The continuous infusion of recombinant activated factor VIIa (rFVIIa) in patients with factor VIII inhibitors activates the coagulation and fibrinolytic systems without clinical complications.

abstract：INTRODUCTION:Hip fracture is common among the elderly and is associated with increased morbidity and mortality, particularly when surgery is delayed. Direct oral anticoagulants (DOACs) use might increase bleeding and postpone hip repair surgery. We aimed to assess the association between preoperative DOACs use and adve...

journal_title：Thrombosis research

authors： Saliba W,Arbel A,Abu-Full Z,Cohen S,Rennert G,Preis M

更新日期：2020-05-01 00:00:00

abstract：INTRODUCTION:In reconstructive head and neck cancer surgery, tissue flaps are transferred to the surgical defect and revascularized by anastomosis of small vessels. Cancer patients are in a hypercoagulable state with high risk of peri- and postoperative thrombotic events. Thrombosis to the tissue flap anastomoses or mi...

journal_title：Thrombosis research

authors： Krag AE,Kiil BJ,Hvas CL,Eschen GT,Hvas AM

更新日期：2016-04-01 00:00:00

abstract：:Patients with protamine allergy present a difficult dilemma when reversal of heparin is required for excessive bleeding. Premedication with steroids and antihistamines has not been shown to effectively prevent anaphylactic reactions in patients with hypersensitivity to protamine. Other heparin antagonists are either n...

journal_title：Thrombosis research

authors： Sloand EM,Kessler CM,McIntosh CL,Klein HG

更新日期：1989-06-15 00:00:00

abstract：:Several clinical trials have demonstrated the benefits of thienopyridine monotherapy in ischaemic stroke patients. Non-human primate models of ischaemic stroke have been used for various antithrombotic agents; however, to the best of our knowledge, there is no data on the effects of P2Y12 antagonists in models, such a...

journal_title：Thrombosis research

authors： Tomizawa A,Ohno K,Jakubowski JA,Mizuno M,Sugidachi A

更新日期：2015-12-01 00:00:00

abstract：:Heparin and other antithrombotic drugs besides their anticoagulant action could have a profibrinolytic effect. We have analyzed the effect of unfractionated heparin (UFH) and hirudin on PAI-1 gene expression in human umbilical vein endothelial cells (HUVEC). Cells were stimulated with UFH (1 and 10 IU/ml) and hirudin ...

journal_title：Thrombosis research

authors： Orbe J,Montes R,Zabalegui N,Pérez-Ruiz A,Páramo JA

更新日期：1999-05-01 00:00:00

abstract：:It has been found in our laboratory that compression induces disaggregation and decompression induces aggregation of human platelets. The experimental design was based on the premise that oppositely charged amino acid residues of fibrinogen are juxtaposed in the specific adhesive site(s). This can be explained by the ...

journal_title：Thrombosis research

authors： Murayama M

更新日期：1987-03-15 00:00:00

abstract：:Three methods commonly used for isolation of blood platelets from plasma were compared. Platelets were isolated by: 1) a washing method; 2) a method of metrizamide-gradient centrifugation; 3) a modified method of gel-filtration. The last method employed BSA-Sepharose gel instead of routinely used Sepharose gel saturat...

journal_title：Thrombosis research

authors： Walkowiak B,Kralisz U,Michalec L,Majewska E,Koziolkiewicz W,Ligocka A,Cierniewski CS

更新日期：2000-09-01 00:00:00

abstract：:The thrombin inhibitory role of antithrombin III (ATIII) and heparin cofactor II (HCII) was studied in vitro using intact and injured rabbit aortae. When intact vessels were loaded with thrombin and then exposed to either heat defibrinogenated human plasma (HDHP) or ATIII the same degree of thrombin inhibition was ach...

journal_title：Thrombosis research

authors： Pasche B,Swedenborg J,Frebelius S,Olsson P

更新日期：1991-06-01 00:00:00

abstract：INTRODUCTION:Several hemostatic system components, including factor X (FX), contribute to cancer progression. The Protein Z (PZ)/protein Z-dependent protease inhibitor (ZPI) complex directly inhibits factor Xa proteolytic activity. The aim of this study was to determine the antigenic distribution of ZPI and PZ, in rela...

journal_title：Thrombosis research

authors： Sierko E,Wojtukiewicz MZ,Zimnoch L,Tokajuk P,Ostrowska-Cichocka K,Kisiel W

更新日期：2012-04-01 00:00:00

abstract：INTRODUCTION:Only sparse information exists on the use of direct oral anticoagulant (DOAC) testing and the impact on clinical management. Here, we evaluated the clinical impact of DOAC measurements in a real-life clinical setting. Moreover, number of tests performed in relation to number of DOAC-treated patients was ev...

journal_title：Thrombosis research

authors： Winther-Larsen A,Hvas AM

更新日期：2019-03-01 00:00:00

abstract：:We examined the effects of verapamil on platelet function. Verapamil (0.5 micrograms/ml) in this study inhibited platelet aggregation induced by threshold amounts of ADP, AA, and epinephrine. With higher concentrations of aggregating stimuli, verapamil caused a dose-dependent inhibition of aggregation. Verapamil reduc...

journal_title：Thrombosis research

authors： Mehta J,Mehta P,Ostrowski N,Crews F

更新日期：1983-06-01 00:00:00

abstract：BACKGROUND:Although patients undergoing coronary stenting routinely receive dual antiplatelet treatment to reduce the risk of stent thrombosis, this undesired event still occurs. A suboptimal response to clopidogrel treatment (low responders) has been suggested to contribute to stent thrombosis. In the present study, p...

journal_title：Thrombosis research

authors： Angiolillo DJ,Fernandez-Ortiz A,Bernardo E,Ramírez C,Barrera-Ramirez C,Sabaté M,Hernández R,Moreno R,Escaned J,Alfonso F,Bañuelos C,Costa MA,Bass TA,Macaya C

更新日期：2005-01-01 00:00:00

abstract：UNLABELLED:Disturbances of coagulation and fibrinolysis have been reported in patients with chronic uremia. Studies of different coagulation and fibrinolysis parameters in regularly dialyzed patients have yielded conflicting results. Global fibrinolytic capacity (GFC) examines the function of the entire fibrinolytic sy...

journal_title：Thrombosis research

authors： Agras PI,Baskin E,Cengiz N,Kirazli S,Saatci U,Ozbek N

更新日期：2005-01-01 00:00:00

abstract：:Using an ACL 300R coagulometer (Instrumentation Laboratory) we assessed the clinical usefulness of a new method to measure PS activity (PS:Act), based on the prolongation of prothrombin time of a mixture of diluted plasma sample, PS depleted plasma previously incubated with Protac for protein C activation, bovine thro...

journal_title：Thrombosis research

authors： Maccaferri M,Legnani C,Preda L,Palareti G

更新日期：1991-12-15 00:00:00

abstract：:The effect of activated protein C (APC) on agonist-induced platelet activation and on thrombin generation after intrinsic (IA) and extrinsic (EA) activation of the coagulation system was studied by flow cytometry and by measuring levels of prothrombin fragment F1+2. In platelet activation studies blood drawn from heal...

journal_title：Thrombosis research

authors： Kaiser B,Jeske W,Hoppensteadt DH,Walenga JM,Drohan W,Fareed J

更新日期：1997-07-15 00:00:00

abstract：BACKGROUND:There is a substantial local release of tissue-type plasminogen activator (t-PA) in the splanchnic vascular bed, and this release is increased at high sympathetic tone. Coronary t-PA release is also significant, and this release increases during cardiac nerve stimulation and during reperfusion after 10 min o...

journal_title：Thrombosis research

authors： Björkman JA,Ilebekk A,Jern C

更新日期：2010-03-01 00:00:00

abstract：:In a double-blind, placebo-controlled trial of 40 patients requiring aortocoronary vene transplant surgery, prostacyclin (PGI2) was infused in a dose of 8 ng/kg/min throughout cardiopulmonary bypass. When compared with the placebo-group, the patients treated with PGI2 were found to have significantly higher platelet c...

journal_title：Thrombosis research

authors： Heinrich D,Schleussner E,Wagner WL,Sellmann-Richter R,Hehrlein FW

更新日期：1983-11-15 00:00:00

abstract：INTRODUCTION:Cytomegalovirus (CMV)-associated thrombosis has been reported sporadically in the medical literature until now. However, thrombosis incidence and its risk factors have never been studied in a cohort of patients with acute CMV infection. MATERIALS AND METHODS:A retrospective case-control study. Medical cha...

journal_title：Thrombosis research

authors： Atzmony L,Halutz O,Avidor B,Finn T,Zimmerman O,Steinvil A,Zeltser D,Giladi M,Justo D

更新日期：2010-12-01 00:00:00

abstract：INTRODUCTION:Unfractionated heparin (UFH) potentiates platelet aggregation induced by some agonists. P2Y12 and P2Y1 receptors play a major role in amplifying platelet aggregation. We assessed the ability of cangrelor, a selective P2Y12 antagonist, A2P5P, a selective P2Y1 antagonist, and aspirin to block the potentiatin...

journal_title：Thrombosis research

authors： Storey RF,May JA,Heptinstall S

更新日期：2005-01-01 00:00:00

abstract：:Current guidelines recommend performing laboratory tests aimed at monitoring unfractionated heparin (UFH) treatments within a delay not exceeding 1 to 2 h(s) after sampling when blood is collected into citrated tubes. As such a short delay could be an issue, we evaluated the potential impact of longer delays. For that...

journal_title：Thrombosis research

authors： Toulon P,Appert-Flory A,Fischer F,Buvat S,Jambou D,Mahagne MH

更新日期：2020-02-01 00:00:00

abstract：INTRODUCTION:Thrombomodulin (TM) has been described as a marker of endothelial injury in atherosclerosis. The role of TM as a predictor of PAD severity is to be proven. The goal of the present study is to compare the level of plasmatic (TMp) in patients with intermittent claudication with patients with critical ischemi...

journal_title：Thrombosis research

authors： Nasser M,Wolosker N,Uint L,Rosoky RA,Lobato M,Wajngarten M,Puech-Leao P

更新日期：2006-01-01 00:00:00

abstract：:It has long been recognised that the function of platelets in health and disease span far beyond their roles in haemostasis and thrombosis. The observation that tumour cells induce platelet aggregation was followed by extensive experimental evidence linking platelets to cancer progression. Aggregated platelets coat tu...

journal_title：Thrombosis research

authors： Lowe KL,Navarro-Nunez L,Watson SP

更新日期：2012-04-01 00:00:00

abstract：:Activation of human plasminogen by human tissue-type plasminogen activator (t-PA) is accelerated in the presence of cyanogen bromide digests of human fibrin(ogen). In the present study a possible species specificity of this phenomenon was investigated. All combinations of the plasminogens, fibrin monomers and cyanogen...

journal_title：Thrombosis research

authors： Nieuwenhuizen W,Keyser J

更新日期：1985-06-15 00:00:00

abstract：:The diagnosis of preeclampsia, with all of its consequences, is at times difficult to establish, especially when the patient has underlying chronic hypertension and is not known from prior prenatal care visits. Many screening tests have been proposed. These should be sensitive, relatively specific, easy to perform, of...

journal_title：Thrombosis research

authors： Saleh AA,Bottoms SF,Gerbasi FR,Mammen EF

更新日期：1994-07-15 00:00:00

abstract：:While the role of platelets in hemostasis is well characterized from a biological perspective, the biophysical interactions between platelets and their mechanical microenvironment are relatively unstudied. The field of cellular mechanics has developed a number of approaches to study the effects of extracellular matrix...

journal_title：Thrombosis research

authors： Ciciliano JC,Tran R,Sakurai Y,Lam WA

更新日期：2014-04-01 00:00:00

abstract：:Thrombolysis is an effective but potential deleterious therapy and should therefore be limited to patients with acute intracerebral vessel occlusion and salvageable tissue. MRI currently develops towards the new diagnostic standard for the selection of stroke patients eligible for acute thrombolytic treatment and acut...

journal_title：Thrombosis research

authors： Röther J

更新日期：2001-09-30 00:00:00

abstract：BACKGROUND:In patients who are receiving warfarin therapy and require cataract surgery, it may be possible to continue warfarin in the perioperative period but the safety of this management strategy has not been systematically evaluated. METHODS:We performed a systematic review of the literature to assess the safety (...

journal_title：Thrombosis research

authors： Jamula E,Anderson J,Douketis JD

更新日期：2009-07-01 00:00:00

abstract：:In this study we examined in 100 patients testing positive for Helicobacter pylori infection whether successful eradication therapy with pantoprazole, clarithromycin, and metronidazole alters fibrinogen and other acute phase response markers. Of 100 patients, only 11 showed a fibrinogen level above 300 mg/dL. Successf...

journal_title：Thrombosis research

authors： Schweeger I,Fitscha P,Sinzinger H

更新日期：2000-03-15 00:00:00

abstract：:Sulfation of the natural polysaccharide curdlan results in anticoagulantly active beta-1,3-glucan sulfates whose activity depends on various structural parameters. In this study the anticoagulant and antithrombotic effects of one of these beta-1,3-glucan sulfates (GS) were compared with those of a porcine mucosal hepa...

journal_title：Thrombosis research

authors： Alban S,Jeske W,Welzel D,Franz G,Fareed J

更新日期：1995-05-01 00:00:00

abstract：BACKGROUND:Nuclear factor kappa B (NF-kappa B) activation and tissue factor (TF) expression may contribute to lethality in sepsis. Inappropriate in vivo expression of TF is likely responsible for fibrin deposition in sepsis-associated disseminated intravascular coagulation (DIC). Clinical assessment of TF expression ha...

journal_title：Thrombosis research

authors： Marsik C,Quehenberger P,Mackman N,Osterud B,Luther T,Jilma B

更新日期：2003-01-01 00:00:00