Isolation of novel mouse genes that were differentially expressed in W/W(V) mouse fundus.

abstract：BACKGROUND:Corticosteroid therapy has been commonly administered to patients with acute liver injury (ALI)/acute liver failure (ALF) in Japan to prevent the development of hepatic encephalopathy, but the appropriate timing to start corticosteroid therapy has not been determined and optimal response evaluation of the th...

journal_title：Journal of gastroenterology

authors： Kakisaka K,Kataoka K,Suzuki Y,Kuroda H,Takikawa Y

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:A prospective, randomized study was performed to determine whether gemcitabine infusion at a low dose (250 mg/m2) is comparable or superior to the standard-dose infusion (1000 mg/m2) in terms of the survival period, clinical benefit, and frequency of adverse effects in patients with advanced pancreatic adeno...

journal_title：Journal of gastroenterology

authors： Sakamoto H,Kitano M,Suetomi Y,Takeyama Y,Ohyanagi H,Nakai T,Yasuda C,Kudo M

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:In Japan, there are few studies of long-term (more than 1 month) interferon (IFN) therapy for chronic hepatitis B (CHB). In this retrospective study, we investigated the efficacy and predictors of response to 6-month IFN therapy. METHODS:We analyzed 66 Japanese patients with CHB who were treated with IFN fo...

journal_title：Journal of gastroenterology

authors： Suzuki F,Arase Y,Akuta N,Tsubota A,Suzuki Y,Sezaki H,Hosaka T,Someya T,Kobayashi M,Saitoh S,Ikeda K,Kobayashi M,Matsuda M,Satoh J,Kumada H

更新日期：2004-10-01 00:00:00

abstract：:The correlation between therapeutic response and liver fibrogenesis was studied in serum and liver specimens taken from 31 patients treated with alpha-interferon (IFN) (14 sustained responders and 17 non-responders) for chronic hepatitis C. Serum samples, collected before therapy, and at further 6-month intervals over...

journal_title：Journal of gastroenterology

authors： Fabris P,Marranconi F,Bozzola L,Biasin MR,De Lazzari F,Plebani M,Benedetti P,Tositti G,Pellizzer G,Stecca C,de Lalla F

更新日期：1999-06-01 00:00:00

abstract：BACKGROUND:Experimental evidence and clinical studies suggest that the renin-angiotensin system and its inhibitors may play a role in regulating the mechanisms of liver fibrosis development. The present study aimed to verify whether carriage of specific angiotensin-converting enzyme (ACE) insertion (I)/deletion (D) all...

journal_title：Journal of gastroenterology

authors： Fabris C,Toniutto P,Bitetto D,Minisini R,Fornasiere E,Smirne C,Pirisi M

更新日期：2007-07-01 00:00:00

abstract：:We reviewed articles on the epidemiology and clinical characteristics of gastroesophageal reflux disease (GERD) in Japan to clarify these features of GERD in this country. Although the definition of GERD depends on the individual study, the prevalence of GERD has been increasing since the end of the 1990s. The reasons...

journal_title：Journal of gastroenterology

authors： Fujiwara Y,Arakawa T

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Studies on the risk of osteoporotic fractures related to the use of proton pump inhibitors (PPIs) have been inconsistent. One recent cohort study reported that there was an interaction between PPIs and bisphosphonates (BPs). Thus we performed a case-control study aimed at evaluating the risk of hip fractures...

journal_title：Journal of gastroenterology

authors： Lee J,Youn K,Choi NK,Lee JH,Kang D,Song HJ,Park BJ

更新日期：2013-09-01 00:00:00

abstract：:A 69-year-old woman was admitted to Hokuso Shiroi Hospital because of recurrent pain in the lower right side of the abdomen. Small-intestinal cancer was strongly suspected after fluoroscopy of the small intestine. Laparotomy showed advanced cancer of the ileum, of complete annular constrictive type, 9.5 x 5cm in size....

journal_title：Journal of gastroenterology

authors： Amano M,Imai Y,Hashimoto T,Saito Y,Miyaoka M,Kawaguchi M,Saito T

更新日期：1998-06-01 00:00:00

abstract：:Gastrointestinal symptoms such as abdominal pain, dyspepsia, and diarrhea are relatively nonspecific and a common cause for seeking medical attention. To date, it is challenging for physicians to differentiate between functional and organic gastrointestinal conditions and it involves the use of serological and endosco...

journal_title：Journal of gastroenterology

authors： Ikhtaire S,Shajib MS,Reinisch W,Khan WI

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:Although pancreatic duct guidewire placement (P-GW) for achieving selective biliary cannulation is reported to be effective in patients in whom endoscopic retrograde cholangiopancreatography (ERCP) is difficult, this technique entails a possible increased risk of post-ERCP pancreatitis. We conducted a prospe...

journal_title：Journal of gastroenterology

authors： Ito K,Fujita N,Noda Y,Kobayashi G,Obana T,Horaguchi J,Takasawa O,Koshita S,Kanno Y,Ogawa T

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND:The p53 tumor suppressor protein plays a fundamental role in maintaining genomic integrity through its ability to arrest the cell cycle in G1 and induce apoptosis. The proapoptotic activity of p53 seems to be strictly related to proline-rich regions, homologous to the SH3 binding domain. In the literature, r...

journal_title：Journal of gastroenterology

authors： Vietri MT,Riegler G,Ursillo A,Caserta L,Cioffi M,Molinari AM

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND:The efficacy, safety, and pharmacokinetics of the combination of three direct-acting antiviral (DAA) agents (adafosbuvir [also known as AL-335], odalasvir, and simeprevir) were investigated in DAA treatment-naïve Japanese patients with genotype (GT)1 or GT2 chronic hepatitis C virus (HCV) infection, with or ...

journal_title：Journal of gastroenterology

authors： Takehara T,Chayama K,Kurosaki M,Yatsuhashi H,Tanaka Y,Hiramatsu N,Sakamoto N,Asahina Y,Nozaki A,Nakano T,Hagiwara Y,Shimizu H,Yoshida H,Huang Y,Biermer M,Vijgen L,Hayashi N

更新日期：2020-06-01 00:00:00

abstract：:An expert meeting was organized by the Swedish and Norwegian Medical Products Agencies in September 1995 in order to review the current literature and opinions on detection and treatment of Helicobacter pylori. Ten people from these Agencies and 23 experts participated in the workshop and all were involved in the fina...

journal_title：Journal of gastroenterology

authors： Unge P

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:Gastric cancer stem cells (CSCs), which require activation of Wnt signaling to maintain their self-renewal and tumorigenicity, are proposed to be critical targets for effective therapy of gastric carcinomas. Gene therapies that are delivered by adenovirus of serotype 5 (Ad5) or chimeric 5/35(Ad5/35) adenovir...

journal_title：Journal of gastroenterology

authors： Wang B,Liu J,Ma LN,Xiao HL,Wang YZ,Li Y,Wang Z,Fan L,Lan C,Yang M,Hu L,Wei Y,Bian XW,Chen D,Wang J

更新日期：2013-07-01 00:00:00

abstract：:Eosinophilic esophagitis (EE) is a rarely diagnosed condition involving eosinophilic infiltration of the esophageal mucosa. Here we present a case of EE in a 69-year-old Japanese man, who presented with abdominal pain, appetite loss, and a history of bronchial asthma. Laboratory findings included peripheral eosinophil...

journal_title：Journal of gastroenterology

authors： Furuta K,Adachi K,Kowari K,Mishima Y,Imaoka H,Kadota C,Koshino K,Miyake T,Kadowaki Y,Furuta K,Kazumori H,Sato S,Ishihara S,Amano Y,Honda M,Kinoshita Y

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND:The causal association between diabetes and pancreatic cancer remains unclear in Asian populations. This study examined whether gallstones, a cholecystectomy, chronic pancreatitis and the treatment of antidiabetic agents affect the risk of subsequent pancreatic cancer for patients with diabetes in a Taiwanes...

journal_title：Journal of gastroenterology

authors： Lai HC,Tsai IJ,Chen PC,Muo CH,Chou JW,Peng CY,Lai SW,Sung FC,Lyu SY,Morisky DE

更新日期：2013-06-01 00:00:00

abstract：:Anomalous arrangement of the pancreaticobiliary ductal system (AAPB), a congenital anomaly defined as a union of the pancreatic and biliary ducts located outside the duodenal wall, is a newly designated disease entity, and is frequently found in adult patients with gallbladder carcinoma (GBX). In the present study, th...

journal_title：Journal of gastroenterology

authors： Yang Y,Fujii H,Matsumoto Y,Suzuki K,Kawaoi A,Suda K

更新日期：1997-12-01 00:00:00

abstract：:A case of Dieulafoy's vascular malformation of the jejunum treated by laparoscopic surgery is described. The patient was a 31-year-old-woman who had complained of melena and had severe anemia needing blood transfusion. Angiography revealed microaneurysms and hypervascularity of the jejunum in the area between the firs...

journal_title：Journal of gastroenterology

authors： Mino A,Ogawa Y,Ishikawa T,Uchima Y,Yamazaki M,Nakamura S,Yukawa T,Matsumoto T,Arakawa T,Hirakawa K

更新日期：2004-01-01 00:00:00

abstract：PURPOSE:In patients chronically infected with hepatitis B virus, interferon has been used for the purpose of viral suppression by loss of hepatitis B e antigen (HBeAg) with or without seroconversion to antibody to HBeAg (anti-HBe). However, discussion about the effect of interferon on the development of hepatocellular ...

journal_title：Journal of gastroenterology

authors： Miyake Y,Kobashi H,Yamamoto K

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND AND AIM:Mac-2 Binding Protein Glycosylation Isomer (M2BPGi) is a novel fibrosis marker. We examined the ability of M2BPGi to predict liver fibrosis in patients with biliary atresia. METHODS:Sixty-four patients who underwent living donor liver transplantation (LDLT) were included [median age, 1.1 years (rang...

journal_title：Journal of gastroenterology

authors： Yamada N,Sanada Y,Tashiro M,Hirata Y,Okada N,Ihara Y,Urahashi T,Mizuta K

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Rice extract has been shown to protect gastric mucosa from stress-induced damage. In this study, the antibiotic effect and the anti-inflammatory effect of orally administered aqueous rice extract on Helicobacter pylori infection and H. pylori-induced gastritis, respectively, in Mongolian gerbils were investi...

journal_title：Journal of gastroenterology

authors： Murakami M,Ota H,Sugiyama A,Ishizone S,Maruta F,Akita N,Okimura Y,Kumagai T,Jo M,Tokuyama T

更新日期：2005-05-01 00:00:00

abstract：:Focal nodular hyperplasia (FNH) of the liver is a rare benign lesion that probably reflects a local hyperplastic response of hepatocytes to a vascular abnormality. Currently, the natural history of the disease remains largely unknown. We present a patient with FNH of the liver who was followed up for 4 years. A 22-yea...

journal_title：Journal of gastroenterology

authors： Ohmoto K,Honda T,Hirokawa M,Mitsui Y,Iguchi Y,Kuboki M,Yamamoto S

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Neutrophil elastase (NE) is a major secretory product from activated neutrophils and a major contributor to tissue destruction. However, little is known about the pathogenic contribution of NE to ulcerative colitis (UC). This study was designed to investigate the contribution of NE by measuring NE activity i...

journal_title：Journal of gastroenterology

authors： Morohoshi Y,Matsuoka K,Chinen H,Kamada N,Sato T,Hisamatsu T,Okamoto S,Inoue N,Takaishi H,Ogata H,Iwao Y,Hibi T

更新日期：2006-04-01 00:00:00

abstract：:Cyclin D1 overexpression is remarkably frequent in several human carcinomas and is believed to be a critical event in oncogenesis. We examined cyclin D1 expression, p53 expression, and the Ki-67 labeling index by immunostaining in human gallbladder mucosa in conditions varying from normal to malignant tissue. We also ...

journal_title：Journal of gastroenterology

authors： Itoi T,Shinohara Y,Takeda K,Nakamura K,Takei K,Sanada J,Horibe T,Saito T,Kasuya K,Ebihara Y

更新日期：2000-01-01 00:00:00

abstract：:Post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis is the most frequent complication of ERCP. Several meta-analyses have examined the effects of protease inhibitors (gabexate mesilate, ulinastatin, and nafamostat mesilate) and non-steroidal anti-inflammatory drugs (NSAIDs) on post-ERCP pancreatiti...

journal_title：Journal of gastroenterology

authors： Yuhara H,Ogawa M,Kawaguchi Y,Igarashi M,Shimosegawa T,Mine T

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:The T-helper (Th)1 immune reaction is essential for the eradication of hepatitis C virus (HCV) during interferon (IFN) therapy in patients with chronic hepatitis C. Osteopontin is a cytokine crucial for the initiation of the Th1 response. Recently, we identified four single-nucleotide polymorphisms (SNPs) in...

journal_title：Journal of gastroenterology

authors： Naito M,Matsui A,Inao M,Nagoshi S,Nagano M,Ito N,Egashira T,Hashimoto M,Mishiro S,Mochida S,Fujiwara K

更新日期：2005-04-01 00:00:00

abstract：BACKGROUND:Acute liver failure is a potentially fatal disease of various etiologies for which liver transplantation is the only known curative treatment. Although the decision-making on transplantation is largely dependent on the severity of liver injury (based on predicting a fatal outcome), a statistical analysis to ...

journal_title：Journal of gastroenterology

authors： Mawatari S,Moriuchi A,Ohba F,Kawano T,Oda K,Takikawa Y,Takikawa H,Ido A,Tsubouchi H

更新日期：2018-07-01 00:00:00

abstract：:As an increase in gastroesophageal reflux disease (GERD) has been reported in Japan, and public interest in GERD has been increasing, the Japanese Society of Gastroenterology published the Evidence-based Clinical Practice Guidelines for GERD (1st edition) in 2009. Six years have passed since its publication, and there...

journal_title：Journal of gastroenterology

authors： Iwakiri K,Kinoshita Y,Habu Y,Oshima T,Manabe N,Fujiwara Y,Nagahara A,Kawamura O,Iwakiri R,Ozawa S,Ashida K,Ohara S,Kashiwagi H,Adachi K,Higuchi K,Miwa H,Fujimoto K,Kusano M,Hoshihara Y,Kawano T,Haruma K,Hongo M

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:NADPH oxidase 1 (Nox1) is preferentially expressed in the colon, but its functional role is not fully understood. This study was designed to elucidate a potential role of Nox1 in inflammation of the colon. METHODS:Superoxide production by T84 cells was measured by the cytochrome c method. Protein and mRNA l...

journal_title：Journal of gastroenterology

authors： Kamizato M,Nishida K,Masuda K,Takeo K,Yamamoto Y,Kawai T,Teshima-Kondo S,Tanahashi T,Rokutan K

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Helicobacter pylori infection is associated not only with gastroduodenal ulcers but with the development of gastric cancer. Interleukin-1 beta (IL-1 beta) is a potent inhibitor of gastric secretion. The -31 C-to-T base transition in the intron of this gene has been reported to be involved in carcinogenic cha...

journal_title：Journal of gastroenterology

authors： Kato S,Onda M,Yamada S,Matsuda N,Tokunaga A,Matsukura N

更新日期：2001-10-01 00:00:00