Abstract:
:Dexter cattle carry a genetic defect causing a dwarf phenotype in the heterozygotes (Dx+/-), while homozygotes (Dx+/+) are stillborn with extreme shortening of limbs and gross craniofacial defects and are described as 'bulldog' calves. The heterozygous phenotype has been likened to achondroplastic dwarfism in humans (ACH), which has recently been shown to be the result of mutations in the transmembrane region of the fibroblast growth factor receptor 3 (FGFR3) gene. We have sequenced the transmembrane region of bovine FGFR3 from normal Dexter cattle (Dx-/-) and bulldog calves (Dx+/+). The sequence from both is identical and therefore excludes mutations in the trans-membrane region of FGFR3 as the cause of Dexter dwarfism.
journal_name
Anim Genetjournal_title
Animal geneticsauthors
Usha AP,Lester DH,Williams JLdoi
10.1111/j.1365-2052.1997.00068.xsubject
Has Abstractpub_date
1997-02-01 00:00:00pages
55-7issue
1eissn
0268-9146issn
1365-2052journal_volume
28pub_type
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