Abstract:
:Pulmonary rejection and infection are the most important complications after lung transplantation. To evaluate the diagnostic value of pulmonary function testing for early detection and discrimination of these complications, seven heart-lung recipients were examined. The diagnosis of each complication was confirmed by clinical and laboratory findings including transbronchial biopsies and bronchoalveolar lavage. Eight episodes of rejection, ten episodes of viral infection and six episodes of bacterial pneumonia were analyzed. Pulmonary rejection was associated with a significant fall in the FEV1/IVC% and the FEF50%. In viral infection, the most impressive finding was a reduction in the DCO, whereas no obstructive or restrictive airway dynamics were observed. During bacterial pneumonia, pulmonary function measurement revealed a decrease in IVC without signs of obstructive airway dynamics. Adequate treatment resulted in reconstitution of pretreatment values. Assessment of lung function provides valuable information for the diagnosis of pulmonary complications following HLTx.
journal_name
Chestjournal_title
Chestauthors
Hoeper MM,Hamm M,Schäfers HJ,Haverich A,Wagner TOdoi
10.1378/chest.102.3.864subject
Has Abstractpub_date
1992-09-01 00:00:00pages
864-70issue
3eissn
0012-3692issn
1931-3543pii
S0012-3692(16)39124-3journal_volume
102pub_type
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