：:We aimed to determine the safety and feasibility of an alternative postoperative oral intake protocol for Japanese patients who had had oncological colorectal surgery, with the goal of shortening the length of postoperative stay to the same level as that in Western countries. The subjects of the study were 42 consecut...

journal_title：Journal of gastroenterology

authors： Kawamura YJ,Uchida H,Watanabe T,Nagawa H

更新日期：2000-01-01 00:00:00

abstract：:We report two cirrhotic patients with gastric antral vascular ectasia (GAVE) in whom chronic blood loss presented a major problem. Case 1, a 69-year-old man, had alcoholic liver cirrhosis, and case 2, a 75-year-old woman, had liver cirrhosis associated with hepatitis C virus. The patients required repeated blood trans...

journal_title：Journal of gastroenterology

authors： Yamada M,Nishimura D,Hoshino H,Katada N,Sano H,Kato K

更新日期：1998-08-01 00:00:00