Reversal of atypical depression, sleepiness, and REM-sleep propensity in narcolepsy with bupropion.

Abstract:

:We successfully treated a 46-year-old narcoleptic woman suffering from atypical depression with bupropion hydrochloride. Diagnostic evaluation revealed a Beck Depression Inventory (BDI) score of 24, a short nocturnal REM-sleep latency, subjective and objective sleepiness (mean sleep latency (MSL) = 1.8 minutes), and three sleep onset REM-sleep periods during the five nap multiple sleep latency test. Bupropion (100 mg t.i.d.) normalized her mood (BDI = 6), sleepiness (MSL = 9.1 minutes), and REM-sleep propensity. Upon discontinuation of bupropion, these parameters reverted to pretreatment levels. This "activating" antidepressant's reversal of the sleepiness and REM-sleep propensity in narcolepsy may be due to blockade of dopamine or norepinephrine reuptake. Clinicians need to be alert to the fact that depression can mask the diagnosis of narcolepsy. Bupropion warrants further investigation as a treatment for narcolepsy in an open-label, double-blind, placebo-controlled paradigm.

journal_name

Depress Anxiety

journal_title

Depression and anxiety

authors

Rye DB,Dihenia B,Bliwise DL

subject

Has Abstract

pub_date

1998-01-01 00:00:00

pages

92-5

issue

2

eissn

1091-4269

issn

1520-6394

pii

10.1002/(SICI)1520-6394(1998)7:2<92::AID-DA9>3.0.C

journal_volume

7

pub_type

杂志文章
  • Is "shy bladder syndrome" a subtype of social anxiety disorder? A survey of people with paruresis.

    abstract::Paruresis is characterized by the fear of not being able to urinate in public bathrooms and has been classified by some to be a sub-type of social anxiety disorder (social phobia). Despite the existence of a consumer advocacy organization, the "Intentional Paruresis Association (www.paruresis.org)," there is sparse li...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.10061

    authors: Vythilingum B,Stein DJ,Soifer S

    更新日期:2002-01-01 00:00:00

  • Millon multiaxial personality patterns differentiate depressed and anxious outpatients.

    abstract::Ninety-three patients, including 47 patients with Generalized Anxiety Disorder (GAD) and 46 patients with Major Depression (MD), were entered into recent clinical trials. Clinicians acknowledge that during the initial screening process, clear separation between depressed and anxious patients may be difficult. By using...

    journal_title:Depression and anxiety

    pub_type: 临床试验,杂志文章

    doi:

    authors: Freeman AM 3rd,Kablinger AS,Rolland PD,Brannon GE

    更新日期:1999-01-01 00:00:00

  • ASSOCIATION STUDY BETWEEN OLIGODENDROCYTE TRANSCRIPTION FACTOR 2 GENE AND OBSESSIVE-COMPULSIVE DISORDER IN A CHINESE HAN POPULATION.

    abstract:BACKGROUND:Oligodendrocyte transcription factor 2 (OLIG2) is primarily concentrated in the brain and spinal cord ventricular zone, where this protein stimulates oligodendrocytes and specific neurons, determines motor neuron and oligodendrocyte differentiation, and sustains replication in early development. Recent studi...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.22394

    authors: Zhang X,Liu J,Guo Y,Jiang W,Yu J

    更新日期:2015-10-01 00:00:00

  • Reduced sensory gating of the P1 potential in rape victims and combat veterans with posttraumatic stress disorder.

    abstract::The P1 midlatency auditory evoked potential was studied in female rape victims with Posttraumatic Stress Disorder (PTSD) and compared to an age-matched female control group; and in male combat veterans with PTSD and compared to three groups of age-matched male control subjects. Sensory gating of the P1 potential was d...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/(sici)1520-6394(1999)9:3<122::aid-da4>3.0.

    authors: Skinner RD,Rasco LM,Fitzgerald J,Karson CN,Matthew M,Williams DK,Garcia-Rill E

    更新日期:1999-01-01 00:00:00

  • Uncertainty increases neural indices of attention in obsessive-compulsive disorder.

    abstract:BACKGROUND:Patients with obsessive-compulsive disorder (OCD) experience abnormally high levels of uncertainty, and unpredictability is evaluated negatively and not well tolerated. The current study examined neural correlates of attentional processing in response to experimentally induced uncertainty in OCD. METHODS:Tw...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.22655

    authors: Dieterich R,Endrass T,Kathmann N

    更新日期:2017-11-01 00:00:00

  • Psychological resilience and neurocognitive performance in a traumatized community sample.

    abstract:BACKGROUND:Whether psychological resilience correlates with neurocognitive performance is largely unknown. Therefore, we assessed association between neurocognitive performance and resilience in individuals with a history of childhood abuse or trauma exposure. METHODS:In this cross-sectional study of 226 highly trauma...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.20675

    authors: Wingo AP,Fani N,Bradley B,Ressler KJ

    更新日期:2010-08-01 00:00:00

  • Attention-deficit/hyperactivity disorder in adolescence predicts onset of major depressive disorder through early adulthood.

    abstract:BACKGROUND:The aim of this study was to examine the prospective relationship between a history of attention-deficit/hyperactivity disorder (ADHD) assessed in mid-adolescence and the onset of major depressive disorder (MDD) through early adulthood in a large school-based sample. A secondary aim was to examine whether th...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.22082

    authors: Meinzer MC,Lewinsohn PM,Pettit JW,Seeley JR,Gau JM,Chronis-Tuscano A,Waxmonsky JG

    更新日期:2013-06-01 00:00:00

  • Recurrence of major depressive episodes is strongly dependent on the number of previous episodes.

    abstract:BACKGROUND:A history of past major depressive episodes (MDEs) is known to be a risk factor for future MDEs. Additional information about the relationship between past and future episodes would be useful in clinical practice, it is therefore important to fully understand the epidemiology of major depression. We asked wh...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.22173

    authors: Bulloch A,Williams J,Lavorato D,Patten S

    更新日期:2014-01-01 00:00:00

  • A placebo-controlled pilot study of a wearable morning bright light treatment for probable PTSD.

    abstract:BACKGROUND:Evidence-based treatments for post-traumatic stress disorder (PTSD) have poor uptake and remission rates, suggesting that alternative treatments are needed. Morning bright light may be an effective treatment for PTSD given its established effects on mood and sleep, however, there are no published trials. ME...

    journal_title:Depression and anxiety

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/da.22897

    authors: Zalta AK,Bravo K,Valdespino-Hayden Z,Pollack MH,Burgess HJ

    更新日期:2019-07-01 00:00:00

  • Psychodynamic psychotherapy versus cognitive behavior therapy for social anxiety disorder: an efficacy and partial effectiveness trial.

    abstract:OBJECTIVES:Comparing the overall and differential effects of psychodynamic psychotherapy (PDT) versus cognitive behavior therapy (CBT) for social anxiety disorder (SAD). DESIGN:Patients with a primary SAD (N = 47) were randomly assigned to PDT (N = 22) or CBT (N = 27). Both PDT and CBT consisted of up to 36 sessions (...

    journal_title:Depression and anxiety

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/da.22246

    authors: Bögels SM,Wijts P,Oort FJ,Sallaerts SJ

    更新日期:2014-05-01 00:00:00

  • Treatment of late-onset OCD following basal ganglia infarct.

    abstract::Current consensus on the treatment of obsessive-compulsive disorder (OCD) includes cognitive behavior therapy (CBT) in the form of exposure and response prevention (ERP). However, the generalizability of these methods to elderly populations remains largely undocumented. This clinical case study examines the effectiven...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.10024

    authors: Carmin CN,Wiegartz PS,Yunus U,Gillock KL

    更新日期:2002-01-01 00:00:00

  • Complicated grief associated with hurricane Katrina.

    abstract:BACKGROUND:Although losses are important consequences of disasters, few epidemiological studies of disasters have assessed complicated grief (CG) and none assessed CG associated with losses other than death of loved one. METHODS:Data come from the baseline survey of the Hurricane Katrina Community Advisory Group, a re...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.20865

    authors: Shear MK,McLaughlin KA,Ghesquiere A,Gruber MJ,Sampson NA,Kessler RC

    更新日期:2011-08-01 00:00:00

  • Relationship between objective and subjective sleep measures in depressed patients and healthy controls.

    abstract::The purpose of this study was to correlate subjective sleep characteristics based on questionnaire response, and objective sleep EEG features based on polysomnography, in 52 patients with major depressive disorders (MDD) and 49 healthy controls. With the exception of the number of awakenings, subjective and objective ...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/(sici)1520-6394(1997)5:2<97::aid-da6>3.0.c

    authors: Armitage R,Trivedi M,Hoffmann R,Rush AJ

    更新日期:1997-01-01 00:00:00

  • Trajectories of childhood adversity and the risk of depression in young adulthood: Results from the Avon Longitudinal Study of Parents and Children.

    abstract:BACKGROUND:The significance of the timing and chronicity of childhood adversity for depression outcomes later in life is unclear. Identifying trajectories of adversity throughout childhood would allow classification of children according to the accumulation, timing, and persistence of adversity, and may provide unique ...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.22887

    authors: Tracy M,Salo M,Slopen N,Udo T,Appleton AA

    更新日期:2019-07-01 00:00:00

  • Symptoms of anxiety in depression: assessment of item performance of the Hamilton Anxiety Rating Scale in patients with depression.

    abstract:BACKGROUND:Although diagnostically dissociable, anxiety is strongly co-morbid with depression. To examine further the clinical symptoms of anxiety in major depressive disorder (MDD), a non-parametric item response analysis on "blinded" data from four pharmaceutical company clinical trials was performed on the Hamilton ...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.20435

    authors: Vaccarino AL,Evans KR,Sills TL,Kalali AH

    更新日期:2008-01-01 00:00:00

  • Symptom profiles of DSM-IV-defined remission, recovery, relapse, and recurrence of depression: the role of the core symptoms.

    abstract:BACKGROUND:Depression outcomes in research and clinical practice are commonly defined by the concepts of remission, recovery, relapse, and recurrence. Despite their widespread use, there has been little empirical examination of these concepts. Therefore, we investigated profiles of individual symptoms during each of th...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.21960

    authors: Conradi HJ,Ormel J,de Jonge P

    更新日期:2012-07-01 00:00:00

  • Amygdala-Cortical Connectivity: Associations with Anxiety, Development, and Threat.

    abstract:BACKGROUND:Amygdala-prefrontal cortex (PFC) functional connectivity may be influenced by anxiety and development. A prior study on anxiety found age-specific dysfunction in the ventromedial PFC (vmPFC), but not amygdala, associated with threat-safety discrimination during extinction recall (Britton et al.). However, tr...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.22470

    authors: Gold AL,Shechner T,Farber MJ,Spiro CN,Leibenluft E,Pine DS,Britton JC

    更新日期:2016-10-01 00:00:00

  • Striatal dopamine D(2) receptor availability in OCD with and without comorbid social anxiety disorder: preliminary findings.

    abstract::Dopamine D(2) receptor availability in the striatum has been reported to be low in generalized social anxiety disorder (GSAD) and obsessive-compulsive disorder (OCD), but it has not been studied in persons with comorbid OCD and GSAD (OCD+GSAD). D(2) receptor availability was assessed in 7 subjects with OCD+GSAD, 8 wit...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.20268

    authors: Schneier FR,Martinez D,Abi-Dargham A,Zea-Ponce Y,Simpson HB,Liebowitz MR,Laruelle M

    更新日期:2008-01-01 00:00:00

  • A biopsychosocial model as a guide for psychoeducation and treatment of depression.

    abstract::Effective treatment of severe or chronic unipolar depression requires the combination of pharmacological and psychotherapeutic interventions, and demands a theoretical paradigm integrating biological and psychosocial aspects of depression. Supported by recent research, we propose in our article a biopsychosocial diath...

    journal_title:Depression and anxiety

    pub_type: 杂志文章,评审

    doi:10.1002/da.20177

    authors: Schotte CK,Van Den Bossche B,De Doncker D,Claes S,Cosyns P

    更新日期:2006-01-01 00:00:00

  • Acute stress disorder versus chronic posttraumatic stress disorder: inhibition of fear as a function of time since trauma.

    abstract:BACKGROUND:Previous work has shown that inhibition of fear is impaired in posttraumatic stress disorder (PTSD) resulting from both civilian and combat trauma. The purpose of the present study was to investigate the inhibition of learned fear in traumatized individuals diagnosed with either acute stress disorder (ASD) o...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.21991

    authors: Jovanovic T,Sakoman AJ,Kozarić-Kovačić D,Meštrović AH,Duncan EJ,Davis M,Norrholm SD

    更新日期:2013-03-01 00:00:00

  • Re-examining the differential familial liability of agoraphobia and panic disorder.

    abstract:BACKGROUND:Controversy surrounds the question of whether agoraphobia (AG) exists as an independent diagnostic entity apart from panic. In favor of this position, AG without panic disorder (PD) in parents was found being unrelated to offsprings' risk for AG or PD, albeit it may enhance the familial transmission of PD (N...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.21975

    authors: Knappe S,Beesdo-Baum K,Nocon A,Wittchen HU

    更新日期:2012-11-01 00:00:00

  • Learning and memory impairment in PTSD: relationship to depression.

    abstract::Memory function was studied in combat veterans with posttraumatic stress disorder (PTSD), combat veterans without PTSD, and noncombat veterans. The Vocabulary and Digit Span subtests of the WAIS and Logical Memory (LMS) and Verbal Paired Associates (VPAS) subtests of the Wechsler Memory Scale III were administered. Co...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.20291

    authors: Burriss L,Ayers E,Ginsberg J,Powell DA

    更新日期:2008-01-01 00:00:00

  • Serotonergic modulation of the balance system in panic disorder: an open study.

    abstract::Experimental evidence suggests that panic disorder is characterized by abnormalities in the balance system function and that these abnormalities might be related to the severity of agoraphobic avoidance. Since the balance system can be modulated by the serotonergic system, we investigated the effect of a 6-week treatm...

    journal_title:Depression and anxiety

    pub_type: 临床试验,杂志文章

    doi:10.1002/da.10092

    authors: Perna G,Alpini D,Caldirola D,Raponi G,Cesarani A,Bellodi L

    更新日期:2003-01-01 00:00:00

  • Mobile assessment of heightened skin conductance in posttraumatic stress disorder.

    abstract:BACKGROUND:Increased psychophysiological reactivity is a hallmark intermediate phenotype of posttraumatic stress disorder (PTSD). Individuals with PTSD exhibit greater skin conductance (SC) responses to trauma scripts than trauma survivors without PTSD. However, trauma scripts require time for development and cannot be...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.22610

    authors: Hinrichs R,Michopoulos V,Winters S,Rothbaum AO,Rothbaum BO,Ressler KJ,Jovanovic T

    更新日期:2017-06-01 00:00:00

  • The Assessment of Depression Inventory (ADI): an appraisal of validity in an inpatient sample.

    abstract::This study examined the validity of the Assessment of Depression Inventory (ADI), a 39-item measure of depression with three embedded validity scales, using inpatient participants. The ADI Depression (Dep) and Feigning (Fg) scales were compared to the corresponding scales of a widely used multiscale instrument, the Pe...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.20183

    authors: Mogge NL

    更新日期:2006-01-01 00:00:00

  • Protein synthesis inhibition before or after stress exposure results in divergent endocrine and BDNF responses disassociated from behavioral responses.

    abstract::This study aimed to assess the effects of anisomycin, a protein synthesis inhibitor, on behavioral responses, brain-derived neurotrophic factor (BDNF) and TrkB mRNA levels, and circulating corticosterone in rats-when administered before or after initial exposure to a predator scent stress stimulus. Magnitude of change...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.20366

    authors: Kozlovsky N,Kaplan Z,Zohar J,Matar MA,Shimon H,Cohen H

    更新日期:2008-01-01 00:00:00

  • Cytokine targets in the brain: impact on neurotransmitters and neurocircuits.

    abstract::Increasing attention has been paid to the role of inflammation in a host of illnesses including neuropsychiatric disorders such as depression and anxiety. Activation of the inflammatory response leads to release of inflammatory cytokines and mobilization of immune cells both of which have been shown to access the brai...

    journal_title:Depression and anxiety

    pub_type: 杂志文章,评审

    doi:10.1002/da.22084

    authors: Miller AH,Haroon E,Raison CL,Felger JC

    更新日期:2013-04-01 00:00:00

  • How willing are you? Willingness as a predictor of change during treatment of adults with obsessive-compulsive disorder.

    abstract:OBJECTIVE:Exposure and response prevention (ERP) is an effective treatment for individuals with obsessive-compulsive disorder (OCD), yet a substantial number of individuals with OCD do not fully respond to this intervention. Based on emerging experimental and clinical research on acceptance, this study sought to explor...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.22672

    authors: Reid AM,Garner LE,Van Kirk N,Gironda C,Krompinger JW,Brennan BP,Mathes BM,Monaghan SC,Tifft ED,André MC,Cattie J,Crosby JM,Elias JA

    更新日期:2017-11-01 00:00:00

  • Transdiagnostic versus diagnosis-specific cbt for anxiety disorders: a preliminary randomized controlled noninferiority trial.

    abstract:BACKGROUND:Transdiagnostic cognitive-behavioral treatments for anxiety disorders have been gaining increased attention and empirical study in recent years. Despite this, research on transdiagnostic anxiety treatments has, to date, relied on open trials, or comparisons to waitlist conditions, published benchmarks, or re...

    journal_title:Depression and anxiety

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/da.21974

    authors: Norton PJ,Barrera TL

    更新日期:2012-10-01 00:00:00

  • Validity of a simpler definition of major depressive disorder.

    abstract:BACKGROUND:In previous reports from the Rhode Island Methods to Improve Diagnostic Assessment and Services project, we developed a briefer definition of major depressive disorder (MDD), and found high levels of agreement between the simplified and DSM-IV definitions of MDD. The goal of the present study was to examine ...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.20710

    authors: Zimmerman M,Galione JN,Chelminski I,Young D,Dalrymple K,Witt CF

    更新日期:2010-10-01 00:00:00