Fatal pulmonary edema due to nitric acid fume inhalation in three pulp-mill workers.

Abstract:

:Three young men died of rapidly progressive pulmonary edema of delayed onset after inhalation of fumes from an accidental nitric acid explosion. Electron microscopy revealed altered neutrophils and necrotic endothelial cells in alveolar capillaries. Immunohistochemistry showed small and large serum proteins, including immunoglobulin M, in the edema fluid and hyaline membranes. Increased permeability is a consequence of direct microvascular injury by inhaled nitrogen dioxide. However, our findings, implicating neutrophils and serum-derived mediators in the pathogenesis of the pulmonary edema, are consistent with recent proposals on their roles in the maintenance and/or progression of edema initiated by toxic inhalations.

journal_name

Chest

journal_title

Chest

authors

Hajela R,Janigan DT,Landrigan PL,Boudreau SF,Sebastian S

doi

10.1378/chest.97.2.487

subject

Has Abstract

pub_date

1990-02-01 00:00:00

pages

487-9

issue

2

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(15)40699-3

journal_volume

97

pub_type

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