Abstract:
:Three young men died of rapidly progressive pulmonary edema of delayed onset after inhalation of fumes from an accidental nitric acid explosion. Electron microscopy revealed altered neutrophils and necrotic endothelial cells in alveolar capillaries. Immunohistochemistry showed small and large serum proteins, including immunoglobulin M, in the edema fluid and hyaline membranes. Increased permeability is a consequence of direct microvascular injury by inhaled nitrogen dioxide. However, our findings, implicating neutrophils and serum-derived mediators in the pathogenesis of the pulmonary edema, are consistent with recent proposals on their roles in the maintenance and/or progression of edema initiated by toxic inhalations.
journal_name
Chestjournal_title
Chestauthors
Hajela R,Janigan DT,Landrigan PL,Boudreau SF,Sebastian Sdoi
10.1378/chest.97.2.487subject
Has Abstractpub_date
1990-02-01 00:00:00pages
487-9issue
2eissn
0012-3692issn
1931-3543pii
S0012-3692(15)40699-3journal_volume
97pub_type
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