Abstract:
:Hereditary motor and sensory neuropathy (Charcot-Marie-Tooth disease) is characterized by chronic degeneration of peripheral nerves and roots, resulting in distal muscle atrophy, beginning in the feet and legs and later involving the hands. The association of this disease with diaphragmatic dysfunction has not been reported. We studied a patient with hereditary motor and sensory neuropathy type 1 (Charcot-Marie-Tooth disease) and type 2 diabetes mellitus who had severe diaphragmatic impairment. Some of the clinical findings are similar to the sleep apnea syndrome, which could lead to incorrect diagnosis and delay in the administration of appropriate therapy. Transdiaphragmatic pressure studies on the subject's brother, who also has Charcot-Marie-Tooth disease and type 2 diabetes mellitus, revealed subclinical impairment of diaphragmatic function. These findings suggest that phrenic nerve involvement may be part of the spectrum of polyneuropathy in Charcot-Marie-Tooth disease in association with diabetes mellitus.
journal_name
Chestjournal_title
Chestauthors
Chan CK,Mohsenin V,Loke J,Virgulto J,Sipski ML,Ferranti Rdoi
10.1378/chest.91.4.567subject
Has Abstractpub_date
1987-04-01 00:00:00pages
567-70issue
4eissn
0012-3692issn
1931-3543pii
S0012-3692(15)43054-5journal_volume
91pub_type
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