当前位置： SCI文献检索 > JOURNAL OF GASTROENTEROLOGY期刊下所有文献 > Impairment of chemical clearance and mucosal integrity distinguishes hypersensitive esophagus from functional heartburn.

Impairment of chemical clearance and mucosal integrity distinguishes hypersensitive esophagus from functional heartburn.

Abstract：

BACKGROUND:Hypersensitive esophagus (HE) is defined by endoscopy-negative heartburn with a normal acid exposure time but positive symptom association probability (SAP) and/or symptom index (SI) on impedance-pH monitoring, and proton pump inhibitor (PPI) responsiveness. Functional heartburn (FH) is distinguished by negative SAP/SI and PPI refractoriness. The clinical value of SAP and SI has been questioned. We aimed to investigate whether impairment of chemical clearance and of mucosal integrity, expressed by the postreflux swallow-induced peristaltic wave (PSPW) index and the mean nocturnal baseline impedance (MNBI), characterize HE independently of SAP and SI. METHODS:Impedance-pH tracings from PPI-responsive endoscopy-negative patients, 125 with nonerosive reflux disease and 108 with HE, distinguished by an abnormal and a normal acid exposure time, and from 70 patients with FH were retrospectively selected and blindly reviewed. RESULTS:The mean PSPW index and MNBI were significantly lower in nonerosive reflux disease (30 %, 1378 Ω) than in HE (51 %; 2274 Ω) and in both of them as compared with FH (76 %; 3445 Ω) (P = 0.0001). Both the PSPW index (adjusted odds ratio 0.863, P = 0.001) and the MNBI (adjusted odds ratio 0.998, P = 0.001) were independent predictors of HE; with their combined assessment, the area under the curve on receiver operating characteristic analysis was 0.957. SAP and/or SI was positive in 67 of the 108 HE patients (62 %), whereas the PSPW index and/or MNBI was abnormal in 99 of the 108 HE patients (92 %; P < 0.0001). CONCLUSIONS:HE is characterized by impairment of chemical clearance and mucosal integrity, which explains the increased reflux perception. When SAP and SI afford uncertain results, the PSPW index and MNBI should be analyzed.

journal_name

J Gastroenterol

journal_title

Journal of gastroenterology

authors

Frazzoni M,de Bortoli N,Frazzoni L,Furnari M,Martinucci I,Tolone S,Farioli A,Marchi S,Fuccio L,Savarino V,Savarino E

doi

10.1007/s00535-016-1226-9

subject

Has Abstract

pub_date

2017-04-01 00:00:00

pages

444-451

issue

4

eissn

0944-1174

issn

1435-5922

pii

10.1007/s00535-016-1226-9

journal_volume

52

pub_type

杂志文章,多中心研究

相关文献

JOURNAL OF GASTROENTEROLOGY文献大全
  • HBV-related fulminant hepatic failure: successful intensive medical therapy in a candidate for liver transplantation.

    abstract：:Fulminant hepatic failure (FHF) usually has a fatal prognosis without liver transplantation. We describe the case of a woman who developed FHF, and was evaluated as a candidate for liver transplantation, but who was cured without transplantation through intensive medical care that included glucagon-insulin therapy, me...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s005350170103

    authors： Masuhara M,Yagawa T,Aoyagi M,Suzuki C,Sakaguchi E,Segawa M,Hironaka K,Kayano K,Tamura F,Seguchi M,Soejima Y,Murakami F,Sakaida I,Tateishi A,Fukumoto Y,Okita K

    更新日期：2001-05-01 00:00:00

  • Matrix metalloproteinase-3 secretion from human colonic subepithelial myofibroblasts: role of interleukin-17.

    abstract：BACKGROUND:Subepithelial myofibroblasts (SEMFs) play a role in extracellular matrix (ECM) metabolism in the colon. In this study, we investigated the effects of interleukin (IL)-17, IL-1beta, and tumor necrosis factor (TNF)-alpha on matrix metalloproteinase (MMP)-3 secretion in colonic SEMFs. METHODS:MMP-3 secretion a...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s00535-002-1101-8

    authors： Bamba S,Andoh A,Yasui H,Araki Y,Bamba T,Fujiyama Y

    更新日期：2003-01-01 00:00:00

  • Superficial elevated-type early gallbladder carcinoma treated by laparoscopic cholecystectomy.

    abstract：:A 60-year-old woman was admitted to our department for detailed examination of a polypoid lesions of the gallbladder detected at the time of a mass survey by ultrasound. Endoscopic ultrasonography (EUS) demonstrated a broad-based mass lesion, about 10 mm in size, with an irregular surface, at the peritoneal side of th...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/BF02934102

    authors： Fujita N,Noda Y,Kobayashi G,Kimura K,Yago A,Okaniwa S

    更新日期：1997-08-01 00:00:00

  • Combination of sorafenib and angiotensin-II receptor blocker attenuates preneoplastic lesion development in a non-diabetic rat model of steatohepatitis.

    abstract：BACKGROUND:Given the well-documented adverse side effects of sorafenib, many sorafenib-treated patients may need the reduced initial dose of the compound, and an alternative sorafenib-based therapy, which exerts similar clinical benefit, is anticipated. An angiostatic therapy with sorafenib is considered one of the pro...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s00535-013-0906-y

    authors： Yoshiji H,Noguchi R,Namisaki T,Moriya K,Kitade M,Aihara Y,Douhara A,Kawaratani H,Nishimura N,Fukui H

    更新日期：2014-10-01 00:00:00

  • Primary CD56+ T/NK cell lymphoma of the colon.

    abstract：:Primary T/natural killer (NK) cell lymphoma of the colon is extremely rare. Despite the advances in histological and immunophenotypic studies, the diagnosis of primary T/NK cell lymphoma of the colon can be delayed because the early symptoms and colonoscopic findings may be very similar to those of inflammatory bowel ...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s005350200158

    authors： Kim HS,Lee DK,Baik SK,Kwon SO,Cho MY,Ko YH

    更新日期：2002-01-01 00:00:00

  • Portal venous blood flow while breath-holding after inspiration or expiration and during normal respiration in controls and cirrhotics.

    abstract：:In this study, we used magnetic resonance (MR) imaging to measure portal blood flow in 12 healthy controls and 17 cirrhotics while they were breath-holding after inspiration and after expiration. We then compared the results with measurements made during normal respiration in the healthy controls and cirrhotics. Blood...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s005350050381

    authors： Sugano S,Yamamoto K,Sasao K,Watanabe M

    更新日期：1999-10-01 00:00:00

  • Carcinoma of the gallbladder and anomalous arrangement of the pancreaticobiliary ductal system: cell kinetic studies of gallbladder epithelial cells.

    abstract：:Anomalous arrangement of the pancreaticobiliary ductal system (AAPB), a congenital anomaly defined as a union of the pancreatic and biliary ducts located outside the duodenal wall, is a newly designated disease entity, and is frequently found in adult patients with gallbladder carcinoma (GBX). In the present study, th...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/BF02936958

    authors： Yang Y,Fujii H,Matsumoto Y,Suzuki K,Kawaoi A,Suda K

    更新日期：1997-12-01 00:00:00

  • Clinical evaluation of 3D-CT cholangiography for preoperative examination in laparoscopic cholecystectomy.

    abstract：:Three-dimensional-computed tomography (3D-CT) cholangiography is a 3D shaded surface display image of the biliary tract obtained by using helical CT after intravenous cholangiography or cholangiography per percutaneous transhepatic cholangio-drainage tube. We investigated whether 3D-CT cholangiography could provide a ...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s005350050225

    authors： Kinami S,Yao T,Kurachi M,Ishizaki Y

    更新日期：1999-02-01 00:00:00

  • Small bowel transit time and colonic fermentation in young and elderly women.

    abstract：:Small bowel transit time (SBTT) in 15 young and 13 elderly women was assessed by measuring breath hydrogen concentrations after they had consumed a solid test meal. The meal consisted of 200 g cooked rice, 50 ml miso (made from fermented soy bean curd) soup, a boiled egg, and 95.5 g of cooked soy beans with mixed vege...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/BF02934082

    authors： Kagaya M,Iwata N,Toda Y,Nakae Y,Kondo T

    更新日期：1997-08-01 00:00:00

  • Effects of submucosal administration of endothelin-3 on rat gastric mucosa.

    abstract：:The present study was carried out to examine the effects of submucosal administration of endothelin on gastric mucosal integrity in rats. Injection of endothelin-3 into the submucosal space of the stomach induced gastric mucosal damage dose-dependently and site-specifically. The gastric injury was localized only at th...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/BF02936360

    authors： Watanabe Y,Okumura T,Harada K,Kohgo Y

    更新日期：1997-04-01 00:00:00

  • Serum trace metals in chronic viral hepatitis and hepatocellular carcinoma in Thailand.

    abstract：:This study was conducted to determine and compare serum trace metal levels in viral hepatitis-associated chronic liver disease. Of 98 patients aged 43 (+/- 13) [mean (+/- SD)] years, 83 (85%) were seropositive for hepatitis B surface antigen (HBsAg) and 15 (15%) were seropositive for anti-hepatitis C virus (HCV). Twen...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/BF02365444

    authors： Pramoolsinsap C,Promvanit N,Komindr S,Lerdverasirikul P,Srianujata S

    更新日期：1994-10-01 00:00:00

  • Colorectal distention induces acute and delayed visceral hypersensitivity: role of peripheral corticotropin-releasing factor and interleukin-1 in rats.

    abstract：BACKGROUND:Most studies evaluating visceral sensation measure visceromotor response (VMR) to colorectal distention (CRD). However, CRD itself induces visceral sensitization, and little is known about the detailed characteristics of this response. The present study tried to clarify this question. METHODS:VMR was determ...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s00535-015-1070-3

    authors： Nozu T,Kumei S,Miyagishi S,Takakusaki K,Okumura T

    更新日期：2015-12-01 00:00:00

  • Characterization of polyethylene glycol-grafted polyethylenimine and superparamagnetic iron oxide nanoparticles (PEG-g-PEI-SPION) as an MRI-visible vector for siRNA delivery in gastric cancer in vitro and in vivo.

    abstract：BACKGROUND:Gene therapy is a promising therapeutic method but is severely hampered due to its lack of an ideal delivery system. Therefore, in this study, a nonviral and magnetic resonance imaging (MRI) visible vector, polyethylene glycol-grafted polyethylenimine and superparamagnetic iron oxide nanoparticles (PEG-g-PEI...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s00535-012-0713-x

    authors： Chen Y,Lian G,Liao C,Wang W,Zeng L,Qian C,Huang K,Shuai X

    更新日期：2013-07-01 00:00:00

  • Granular cell tumor occurring in the sigmoid colon treated by endoscopic mucosal resection using a transparent cap (EMR-C).

    abstract：:A case of granular cell tumor occurring in the sigmoid colon is reported. The patient, a 56-year-old man, visited our hospital for further evaluation of occult blood in his stool. Endoscopic examination revealed a yellowish, hemispheric submucosal tumor (SMT) with redness, about 6 mm in diameter, in the sigmoid colon....

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章,评审

    doi：10.1007/s005350300068

    authors： Endo S,Hirasaki S,Doi T,Endo H,Nishina T,Moriwaki T,Nakauchi M,Masumoto T,Tanimizu M,Hyodo I

    更新日期：2003-01-01 00:00:00

  • Gastrojejunal fistula caused by gastric ulcer.

    abstract：:We report a case of gastrojejunal fistula caused by benign gastric ulcer, a very rare condition. The patient was an 81-year-old-woman who had had multiple recurrences of gastric ulcer. She also had diabetes mellitus. She was admitted to our hospital because of a left femoral head fracture, necessitating a mechanical b...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章,评审

    doi：10.1007/s005350050081

    authors： Matsuoka M,Yoshida Y,Hayakawa K,Fukuchi S

    更新日期：1998-04-01 00:00:00

  • Deletion of Nrf2 leads to rapid progression of steatohepatitis in mice fed atherogenic plus high-fat diet.

    abstract：BACKGROUND:The transcription factor nuclear factor-E2-related factor-2 (Nrf2) inhibits lipid accumulation and oxidative stress in the liver by interfering with lipogenic pathways and inducing antioxidative stress genes. METHODS:The involvement of Nrf2 in defense against the development of steatohepatitis was studied i...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s00535-012-0659-z

    authors： Okada K,Warabi E,Sugimoto H,Horie M,Gotoh N,Tokushige K,Hashimoto E,Utsunomiya H,Takahashi H,Ishii T,Yamamoto M,Shoda J

    更新日期：2013-05-01 00:00:00

  • Cyclooxygenase, NSAIDs, and colorectal cancer.

    abstract：:Prevention of human diseases has become a major focus of biomedical investigators around the world. Our current screening and treatment regimens for colorectal cancer are not effective, as indicated by the fact that this disease is the second leading cause of death from cancer in the United States. Recently published ...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章,评审

    doi：10.1007/BF02358623

    authors： DuBois RN,Smalley WE

    更新日期：1996-12-01 00:00:00

  • Acetaldehyde accumulation suppresses Kupffer cell release of TNF-Alpha and modifies acute hepatic inflammation in rats.

    abstract：BACKGROUND:Alcohol-related diseases have multiple and varied associations with acetaldehyde, a highly toxic product of ethanol oxidation that accumulates in the absence of active aldehyde dehydrogenase (ALDH). This study was designed to clarify the role of acetaldehyde in liver injury, specifically in vivo and in vitro...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s00535-003-1278-5

    authors： Nakamura Y,Yokoyama H,Higuchi S,Hara S,Kato S,Ishii H

    更新日期：2004-01-01 00:00:00

  • Pancreatic ductal adenocarcinoma associated with Potter type III cystic disease.

    abstract：:Although polycystic liver disease (PLD) is known to be associated with autosomal dominant polycystic kidney disease, a finding of PLD with pancreatic ductal adenocarcinoma is extremely rare. We have experienced one such case of a ductal adenocarcinoma of the pancreas in a patient with Potter type III cystic disease of...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s005350170088

    authors： Sakurai Y,Shoji M,Matsubara T,Ochiai M,Funabiki T,Urano M,Mizoguchi Y,Fuwa N

    更新日期：2001-06-01 00:00:00

  • Biphasic effect of alcohol intake on the development of fatty liver disease.

    abstract：BACKGROUND:Fatty liver is an important clinical feature not only in alcoholic and non-alcoholic fatty liver diseases, but in other chronic liver diseases as well. Our aim was to elucidate the effect and relationship between habitual alcohol intake and obesity in the development of fatty liver disease. METHODS:We enrol...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s00535-015-1058-z

    authors： Takahashi H,Ono M,Hyogo H,Tsuji C,Kitajima Y,Ono N,Eguchi T,Fujimoto K,Chayama K,Saibara T,Anzai K,Eguchi Y

    更新日期：2015-11-01 00:00:00

  • Elevation of interleukin 6 levels in patients with chronic hepatitis due to hepatitis C virus.

    abstract：:Interleukin 6 (IL-6) is a pleiotropic cytokine produced by a wide variety of lymphoid and non-lymphoid tissues. We studied the relationship between IL-6 and the liver in an attempt to elucidate this cytokine's role in hepatitis C-induced liver inflammation. We investigated the behavior of serum IL-6 in 25 patients wit...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/BF02936370

    authors： Malaguarnera M,Di Fazio I,Romeo MA,Restuccia S,Laurino A,Trovato BA

    更新日期：1997-04-01 00:00:00

  • Electronic endoscopy in perspective.

    abstract：:Electronic endoscopy, developed in 1983, enables the endoscopic image to be transmitted through electric signals that can be easily processed by computer. An electronic endoscope is composed of three vital parts, i.e., a charge-coupled device (CCD) that converts the image to electric signals, a video processor that co...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章,评审

    doi：

    authors： Fujino MA,Morozumi A,Nakamura T,Kojima Y,Kawai T,Sato T,Kubo K,Ohtsuka H,Otaka M,Yamamoto Y

    更新日期：1994-07-01 00:00:00

  • The recovery of the PT-INR to less than 1.3 predicts survival in patients with severe acute liver injury.

    abstract：BACKGROUND:Acute liver failure is a potentially fatal disease of various etiologies for which liver transplantation is the only known curative treatment. Although the decision-making on transplantation is largely dependent on the severity of liver injury (based on predicting a fatal outcome), a statistical analysis to ...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s00535-017-1421-3

    authors： Mawatari S,Moriuchi A,Ohba F,Kawano T,Oda K,Takikawa Y,Takikawa H,Ido A,Tsubouchi H

    更新日期：2018-07-01 00:00:00

  • Spontaneous regression of focal nodular hyperplasia of the liver.

    abstract：:Focal nodular hyperplasia (FNH) of the liver is a rare benign lesion that probably reflects a local hyperplastic response of hepatocytes to a vascular abnormality. Currently, the natural history of the disease remains largely unknown. We present a patient with FNH of the liver who was followed up for 4 years. A 22-yea...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s005350200140

    authors： Ohmoto K,Honda T,Hirokawa M,Mitsui Y,Iguchi Y,Kuboki M,Yamamoto S

    更新日期：2002-01-01 00:00:00

  • Living-related partial liver transplantation for decompensated hepatitis B without reactivation of hepatitis B in the following 30 months.

    abstract：:We report a case of living-related partial liver transplantation for decompensated hepatitis B without reactivation of hepatitis B in the following 30 months, and we analyze the factors that indicate a favorable prognosis for transplantation. The 42-year-old female patient received continuously administered lamivudine...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s005350170050

    authors： Hasegawa K,Hashimoto E,Kanai N,Ogawa M,Naritomi T,Taniai M,Takasaki K,Hayashi N

    更新日期：2001-09-01 00:00:00

  • Meta-analysis: the effect of interferon on development of hepatocellular carcinoma in patients with chronic hepatitis B virus infection.

    abstract：PURPOSE:In patients chronically infected with hepatitis B virus, interferon has been used for the purpose of viral suppression by loss of hepatitis B e antigen (HBeAg) with or without seroconversion to antibody to HBeAg (anti-HBe). However, discussion about the effect of interferon on the development of hepatocellular ...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章,meta分析

    doi：10.1007/s00535-009-0024-z

    authors： Miyake Y,Kobashi H,Yamamoto K

    更新日期：2009-01-01 00:00:00

  • p53 codon 72 polymorphism in patients affected with ulcerative colitis.

    abstract：BACKGROUND:The p53 tumor suppressor protein plays a fundamental role in maintaining genomic integrity through its ability to arrest the cell cycle in G1 and induce apoptosis. The proapoptotic activity of p53 seems to be strictly related to proline-rich regions, homologous to the SH3 binding domain. In the literature, r...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s00535-007-2026-z

    authors： Vietri MT,Riegler G,Ursillo A,Caserta L,Cioffi M,Molinari AM

    更新日期：2007-06-01 00:00:00

  • Mutation assay of the novel gene DOG1 in gastrointestinal stromal tumors (GISTs).

    abstract：BACKGROUND:Recently, the novel gene DOG1 has been found to be overexpressed in most gastrointestinal stromal tumors (GISTs) specifically within the field of soft tissue tumors. DOG1 might play a role in development of GISTs and have potential as a diagnostic marker and therapeutic target, but the biological function an...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s00535-008-2195-4

    authors： Miwa S,Nakajima T,Murai Y,Takano Y,Sugiyama T

    更新日期：2008-01-01 00:00:00

  • Early decline of hemoglobin correlates with progression of ribavirin-induced hemolytic anemia during interferon plus ribavirin combination therapy in patients with chronic hepatitis C.

    abstract：BACKGROUND:The aim of this study was to examine the factors correlated with the progression of ribavirin-induced hemolytic anemia in patients with chronic hepatitis C treated by interferon and ribavirin combination therapy. METHODS:This study was conducted on 505 patients by the Osaka Liver Disease Study Group. A decl...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s00535-006-1858-2

    authors： Oze T,Hiramatsu N,Kurashige N,Tsuda N,Yakushijin T,Kanto T,Takehara T,Kasahara A,Kato M,Yoshihara H,Katayama K,Kubota S,Hijioka T,Ishibashi K,Oshita M,Hagiwara H,Haruna Y,Mita E,Tamura S,Hayashi N

    更新日期：2006-09-01 00:00:00

  • Epstein-Barr virus-associated gastric carcinoma in the remnant stomach: de novo and metachronous gastric remnant carcinoma.

    abstract：BACKGROUND:The remnant stomach corresponds to the gastric cardia, but is exposed to a completely different environment. The present study was performed to investigate the role of Epstein-Barr virus (EBV) infection in patients with gastric remnant carcinoma (GRC). METHODS:Clinicopathological features, gastritis, and in...

    journal_title：Journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1007/s00535-005-1590-3

    authors： Kaizaki Y,Hosokawa O,Sakurai S,Fukayama M

    更新日期：2005-06-01 00:00:00