Pulmonary emboli in patients receiving chemotherapy for non-Hodgkin's lymphoma.


:Combination chemotherapy has dramatically improved the prognosis of patients with intermediate and high grade histologic subtypes of non-Hodgkin's lymphomas. Treatment-related complications, however, are considerable, and a common problem encountered is respiratory distress or respiratory insufficiency. Usually these difficulties have been attributed to infectious etiologies or to chemotherapy-induced interstitial fibrosis, most often involving bleomycin. We describe five patients presenting with respiratory problems several weeks after the initiation of chemotherapy. These patients, who represent 3 percent of all patients treated with a single bleomycin-containing regimen for intermediate or high grade non-Hodgkin's lymphoma, were all initially thought to have chemotherapy-induced interstitial fibrosis but were found on subsequent evaluation to have pulmonary emboli. Of the three patients in whom pulmonary emboli were diagnosed antemortem, two had symptoms suggestive of pulmonary emboli and all were successfully treated and remained well and free of lymphoma for over 24 months. Two additional patients were diagnosed at autopsy. We suggest that pulmonary emboli may contribute significantly to the morbidity and mortality of patients undergoing chemotherapy for non-Hodgkin's lymphoma and recommend that patients presenting with respiratory difficulties be evaluated for pulmonary emboli.






Glenn LD,Armitage JO,Goldsmith JC,Sorensen S,Howe D,Weisenberger DD




Has Abstract


1988-09-01 00:00:00
















  • Coronary atherosclerosis in mitral stenosis.

    abstract::Eighty-two patients with mitral stenosis underwent cardiac catheterization with coronary angiography. Twenty-one patients (26 percent) had coronary artery disease. Characteristics of the mitral valve area, cardiac output, pulmonary artery pressure, pulmonary vascular resistance, left ventricular end-diastolic pressure...


    pub_type: 杂志文章


    authors: Chun PK,Gertz E,Davia JE,Cheitlin MD

    更新日期:1982-01-01 00:00:00

  • Specific expiratory muscle training in COPD.

    abstract:BACKGROUND:There are several reports showing that expiratory muscle strength and endurance can be impaired in patients with COPD. This muscle weakness may have clinically relevant implications. Expiratory muscle training tended to improve cough and to reduce the sensation of respiratory effort during exercise in patien...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Weiner P,Magadle R,Beckerman M,Weiner M,Berar-Yanay N

    更新日期:2003-08-01 00:00:00

  • Pharmacologic therapy for pulmonary arterial hypertension in adults: CHEST guideline and expert panel report.

    abstract:OBJECTIVE:Choices of pharmacologic therapies for pulmonary arterial hypertension (PAH) are ideally guided by high-level evidence. The objective of this guideline is to provide clinicians advice regarding pharmacologic therapy for adult patients with PAH as informed by available evidence. METHODS:This guideline was bas...


    pub_type: 杂志文章,评审


    authors: Taichman DB,Ornelas J,Chung L,Klinger JR,Lewis S,Mandel J,Palevsky HI,Rich S,Sood N,Rosenzweig EB,Trow TK,Yung R,Elliott CG,Badesch DB

    更新日期:2014-08-01 00:00:00

  • Commonly Used Patient-Reported Outcomes Do Not Improve Prediction of COPD Exacerbations: A Multicenter 4½ Year Prospective Cohort Study.

    abstract:BACKGROUND:Several cross-sectional and short-term studies suggest that patient-reported outcomes (PROs) may be useful to help predict COPD exacerbations, but evidence from long-term prospective cohort studies is lacking. Our aim was to assess if PROs add to the prediction of exacerbations. METHODS:Four hundred eight p...


    pub_type: 杂志文章,多中心研究


    authors: Strassmann A,Frei A,Haile SR,Ter Riet G,Puhan MA

    更新日期:2017-12-01 00:00:00

  • Radiation effect on implanted pacemakers.

    abstract::It was previously thought that diagnostic or therapeutic ionizing radiation did not have an adverse effect on the function of cardiac pacemakers. Recently, however, some authors have reported damaging effect of the therapeutic radiation on cardiac pulse generators. An analysis of a recently-extracted pacemaker documen...


    pub_type: 杂志文章


    authors: Pourhamidi AH

    更新日期:1983-10-01 00:00:00

  • Determination of static pulmonary volumes after bronchodilator therapy.

    abstract::Increased (more positive) end-expiratory and decreased (more negative) end-inspiratory values for intrapleural pressure (PpI) invariably accompany acute bronchoconstriction. We hypothesize that both the increase in vital capacity (VC) and the decrease in residual volume (RV) observed after dilation of the central airw...


    pub_type: 杂志文章


    authors: Lavietes MH,Taylor DW

    更新日期:1979-10-01 00:00:00

  • Increased expression of leukocyte function associated antigen-1 (LFA-1) and intercellular adhesion molecule-1 (ICAM-1) by alveolar macrophages of patients with pulmonary sarcoidosis.

    abstract::Leukocyte function associated antigen-1 (LFA-1) and its ligand intercellular adhesion molecule-1 (ICAM-1) are cell adhesion molecules that play an important role in the capacity of monoculear phagocytes (MPs) to present antigens to T lymphocytes. Since in pulmonary sarcoidosis (PS) this capacity is increased at sites ...


    pub_type: 杂志文章


    authors: Melis M,Gjomarkaj M,Pace E,Malizia G,Spatafora M

    更新日期:1991-10-01 00:00:00

  • Relevance of latent TB infection in areas of high TB prevalence.

    abstract::About one-third of the world population has latent TB infection (LTBI), the majority of which is distributed in 22 high-burden countries. Early diagnosis and treatment of active TB remains the top priority in resource-poor countries with high TB prevalence. Notwithstanding, because LTBI contributes significantly to th...


    pub_type: 杂志文章,评审


    authors: Sharma SK,Mohanan S,Sharma A

    更新日期:2012-09-01 00:00:00

  • Pulmonary, chest wall, and lung-thorax elastances in acute respiratory failure.

    abstract::The usefulness of lung-thorax compliance (or elastance) as an index of pulmonary compliance (or elastance) was examined in 15 patients being ventilated for acute respiratory failure. Mean lung-thorax elastance (ELT) was 27.9 +/- 2.6 cm H2O/L, and the chest wall accounted for 34 +/- 2 percent of the mean total value. C...


    pub_type: 杂志文章


    authors: Katz JA,Zinn SE,Ozanne GM,Fairley HB

    更新日期:1981-09-01 00:00:00

  • Paradoxical trough effects of triple therapy with budesonide/formoterol and tiotropium bromide on pulmonary function outcomes in COPD.

    abstract:BACKGROUND:Lowest receptor occupancy for a drug occurs at trough prior to the next dose. Previous studies have focused on the effects of triple therapy at peak dose intervals using forced expiratory maneuvers. Impulse oscillometry (IOS) and body plethysmography (PLETH) are more sensitive than spirometry to assess inhal...


    pub_type: 杂志文章,随机对照试验


    authors: Williamson PA,Short PM,Clearie KL,Vaidyanathan S,Fardon TC,Howaniec LJ,Lipworth BJ

    更新日期:2010-09-01 00:00:00

  • An Audit of medical thoracoscopy and talc poudrage for pneumothorax prevention in advanced COPD.

    abstract:OBJECTIVES:To prospectively study all patients with COPD and spontaneous pneumothorax (SP) who underwent thoracoscopic talc poudrage (TP) under local anesthesia to determine its efficacy and safety in recurrence prevention. METHODS:Data on clinical measurements, complications, duration of chest tube drainage, length o...


    pub_type: 杂志文章


    authors: Lee P,Yap WS,Pek WY,Ng AW

    更新日期:2004-04-01 00:00:00

  • Investigation of occupational asthma: sputum cell counts or exhaled nitric oxide?

    abstract:BACKGROUND:The measure of sputum eosinophil counts is a useful tool in the investigation of occupational asthma (OA), but processing sputum is time consuming. Measuring the fractional concentration of exhaled nitric oxide (FENO) may be an alternative in clinical practice. The aim of this study was to assess the respect...


    pub_type: 杂志文章,多中心研究


    authors: Lemière C,D'Alpaos V,Chaboillez S,César M,Wattiez M,Chiry S,Vandenplas O

    更新日期:2010-03-01 00:00:00

  • Abnormal swallowing reflex and COPD exacerbations.

    abstract:BACKGROUND:It is unclear whether an abnormal swallowing reflex affects COPD exacerbations. This study investigated the prevalence of abnormal swallowing reflexes and its relationship with COPD exacerbation prospectively. We also clarified its association with gastroesophageal reflux disease (GERD) and airway bacterial ...


    pub_type: 杂志文章


    authors: Terada K,Muro S,Ohara T,Kudo M,Ogawa E,Hoshino Y,Hirai T,Niimi A,Chin K,Mishima M

    更新日期:2010-02-01 00:00:00

  • Some epidemiologic aspects of acute myocardial infarction in Israel.

    abstract::A nationwide study of acute myocardial infarction in Israel was carried out during a one-year period. There were 2,504 new and 968 repeated attacks. Annual incidence rate of first attacks was 0.9 per 1,000 (1.3 in men and 0.5 in women). Incidence was highest among the European born in both sexes. But, while the patter...


    pub_type: 杂志文章


    authors: Shani M,Schor S,Modan B

    更新日期:1975-08-01 00:00:00

  • AIDS, public policy and biomedical research.

    abstract::The current epidemic of acquired immune deficiency syndrome (AIDS) raises numerous public policy concerns for the medical community. The issues can be divided into two groups. Those concerns which require both immediate action and results are referred to as short-term issues. Those issues whose results will not be for...


    pub_type: 杂志文章


    authors: Panem S

    更新日期:1984-03-01 00:00:00

  • Distinguishing left ventricular aneurysm from pseudoaneurysm. A review of the literature.

    abstract::A postmyocardial infarction left ventricular pseudoaneurysm occurs when a rupture of the ventricular free wall is contained by overlying, adherent pericardium. A postinfarction aneurysm, in contrast, is caused by scar formation resulting in thinning of the myocardium. Although the usual treatment for patients with pse...


    pub_type: 杂志文章,评审


    authors: Brown SL,Gropler RJ,Harris KM

    更新日期:1997-05-01 00:00:00

  • Understanding cardiopulmonary resuscitation decision making: perspectives of seriously ill hospitalized patients and family members.

    abstract:BACKGROUND:To improve communication and decision making related to cardiopulmonary resuscitation (CPR), a greater understanding of the perspectives of hospitalized patients with advanced diseases and their family members are needed. METHODS:In five Canadian hospitals, we administered a face-to-face questionnaire to ol...


    pub_type: 杂志文章,多中心研究


    authors: Heyland DK,Frank C,Groll D,Pichora D,Dodek P,Rocker G,Gafni A

    更新日期:2006-08-01 00:00:00

  • A Man in His 20s With Cough, Unilateral Pleural Effusion, and Nodular Pleural Thickening.

    abstract:CASE PRESENTATION:A man in his 20s presented to the ED after several months of progressive dyspnea, dry cough, and night sweats. He had no chest pain, fevers, weight loss, or sick contacts. He was previously healthy and took no medications. Social history was notable for 5 pack-years of tobacco use. The patient was sex...


    pub_type: 杂志文章


    authors: Sonnick MA,Weisman S,Borczuk AC,Turetz ML

    更新日期:2019-12-01 00:00:00

  • Evaluation of an abbreviated adenosine monophosphate bronchial challenge.

    abstract:RATIONALE:Airway hyperresponsiveness to adenosine monophosphate (AMP) has been validated as a surrogate marker for airway inflammation. We wished to know whether an abbreviated challenge at the final threshold dose would produce the same fall in FEV1 as a full, conventional dose-response challenge. METHODS:Seventeen p...


    pub_type: 病人教育讲义


    authors: Fardon TC,Hodge MR,Lipworth BJ

    更新日期:2005-06-01 00:00:00

  • Use of a panel of tumor markers (carcinoembryonic antigen, cancer antigen 125, carbohydrate antigen 15-3, and cytokeratin 19 fragments) in pleural fluid for the differential diagnosis of benign and malignant effusions.

    abstract:STUDY OBJECTIVE:The diagnostic value of tumor markers in pleural fluid is subject to debate. The aim of this study was to evaluate the diagnostic performance of several tumor markers in common use for detecting malignant pleural disease. DESIGN:Blinded comparison of four tumor markers in pleural fluid with a confirmat...


    pub_type: 杂志文章


    authors: Porcel JM,Vives M,Esquerda A,Salud A,Pérez B,Rodríguez-Panadero F

    更新日期:2004-12-01 00:00:00

  • Maximal sniff mouth pressure compared with maximal inspiratory pressure in acute respiratory failure.

    abstract::Inspiratory muscle strength most often is better reflected by sniff Pes than PImax against occlusion. Furthermore, sniff Pes can be estimated noninvasively by the measurement of sniff Pmo in normal subjects and in patients with respiratory muscle weakness. The aim of this study was to compare sniff Pmo and P.PImax to ...


    pub_type: 杂志文章


    authors: Héritier F,Perret C,Fitting JW

    更新日期:1991-07-01 00:00:00

  • Serologic IgE immune responses against Aspergillus fumigatus and Candida albicans in patients with cystic fibrosis.

    abstract:OBJECTIVES:The objectives of this study were to determine the prevalence of Aspergillus fumigatus and Candida albicans in the sputa of patients with cystic fibrosis (CF), to assess serologic IgE responses of these patients to the presence of fungi in the sputum, to evaluate what effect this may have on clinical status,...


    pub_type: 杂志文章


    authors: Máiz L,Cuevas M,Quirce S,Cañón JF,Pacheco A,Sousa A,Escobar H

    更新日期:2002-03-01 00:00:00

  • Maximum insufflation capacity.

    abstract:OBJECTIVE:To investigate the effect of deep lung insufflations on maximum insufflation capacities (MICs) and peak cough flows (PCFs) for patients with neuromuscular disease. METHOD:Forty-three patients with neuromuscular disease were trained in stacking delivered volumes of air to deep lung insufflation and were presc...


    pub_type: 杂志文章


    authors: Kang SW,Bach JR

    更新日期:2000-07-01 00:00:00

  • Sleep-disordered breathing in Down syndrome.

    abstract::OSA is associated with significant adverse outcomes with far-reaching health-care implications. OSA is much more common and severe in patients with Down syndrome (DS) than in the general population, yet there is a striking lack of literature in this area. In this review article, we have summarized the current state of...


    pub_type: 杂志文章,评审


    authors: Lal C,White DR,Joseph JE,van Bakergem K,LaRosa A

    更新日期:2015-02-01 00:00:00

  • Age and Sex Disparities in Adherence to CPAP.

    abstract:BACKGROUND:CPAP effectiveness is limited by suboptimal adherence. Prior studies of adherence have focused on middle-aged men. RESEARCH QUESTION:Does CPAP adherence vary by age and sex? STUDY DESIGN AND METHODS:Telemonitoring data from a CPAP manufacturer database were used to assess adherence in patients initiating C...


    pub_type: 杂志文章


    authors: Patel SR,Bakker JP,Stitt CJ,Aloia MS,Nouraie SM

    更新日期:2021-01-01 00:00:00

  • Preoperative spirometry and laparotomy: blowing away dollars.

    abstract:STUDY OBJECTIVE:Increasing evidence indicates that routine preoperative diagnostic spirometry (pulmonary function tests [PFTs]) before elective abdominal surgery does not predict individual risk of postoperative pulmonary complications and is overutilized. This economic evaluation estimates potential savings from reduc...


    pub_type: 杂志文章


    authors: De Nino LA,Lawrence VA,Averyt EC,Hilsenbeck SG,Dhanda R,Page CP

    更新日期:1997-06-01 00:00:00

  • Bronchoalveolar lavage cell data in amiodarone-associated pneumonitis. Evaluation in 22 patients.

    abstract::To assess the value of bronchoalveolar lavage (BAL) for diagnosis, understanding, and treatment of amiodarone-associated pneumonitis, we examined the results of BAL total and differential cell counts and phenotyping of lymphocytes in 22 patients with this lung disorder and in 33 normal subjects. Overall, the total cel...


    pub_type: 杂志文章


    authors: Akoun GM,Cadranel JL,Blanchette G,Milleron BJ,Mayaud CM

    更新日期:1991-05-01 00:00:00

  • Childhood obstructive sleep-disordered breathing: a clinical update and discussion of technological innovations and challenges.

    abstract::Childhood sleep-disordered breathing (SDB) has been known to be associated with health and cognitive impacts for more than a century, and yet our understanding of this disorder is in its infancy. Neuropsychological consequences in children with snoring or subtle breathing disturbances not meeting the traditional defin...


    pub_type: 杂志文章,评审


    authors: Halbower AC,Ishman SL,McGinley BM

    更新日期:2007-12-01 00:00:00

  • Lymphocytic alveolitis in a crematorium worker.

    abstract::An asymptomatic cremator was found incidentally to have lymphocytic alveolitis by bronchoalveolar lavage, and the basis for this finding was investigated. No known causes of lymphocyte alveolitis including sarcoidosis, hypersensitivity pneumonitis, berylliosis, tuberculosis, or fungal diseases of the lung were found. ...


    pub_type: 杂志文章


    authors: Schauble TL,Rich EA

    更新日期:1994-02-01 00:00:00

  • Short- and long-term outcomes of critically ill patients with cancer and prolonged ICU length of stay.

    abstract:BACKGROUND:Data on patients with cancer who have a prolonged length of stay (LOS) in the ICU are scarce. The aim of the present study was to evaluate the characteristics and the outcomes of cancer patients with life-threatening complications with an ICU stay > or = 21 days. METHODS:A cohort study performed at a 10-bed...


    pub_type: 杂志文章


    authors: Soares M,Salluh JIF,Torres VBL,Leal JVR,Spector N

    更新日期:2008-09-01 00:00:00