Pulmonary emboli in patients receiving chemotherapy for non-Hodgkin's lymphoma.

Abstract:

:Combination chemotherapy has dramatically improved the prognosis of patients with intermediate and high grade histologic subtypes of non-Hodgkin's lymphomas. Treatment-related complications, however, are considerable, and a common problem encountered is respiratory distress or respiratory insufficiency. Usually these difficulties have been attributed to infectious etiologies or to chemotherapy-induced interstitial fibrosis, most often involving bleomycin. We describe five patients presenting with respiratory problems several weeks after the initiation of chemotherapy. These patients, who represent 3 percent of all patients treated with a single bleomycin-containing regimen for intermediate or high grade non-Hodgkin's lymphoma, were all initially thought to have chemotherapy-induced interstitial fibrosis but were found on subsequent evaluation to have pulmonary emboli. Of the three patients in whom pulmonary emboli were diagnosed antemortem, two had symptoms suggestive of pulmonary emboli and all were successfully treated and remained well and free of lymphoma for over 24 months. Two additional patients were diagnosed at autopsy. We suggest that pulmonary emboli may contribute significantly to the morbidity and mortality of patients undergoing chemotherapy for non-Hodgkin's lymphoma and recommend that patients presenting with respiratory difficulties be evaluated for pulmonary emboli.

journal_name

Chest

journal_title

Chest

authors

Glenn LD,Armitage JO,Goldsmith JC,Sorensen S,Howe D,Weisenberger DD

doi

10.1378/chest.94.3.589

subject

Has Abstract

pub_date

1988-09-01 00:00:00

pages

589-94

issue

3

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(16)30169-6

journal_volume

94

pub_type

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