Two-year follow-up in patients treated with emphysematous lung sealant for advanced emphysema.

Abstract:

:Endoscopic lung volume-reduction therapy for emphysema has been associated with therapeutic responses smaller in magnitude and less durable than surgical volume reduction (LVRS). Bronchoscopic emphysematous lung sealant (ELS) therapy has been shown to produce improvements in pulmonary function similar to surgery at 1 year. This case series summarizes safety and efficacy data of all patients from the initial ELS study out to 2 years. Between 1 and 2 years, there were three all-cause adverse events requiring hospitalization. One patient went on to successful lung transplant. Improvements relative to baseline in spirometry (change in FEV1: + 14.3 ± 33.1%; change in FVC: + 5.8 ± 23.2%) and diffusing capacity (change in diffusing capacity of the lung for carbon monoxide: + 10.6 ± 20.6%) were observed at 2 years. An exponential model fit to FEV₁ data at 6, 12, 18, and 24 months predicted improvements from a baseline of > 5% out to 4.1 years, similar to what has been reported following surgery. This report confirms long-term safety and efficacy following ELS therapy in advanced emphysema. Studies in a larger cohort are needed to define the role of ELS therapy in the treatment algorithm of patients with this condition.

journal_name

Chest

journal_title

Chest

authors

Kramer MR,Refaely Y,Maimon N,Rosengarten D,Fruchter O

doi

10.1378/chest.13-0446

subject

Has Abstract

pub_date

2013-11-01 00:00:00

pages

1677-1680

issue

5

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(13)60746-1

journal_volume

144

pub_type

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