Abstract:
:We successfully treated a 46-year-old narcoleptic woman suffering from atypical depression with bupropion hydrochloride. Diagnostic evaluation revealed a Beck Depression Inventory (BDI) score of 24, a short nocturnal REM-sleep latency, subjective and objective sleepiness (mean sleep latency (MSL) = 1.8 minutes), and three sleep onset REM-sleep periods during the five nap multiple sleep latency test. Bupropion (100 mg t.i.d.) normalized her mood (BDI = 6), sleepiness (MSL = 9.1 minutes), and REM-sleep propensity. Upon discontinuation of bupropion, these parameters reverted to pretreatment levels. This "activating" antidepressant's reversal of the sleepiness and REM-sleep propensity in narcolepsy may be due to blockade of dopamine or norepinephrine reuptake. Clinicians need to be alert to the fact that depression can mask the diagnosis of narcolepsy. Bupropion warrants further investigation as a treatment for narcolepsy in an open-label, double-blind, placebo-controlled paradigm.
journal_name
Depress Anxietyjournal_title
Depression and anxietyauthors
Rye DB,Dihenia B,Bliwise DLsubject
Has Abstractpub_date
1998-01-01 00:00:00pages
92-5issue
2eissn
1091-4269issn
1520-6394pii
10.1002/(SICI)1520-6394(1998)7:2<92::AID-DA9>3.0.Cjournal_volume
7pub_type
杂志文章abstract::Paruresis is characterized by the fear of not being able to urinate in public bathrooms and has been classified by some to be a sub-type of social anxiety disorder (social phobia). Despite the existence of a consumer advocacy organization, the "Intentional Paruresis Association (www.paruresis.org)," there is sparse li...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.10061
更新日期:2002-01-01 00:00:00
abstract::Ninety-three patients, including 47 patients with Generalized Anxiety Disorder (GAD) and 46 patients with Major Depression (MD), were entered into recent clinical trials. Clinicians acknowledge that during the initial screening process, clear separation between depressed and anxious patients may be difficult. By using...
journal_title:Depression and anxiety
pub_type: 临床试验,杂志文章
doi:
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND:Oligodendrocyte transcription factor 2 (OLIG2) is primarily concentrated in the brain and spinal cord ventricular zone, where this protein stimulates oligodendrocytes and specific neurons, determines motor neuron and oligodendrocyte differentiation, and sustains replication in early development. Recent studi...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22394
更新日期:2015-10-01 00:00:00
abstract::The P1 midlatency auditory evoked potential was studied in female rape victims with Posttraumatic Stress Disorder (PTSD) and compared to an age-matched female control group; and in male combat veterans with PTSD and compared to three groups of age-matched male control subjects. Sensory gating of the P1 potential was d...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/(sici)1520-6394(1999)9:3<122::aid-da4>3.0.
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND:Patients with obsessive-compulsive disorder (OCD) experience abnormally high levels of uncertainty, and unpredictability is evaluated negatively and not well tolerated. The current study examined neural correlates of attentional processing in response to experimentally induced uncertainty in OCD. METHODS:Tw...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22655
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND:Whether psychological resilience correlates with neurocognitive performance is largely unknown. Therefore, we assessed association between neurocognitive performance and resilience in individuals with a history of childhood abuse or trauma exposure. METHODS:In this cross-sectional study of 226 highly trauma...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20675
更新日期:2010-08-01 00:00:00
abstract:BACKGROUND:The aim of this study was to examine the prospective relationship between a history of attention-deficit/hyperactivity disorder (ADHD) assessed in mid-adolescence and the onset of major depressive disorder (MDD) through early adulthood in a large school-based sample. A secondary aim was to examine whether th...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22082
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND:A history of past major depressive episodes (MDEs) is known to be a risk factor for future MDEs. Additional information about the relationship between past and future episodes would be useful in clinical practice, it is therefore important to fully understand the epidemiology of major depression. We asked wh...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22173
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Evidence-based treatments for post-traumatic stress disorder (PTSD) have poor uptake and remission rates, suggesting that alternative treatments are needed. Morning bright light may be an effective treatment for PTSD given its established effects on mood and sleep, however, there are no published trials. ME...
journal_title:Depression and anxiety
pub_type: 杂志文章,随机对照试验
doi:10.1002/da.22897
更新日期:2019-07-01 00:00:00
abstract:OBJECTIVES:Comparing the overall and differential effects of psychodynamic psychotherapy (PDT) versus cognitive behavior therapy (CBT) for social anxiety disorder (SAD). DESIGN:Patients with a primary SAD (N = 47) were randomly assigned to PDT (N = 22) or CBT (N = 27). Both PDT and CBT consisted of up to 36 sessions (...
journal_title:Depression and anxiety
pub_type: 杂志文章,随机对照试验
doi:10.1002/da.22246
更新日期:2014-05-01 00:00:00
abstract::Current consensus on the treatment of obsessive-compulsive disorder (OCD) includes cognitive behavior therapy (CBT) in the form of exposure and response prevention (ERP). However, the generalizability of these methods to elderly populations remains largely undocumented. This clinical case study examines the effectiven...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.10024
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:Although losses are important consequences of disasters, few epidemiological studies of disasters have assessed complicated grief (CG) and none assessed CG associated with losses other than death of loved one. METHODS:Data come from the baseline survey of the Hurricane Katrina Community Advisory Group, a re...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20865
更新日期:2011-08-01 00:00:00
abstract::The purpose of this study was to correlate subjective sleep characteristics based on questionnaire response, and objective sleep EEG features based on polysomnography, in 52 patients with major depressive disorders (MDD) and 49 healthy controls. With the exception of the number of awakenings, subjective and objective ...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/(sici)1520-6394(1997)5:2<97::aid-da6>3.0.c
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:The significance of the timing and chronicity of childhood adversity for depression outcomes later in life is unclear. Identifying trajectories of adversity throughout childhood would allow classification of children according to the accumulation, timing, and persistence of adversity, and may provide unique ...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22887
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:Although diagnostically dissociable, anxiety is strongly co-morbid with depression. To examine further the clinical symptoms of anxiety in major depressive disorder (MDD), a non-parametric item response analysis on "blinded" data from four pharmaceutical company clinical trials was performed on the Hamilton ...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20435
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Depression outcomes in research and clinical practice are commonly defined by the concepts of remission, recovery, relapse, and recurrence. Despite their widespread use, there has been little empirical examination of these concepts. Therefore, we investigated profiles of individual symptoms during each of th...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.21960
更新日期:2012-07-01 00:00:00
abstract:BACKGROUND:Amygdala-prefrontal cortex (PFC) functional connectivity may be influenced by anxiety and development. A prior study on anxiety found age-specific dysfunction in the ventromedial PFC (vmPFC), but not amygdala, associated with threat-safety discrimination during extinction recall (Britton et al.). However, tr...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22470
更新日期:2016-10-01 00:00:00
abstract::Dopamine D(2) receptor availability in the striatum has been reported to be low in generalized social anxiety disorder (GSAD) and obsessive-compulsive disorder (OCD), but it has not been studied in persons with comorbid OCD and GSAD (OCD+GSAD). D(2) receptor availability was assessed in 7 subjects with OCD+GSAD, 8 wit...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20268
更新日期:2008-01-01 00:00:00
abstract::Effective treatment of severe or chronic unipolar depression requires the combination of pharmacological and psychotherapeutic interventions, and demands a theoretical paradigm integrating biological and psychosocial aspects of depression. Supported by recent research, we propose in our article a biopsychosocial diath...
journal_title:Depression and anxiety
pub_type: 杂志文章,评审
doi:10.1002/da.20177
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Previous work has shown that inhibition of fear is impaired in posttraumatic stress disorder (PTSD) resulting from both civilian and combat trauma. The purpose of the present study was to investigate the inhibition of learned fear in traumatized individuals diagnosed with either acute stress disorder (ASD) o...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.21991
更新日期:2013-03-01 00:00:00
abstract:BACKGROUND:Controversy surrounds the question of whether agoraphobia (AG) exists as an independent diagnostic entity apart from panic. In favor of this position, AG without panic disorder (PD) in parents was found being unrelated to offsprings' risk for AG or PD, albeit it may enhance the familial transmission of PD (N...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.21975
更新日期:2012-11-01 00:00:00
abstract::Memory function was studied in combat veterans with posttraumatic stress disorder (PTSD), combat veterans without PTSD, and noncombat veterans. The Vocabulary and Digit Span subtests of the WAIS and Logical Memory (LMS) and Verbal Paired Associates (VPAS) subtests of the Wechsler Memory Scale III were administered. Co...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20291
更新日期:2008-01-01 00:00:00
abstract::Experimental evidence suggests that panic disorder is characterized by abnormalities in the balance system function and that these abnormalities might be related to the severity of agoraphobic avoidance. Since the balance system can be modulated by the serotonergic system, we investigated the effect of a 6-week treatm...
journal_title:Depression and anxiety
pub_type: 临床试验,杂志文章
doi:10.1002/da.10092
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:Increased psychophysiological reactivity is a hallmark intermediate phenotype of posttraumatic stress disorder (PTSD). Individuals with PTSD exhibit greater skin conductance (SC) responses to trauma scripts than trauma survivors without PTSD. However, trauma scripts require time for development and cannot be...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22610
更新日期:2017-06-01 00:00:00
abstract::This study examined the validity of the Assessment of Depression Inventory (ADI), a 39-item measure of depression with three embedded validity scales, using inpatient participants. The ADI Depression (Dep) and Feigning (Fg) scales were compared to the corresponding scales of a widely used multiscale instrument, the Pe...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20183
更新日期:2006-01-01 00:00:00
abstract::This study aimed to assess the effects of anisomycin, a protein synthesis inhibitor, on behavioral responses, brain-derived neurotrophic factor (BDNF) and TrkB mRNA levels, and circulating corticosterone in rats-when administered before or after initial exposure to a predator scent stress stimulus. Magnitude of change...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20366
更新日期:2008-01-01 00:00:00
abstract::Increasing attention has been paid to the role of inflammation in a host of illnesses including neuropsychiatric disorders such as depression and anxiety. Activation of the inflammatory response leads to release of inflammatory cytokines and mobilization of immune cells both of which have been shown to access the brai...
journal_title:Depression and anxiety
pub_type: 杂志文章,评审
doi:10.1002/da.22084
更新日期:2013-04-01 00:00:00
abstract:OBJECTIVE:Exposure and response prevention (ERP) is an effective treatment for individuals with obsessive-compulsive disorder (OCD), yet a substantial number of individuals with OCD do not fully respond to this intervention. Based on emerging experimental and clinical research on acceptance, this study sought to explor...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22672
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND:Transdiagnostic cognitive-behavioral treatments for anxiety disorders have been gaining increased attention and empirical study in recent years. Despite this, research on transdiagnostic anxiety treatments has, to date, relied on open trials, or comparisons to waitlist conditions, published benchmarks, or re...
journal_title:Depression and anxiety
pub_type: 杂志文章,随机对照试验
doi:10.1002/da.21974
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND:In previous reports from the Rhode Island Methods to Improve Diagnostic Assessment and Services project, we developed a briefer definition of major depressive disorder (MDD), and found high levels of agreement between the simplified and DSM-IV definitions of MDD. The goal of the present study was to examine ...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20710
更新日期:2010-10-01 00:00:00