Hypoxia regulates the cAMP- and Ca2+/calmodulin signaling systems in PC12 cells.

abstract：:Previous studies have demonstrated an important interaction between angiotension II type 1 receptor (AT1R) and angiotension II (Ang II) -induced capillary formation from endothelial cells and vascular endothelial growth factor (VEGF). However, the underlying mechanism remains elusive. Recent studies revealed that the ...

journal_title：Biochemical and biophysical research communications

authors： Wang X,Bai YP,Hong D,Gao HC,Li LF,Li CC,Zhu LP,Sun Q,Zhang GG

更新日期：2013-05-10 00:00:00

abstract：:Vinca alkaloids are among a number of cytotoxic agents which target tumor cell microtubules. Studies described herein document the basis for one form of acquired resistance to these plant alkaloids involving an alteration of tubulin in a variant (DC-3F/VCRd-5L) of DC-3F Chinese hamster cells. Our results revealed a ma...

journal_title：Biochemical and biophysical research communications

authors： Sirotnak FM,Danenberg KD,Chen J,Fritz F,Danenberg PV

更新日期：2000-03-05 00:00:00

abstract：:Interleukin (IL)-19 belongs to the IL-10 family which includes IL-19, IL-20, IL-22, AK155, and MDA-7. IL-10 is a potent immunomodulatory cytokine with implications for pathogenesis in various autoimmune diseases. Polymorphism of the IL-10 promoter region correlates with disease outcome. To understand the gene regulati...

journal_title：Biochemical and biophysical research communications

authors： Chen PJ,Wei CC,Wang C,Chen FW,Hsu YH,Chang MS

更新日期：2006-06-09 00:00:00

abstract：:As a first step toward improving dideoxynucleoside inhibition of human immunodeficiency virus replication in human lymphocytes, we examined the kinetics of 5'-phosphorylation of a series of 2',3'-dideoxynucleosides, using deoxycytidine kinase purified from human thymus extracts. Nucleosides with the 2'-deoxyribose moi...

journal_title：Biochemical and biophysical research communications

authors： Johnson MA,Johns DG,Fridland A

更新日期：1987-11-13 00:00:00

abstract：:Recent reports have indicated that circular RNA (circRNA) may regulate Lung adenocarcinoma (LAC) development. Our previous studies showed that hsa_circ_0012673 was up-regulated in a circRNA microarray. However, its expression level in LAC has not been verified, and the underlying molecular mechanisms in LAC are unknow...

journal_title：Biochemical and biophysical research communications

authors： Wang X,Zhu X,Zhang H,Wei S,Chen Y,Chen Y,Wang F,Fan X,Han S,Wu G

更新日期：2018-02-19 00:00:00

abstract：:microRNAs have been demonstrated to play important roles in cancer development and progression. Hence, identifying functional microRNAs and better understanding of the underlying molecular mechanisms would provide new clues for the development of targeted cancer therapies. Herein, we reported that a microRNA, miR-421 ...

journal_title：Biochemical and biophysical research communications

authors： Chen L,Tang Y,Wang J,Yan Z,Xu R

更新日期：2013-06-14 00:00:00

abstract：:N-terminal of Leu-norleucinal or Leu-methioninal was modified to obtain a cell penetrative peptide inhibitor against calpain. Benzyloxycarbonyl (Z) derivatives had less active against papain than phenylbutyryl derivatives and leupeptin. Z-Leu-nLeu-H (calpeptin) was more sensitive to calpain I than Z-Leu-Met-H and leup...

journal_title：Biochemical and biophysical research communications

authors： Tsujinaka T,Kajiwara Y,Kambayashi J,Sakon M,Higuchi N,Tanaka T,Mori T

更新日期：1988-06-30 00:00:00

abstract：:The cellular actions of nerve growth factor (NGF) involve regulation of protein phosphorylation. In PC-12 pheochromocytoma cells, exposure of [125I]NGF followed by crosslinking indicates that the ligand binds to two discreet receptors, the previously described 75 kd protein, as well as the trk proto-oncogene product p...

journal_title：Biochemical and biophysical research communications

authors： Ohmichi M,Decker SJ,Pang L,Saltiel AR

更新日期：1991-08-30 00:00:00

abstract：:We developed the real-time PCR quantification of endothelin-A (ET-A) and endothelin-B (ET-B) receptor genes and present their relative expression levels in various adult tissues and during development in mouse using the 2(-Delta Delta C(T)) method. ET-A and ET-B receptors were detected in all tissues examined. Gene ex...

journal_title：Biochemical and biophysical research communications

authors： Adur J,Takizawa S,Quan J,Uchide T,Saida K

更新日期：2003-06-06 00:00:00

abstract：BACKGROUND:Adiponectin (APN) is an adipocyte-derived bioactive molecule with anti-diabetic and anti-atherogenic properties. Although anti-diabetic effects are mostly mediated by the adiponectin receptors AdipoR1 and AdipoR2, the anti-atherogenic mechanisms have not been fully elucidated. METHODS AND RESULTS:In this st...

journal_title：Biochemical and biophysical research communications

authors： Yamamoto H,Kuroda N,Uekita H,Kochi I,Matsumoto A,Niinaga R,Funahashi T,Shimomura I,Kihara S

更新日期：2016-02-05 00:00:00

abstract：:The molecular mechanism of smooth muscle contraction was approached by a novel method, covalent 14C-labeling. Intra- and intermolecular protein interactions during contractile activity are reflected by changed reactivity of protein side chains; these can be detected by reagents which readily permeate through the muscl...

journal_title：Biochemical and biophysical research communications

authors： Bárány K,Polyák E,Bárány M

更新日期：1992-09-16 00:00:00

abstract：:A glycerol kinase (Gyk) knock-out (KO) mouse model permits improved understanding of glycerol kinase (GK) deficiency (GKD) pathogenesis, however, early death of affected mice limits its utility. The purpose of this work was to delay death of affected males to investigate thoroughly their phenotypes. An adenoviral vect...

journal_title：Biochemical and biophysical research communications

authors： Kuwada N,Nagano K,MacLennan N,Havens J,Kumar M,Dipple KM,McCabe ER

更新日期：2005-09-16 00:00:00

abstract：:Unlike unsaturated fatty acids, which almost fully activated purified brain protein kinase C in a phosphatidylserine- and Ca2(+)-free reaction, related methyl esters were poorly active in vitro. In contrast, methyl arachidonate was revealed to be as potent as arachidonic acid in activating protein kinase C in intact p...

journal_title：Biochemical and biophysical research communications

authors： Fan XT,Huang XP,Da Silva C,Castagna M

更新日期：1990-06-29 00:00:00

abstract：:To elucidate the physiological importance of neuronal (N)-type calcium channels in sympathetic controls, we analyzed N-type channel-deficient (NKO) mice. Immunoprecipitation analysis revealed increased interaction between beta3 (a major accessory subunit of N-type channels) and R-type channel-forming CaV2.3 in NKO mic...

journal_title：Biochemical and biophysical research communications

authors： Murakami M,Ohba T,Wu TW,Fujisawa S,Suzuki T,Takahashi Y,Takahashi E,Watanabe H,Miyoshi I,Ono K,Sasano H,Ito H,Iijima T

更新日期：2007-03-23 00:00:00

abstract：:CH31 B lymphomas represent a model for antigen-induced deletional tolerance of immature B lymphocytes, because cross-linking the B cell antigen receptor (BCR) induces G(1) phase arrest and apoptosis. We have recently demonstrated that BCR cross-linking leads to a transient activation of p38 mitogen-activated protein k...

journal_title：Biochemical and biophysical research communications

authors： Swart JM,Chiles TC

更新日期：2000-09-24 00:00:00

abstract：:Tetrahydrobiopterin (BH(4)) synthesis is reported to be stimulated by nerve growth factor (NGF) in PC12 cells, suggesting involvement of BH(4) in the trophic effect of NGF. We have recently reported that erythropoietin (EPO) and BH(4) enhance survival of PC12 cells. In the present study, we investigated involvement of...

journal_title：Biochemical and biophysical research communications

authors： Tanaka J,Koshimura K,Sohmiya M,Murakami Y,Kato Y

更新日期：2001-11-30 00:00:00

abstract：:A mathematical model that includes biochemical interactions among the PTS system, phosphofructokinase (PFK), and pyruvate kinase (PK) is used to evaluate the dynamic behavior of the glycolytic pathway of Escherichia coli under steady-state conditions. The influence of ADP, phosphoenolpyruvate (PEP), and fructose-6-pho...

journal_title：Biochemical and biophysical research communications

authors： Diaz Ricci JC

更新日期：2000-04-29 00:00:00

abstract：:We previously found a new endogenous factor in rat liver cytosol, named ATP-stimulated glucocorticoid-receptor translocation promoter (ASTP), that increased the binding of activated glucocorticoid-receptor to nuclei in the presence of ATP. We have cloned and sequenced a cDNA (2989 bp) encoding the ASTP protein. An ope...

journal_title：Biochemical and biophysical research communications

authors： Okamoto K,Hirano H,Isohashi F

更新日期：1993-06-30 00:00:00

abstract：:Much of the knowledge about the cell biology of lipoprotein lipase (LPL) in vitro has been gained from adipose tissue model systems. However, the importance of skeletal muscle lipoprotein lipase (SMLPL) to both lipoprotein and muscle metabolism remains unclear. Although the production of LPL in cultured myocytes has b...

journal_title：Biochemical and biophysical research communications

authors： Poirier P,Marcell T,Huey PU,Schlaepfer IR,Owens GC,Jensen DR,Eckel RH

更新日期：2000-04-21 00:00:00

abstract：:Serine palmitoyltransferase long chain-1 (SPTLC1), which is the rate-limiting enzyme for sphingolipid biosynthesis, has been indicated to be essential for carcinoma cell survival and proliferation in recent, but its role in the regulation of renal cell carcinoma (RCC) remains unknown. In the present study, we found th...

journal_title：Biochemical and biophysical research communications

authors： Kong Z,Guo X,Zhao Z,Wu W,Luo L,Zhu Z,Yin S,Cai C,Wu W,Wang D,Liu Y,Duan X

更新日期：2019-11-26 00:00:00

abstract：:Oxidative stress plays a key role in the pathogenesis of diabetic nephropathy (DN). The anti-aging protein Klotho has been demonstrated to have antioxidant capacity. Nuclear factor-erythroid 2-related factor 2 (Nrf2) is a central transcription factor regulating antioxidant responses. The present study aimed to explore...

journal_title：Biochemical and biophysical research communications

authors： Xing L,Guo H,Meng S,Zhu B,Fang J,Huang J,Chen J,Wang Y,Wang L,Yao X,Wang H

更新日期：2021-01-01 00:00:00

abstract：:Tooth and bone are major tissues involved in physiological calcification in the body, and they use similar molecular pathways for development, homeostasis, and regeneration. Harmine (HMN) is a natural small compound that stimulates osteoblast differentiation in vitro and in vivo. Here we examined the biological effect...

journal_title：Biochemical and biophysical research communications

authors： Fujiwara N,Lee JW,Kumakami-Sakano M,Otsu K,Woo JT,Iseki S,Ota MS

更新日期：2018-03-11 00:00:00

abstract：:The polyamines associated to human erythrocytes from healthy donors are mainly localized intracellularly. In fact chromatography of the erythrocytes on a resin which has a high affinity and capacity for polyamines does not affect the amount of polyamines associated to the erythrocytes. The low ability of spermine to a...

journal_title：Biochemical and biophysical research communications

authors： Tadolini B,Hakim G,Orlandini G,Casti A

更新日期：1986-02-13 00:00:00

abstract：:Predicting acute clinical events caused by atherosclerotic plaque rupture remains a clinical challenge. Anatomic mapping of the vascular tree provided by standard imaging technologies is not always sufficient for a robust diagnosis. Yet biological mechanisms leading to unstable plaques have been identified and corresp...

journal_title：Biochemical and biophysical research communications

authors： Juenet M,Varna M,Aid-Launais R,Chauvierre C,Letourneur D

更新日期：2015-12-18 00:00:00

abstract：:Peroxisome proliferator-activated receptors (PPARs) have been considered to be desirable targets for metabolic syndrome, even though their specific agonists have several side effects including body weight gain, edema and tissue failure. Previously, we have reported in vitro effects of Sargassum yezoense (SY) and its i...

journal_title：Biochemical and biophysical research communications

authors： Kim SN,Lee W,Bae GU,Kim YK

更新日期：2012-08-10 00:00:00

abstract：:Labelling of membrane phospholipids with 32P was compared in rat and rabbit aorta under basal conditions and during alpha 1-receptor stimulation. Incorporation of 32P proceeded at a significantly higher rate in rat tissue. The ratio of basal labelling following 30 min of incubation for rat/rabbit arteries was 4.8 for ...

journal_title：Biochemical and biophysical research communications

authors： Campbell MD,Danthuluri NR,Deth RC

更新日期：1986-12-30 00:00:00

abstract：:Estrogen and androgen and their receptors play critical roles in physiological processes such as sexual differentiation and development. Using the available structural models for the human estrogen receptors alpha and beta and androgen receptor as templates, we designed in silico agonist and antagonist models of medak...

journal_title：Biochemical and biophysical research communications

authors： Cui J,Shen X,Yan Z,Zhao H,Nagahama Y

更新日期：2009-02-27 00:00:00

abstract：:Streptococcus pneumoniae is a major pathogen of community-acquired pneumonia and one of its major virulence factors is pneumolysin, which functions as a cholesterol-dependent cytolytic pore-forming toxin. In this study, we identified the ply-like gene spd0729 in a BLAST search. Unexpectedly, hemolytic and cytotoxic as...

journal_title：Biochemical and biophysical research communications

authors： Yamaguchi M,Minamide Y,Terao Y,Isoda R,Ogawa T,Yokota S,Hamada S,Kawabata S

更新日期：2009-12-04 00:00:00

abstract：:Brassica campestris Male Fertility 20 (BcMF20) is a typical zinc-finger transcription factor that was previously isolated from flower buds of Chinese cabbage (Brassica campestris ssp. chinensis). By applying expression pattern analysis, it can be known that BcMF20 was specifically and strongly expressed in tapetum and...

journal_title：Biochemical and biophysical research communications

authors： Han YY,Zhou HY,Xu LA,Liu XY,Fan SX,Cao JS

更新日期：2018-09-05 00:00:00

abstract：:Pseudouridine in yeast 5S RNA was modified with 4-bromomethyl-7-methoxy-coumarin(BMC). Temperature dependence of fluorescence intensity was measured at various concentrations of Mg2+ and K+ cations. Hyperchromicity was also measured. At 100mM KCl and 10mM Mg2+, fluorescence intensity decreased with temperature as free...

journal_title：Biochemical and biophysical research communications

authors： Nagamatsu K,Miyazawa Y

更新日期：1983-07-18 00:00:00