Myocardial contractile reserve as prognostic determinant in patients with idiopathic dilated cardiomyopathy without overt heart failure.

Abstract:

:To assess the prognostic significance of myocardial contractile reserve in patients with idiopathic dilated cardiomyopathy (DCM) without overt heart failure (New York Heart Association functional class I or II), seventy-one patients underwent exercise radionuclide angiography in addition to clinical, radiographic, hemodynamic, and echocardiographic evaluations. Myocardial contractile reserve was assessed as left ventricular ejection fraction (LVEF) during peak exercise minus LVEF at rest (delta LVEF). During an average of 49 months, 18 patients died of the disease. Cox's proportional-hazards regression analysis showed that the delta LVEF was the most powerful and independent discriminator for survival (p = 0.0002). Ejection time (p = 0.0029) and cardiothoracic ratio (p = 0.017) were the second and third most predictive variables, respectively. Evaluation of the delta LVEF, which reflects residual myocardial contractile reserve, can provide important information about the prognosis of patients with DCM and mild symptoms.

journal_name

Chest

journal_title

Chest

authors

Nagaoka H,Isobe N,Kubota S,Iizuka T,Imai S,Suzuki T,Nagai R

doi

10.1378/chest.111.2.344

subject

Has Abstract

pub_date

1997-02-01 00:00:00

pages

344-50

issue

2

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(15)52532-4

journal_volume

111

pub_type

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