Abstract:
BACKGROUND:There are several reports showing that expiratory muscle strength and endurance can be impaired in patients with COPD. This muscle weakness may have clinically relevant implications. Expiratory muscle training tended to improve cough and to reduce the sensation of respiratory effort during exercise in patients other than those with COPD. METHODS:Twenty-six patients with COPD (FEV(1) 38% predicted) were recruited for the study. The patients were randomized into two groups: group 1, 13 patients were assigned to receive specific expiratory muscle training (SEMT) daily, six times a week, each session consisting of 1/2 h of training, for 3 months; and group 2, 13 patients were assigned to be a control group and received training with very low load. Spirometry, respiratory muscle strength and endurance, 6-min walk test, Mahler baseline dyspnea index (before), and the transitional dyspnea index (after) were measured before and after training. RESULTS:The training-induced changes were significantly greater in the SEMT group than in the control group for the following variables: expiratory muscle strength (from 86 +/- 4.1 to 104 +/- 4.9 cm H(2)O, p < 0.005; mean difference from the control group, 24%; 95% confidence interval, 18 to 32%), expiratory muscle endurance (from 57 +/- 2.9% to 76 +/- 4.0%, p < 0.001; mean difference from the control group, 29%; 95% confidence interval, 21 to 39%), and in the distance walked in 6 min (from 262 +/- 38 to 312 +/- 47 m, p < 0.05; mean difference from the control group, 14%; 95% confidence interval, 9 to 20%). There was also a small but not significant increase (from 5.1 +/- 0.9 to 5.6 +/- 0.7, p = 0.14) in the dyspnea index. CONCLUSIONS:The expiratory muscles can be specifically trained with improvement of both strength and endurance in patients with COPD. This improvement is associated with increase in exercise performance and no significant change in the sensation of dyspnea in daily activities.
journal_name
Chestjournal_title
Chestauthors
Weiner P,Magadle R,Beckerman M,Weiner M,Berar-Yanay Ndoi
10.1378/chest.124.2.468subject
Has Abstractpub_date
2003-08-01 00:00:00pages
468-73issue
2eissn
0012-3692issn
1931-3543pii
S0012-3692(15)33326-2journal_volume
124pub_type
临床试验,杂志文章,随机对照试验相关文献
CHEST文献大全abstract:BACKGROUND:D6 is an atypical chemokine receptor involved in chemokine degradation and resolution of acute inflammatory responses in mice. Emerging evidence suggests that D6 might behave differently in human chronic inflammatory conditions. We, therefore, investigated the involvement of D6 in the immune responses in COP...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.11-3220
更新日期:2013-01-01 00:00:00
abstract::Angiofollicular lymph node hyperplasia, known more commonly as Castleman disease, is a rare lymphoproliferative disorder. Castleman disease has two distinct clinical manifestations described as unicentric and multicentric disease. These presentations have distinct treatment algorithms and portend very different progno...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.09-2084
更新日期:2010-11-01 00:00:00
abstract::Fourteen of 22 patients (64%) with normally functioning porcine prosthetic valves in the mitral position had apical diastolic rumbles on phonocardiogram and by auscultation. Six (27%) had opening snaps. Factors necessary for the production of a diastolic rumble appear to include central flow, a flexible stent, and the...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.73.2.189
更新日期:1978-02-01 00:00:00
abstract::We encountered a clinical problem in a young man who presented with a left upper lobe mass and a diffuse reticular-nodular infiltrate. We thought we had appropriately applied Murphy's Law (the famed bank robber who "went where the money is"), and Ockham's Razor (the philosopher William of Ockham [1285 to 1349]-"Entiti...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.105.6.1864
更新日期:1994-06-01 00:00:00
abstract:BACKGROUND:COPD is often associated with changes of the structure and the function of the heart. Although functional abnormalities of the right ventricle (RV) have been well described in COPD patients with severe hypoxemia, little is known about these changes in patients with normoxia and mild hypoxemia. STUDY OBJECTI...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.127.6.1898
更新日期:2005-06-01 00:00:00
abstract::Dieulafoy's disease is a vascular anomaly characterized by the presence of a dysplastic artery that is related to an epithelial ulcer. While it is most frequently a GI condition, occurrence in the bronchus has been reported previously in six cases. We present the case of a 51-year-old man with severe hemoptysis and ep...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.119.1.292
更新日期:2001-01-01 00:00:00
abstract:CASE PRESENTATION:A 62-year-old woman with a history of partially treated Graves disease and hypertension presented with approximately 3 weeks of worsening fatigue, lower extremity myalgias, and shortness of breath. Her medical history included a thyroid radiofrequency ablation several years earlier. Following the abla...
journal_title:Chest
pub_type:
doi:10.1016/j.chest.2019.09.041
更新日期:2020-03-01 00:00:00
abstract::Streptococcus pneumoniae has been known for > 100 years as the most important bacterial pathogen of the respiratory tract in adults and children. In recent years, the pneumococcus has begun to exhibit increasing resistance to antimicrobial agents. Because of the huge number of infections caused by this organism, the d...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.117.2.530
更新日期:2000-02-01 00:00:00
abstract::We report an unusual case of a patient with a bronchopleural-subcutaneous fistula that occurred 3 years following a lobectomy and en bloc chest wall resection for carcinoma. Following a sudden resolution of subcutaneous emphysema, an epidural air collection developed. Spontaneous pneumorrhachis is a previously unrepor...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.121.5.1712
更新日期:2002-05-01 00:00:00
abstract::At the cardiac sympathetic nerve terminal the alpha 2-adrenoceptor is presynaptic and appears to be located at an extrasynaptic site. This is suggested by (1) absence of evidence of autoinhibitory feedback at physiologic stimulus levels up to about 50 percent of the maximum chronotropic response in the isolated guinea...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.83.2_supplement.345
更新日期:1983-02-01 00:00:00
abstract:BACKGROUND:Lung cancer screening, despite its proven mortality benefit, remains vastly underutilized. Previous studies examined knowledge, attitudes, and beliefs to better understand the reasons underlying the low screening rates. These investigations may have limited generalizability because of traditional participant...
journal_title:Chest
pub_type: 杂志文章
doi:10.1016/j.chest.2019.12.048
更新日期:2020-07-01 00:00:00
abstract::Eighteen asymptomatic postmenopausal women volunteered to ingest 2 ml of 100-proof vodka per kg of body weight in orange juice on one night and a placebo on another. Overnight sleep monitoring was performed immediately thereafter. Alcohol ingestion caused reduction in total sleep time from 329 to 281 minutes and a dec...
journal_title:Chest
pub_type: 临床试验,杂志文章
doi:10.1378/chest.88.2.181
更新日期:1985-08-01 00:00:00
abstract::The surgical treatment of the completely obstructed left main coronary artery is aortocoronary saphenous-vein bypass to the left coronary artery system. Without surgical intervention, this lesion has an exceedingly poor prognosis. This report describes a patient with atherosclerotic obstruction of the left main corona...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.69.2.238
更新日期:1976-02-01 00:00:00
abstract::This is the first reported case of discrete fibrous subaortic stenosis in tetralogy of Fallot. Transaortic excision of the subaortic membrane was readily accomplished. To detect this and other forms of left ventricular outflow-tract obstruction in tetralogy of Fallot before surgery, routine selective left ventriculogr...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.69.4.543
更新日期:1976-04-01 00:00:00
abstract:BACKGROUND:Studies evaluating the dose of epinephrine required to optimize return of spontaneous circulation and survival after CPR have shown that doses greater than recommended by advanced cardiac life support (ACLS) improve coronary perfusion pressure and short-term resuscitation rates. Since survival has not improv...
journal_title:Chest
pub_type: 临床试验,杂志文章
doi:10.1378/chest.106.5.1499
更新日期:1994-11-01 00:00:00
abstract::The resurgence of tuberculosis (TB) in the early 1990s, including multidrug-resistant strains, led health officials to recommend the use of involuntary detention for persistently nonadherent patients. Using a series of recently published articles on the subject, this paper offers some opinions on how detention program...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.115.1.236
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND:D-dimer, a degradation product of fibrin, has been increasingly used as a marker or prognostic factor in various thrombotic diseases. OBJECTIVE:To assess the significance of a d-dimer test in patients with primary pulmonary hypertension (PPH). PATIENTS AND METHODS:Fourteen patients with PPH (12 women and 2...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.122.5.1674
更新日期:2002-11-01 00:00:00
abstract:OBJECTIVE:To assess, by systematic review, the efficacy and safety of recombinant tissue plasminogen activator (rt-PA) in the treatment of lower extremity deep venous thrombosis (DVT). A secondary objective is to assess the optimal dose and route of administration of rt-PA. METHODS:Included studies were randomized, co...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.119.2.572
更新日期:2001-02-01 00:00:00
abstract::The purpose of this study was to determine the frequency and severity of arterial oxygen desaturation during and after endotracheal suctioning in a group of ventilator-dependent patients with acute respiratory failure (the majority of whom had underlying obstructive lung disease) and to evaluate the efficacy of severa...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.83.4.621
更新日期:1983-04-01 00:00:00
abstract:OBJECTIVES:Though numerous studies have demonstrated the short-term efficacy of lung volume reduction surgery (LVRS) in select patients with emphysema, the longer-term follow-up studies are just being reported. The primary objectives of this study were to assess long-term health-related quality of life, satisfaction, p...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.123.4.1026
更新日期:2003-04-01 00:00:00
abstract:STUDY OBJECTIVES:The purpose of this 12-week study was to evaluate the efficacy and safety of adjunct modafinil to treat excessive sleepiness in patients with obstructive sleep apnea (OSA) who experience residual sleepiness despite regular nasal continuous positive airway pressure (nCPAP) use. DESIGN:Twelve-week, open...
journal_title:Chest
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1378/chest.124.6.2192
更新日期:2003-12-01 00:00:00
abstract::It has been suggested that spirometry should be incorporated into the routine examination of every patient, analogous to obtaining vital signs. To determine the impact of spirometry on the management of outpatients with respiratory disease, spirometry was performed on 150 consecutive patients (123 men and 27 women, me...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.99.3.730
更新日期:1991-03-01 00:00:00
abstract::Pneumocystis carinii pneumonia is a frequent manifestation of the acquired immune deficiency syndrome (AIDS). It usually presents radiologically as diffuse bilateral infiltrates and histologically as a foamy, eosinophilic intra-alveolar exudate containing the organisms' cysts. We recently studied two rare cases of P c...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.94.3.580
更新日期:1988-09-01 00:00:00
abstract:STUDY OBJECTIVES:To investigate intracranial pressure (ICP) changes and their mechanisms in chronic hypercapnia. DESIGN:After 12 male Wistar rats were maintained in CO2-mixed air (mean PaCO2, 71.0 mm Hg) for 21 weeks, their ICP levels were measured during the breathing of 0, 5, 10, 12, and 14% CO2-mixed air before and...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.115.5.1402
更新日期:1999-05-01 00:00:00
abstract:STUDY OBJECTIVE:To determine the prevalence of left ventricular diastolic dysfunction in patients with biopsy specimen-proved pulmonary sarcoidosis without clinical evidence of cardiac disease. DESIGN:A cross-sectional study. SETTING:A large tertiary care university teaching hospital. PATIENTS AND CONTROL SUBJECTS:F...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.109.1.62
更新日期:1996-01-01 00:00:00
abstract::A report of pulmonary edema following acute upper airway obstruction in an adult is presented, and the literature involving 25 additional cases is reviewed. This form of pulmonary edema appears to be related to markedly negative intrathoracic pressure due to forced inspiration against a closed upper airway resulting i...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.94.5.1090
更新日期:1988-11-01 00:00:00
abstract::The utility of the apnea index (number of apneic events per hour of sleep) in diagnosing sleep apnea syndrome is reviewed. Data from currently extant reports indicate that many otherwise normal, aging subjects may be classified as having sleep apnea syndrome based on the current diagnostic threshold of five apneic epi...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.86.4.529
更新日期:1984-10-01 00:00:00
abstract:BACKGROUND:Angiogenesis is a prerequisite for airway remodeling in bronchial asthma. Several factors may play important roles in inflammation and angiogenesis through effects on inflammatory cell infiltration or neovascularization. OBJECTIVES:(1) To determine the levels of vascular endothelial growth factor (VEGF) and...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.129.2.266
更新日期:2006-02-01 00:00:00
abstract:BACKGROUND:Obstructive sleep apnea (OSA) is a highly prevalent disorder that has been associated with an increased risk for cardiovascular morbidity, even in children. However, not all children with OSA manifest alterations in endothelial postocclusive hyperemia, an endothelial nitric oxide synthase (eNOS)-dependent re...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.12-2026
更新日期:2013-04-01 00:00:00
abstract:STUDY OBJECTIVE:Low-grade systemic inflammation may cause a chronic catabolic state that may affect trainability in patients with COPD as has been seen previously in healthy elderly. Therefore, the aim of the present study was to study the relationship between baseline circulating levels of inflammatory markers and the...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.128.5.3183
更新日期:2005-11-01 00:00:00