Epigenetics and prenatal influences on asthma and allergic airways disease.


:Uterine life is arguably the most critical time in developmental programming, when environmental exposures may have the greatest potential to influence evolving fetal structure and function. There has been substantial progress in understanding the epigenetic mechanisms through which environmental exposures can permanently alter the expression of fetal genes and contribute to the increasing propensity for many complex diseases. These concepts of "developmental origins" of disease are being applied across virtually all fields of medicine, and emerging epigenetic paradigms are the likely mechanism behind the environment-driven epidemic of asthma and allergic disease. Here, we examine the epigenetic regulation of immune development and the early immune profiles that contribute to allergic risk. In particular we review new evidence that key environmental exposures, such as microbial exposure, dietary changes, tobacco smoke, and pollutants, can induce epigenetic changes in gene expression and alter disease risk. Although most of these factors have already been clearly implicated in epidemiologic studies of asthma and allergic disease, new studies investigating the mechanisms of these effects may provide new avenues for using these pathways for disease prevention.






Martino D,Prescott S




Has Abstract


2011-03-01 00:00:00
















  • Liposarcoma of the posterior mediastinum in a child.

    abstract::Liposarcoma is rare in children and rarely occurs in the posterior mediastinum in any age group. A massive intrathoracic tumor in a 17-year-old young man was a diagnostic dilemma; preoperative radiographic evaluation and biopsy led us to believe it was a teratoma. At operation, a poorly differentiated myxoid liposarco...


    pub_type: 杂志文章,评审


    authors: Mikkilineni RS,Bhat S,Cheng AW,Prevosti LG

    更新日期:1994-10-01 00:00:00

  • Two aerosolized nitric oxide adducts as selective pulmonary vasodilators for acute pulmonary hypertension.

    abstract:STUDY OBJECTIVES:To determine the selective vasodilatory effects of two inhaled "NONOate" aerosols in a closed chest pig model of acute pulmonary hypertension (APH). METHODS:APH was induced by IV infusion of the prostaglandin H(2)/thromboxane A(2) receptor agonist (U46619). Aerosolized diethylenetriamine nitric oxide ...


    pub_type: 杂志文章


    authors: Lam CF,van Heerden PV,Ilett KF,Caterina P,Filion P

    更新日期:2003-03-01 00:00:00

  • The role of thoracic radiotherapy in the management of limited-stage small cell lung cancer: past, present, and future.

    abstract::The role of thoracic radiation therapy in the management of limited-stage small cell lung cancer (SCLC) is reviewed. Although chest irradiation has been used to treat SCLC for over four decades, its standard role in the management of limited-stage disease was established only during the last decade. Multiple prospecti...


    pub_type: 杂志文章,评审


    authors: Kumar P

    更新日期:1997-10-01 00:00:00

  • Longitudinal changes in bronchial responsiveness associated with swine confinement dust exposure.

    abstract:STUDY OBJECTIVES:Acute exposure to the air in swine confinement units causes bronchial hyperresponsiveness and inflammation of the airways. This study was performed to assess the longitudinal development of bronchial responsiveness in pig farmers and to establish exposure-response relationships. METHODS:A cohort of 17...


    pub_type: 杂志文章


    authors: Vogelzang PF,van der Gulden JW,Folgering H,Heederik D,Tielen MJ,van Schayck CP

    更新日期:2000-05-01 00:00:00

  • Sensitivity and specificity of radioisotope right-left shunt measurements and pulse oximetry for the early detection of pulmonary arteriovenous malformations.

    abstract:STUDY OBJECTIVES:To assess the effectiveness of pulse oximetry and radioisotope measurement of right-to-left (R-L) shunt for the early detection of pulmonary arteriovenous malformations (PAVMs) in patients with hereditary hemorrhagic telangiectasia (HHT). DESIGN:Patients with HHT had serial measurements of the followi...


    pub_type: 杂志文章


    authors: Thompson RD,Jackson J,Peters AM,Doré CJ,Hughes JM

    更新日期:1999-01-01 00:00:00

  • Gas exchange and pulmonary hemodynamics during lung resection in patients at increased risk: relationship with preoperative exercise testing.

    abstract:STUDY OBJECTIVES:To evaluate the intraoperative evolution of patients with COPD during lung resection and to test whether exercise testing could be helpful in the prediction of the intraoperative course. DESIGN:Prospective study. SETTING:University teaching hospital. PATIENTS:Forty patients (mean [+/- SD] age, 65 +/...


    pub_type: 杂志文章


    authors: Ribas J,Jiménez MJ,Barberà JA,Roca J,Gomar C,Canalís E,Rodriguez-Roisin R

    更新日期:2001-09-01 00:00:00

  • Percutaneous transluminal coronary angioplasty improves oxygen uptake kinetics during the onset of exercise in patients with coronary artery disease.

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    pub_type: 杂志文章


    authors: Adachi H,Koike A,Niwa A,Sato A,Takamoto T,Marumo F,Hiroe M

    更新日期:2000-08-01 00:00:00

  • Allograft colonization and infections with pseudomonas in cystic fibrosis lung transplant recipients.

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    pub_type: 杂志文章


    authors: Nunley DR,Grgurich W,Iacono AT,Yousem S,Ohori NP,Keenan RJ,Dauber JH

    更新日期:1998-05-01 00:00:00

  • Detection of left ventricular diverticulum by cross-sectional echocardiography.

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    pub_type: 杂志文章


    authors: Estevez CM,Weyman AE,Feigenbaum H

    更新日期:1976-04-01 00:00:00

  • Respiratory disease in tungsten carbide production workers.

    abstract::We carried out a medical and environmental survey to evaluate respiratory disease at two tungsten carbide (TC) production plants. The study population of 290 subjects (19.2 percent of the total work force) was chosen to focus on those with the greatest potential exposures to cobalt, a binding agent which is probably t...


    pub_type: 杂志文章


    authors: Sprince NL,Chamberlin RI,Hales CA,Weber AL,Kazemi H

    更新日期:1984-10-01 00:00:00

  • Treatment of a solitary pulmonary sarcoidosis mass by CT-guided direct intralesional injection of corticosteroid.

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    pub_type: 杂志文章


    authors: Judson MA,Uflacker R

    更新日期:2001-07-01 00:00:00

  • Dynamic respiratory patterns after laparoscopic cholecystectomy.

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    pub_type: 杂志文章


    authors: Shulman SM,Chuter T,Weissman C

    更新日期:1993-04-01 00:00:00

  • Heart rate pattern during sleep in an infant with congenital prolongation of the Q-T interval (Romano-Ward syndrome).

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    pub_type: 杂志文章


    authors: Leistner HL,Haddad GG,Lai TL,Mellins RB

    更新日期:1983-08-01 00:00:00

  • Cardiogenic shock secondary to Tako-tsubo syndrome after debridement of malignant endobronchial obstruction.

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    pub_type: 杂志文章


    authors: Guerrero J,Majid A,Ernst A

    更新日期:2009-01-01 00:00:00

  • Clinical significance of nontuberculous mycobacteria isolated from respiratory specimens in Korea.

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    pub_type: 杂志文章


    authors: Koh WJ,Kwon OJ,Jeon K,Kim TS,Lee KS,Park YK,Bai GH

    更新日期:2006-02-01 00:00:00

  • Clinical and Imaging Features of COVID-19 in a Neonate.

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    authors: Xiong Y,Zhang Q,Zhao L,Shao J,Zhu W

    更新日期:2020-07-01 00:00:00

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    pub_type: 杂志文章


    authors: Curiel R,Tortoledo F,Rodriguez L,Soto R,Perez-Gonzalez J

    更新日期:1982-02-01 00:00:00

  • Long-term effects of nitrendipine on hemodynamics and oxygen transport in patients with cor pulmonale.

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    pub_type: 杂志文章


    authors: Rubin LJ,Moser K

    更新日期:1986-01-01 00:00:00

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    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Weiner P,Azgad Y,Ganam R

    更新日期:1992-11-01 00:00:00

  • Thoracocentesis. Clinical value, complications, technical problems, and patient experience.

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    pub_type: 杂志文章


    authors: Collins TR,Sahn SA

    更新日期:1987-06-01 00:00:00

  • Gastroesophageal reflux disease and asthma: a longitudinal study in UK general practice.

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    pub_type: 杂志文章


    authors: Ruigómez A,Rodríguez LA,Wallander MA,Johansson S,Thomas M,Price D

    更新日期:2005-07-01 00:00:00

  • Improvement in pulmonary function in mitral stenosis after percutaneous transvenous mitral commissurotomy.

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    pub_type: 杂志文章


    authors: Yoshioka T,Nakanishi N,Okubo S,Kunieda T,Ishikura F,Nagata S

    更新日期:1990-08-01 00:00:00

  • Detection and evaluation of asymptomatic myocarditis in schoolchildren: report of four cases.

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    pub_type: 杂志文章


    authors: Nakagawa M,Sato A,Okagawa H,Kondo M,Okuno M,Takamatsu T

    更新日期:1999-08-01 00:00:00

  • Early post-pneumonectomy bronchial stump fistula.

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    pub_type: 杂志文章


    authors: Pomerantz AH,Derasari MD,Sethi SS,Khan S

    更新日期:1988-03-01 00:00:00

  • Pulmonary Functional MRI and CT in a Survivor of Bronchiolitis and Respiratory Failure Caused by e-Cigarette Use.

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    authors: Eddy RL,Serajeddini H,Knipping D,Landman ST,Bosma KJ,Mackenzie CA,Dhaliwal I,Parraga G

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  • Expanded clinical presentation of community-acquired methicillin-resistant Staphylococcus aureus pneumonia.

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    pub_type: 杂志文章


    authors: Lobo LJ,Reed KD,Wunderink RG

    更新日期:2010-07-01 00:00:00

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    pub_type: 杂志文章,评审


    authors: Evans TW,Nava S,Mata GV,Guidet B,Estenssoro E,Fowler R,Scheunemann LP,White D,Manthous CA

    更新日期:2011-12-01 00:00:00

  • The effect of secondhand smoke exposure on markers of elastin degradation.

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    pub_type: 杂志文章


    authors: Slowik N,Ma S,He J,Lin YY,Soldin OP,Robbins RA,Turino GM

    更新日期:2011-10-01 00:00:00

  • Predictors of symptoms are different from predictors of severe exacerbations from asthma in children.

    abstract:BACKGROUND:Asthma therapy is typically prescribed and titrated based on patient or parent self-report of symptoms. No longitudinal studies have assessed the relationship between symptoms and severe asthma exacerbations in children. The goal of our study was (1) to assess the association of asthma symptoms with severe a...


    pub_type: 杂志文章,多中心研究,随机对照试验


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    更新日期:2011-07-01 00:00:00

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    pub_type: 杂志文章


    authors: Vizioli LD,Cho S

    更新日期:1994-01-01 00:00:00