Chemotaxis and motility of Helicobacter pylori in a viscous environment.

abstract：:This paper describes a program of research undertaken by the Inflammatory Bowel Disease Study Group at the Royal Free Hospital School of Medicine. The Group has tested the hypothesis that the primary pathological abnormality in Crohn's disease is in the mesenteric blood supply. The first experiments involved microcorr...

journal_title：Journal of gastroenterology

authors： Pounder RE

更新日期：1994-07-01 00:00:00

abstract：BACKGROUND:Anemia of inflammation, commonly observed in patients with chronic diseases, is associated with decreased serum iron. Hepcidin, mainly produced by hepatocytes in a STAT3- and/or SMAD-dependent manner, is involved in iron homeostasis. What remains to be established is whether or not the hepatic IL-6/STAT3 sig...

journal_title：Journal of gastroenterology

authors： Sakamori R,Takehara T,Tatsumi T,Shigekawa M,Hikita H,Hiramatsu N,Kanto T,Hayashi N

更新日期：2010-02-01 00:00:00

abstract：:Reducing the incidence of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B (CHB) is the key ultimate goal set in essentially all treatment guidelines. There has been solid evidence supporting the relationship between serum hepatitis B virus (HBV) DNA level and risk of HCC. Antiviral treatment with o...

journal_title：Journal of gastroenterology

authors： Yip TC,Lai JC,Wong GL

更新日期：2020-11-01 00:00:00

abstract：:Sixty-two colorectal adenomas 10 mm or less in diameter, resected endoscopically and fixed in formalin for 3 days or less, were evaluated with antiproliferating cell nuclear antigen/cyclin (PCNA) monoclonal antibody to investigate the cell proliferation kinetics. All lesions were tubular adenoma with low-grade atypia....

journal_title：Journal of gastroenterology

authors： Kobayashi M,Watanabe H,Ajioka Y,Honma T,Asakura H

更新日期：1994-04-01 00:00:00

abstract：BACKGROUND:We recently reported the efficacy of indigo naturalis (IN) in patients with active ulcerative colitis (UC) in a randomized controlled trial (INDIGO study). However, few studies have been conducted to investigate whether IN is effective even in treatment-refractory cases, such as in those with steroid depende...

journal_title：Journal of gastroenterology

authors： Naganuma M,Sugimoto S,Fukuda T,Mitsuyama K,Kobayashi T,Yoshimura N,Ohi H,Tanaka S,Andoh A,Ohmiya N,Saigusa K,Yamamoto T,Morohoshi Y,Ichikawa H,Matsuoka K,Hisamatsu T,Watanabe K,Mizuno S,Abe T,Suzuki Y,Kanai T,IN

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:Subepithelial myofibroblasts (SEMFs) play a role in extracellular matrix (ECM) metabolism in the colon. In this study, we investigated the effects of interleukin (IL)-17, IL-1beta, and tumor necrosis factor (TNF)-alpha on matrix metalloproteinase (MMP)-3 secretion in colonic SEMFs. METHODS:MMP-3 secretion a...

journal_title：Journal of gastroenterology

authors： Bamba S,Andoh A,Yasui H,Araki Y,Bamba T,Fujiyama Y

更新日期：2003-01-01 00:00:00

abstract：:Patients with longstanding extensive colitis, both ulcerative colitis and Crohn's colitis, have an increased risk of developing colorectal cancer. Because of this risk, colonoscopic surveillance for neoplasia is recommended by most authorities. Although there has been no randomised controlled trial to demonstrate surv...

journal_title：Journal of gastroenterology

authors： Rutter MD

更新日期：2011-01-01 00:00:00

abstract：:Human glucagonoma cells were isolated and maintained in vitro. Incubation experiments showed that carbachol (Cch) induced the simultaneous release of glucagon, VIP (vasoactive intestinal polypeptide), and pancreatic polypeptide (PP) at levels significantly higher than basal levels. Atropine abolished the stimulatory e...

journal_title：Journal of gastroenterology

authors： Funakoshi A,Yasunami Y,Ryu S,Shinozaki H,Jimi A,Ikeda S

更新日期：1994-12-01 00:00:00

abstract：BACKGROUND:The (13)C-urea breath test (UBT) is a simple breath test for the diagnosis of Helicobacter pylori infection, but several factors have been reported to affect the results of this test. In this study, the effects of the antiulcer drugs used in Japan on the results of UBT were determined. METHODS:The subjects ...

journal_title：Journal of gastroenterology

authors： Murakami K,Sato R,Okimoto T,Watanabe K,Nasu M,Fujioka T,Kodama M,Kagawa J

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:The efficacy, safety, and pharmacokinetics of the combination of three direct-acting antiviral (DAA) agents (adafosbuvir [also known as AL-335], odalasvir, and simeprevir) were investigated in DAA treatment-naïve Japanese patients with genotype (GT)1 or GT2 chronic hepatitis C virus (HCV) infection, with or ...

journal_title：Journal of gastroenterology

authors： Takehara T,Chayama K,Kurosaki M,Yatsuhashi H,Tanaka Y,Hiramatsu N,Sakamoto N,Asahina Y,Nozaki A,Nakano T,Hagiwara Y,Shimizu H,Yoshida H,Huang Y,Biermer M,Vijgen L,Hayashi N

更新日期：2020-06-01 00:00:00

abstract：:Focal nodular hyperplasia (FNH) is a benign lesion of the liver which usually presents with one or two localizations. We report a patient with history of resection of a biliary cyst, and who had been taking oral contraceptives for the past 18 years, who had multiple localizations of FNH (more than 30 lesions). The lar...

journal_title：Journal of gastroenterology

authors： Colle I,de Beeck BO,Hoorens A,Hautekeete M

更新日期：1998-12-01 00:00:00

abstract：:We measured urokinase-type plasminogen activator (u-PA) plasma levels in patients with various chronic liver diseases, including hepatocellular carcinoma (HCC), also measuring these levels in healthy volunteers. Plasma u-PA levels in the group of patients with decompensated liver cirrhosis (mean modified Pugh score of...

journal_title：Journal of gastroenterology

authors： Sato S,Higashi T,Ouguchi S,Hino N,Tsuji T

更新日期：1994-12-01 00:00:00

abstract：:Chronic inflammatory bowel disease (IBD) is an important etiologic factor in the development of colorectal cancer. However, the mechanism underlying the development of colorectal cancers through chronic inflammation is not known. Activation-induced cytidine deaminase (AID) was originally identified as an inducer of so...

journal_title：Journal of gastroenterology

authors： Endo Y,Marusawa H,Chiba T

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Cytotoxin-associated gene A (CagA) product is a bacterial virulence factor contributing to the pathogenicity of Helicobacter pylori (HP) infection in humans. Host factors, which vary in different countries, interact with bacterial factors to determine the disease state. Our objective was to investigate the f...

journal_title：Journal of gastroenterology

authors： Sökücü S,Ozden AT,Süoğlu OD,Elkabes B,Demir F,Cevikbaş U,Gökçe S,Saner G

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND:In this study, to clarify whether Helicobacter pylori eradication alters the course of the development of gastric mucosal changes in the stomach, we examined the long-term effects of H. pylori eradication on H. pylori-inoculated gerbils. METHODS:A total of 40 H. pylori-inoculated gerbils were randomized and...

journal_title：Journal of gastroenterology

authors： Hirayama F,Takagi S,Yokoyama Y,Yamamoto K,Iwao E,Haga K

更新日期：2002-01-01 00:00:00

abstract：:In the original publication of the article, the following errors were noted and corrected in this correction. ...

journal_title：Journal of gastroenterology

authors： Koterazawa Y,Koyanagi-Aoi M,Uehara K,Kakeji Y,Aoi T

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:The risk for lymph node metastasis and the prognostic significance of pedunculated-type T1 colorectal carcinomas (CRCs) require further study. We aimed to assess the validity of the 2014 Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines based on long-term outcomes of pedunculated-type T1...

journal_title：Journal of gastroenterology

authors： Asayama N,Oka S,Tanaka S,Nagata S,Furudoi A,Kuwai T,Onogawa S,Tamura T,Kanao H,Hiraga Y,Okanobu H,Kuwabara T,Kunihiro M,Mukai S,Goto E,Shimamoto F,Chayama K

更新日期：2016-07-01 00:00:00

abstract：:Magnetic resonance imaging (MRI) findings in three patients with primary anorectal malignant melanoma are described. Two patients had melanotic and one had amelanotic anorectal melanoma. The findings of MRI with a pelvic coil and an endorectal coil were consistent with pathologic findings. MRI with a pelvic coil demon...

journal_title：Journal of gastroenterology

authors： Matsuoka H,Nakamura A,Iwamoto K,Sugiyama M,Hachiya J,Atomi Y,Masaki T

更新日期：2005-08-01 00:00:00

abstract：BACKGROUND:A combination of hepatitis B immunoglobulin and nucleos(t)ide analogues is the current standard of care for controlling hepatitis B recurrence after orthotopic liver transplantation (OLT). However, frequent immunoglobulin treatment is expensive and inconvenient. This study investigated the efficacy of hepati...

journal_title：Journal of gastroenterology

authors： Takaki A,Yagi T,Yasunaka T,Sadamori H,Shinoura S,Umeda Y,Yoshida R,Sato D,Nobuoka D,Utsumi M,Yasuda Y,Nakayama E,Miyake Y,Ikeda F,Shiraha H,Nouso K,Fujiwara T,Yamamoto K

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Endoscopic sphincterotomy (ES) is widely performed in patients with common bile duct stones (CBDS). However, the long-term outcomes of patients following ES have not been sufficiently elucidated. Impaired papillary function following ES may result in additional late complications. In contrast, endoscopic pap...

journal_title：Journal of gastroenterology

authors： Doi S,Yasuda I,Mukai T,Iwashita T,Uemura S,Yamauchi T,Nakashima M,Adachi S,Shimizu M,Tomita E,Itoi T,Moriwaki H

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Endotoxin modulates esophageal motor function by increasing nitric oxide (NO) production. The aims of this study were to examine inducible nitric oxide synthase (iNOS) induction in the lower esophageal sphincter (LES) of endotoxemic opossums and to investigate the effects of aminoguanidine (AG), a selective ...

journal_title：Journal of gastroenterology

authors： Park H,Clark E,Cullen JJ,Koland JG,Kim MS,Conklin JL

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Crohn's disease (CD) and ulcerative colitis (UC) are two major forms of inflammatory bowel disease (IBD). Meta-analyses of genome-wide association studies (GWAS) have identified 163 susceptibility loci for IBD among European populations; however, there is limited information for IBD susceptibility in a Japan...

journal_title：Journal of gastroenterology

authors： Fuyuno Y,Yamazaki K,Takahashi A,Esaki M,Kawaguchi T,Takazoe M,Matsumoto T,Matsui T,Tanaka H,Motoya S,Suzuki Y,Kiyohara Y,Kitazono T,Kubo M

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:We examined the effects of cholecystokinin (CCK) on the development of ethionine-induced pancreatitis and pancreatic recovery. We used Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a model lacking pancreatic CCK-A receptor gene expression. METHODS:Ethionine-induced pancreatitis was induced in the 7-week-o...

journal_title：Journal of gastroenterology

authors： Sato T,Niikawa J,Usui I,Imamura T,Yoshida H,Tanaka S,Mitamura K

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Subunit A of coagulation factor XIII (FXIII-A) is important for clot stability and acts in the subsequent wound healing process. Loss of plasma FXIII-A has been reported after surgery, sepsis, and inflammatory conditions. In the intestinal mucosa, FXIII-A is expressed by macrophages and cellular FXIII-A has ...

journal_title：Journal of gastroenterology

authors： Soendergaard C,Kvist PH,Seidelin JB,Pelzer H,Nielsen OH

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:Aberrant methylation of some cancer-related genes has been reported to correlate with sensitivity to chemotherapeutic agents. The present study was designed to determine whether DNA methylation in six cancer-related genes affects recurrence of gastric cancer in patients who received 5-fluorouracil-based adju...

journal_title：Journal of gastroenterology

authors： Mitsuno M,Kitajima Y,Ide T,Ohtaka K,Tanaka M,Satoh S,Miyazaki K

更新日期：2007-11-01 00:00:00

abstract：:Although stomal varices are a rare complication, bleeding stomal varices often need to be treated owing to symptoms of hypovolemic shock, recurrence of stomal bleeding, or deterioration in the quality of life. Various treatment strategies for the management of bleeding stomal varices have thus far been reported. We re...

journal_title：Journal of gastroenterology

authors： Minami S,Okada K,Matsuo M,Kamohara Y,Sakamoto I,Kanematsu T

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Acute liver failure is a potentially fatal disease of various etiologies for which liver transplantation is the only known curative treatment. Although the decision-making on transplantation is largely dependent on the severity of liver injury (based on predicting a fatal outcome), a statistical analysis to ...

journal_title：Journal of gastroenterology

authors： Mawatari S,Moriuchi A,Ohba F,Kawano T,Oda K,Takikawa Y,Takikawa H,Ido A,Tsubouchi H

更新日期：2018-07-01 00:00:00

abstract：:Eosinophilic esophagitis (EE) is a rarely diagnosed condition involving eosinophilic infiltration of the esophageal mucosa. Here we present a case of EE in a 69-year-old Japanese man, who presented with abdominal pain, appetite loss, and a history of bronchial asthma. Laboratory findings included peripheral eosinophil...

journal_title：Journal of gastroenterology

authors： Furuta K,Adachi K,Kowari K,Mishima Y,Imaoka H,Kadota C,Koshino K,Miyake T,Kadowaki Y,Furuta K,Kazumori H,Sato S,Ishihara S,Amano Y,Honda M,Kinoshita Y

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND:Photodynamic therapy (PDT) has not been reported for human hepatoma, because cancer cells only weakly take up the photosensitizer. Indocyanine green (ICG) is a photosensitizer normally excreted into the bile, and bile excretion is impaired in human hepatomas. We examined whether human hepatoma cell lines pre...

journal_title：Journal of gastroenterology

authors： Kaneko J,Inagaki Y,Ishizawa T,Gao J,Tang W,Aoki T,Sakamoto Y,Hasegawa K,Sugawara Y,Kokudo N

更新日期：2014-01-01 00:00:00

abstract：:We present herein a case of a 75-year-old Japanese man who had developed a pancreatic abscess 7 years after a longitudinal pancreatojejunostomy for chronic pancreatitis. The patient, a heavy drinker of alcohol, underwent surgical decompression of a ductal obstruction to relieve persistent abdominal pain due to severel...

journal_title：Journal of gastroenterology

authors： Suzuki A,Matsunaga T,Aoki S,Hirayama T,Nakagawa N,Shibata K,Yabana T,Kawasaki H,Takasaka H,Sasaki K,Katsuramaki T,Mukaiya M,Hirata K,Imai K

更新日期：2002-01-01 00:00:00