Epigenetics and prenatal influences on asthma and allergic airways disease.

Abstract:

:Uterine life is arguably the most critical time in developmental programming, when environmental exposures may have the greatest potential to influence evolving fetal structure and function. There has been substantial progress in understanding the epigenetic mechanisms through which environmental exposures can permanently alter the expression of fetal genes and contribute to the increasing propensity for many complex diseases. These concepts of "developmental origins" of disease are being applied across virtually all fields of medicine, and emerging epigenetic paradigms are the likely mechanism behind the environment-driven epidemic of asthma and allergic disease. Here, we examine the epigenetic regulation of immune development and the early immune profiles that contribute to allergic risk. In particular we review new evidence that key environmental exposures, such as microbial exposure, dietary changes, tobacco smoke, and pollutants, can induce epigenetic changes in gene expression and alter disease risk. Although most of these factors have already been clearly implicated in epidemiologic studies of asthma and allergic disease, new studies investigating the mechanisms of these effects may provide new avenues for using these pathways for disease prevention.

journal_name

Chest

journal_title

Chest

authors

Martino D,Prescott S

doi

10.1378/chest.10-1800

subject

Has Abstract

pub_date

2011-03-01 00:00:00

pages

640-647

issue

3

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(11)60133-5

journal_volume

139

pub_type

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