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Factors affecting in-hospital mortality in patients with lower gastrointestinal tract bleeding: a retrospective study using a national database in Japan.

Abstract：

BACKGROUND:Bleeding of the lower gastrointestinal tract requires hospitalization and can cause in-hospital death in the most serious cases; however, only a few studies have evaluated in-hospital death from bleeding of the lower gastrointestinal tract. The aim of this study was to investigate the in-hospital mortality of patients with bleeding of the lower gastrointestinal tract and elucidate the factors associated with it using a large-scale database. METHODS:We analyzed a nationwide database in Japan retrospectively. From the Diagnosis Procedure Combination database, we extracted data on patients who were admitted with visible blood in stool between July 1, 2010 and March 31, 2012. We assessed age, sex, comorbidity, cause of bleeding, type of hospital, medications, body mass index (BMI), and need for blood transfusion and treatments. A multivariable logistic regression model was used to examine factors associated with blood transfusion and in-hospital death. RESULTS:A total of 30,846 patients were identified. The median age was 74 years, and 52.0% of patients were male. A total of 782 patients died in hospital (2.5%), and 8,060 patients (26.1%) needed blood transfusion. In a multivariate analysis, in-hospital death was significantly associated with being older or male; comorbidities, including congestive heart failure, renal disease, and mild to severe liver disease; the cause of bleeding; a nonacademic hospital; nonsteroidal anti-inflammatory drug use; lower BMI; and requirements for blood transfusion, interventional radiology, and surgery. Most factors were similarly associated with blood transfusion. CONCLUSIONS:In-hospital mortality was 2.5% and was associated with age, sex, comorbidities, cause of bleeding, type of hospital, nonsteroidal anti-inflammatory drug use, BMI, blood transfusion, and requirements for treatments.

journal_name

J Gastroenterol

journal_title

Journal of gastroenterology

authors

Niikura R,Yasunaga H,Yamaji Y,Horiguchi H,Fushimi K,Yamada A,Hirata Y,Koike K

doi

10.1007/s00535-014-0994-3

subject

Has Abstract

pub_date

2015-05-01 00:00:00

pages

533-40

issue

eissn

0944-1174

issn

1435-5922

journal_volume

pub_type

杂志文章,多中心研究

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Factors affecting in-hospital mortality in patients with lower gastrointestinal tract bleeding: a retrospective study using a national database in Japan.