Abstract:
:We investigated the therapeutic effects of egualen sodium (KT1-32), a new antiulcer agent, on chronic erosive and atrophic gastritis induced by 5 months' administration of sodium taurocholate (TCA; 5 mM) in rats. The chronic gastritis was manifested by mucosal surface injuries (erosions), reduced mucosal thickness, reduction of the number of parietal cells, infiltration of inflammatory cells, and proliferation of collagenous fiber. Egualen sodium, (10-100 mg/kg, t.i.d.) administered orally to the rats for 2 weeks after the withdrawal of TCA, dose-dependently and significantly decreased the total length of erosions. The indicators of atrophic gastritis, i.e., reduced mucosal thickness and reduction in the number of parietal cells, were improved dose-dependently by the administration of this agent. Egualen sodium also reduced the inflammatory cell infiltration and the proliferation of collagenous fiber in the gastric mucosa in a dose-dependent manner. The reduced staining of neutral gastric mucus was improved by a high dose (100 mg/kg) of egualen sodium. The therapeutic effects of egualen sodium on experimental gastritis were superior to those of sofalcone and sodium guaiazulene 3-sulfonate. These results suggest that egualen sodium may be a promising agent for the treatment of erosive and atrophic gastritis.
journal_name
J Gastroenteroljournal_title
Journal of gastroenterologyauthors
Mochizuki S,Matsumoto M,Wakabayashi S,Kosakai K,Tomiyama A,Kishimoto Sdoi
10.1007/BF02358603subject
Has Abstractpub_date
1996-12-01 00:00:00pages
785-92issue
6eissn
0944-1174issn
1435-5922journal_volume
31pub_type
杂志文章abstract:BACKGROUND:At clinical scintigraphic examinations of the abdomen using single photon emission computed tomography (SPECT), we have observed a different distribution between the left and right main liver lobes of various radiopharmaceuticals. This was studied retrospectively in clinical patients. METHODS:Examinations w...
journal_title:Journal of gastroenterology
pub_type: 杂志文章
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abstract:BACKGROUND:The (13)C-urea breath test (UBT) is a simple breath test for the diagnosis of Helicobacter pylori infection, but several factors have been reported to affect the results of this test. In this study, the effects of the antiulcer drugs used in Japan on the results of UBT were determined. METHODS:The subjects ...
journal_title:Journal of gastroenterology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2015-04-01 00:00:00
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更新日期:2014-12-01 00:00:00
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journal_title:Journal of gastroenterology
pub_type: 杂志文章,评审
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更新日期:2007-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:1999-08-01 00:00:00
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更新日期:2008-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2006-04-01 00:00:00
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更新日期:2016-03-01 00:00:00
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journal_title:Journal of gastroenterology
pub_type: 杂志文章,meta分析
doi:10.1007/s00535-012-0631-y
更新日期:2013-02-01 00:00:00
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journal_title:Journal of gastroenterology
pub_type: 临床试验,杂志文章
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更新日期:2007-11-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2011-07-01 00:00:00
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journal_title:Journal of gastroenterology
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pub_type: 杂志文章
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更新日期:1994-10-01 00:00:00