Pharmacologic therapy for pulmonary arterial hypertension in adults: CHEST guideline and expert panel report.

Abstract:

OBJECTIVE:Choices of pharmacologic therapies for pulmonary arterial hypertension (PAH) are ideally guided by high-level evidence. The objective of this guideline is to provide clinicians advice regarding pharmacologic therapy for adult patients with PAH as informed by available evidence. METHODS:This guideline was based on systematic reviews of English language evidence published between 1990 and November 2013, identified using the MEDLINE and Cochrane Library databases. The strength of available evidence was graded using the Grades of Recommendations, Assessment, Development, and Evaluation methodology. Guideline recommendations, or consensus statements when available evidence was insufficient to support recommendations, were developed using a modified Delphi technique to achieve consensus. RESULTS:Available evidence is limited in its ability to support high-level recommendations. Therefore, we drafted consensus statements to address many clinical questions regarding pharmacotherapy for patients with PAH. A total of 79 recommendations or consensus statements were adopted and graded. CONCLUSIONS:Clinical decisions regarding pharmacotherapy for PAH should be guided by high-level recommendations when sufficient evidence is available. Absent higher level evidence, consensus statements based upon available information must be used. Further studies are needed to address the gaps in available knowledge regarding optimal pharmacotherapy for PAH.

journal_name

Chest

journal_title

Chest

authors

Taichman DB,Ornelas J,Chung L,Klinger JR,Lewis S,Mandel J,Palevsky HI,Rich S,Sood N,Rosenzweig EB,Trow TK,Yung R,Elliott CG,Badesch DB

doi

10.1378/chest.14-0793

subject

Has Abstract

pub_date

2014-08-01 00:00:00

pages

449-475

issue

2

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(15)48834-8

journal_volume

146

pub_type

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