Abstract:
BACKGROUND:Ghrelin is a novel 28-amino-acid peptide isolated from rat and human stomach. This peptide is an endogenous ligand for the growth hormone secretagogue receptor and stimulates the release of growth hormones. Although the principal site of ghrelin synthesis has been reported to be in the stomach, there have been no reports of detailed descriptions of the distribution of ghrelin-immunoreactive cells in the stomach. We examined the distribution of ghrelin-immunoreactive cells in human gastric mucosa. METHODS:We studied the tumor-free mucosa along the lesser curvature in 30 patients with gastric cancer. Sections were stained with hematoxylin and eosin and then subjected to ghrelin immunohistochemistry. The distribution of ghrelin-immunoreactive and parietal cells was studied by continuous cell counting in restricted fields along the lamina muscularis mucosa. RESULTS:Ghrelin-immunoreactive cells were found in all regions, but were distributed mainly in the fundic region. The distribution of ghrelin-immunoreactive cells was positively correlated with that of parietal cells. CONCLUSIONS:The results of this study suggested that the distribution of ghrelin-immunoreactive cells follows that of parietal cells.
journal_name
J Gastroenteroljournal_title
Journal of gastroenterologyauthors
Tanaka-Shintani M,Watanabe Mdoi
10.1007/s00535-004-1550-3subject
Has Abstractpub_date
2005-04-01 00:00:00pages
345-9issue
4eissn
0944-1174issn
1435-5922journal_volume
40pub_type
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