Alpha 1-antitrypsin deficiency deaths in the United States from 1979-1991. An analysis using multiple-cause mortality data.

Abstract:

OBJECTIVE:To describe trends of reported alpha 1-antitrypsin deficiency mortality in the United States from 1979-1991. METHODS:We analyzed death certificate reports in the multiple-cause mortality files compiled by the National Center for Health Statistics. RESULTS:Of the 26,866,600 deaths that occurred during the 13-year period, 1,930 had alpha 1-antitrypsin deficiency listed as a cause of death. Over this period, we would have expected 5,400 to 13,400 persons with this condition to die. The age-adjusted mortality rate with reported alpha 1-antitrypsin deficiency listed increased 86%, from 4.3 per 10 million in 1979 to 8.0 per 10 million in 1991. alpha 1-Antitrypsin deficiency mortality rates were higher among whites than among blacks or persons of other races. alpha 1-Antitrypsin deficiency was listed in 2.7% of all deaths with obstructive lung disease among persons aged 35-44 years old and in 1.2% of all deaths listing hepatic disease among children aged 1 to 14 years old. CONCLUSIONS:alpha 1-Antitrypsin deficiency is an important risk factor for obstructive lung disease and hepatic disease in the United States, and it was reported with increasing frequency through the study period, although it is still likely underreported.

journal_name

Chest

journal_title

Chest

authors

Browne RJ,Mannino DM,Khoury MJ

doi

10.1378/chest.110.1.78

subject

Has Abstract

pub_date

1996-07-01 00:00:00

pages

78-83

issue

1

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(15)46346-9

journal_volume

110

pub_type

杂志文章

相关文献

CHEST文献大全
  • Management of malignant air leak in a child with a neonatal high-frequency oscillatory ventilator.

    abstract::A 10-year-old, 36-kg child with a malignant air leak who failed conventional mechanical ventilation and high-frequency jet ventilation was successfully treated with a neonatal high-frequency oscillatory ventilator for 31 days. Since the air leak resolved with minimal hemodynamic compromise, this technique may have app...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.100.1.263

    authors: Mayes TC,Jefferson LS,David Y,Louis PT,Fortenberry JD

    更新日期:1991-07-01 00:00:00

  • Antibiotic utilization: is there an effect on antimicrobial resistance?

    abstract::The antimicrobial resistance problem in hospitals continues to worsen. In particular, extended-spectrum beta-lactamase-producing Klebsiella pneumoniae (ESBL-KP) and vancomycin-resistant enterococci (VRE) are significant causes of morbidity and mortality among critically ill patients. Treating infections caused by thes...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.119.2_suppl.426s

    authors: Patterson JE

    更新日期:2001-02-01 00:00:00

  • Pulmonary Langerhans cell histiocytosis-associated pulmonary hypertension: clinical characteristics and impact of pulmonary arterial hypertension therapies.

    abstract:BACKGROUND:Precapillary pulmonary hypertension (PH) is a complication of pulmonary Langerhans cell histiocytosis (PLCH) associated with increased mortality. However, outcomes and efficacy of pulmonary arterial hypertension (PAH) therapies in patients with PH complicating PLCH(PLCH-PH) remain unknown. METHODS:Consecuti...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.11-2490

    authors: Le Pavec J,Lorillon G,Jaïs X,Tcherakian C,Feuillet S,Dorfmüller P,Simonneau G,Humbert M,Tazi A

    更新日期:2012-11-01 00:00:00

  • Up-regulated membrane and nuclear leukotriene B4 receptors in COPD.

    abstract:STUDY OBJECTIVES:We investigated the role of two leukotriene B4 (LTB4) receptors, BLT1 and peroxisome proliferator-activated receptor (PPAR)-alpha, in conferring the susceptibility to develop COPD in smokers. Proinflammatory LTB4 activities are mediated by BLT1, while the inactivation of LTB4 is promoted by PPARalpha. ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.129.6.1523

    authors: Marian E,Baraldo S,Visentin A,Papi A,Saetta M,Fabbri LM,Maestrelli P

    更新日期:2006-06-01 00:00:00

  • CT scan-measured pulmonary artery to aorta ratio and echocardiography for detecting pulmonary hypertension in severe COPD.

    abstract:BACKGROUND:COPD is associated with significant morbidity primarily driven by acute exacerbations. Relative pulmonary artery (PA) enlargement, defined as a PA to ascending aorta (A) diameter ratio greater than one (PA:A>1) identifies patients at increased risk for exacerbations. However, little is known about the correl...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.13-1422

    authors: Iyer AS,Wells JM,Vishin S,Bhatt SP,Wille KM,Dransfield MT

    更新日期:2014-04-01 00:00:00

  • Is it possible to differentiate malignant mediastinal nodes from benign nodes by size? Reevaluation by CT, transesophageal echocardiography, and nodal specimen.

    abstract:STUDY OBJECTIVE:To reevaluate whether it is possible to reliably differentiate malignant mediastinal lymph nodes from benign nodes by size, and to determine the frequency of metastases to normal-sized mediastinal lymph nodes that directly affects the sensitivity for detecting malignant mediastinal lymph nodes (N2 nodes...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.110.4.1004

    authors: Arita T,Matsumoto T,Kuramitsu T,Kawamura M,Matsunaga N,Sugi K,Esato K

    更新日期:1996-10-01 00:00:00

  • The use of learning resource centers in the teaching of pulmonary medicine.

    abstract::Learning resource centers (LRC) are areas designed for individual study which contain a variety of self-instructional materials. To evaluate the use of LRC in teaching pulmonary medicine, a survey was conducted of medical school pulmonary sections; responses were obtained from 30 sections with an NHLBI pulmonary Acade...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.82.5.639

    authors: Make BJ

    更新日期:1982-11-01 00:00:00

  • The prevalence and predictors of respiratory-related work limitation and occupational disability in an international study.

    abstract:BACKGROUND:Work-related symptoms and disability due to respiratory disease are common and costly among working-age adults. To investigate this problem, we analyzed data on respiratory symptoms related to the workplace and occupational disability from the European Community Respiratory Health Survey (ECRHS). METHODS:Th...

    journal_title:Chest

    pub_type: 杂志文章,多中心研究

    doi:

    authors: Blanc PD,Burney P,Janson C,Torén K

    更新日期:2003-09-01 00:00:00

  • Smoking and timing of cessation: impact on pulmonary complications after thoracotomy.

    abstract:STUDY OBJECTIVE:The benefit of smoking cessation just prior to surgery in preventing postoperative pulmonary complications has not been proven. Some studies actually show a paradoxical increase in complications in those quitting smoking only a few weeks or days prior to surgery. We studied the effect of smoking and the...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.127.6.1977

    authors: Barrera R,Shi W,Amar D,Thaler HT,Gabovich N,Bains MS,White DA

    更新日期:2005-06-01 00:00:00

  • Fatal pulmonary edema due to nitric acid fume inhalation in three pulp-mill workers.

    abstract::Three young men died of rapidly progressive pulmonary edema of delayed onset after inhalation of fumes from an accidental nitric acid explosion. Electron microscopy revealed altered neutrophils and necrotic endothelial cells in alveolar capillaries. Immunohistochemistry showed small and large serum proteins, including...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.97.2.487

    authors: Hajela R,Janigan DT,Landrigan PL,Boudreau SF,Sebastian S

    更新日期:1990-02-01 00:00:00

  • Systolic time intervals in atrial fibrillation.

    abstract::Forty patients with atrial fibrillation and 20 patients with congestive heart failure and sinus rhythm were studied. Patients were divided into two groups. Group A consisted of 20 patients with atrial fibrillation in whom systolic time intervals were measured. Twenty to 50 beats were analyzed. Five of the patients had...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.74.6.629

    authors: Boudoulas H,Lewis RP,Sherman JA,Bush CA,Dalamangas G,Forester WF

    更新日期:1978-12-01 00:00:00

  • Efficacy and Safety of Pulmonary Arterial Hypertension-specific Therapy in Pulmonary Arterial Hypertension: A Meta-analysis of Randomized Controlled Trials.

    abstract:BACKGROUND:Previous meta-analyses of pulmonary arterial hypertension (PAH)-specific therapy for PAH pooled PAH-specific combination therapy and monotherapy. This flaw may threaten the authenticity of their findings. METHODS:PubMed, Embase, and the Cochrane Library were searched for randomized controlled trials that ev...

    journal_title:Chest

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.chest.2016.03.031

    authors: Liu HL,Chen XY,Li JR,Su SW,Ding T,Shi CX,Jiang YF,Zhu ZN

    更新日期:2016-08-01 00:00:00

  • The undervaluation of evaluation and management professional services: the lasting impact of current procedural terminology code deficiencies on physician payment.

    abstract::The Resource-Based Relative Value Scale (RBRVS) is fundamentally undermined by the following foundational errors: (1) The full range of office-based evaluation and management (E/M) activities are not captured by the Current Procedural Terminology (CPT) code choices, (2) it places relatively high values on procedural s...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.13-0381

    authors: Kumetz EA,Goodson JD

    更新日期:2013-09-01 00:00:00

  • Myocardial oxygen supply and demand.

    abstract::The supply of oxygen to the myocardium is determined by coronary blood flow and oxygen carrying capacity. Coronary blood flow is a dynamic process modulated via multiple parameters. Cardiac metabolism is also affected by several factors. Under normal physiologic conditions, the demand is easily met by the supply of ox...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.98.3.699

    authors: Ardehali A,Ports TA

    更新日期:1990-09-01 00:00:00

  • Myocardial contractile reserve as prognostic determinant in patients with idiopathic dilated cardiomyopathy without overt heart failure.

    abstract::To assess the prognostic significance of myocardial contractile reserve in patients with idiopathic dilated cardiomyopathy (DCM) without overt heart failure (New York Heart Association functional class I or II), seventy-one patients underwent exercise radionuclide angiography in addition to clinical, radiographic, hem...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.111.2.344

    authors: Nagaoka H,Isobe N,Kubota S,Iizuka T,Imai S,Suzuki T,Nagai R

    更新日期:1997-02-01 00:00:00

  • Airway hyperreactivity in cystic fibrosis. Clinical correlates and possible effects on the course of the disease.

    abstract::To evaluate whether increased airway reactivity affected the course of patients with cystic fibrosis (CF), we categorized 40 CF patients as to methacholine sensitivity and then evaluated their disease activity and natural history. Twenty methacholine reactors had more severe lung disease (lower S-K clinical scores and...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.94.2.360

    authors: Eggleston PA,Rosenstein BJ,Stackhouse CM,Alexander MF

    更新日期:1988-08-01 00:00:00

  • CA-125 in Disease Progression and Treatment of Lymphangioleiomyomatosis.

    abstract:BACKGROUND:Lymphangioleiomyomatosis (LAM) is a destructive lung disease of women caused by proliferation of neoplastic-like LAM cells, with mutations in the TSC1/2 tumor suppressor genes. Based on case reports, levels of cancer antigen 125 (CA-125), an ovarian cancer biomarker, can be elevated in patients with LAM. We ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1016/j.chest.2017.05.018

    authors: Glasgow CG,Pacheco-Rodriguez G,Steagall WK,Haughey ME,Julien-Williams PA,Stylianou MP,Gochuico BR,Moss J

    更新日期:2018-02-01 00:00:00

  • Post-pneumonectomy syndrome. Surgical correction using Silastic implants.

    abstract::A post-right pneumonectomy syndrome is described which manifests symptoms of exertional dyspnea and inspiratory stridor on rapid inspiration. These symptoms were associated with marked rightward and posterior deviation of the trachea, over-distention of the left lung with its herniation into the right side of the ches...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.75.1.78

    authors: Wasserman K,Jamplis RW,Lash H,Brown HV,Cleary MG,Lafair J

    更新日期:1979-01-01 00:00:00

  • A technique for isolated airway segment lavage.

    abstract::A novel technique has been developed for the isolation and lavaging of a central airway segment in humans. The procedure uses a double-balloon airway-sampling catheter that is placed into the airways with fiberoptic bronchoscopic guidance. A protocol using this technique was attempted in 32 subjects (18 normal subject...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.92.1.105

    authors: Eschenbacher WL,Gravelyn TR

    更新日期:1987-07-01 00:00:00

  • Effect of CPAP on Cognition, Brain Function, and Structure Among Elderly Patients With OSA: A Randomized Pilot Study.

    abstract:BACKGROUND:Despite the increasing aging population and the high prevalence of OSA in elderly adults, little is known about cognitive effects of OSA and the effectiveness of CPAP treatment. Therefore, this study investigated whether elderly patients with OSA present cognitive deficits and functional and structural alter...

    journal_title:Chest

    pub_type: 杂志文章,随机对照试验

    doi:10.1378/chest.15-0171

    authors: Dalmases M,Solé-Padullés C,Torres M,Embid C,Nuñez MD,Martínez-Garcia MÁ,Farré R,Bargalló N,Bartrés-Faz D,Montserrat JM

    更新日期:2015-11-01 00:00:00

  • Left ventricular diastolic dysfunction in patients with COPD in the presence and absence of elevated pulmonary arterial pressure.

    abstract:BACKGROUND:Increased right ventricular afterload leads to left ventricular diastolic dysfunction due to ventricular interdependence. Increased right ventricular afterload is frequently present in patients with COPD. The purpose of this study was to determine whether left ventricular diastolic dysfunction could be detec...

    journal_title:Chest

    pub_type: 临床试验,杂志文章

    doi:10.1378/chest.07-2685

    authors: Funk GC,Lang I,Schenk P,Valipour A,Hartl S,Burghuber OC

    更新日期:2008-06-01 00:00:00

  • Recommendations for the management of COPD.

    abstract::Three sets of guidelines for the management of COPD that are widely recognized (from the European Respiratory Society [ERS], American Thoracic Society [ATS], and British Thoracic Society [BTS]) are reviewed and compared. None of the documents uses classic evidence-based documentation, and, in many instances, the recom...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.117.2_suppl.23s

    authors: Ferguson GT

    更新日期:2000-02-01 00:00:00

  • Breathlessness in patients with severe chronic airflow limitation. Physiologic correlations.

    abstract::We wished to identify the physiologic abnormalities that distinguish severely breathless (SB) patients with chronic airflow limitation (CAL) from mildly breathless (MB) patients. Thirty-seven patients with stable, advanced CAL (FEV1 = 38 +/- 10 percent predicted, mean +/- SD) were separated into two distinct groups, S...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.102.3.824

    authors: O'Donnell DE,Webb KA

    更新日期:1992-09-01 00:00:00

  • New procedure: bronchoscopic endobronchial sealing; a new mode of managing hemoptysis.

    abstract::Six patients with hemoptysis were treated by endobronchial sealing, with n-butyl cyanoacrylate, of the bleeding segment or subsegment. There was an immediate arrest of bleeding without any recurrence for a mean follow-up period of 127 (+/- 67.17) days. Endobronchial sealing appears to be an effective method of managin...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.121.6.2066

    authors: Bhattacharyya P,Dutta A,Samanta AN,Chowdhury SR

    更新日期:2002-06-01 00:00:00

  • The Burden of Community-Acquired Pneumonia Requiring Admission to ICU in the United States.

    abstract:BACKGROUND:A paucity of studies have assessed the epidemiology of community-acquired pneumonia (CAP) that require ICU admission. We conducted a study on this group of patients with the primary objective of defining the incidence, epidemiology, and mortality rate of CAP in the ICUs in Louisville, Kentucky. The secondary...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1016/j.chest.2020.03.051

    authors: Cavallazzi R,Furmanek S,Arnold FW,Beavin LA,Wunderink RG,Niederman MS,Ramirez JA

    更新日期:2020-09-01 00:00:00

  • Loculated interlobar air-fluid collection in congestive heart failure.

    abstract::Two patients are described who had congestive heart failure with loculated interlobar air-fluid collections. Although pseudotumor (interlobar effusion) is a well-known finding in congestive heart failure, the additional presence of air is unique. Both are somewhat related to the underlying failure. ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.74.6.681

    authors: Rabinowitz JG,Kongtawng T

    更新日期:1978-12-01 00:00:00

  • Subaortic stenosis caused by two discrete membranes.

    abstract::A case of subaortic stenosis caused by two discrete membranes is presented. Following demonstration of the two distinct sites of obstruction by intraventricular pressure gradients and angiocardiogram, the two membranes were excised through a transaortic approach. The importance of being aware of the occurrence of this...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.69.1.104

    authors: Lemole GM,Tesler UF,Colombi M,Eldredge WJ

    更新日期:1976-01-01 00:00:00

  • International trends in asthma mortality rates in the 5- to 34-year age group: a call for closer surveillance.

    abstract:BACKGROUND:International time trends in asthma mortality have played an important sentinel role in the identification of two epidemics of asthma mortality in some countries in the 1960s and the 1970s and 1980s. Since then, little attention has been paid to the ongoing international time trends. METHODS:Country-specifi...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.08-2082

    authors: Wijesinghe M,Weatherall M,Perrin K,Crane J,Beasley R

    更新日期:2009-04-01 00:00:00

  • Is a raised bicarbonate, without hypercapnia, part of the physiologic spectrum of obesity-related hypoventilation?

    abstract:BACKGROUND:Obesity hypoventilation syndrome (OHS) conventionally includes awake hypercapnia, but an isolated raised bicarbonate, even in the absence of awake hypercapnia, may represent evidence of "early" OHS. We investigated whether such individuals exhibit certain features characteristic of established OHS. METHODS:...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.14-1279

    authors: Manuel ARG,Hart N,Stradling JR

    更新日期:2015-02-01 00:00:00

  • Safety and efficacy of combined long-acting beta-agonists and inhaled corticosteroids vs long-acting beta-agonists monotherapy for stable COPD: a systematic review.

    abstract:BACKGROUND:Current guidelines recommend the use of inhaled corticosteroids (ICSs) added to long-acting beta(2)-agonists (LABAs) for treatment of symptomatic patients with severe and very severe COPD. However, the evidence has been inconclusive. The aim of this review was to assess the safety and efficacy of LABAs/ICSs ...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.09-0821

    authors: Rodrigo GJ,Castro-Rodriguez JA,Plaza V

    更新日期:2009-10-01 00:00:00