Abstract:
BACKGROUND:Thoracentesis can be accomplished by active aspiration or drainage with gravity. This trial investigated whether gravity drainage could protect against negative pressure-related complications such as chest discomfort, re-expansion pulmonary edema, or pneumothorax compared with active aspiration. METHODS:This prospective, multicenter, single-blind, randomized controlled trial allocated patients with large free-flowing effusions estimated ≥ 500 mL 1:1 to undergo active aspiration or gravity drainage. Patients rated chest discomfort on 100-mm visual analog scales prior to, during, and following drainage. Thoracentesis was halted at complete evacuation or for persistent chest discomfort, intractable cough, or other complication. The primary outcome was overall procedural chest discomfort scored 5 min following the procedure. Secondary outcomes included measures of discomfort and breathlessness through 48 h postprocedure. RESULTS:A total of 142 patients were randomized to undergo treatment, with 140 in the final analysis. Groups did not differ for the primary outcome (mean visual analog scale score difference, 5.3 mm; 95% CI, -2.4 to 13.0; P = .17). Secondary outcomes of discomfort and dyspnea did not differ between groups. Comparable volumes were drained in both groups, but the procedure duration was significantly longer in the gravity arm (mean difference, 7.4 min; 95% CI, 10.2 to 4.6; P < .001). There were no serious complications. CONCLUSIONS:Thoracentesis via active aspiration and gravity drainage are both safe and result in comparable levels of procedural comfort and dyspnea improvement. Active aspiration requires less total procedural time. TRIAL REGISTRY:ClinicalTrials.gov; No.: NCT03591952; URL: www.clinicaltrials.gov.
journal_name
Chestjournal_title
Chestauthors
Lentz RJ,Shojaee S,Grosu HB,Rickman OB,Roller L,Pannu JK,DePew ZS,Debiane LG,Cicenia JC,Akulian J,Walston C,Sanchez TM,Davidson KR,Jagan N,Ahmad S,Gilbert C,Huggins JT,Chen H,Light RW,Yarmus L,Feller-Kopman D,Ledoi
10.1016/j.chest.2019.10.025subject
Has Abstractpub_date
2020-03-01 00:00:00pages
702-711issue
3eissn
0012-3692issn
1931-3543pii
S0012-3692(19)34190-Xjournal_volume
157pub_type
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