Abstract:
:To assess the value of bronchoalveolar lavage (BAL) for diagnosis, understanding, and treatment of amiodarone-associated pneumonitis, we examined the results of BAL total and differential cell counts and phenotyping of lymphocytes in 22 patients with this lung disorder and in 33 normal subjects. Overall, the total cell count was found to be almost the same as that seen in control subjects; the macrophage population was significantly reduced, and the lymphocyte, neutrophil, and eosinophil populations were increased in absolute number and percentage. When results were analyzed individually, BAL data appeared to be distributed according to two patterns. In the first pattern, there was no abnormal lymphocytosis. In the second pattern a lymphocyte alveolitis was found in percentage and in absolute number. This lymphocyte alveolitis was present either alone or associated with neutrophil alveolitis or with eosinophil alveolitis. In the first pattern, despite the normal level of the lymphocyte population, the percentage of CD4 T-lymphocytes and the CD4:CD8 T-lymphocyte ratio were significantly lowered. In the second pattern the CD8 T-lymphocyte count was increased in absolute number and percentage, with a low CD4:CD8 ratio. In six patients relavaged two to four months after amiodarone withdrawal, there was a significant fall in alveolar lymphocytosis, but the progressive increase in the neutrophil population over time seemed to be associated with the seriousness and progression of the disease. Finally, these findings closely resembled those obtained in patients with hypersensitivity pneumonitis due to inhalation of organic dust and suggest that an underlying immunologic cell-mediated mechanism may play a role in this iatrogenic pulmonary disease.
journal_name
Chestjournal_title
Chestauthors
Akoun GM,Cadranel JL,Blanchette G,Milleron BJ,Mayaud CMdoi
10.1378/chest.99.5.1177subject
Has Abstractpub_date
1991-05-01 00:00:00pages
1177-82issue
5eissn
0012-3692issn
1931-3543pii
S0012-3692(16)31157-6journal_volume
99pub_type
杂志文章相关文献
CHEST文献大全abstract::Bronchopulmonary Kaposi's sarcoma (KS) occurs in 20 percent of AIDS patients with cutaneous involvement; however, complete endobronchial occlusion is uncommon. Moreover, bronchopulmonary KS is infrequent in the absence of cutaneous manifestations. We report a case of documented complete endobronchial obstruction by KS...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.105.5.1581
更新日期:1994-05-01 00:00:00
abstract::A diagnosis of severe obstructive sleep apnea was made after a 52-year-old hypertensive man developed a large intracranial hemorrhage. Therapeutic noninvasive positive pressure ventilation (NPPV) for obstructive sleep apnea and hypoventilation was complicated by transient unilateral orbital herniation. As best as can ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.113.3.841
更新日期:1998-03-01 00:00:00
abstract::Endobronchial tuberculosis, while relatively common before the advent of effective antituberculosis chemotherapy, is seldom recognized now. Four patients with what appeared to be primary tuberculosis complicated by endobronchial spread were recently seen by us. Three of the four patients presented with anterior segmen...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.86.4.642
更新日期:1984-10-01 00:00:00
abstract:STUDY OBJECTIVE:To validate a noninvasive first-pass radionuclide ventriculographic (FPRV) measurement of maximum cardiac output (Qv) during exercise. DESIGN:Comparison of Qv to that measured by the Fick principle (Qf) at peak exercise. SETTING:Academic cardiopulmonary exercise laboratory. PATIENTS:Seventy-eight con...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.114.2.457
更新日期:1998-08-01 00:00:00
abstract:INTRODUCTION:The specific causes and mechanism(s) for asthma occurring among occupants of non-residential buildings with poor indoor air quality are not known, but allergic and nonallergic processes are possible explanations METHODS:Repeated indoor air quality measurements were made while employees were working in a b...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.128.3.1720
更新日期:2005-09-01 00:00:00
abstract:STUDY OBJECTIVES:The objective of this study was to evaluate the feasibility of the sentinel lymph node (SLN) biopsy in peripheral clinically stage I or II non-small cell lung cancer (NSCLC) using (99m)Tc colloid and a hand-held gamma detection probe, associated with a blue dye technique. DESIGN:Prospective study. SE...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.127.2.443
更新日期:2005-02-01 00:00:00
abstract::To clarify the interrelation between interleukin-2 (IL-2) and soluble IL-2R receptor (sIL-2R), as products of T-cell activation in the bronchial tree of patients with bronchial asthma, we measured the concentration of IL-2, sIL-2R, and the cellular composition in bronchoalveolar lavage (BAL) fluid. We also measured ph...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.106.2.400
更新日期:1994-08-01 00:00:00
abstract::Atrioventricular nodal alternating Wenckebach periods were defined as episodes of 2:1 atrioventricular block in which there was a gradual increase in transmission intervals of conducted beats ending in two or three consecutively blocked atrial impulses. This is one of the mechanisms whereby 2:1 atrioventricular block ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.73.1.69
更新日期:1978-01-01 00:00:00
abstract:BACKGROUND:Angiogenesis is a prerequisite for airway remodeling in bronchial asthma. Several factors may play important roles in inflammation and angiogenesis through effects on inflammatory cell infiltration or neovascularization. OBJECTIVES:(1) To determine the levels of vascular endothelial growth factor (VEGF) and...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.129.2.266
更新日期:2006-02-01 00:00:00
abstract::To determine the prevalence of carboxyhemoglobin levels in banked blood exceeding Air Quality Standards (level of carboxyhemoglobin greater than 1.5 percent), we analyzed banked blood for the level of carboxyhemoglobin from 101 randomly selected samples. Of 101 units of banked blood, 49 (49 percent) had carboxyhemoglo...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.85.5.694
更新日期:1984-05-01 00:00:00
abstract::We report two cases of pneumothorax detected by echographic examination immediately after ultrasonically guided aspiration biopsy and confirmed by chest x-ray film. The pneumothorax was characterized by the disappearance of the lung tumor. In the real-time image, the respiratory excursions of the visceral pleura also ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.101.3.855
更新日期:1992-03-01 00:00:00
abstract::Impedance measurement of the respiratory system by forced oscillations is a sensitive and accurate method to detect mechanical parameters, especially in normal subjects. The effects of inhalation of 0.2 mg of fenoterol and 0.02 mg of ipratropium bromide on the impedance of the respiratory system was studied in 20 heal...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.97.5.1137
更新日期:1990-05-01 00:00:00
abstract::To assess the pulmonary and systemic hemodynamic effects of oral captopril in patients with connective tissue disease and pulmonary hypertension, we performed right heart catheterization in eight patients with diffuse systemic sclerosis, the CREST syndrome, or mixed connective tissue diseases prior to and immediately ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.102.5.1407
更新日期:1992-11-01 00:00:00
abstract::Bronchodilator responses to both nebulized albuterol (salbutamol) and ipratropium bromide and aerosol delivery to the tracheobronchial tree have been assessed in eight patients with chronic stable asthma (mean baseline FEV1, 50 percent; reversibility greater than 20 percent). Two commercially available nebulizer syste...
journal_title:Chest
pub_type: 临床试验,杂志文章
doi:10.1378/chest.96.1.6
更新日期:1989-07-01 00:00:00
abstract::Atherosclerosis occurred in a coronary artery saphenous vein bypass graft. Serial angiograms are presented documenting subtotal occlusion of this graft which occurred over a nine-month period. Pathologic examination of graft material obtained at surgery demonstrated ulcerating atherosclerotic plaque. The occurrence of...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.79.1.96
更新日期:1981-01-01 00:00:00
abstract:STUDY OBJECTIVE:To determine if screening by specialists could reduce unnecessary test ordering and reduce costs related to diagnostic workup in patients undergoing evaluation for tuberculosis. DESIGN:Prospective evaluation of expert opinion in consecutive patients suspected of having tuberculosis. SETTING:A large mu...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.114.3.681
更新日期:1998-09-01 00:00:00
abstract::We attempted to assess recent changes in the prevalence of physician-diagnosed asthma and the possible influence of diagnostic exchange on these trends. The routinely collected data of the provincial Health Insurance Plan (physicians' claims) were used to determine the annual prevalence of physician-diagnosed asthma i...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.103.1.151
更新日期:1993-01-01 00:00:00
abstract::The field of lung transplant has made significant advances over the last several decades. Despite these advances, morbidity and mortality remain high when compared with other solid organ transplants. As the field moves forward, the speed by which progress can be made will in part be determined by our ability to overco...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1016/j.chest.2018.08.1036
更新日期:2019-03-01 00:00:00
abstract:OBJECTIVE:To evaluate the accuracy of a flow-proportional delivery system and the pattern of inspiratory nitric oxide (NO) concentration during different flow conditions. DESIGN:Laboratory study in a lung model. SETTING:University experimental laboratory. SUBJECT:With a new delivery system, NO was administered propo...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.112.2.496
更新日期:1997-08-01 00:00:00
abstract:BACKGROUND:A pulmonary right-to-left shunt (RLS) carries the risk of cerebral paradoxical embolization and severe neurologic complications. Recognizing patients at risk is important to facilitate appropriate management strategies, but a direct relation between pulmonary shunt size and risk of complications remains cont...
journal_title:Chest
pub_type: 杂志文章,多中心研究
doi:10.1378/chest.12-1599
更新日期:2013-08-01 00:00:00
abstract::We studied the reproducibility of tests of RM performance in normal elderly subjects and compared their performance with that of patients with COPD. The RM strength was measured as MIP and MEP. The RM endurance was measured using a two-minute incremental threshold loading test. The max load, the average Ppk as %MIP at...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.95.1.90
更新日期:1989-01-01 00:00:00
abstract::Propofol, a new intravenous sedative agent, was investigated in 41 asthmatic patients undergoing day-case (outpatient) fiberoptic bronchoscopy. The study design was a randomized comparison between propofol and midazolam, which is a well-established intravenous sedative agent. The age, weight, and American Society of A...
journal_title:Chest
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1378/chest.104.4.1029
更新日期:1993-10-01 00:00:00
abstract::Prevalence rates for asthma in various parts of the world are different and this cannot be entirely explained by differences in methodology. Low prevalence rates are found in third world countries, particularly marked for children. The reasons for these differences are obscure but are largely environmental. Some sugge...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.91.6_supplement.97s
更新日期:1987-06-01 00:00:00
abstract:STUDY OBJECTIVE:Our objective was to compare the efficacy of ultrahigh frequency ventilation (UHFV) (frequencies > 3 Hz) with respect to oxygenation, airway pressures, and hemodynamic parameters in patients with adult respiratory distress syndrome (ARDS) who were not responding to conventional ventilation. DESIGN:We u...
journal_title:Chest
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1378/chest.103.5.1413
更新日期:1993-05-01 00:00:00
abstract:BACKGROUND:Excessive daytime sleepiness (EDS) in individuals with OSA syndrome persisting despite good adherence to CPAP is a disabling condition. Pitolisant is a selective histamine H3-receptor antagonist with wake-promoting effects. RESEARCH QUESTION:Is pitolisant effective and safe for reducing daytime sleepiness i...
journal_title:Chest
pub_type: 杂志文章
doi:10.1016/j.chest.2020.09.281
更新日期:2020-10-26 00:00:00
abstract:BACKGROUND:The clinical course of idiopathic pulmonary fibrosis (IPF) is characterized by progressive decline in lung function and eventual mortality. We sought to determine if future declines in pulmonary function, mortality, or both can be predicted from prior trends in pulmonary function tests (PFTs). METHODS:Data ...
journal_title:Chest
pub_type: 杂志文章,多中心研究
doi:10.1378/chest.13-0844
更新日期:2014-03-01 00:00:00
abstract:OBJECTIVE:To compare sublingual PCO(2) (PslCO(2)) measurements with gastric intramucosal PCO(2) (PimCO(2)) as well as with the traditional indexes of tissue oxygenation in hemodynamically unstable ICU patients. DESIGN:A prospective, validation study. SETTING:The medical and coronary ICUs of a community teaching hospi...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.120.3.923
更新日期:2001-09-01 00:00:00
abstract::Pulmonary hypertension and related pulmonary vascular diseases cause significant morbidities and high mortality and present many unique challenges toward improving outcomes in neonates, infants, and children. Differences between pediatric and adult disease are reflected in controversies regarding etiologies, classific...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1016/j.chest.2016.01.007
更新日期:2016-07-01 00:00:00
abstract::The concentrations of gentamicin, netilmicin, and amikacin were determined after one single intravenous injection in uninfected pleural fluid after thoracotomy and in purulent pleural empyemas. The mean peak concentrations in the pleural fluid after the injection of gentamicin (1.5 mg/kg), netilmicin (2.0 mg/kg), and ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.93.3.530
更新日期:1988-03-01 00:00:00
abstract::Immunohistochemistry has come to occupy a key position among the armamentarium of tools pathologists apply to the evaluation of lung and pleural neoplasms. This technique uses antibodies that bind to specific antigens, usually proteins, enabling microscopic detection of the antigens. Over the last several decades, an ...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.11-3327
更新日期:2012-11-01 00:00:00