Abstract:
BACKGROUND:Some studies have demonstrated that the function of the growth hormone (GH)-insulin-like growth factor (IGF)-1 axis is significantly impaired in patients with oral corticosteroid (CS)-induced osteoporosis. The aim of study was to investigate the effects of long-term therapy with inhaled CSs (ICSs) on the hypothalamic-pituitary-GH axis by the GH response to GH-releasing hormone (GHRH), as well as bone turnover, in adult asthmatic patients. DESIGN:Cross-sectional study. PATIENTS:Twenty-seven adult subjects with mild-to-moderate persistent asthma (long-term ICS therapy [ie, > 1 year], 20 patients; naive to ICS treatment, 7 patients) and 10 control subjects. MEASUREMENTS:Each subject underwent testing with an IV bolus (1 mug/kg) injection of human GHRH, and samples of GH were taken 15 min before the GHRH injection, at 0 min (ie, at the time of GHRH injection), and at 15, 30, 45, 60, and 90 min after injection to obtain values for peak GH and DeltaGH. At baseline, samples of serum IGF-1 and blood-urine were collected for bone turnover markers. RESULTS:The GH response to GHRH was significantly reduced in asthmatic patients receiving ICSs (peak GH, p < 0.05; and DeltaGH, p < 0.01) in comparison with control subjects and asthmatic patients who were naive to ICS therapy (peak GH and DeltaGH, p < 0.01). Baseline IGF-1 levels were similar in the three groups. Serum osteocalcin, a marker of bone formation, was significantly reduced (p < 0.01) and correlated with GH peak (r(2) = 0.34; p = 0.007) in asthmatic patients who were treated with ICSs. CONCLUSIONS:We conclude that GH secretion in response to GHRH is significantly reduced in adult asthmatic patients receiving therapy with ICS and that such inhibition could play a negative role in bone metabolism.
journal_name
Chestjournal_title
Chestauthors
Malerba M,Bossoni S,Radaeli A,Mori E,Bonadonna S,Giustina A,Tantucci Cdoi
10.1378/chest.127.2.515subject
Has Abstractpub_date
2005-02-01 00:00:00pages
515-21issue
2eissn
0012-3692issn
1931-3543pii
S0012-3692(15)32589-7journal_volume
127pub_type
临床试验,杂志文章相关文献
CHEST文献大全abstract:OBJECTIVE:To evaluate the effect of repeated thoracenteses on the fluid characteristics and the levels of various cytokines, including tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-5, IL-6, and IL-8, and of plasminogen activator inhibitor type 1 (PAI-1) and tissue type plasminogen activator in malignant...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.123.4.1188
更新日期:2003-04-01 00:00:00
abstract:BACKGROUND:This study reports the effect of thoracentesis on respiratory mechanics and gas exchange in patients receiving mechanical ventilation. STUDY DESIGN:Prospective. SETTING:University hospital. PATIENTS:Eight patient receiving mechanical ventilation with unilateral (n = 7) or bilateral (n = 1) large pleural e...
journal_title:Chest
pub_type: 临床试验,杂志文章
doi:10.1378/chest.130.5.1354
更新日期:2006-11-01 00:00:00
abstract:BACKGROUND:The effects of regular inhaled beta-agonist treatment on lung function remain a controversial issue. In an earlier study, the administration of regular inhaled salbutamol resulted in negative changes in FEV1 not only in asthmatics, but also in nonasthmatic atopic subjects. OBJECTIVE:The aim of this study wa...
journal_title:Chest
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1378/chest.112.1.12
更新日期:1997-07-01 00:00:00
abstract:BACKGROUND:Although alveolar epithelial injury is a major determinant of outcome in patients with acute lung injury, there is no reliable biological marker of alveolar epithelial injury. The primary objective was to determine whether elevated levels of the receptor for advanced glycation end products (RAGE), a marker o...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.08-0919
更新日期:2009-02-01 00:00:00
abstract::Forty-seven cases of quadricuspid semilunar valves which were autopsied were reviewed. The ratio of quadricuspid pulmonic valve to quadricuspid aortic valve was 5:1. Among the 35 patients with quadricuspid pulmonic valves, there were ten patients with clinical and pathologic evidence of coexisting congenital cardiac d...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.72.2.186
更新日期:1977-08-01 00:00:00
abstract::A ventricular inhibited unipolar pacing system in a case of so-called pacemaker syndrome was successfully converted into an atrioventricular sequential system without replacing the ventricular lead. ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.77.3.436
更新日期:1980-03-01 00:00:00
abstract::Because T-piece breathing may impair oxygenation, the best airway pressure from which to extubate ventilated patients is controversial. We compared the effects of extubation after 1 h of either CPAP 5 and T-piece/ZEEP. Once weaned from mechanical ventilation and breathing spontaneously, 106 patients were randomized to...
journal_title:Chest
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1378/chest.100.6.1655
更新日期:1991-12-01 00:00:00
abstract::Actinomyces israelii is a rare cause of pericarditis. Infection spreads to pericardium from an intrathoracic focus. Branching gram-positive filaments are seen on microscopic examination of clinical specimens. Cultures should be performed under anaerobic conditions. Both surgical drainage and antibiotics (penicillin) a...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.69.5.680
更新日期:1976-05-01 00:00:00
abstract:BACKGROUND:The mid-portion of the maximal expiratory flow-volume (MEFV) curve is often described by values of the mean forced expired flow as lung volume decreases from 75% to 25% of vital capacity (ie, forced expiratory flow, midexpiratory phase [FEF(25-75)]). It is common practice to report also forced expired flow a...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.123.3.731
更新日期:2003-03-01 00:00:00
abstract::Survival from reversible forms of severe pulmonary insufficiency remains dismal despite the development of artificial oxygenators. We hypothesized that an intraabdominal heterotopic lung could help maintain adequate oxygenation during acute pulmonary insufficiency. Five mongrel dogs underwent an acute heterotopic lung...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.106.1.257
更新日期:1994-07-01 00:00:00
abstract::Lung cancer is the leading cause of cancer-related mortality in the developed world. Non-small cell lung cancer (NSCLC) represents 85% of cases of lung cancer, and patients have a poor 5-year survival rate. Approximately one third of NSCLC patients present with early-stage disease that is amenable to potentially curat...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.128.4.2933
更新日期:2005-10-01 00:00:00
abstract:INTRODUCTION:Gastroesophageal reflux has been suggested as an underlying cause of chronic lung disease. The aim of this study was to assess the value of pepsin and bile acids, both components of GI secretions, in the lungs of children with chronic lung diseases as possible markers for gastroesophageal reflux disease an...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.07-0316
更新日期:2007-11-01 00:00:00
abstract:SETTING:Seven primary health clinics and a pulmonary disease specialty clinic in Rio de Janeiro City, Brazil. OBJECTIVE:To evaluate a commercial immunochromatographic test kit (ICT Tuberculosis; AMRAD-ICT; Sidney, Australia) employing five recombinant Mycobacterium tuberculosis proteins for the detection of pulmonary ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.123.1.107
更新日期:2003-01-01 00:00:00
abstract:STUDY OBJECTIVE:Data on the prevalence of myocarditis in children are limited. Autopsy studies have shown that myocarditis is often undiagnosed. We attempted to investigate the clinical features of asymptomatic myocarditis in four schoolchildren detected during a mass ECG screening in schoolchildren. DESIGN AND SETTIN...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.116.2.340
更新日期:1999-08-01 00:00:00
abstract::A 35-year-old male homosexual, a former intravenous drug abuser, was found to be human immunodeficiency virus (HIV) positive in 1984. He developed AIDS in 1987 and began treatment with zidovudine in 1989. One year later he developed left apical pleural blebs, a pneumothorax and an exudative pleural effusion. A maligna...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.103.4.1268
更新日期:1993-04-01 00:00:00
abstract::The efficacy of a nasopharyngeal tube was evaluated in 44 patients with obstructive sleep apnea syndrome. Twenty-four of these patients underwent repeated polysomnographic studies with the nasopharyngeal tube in place. They had a 62.3 percent decrease in apnea index and a 39.2 percent decrease in disordered breathing ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.94.6.1142
更新日期:1988-12-01 00:00:00
abstract::Endocardial involvement associated with disseminated histoplasmosis has been infrequently documented, especially among patients with prosthetic valves. The therapeutic approach to these patients is also not yet clearly defined. A 54-year-old man with prosthetic valve endocarditis due to histoplasmosis was successfully...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.99.1.253
更新日期:1991-01-01 00:00:00
abstract::The first report of coincident IHSS and ostium secundum ASD is corroborated and successful septal myotomy and myectomy with patch closure of the ASD is described. ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.68.2.246
更新日期:1975-08-01 00:00:00
abstract:CASE PRESENTATION:A 76-year-old nonsmoking woman visiting from Honduras for the last 6 months with no known medical history originally presented to the ED complaining of abdominal pain. While in the ED, an incidental right middle lobe collapse was found on CT abdomen scan. Review of systems was positive for a chronic p...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1016/j.chest.2018.10.030
更新日期:2019-05-01 00:00:00
abstract::Recent studies emphasize the importance of heart rate in the genesis of ventricular arrhythmias during myocardial ischemia. The role of alterations in rhythm has not previously been systematically investigated. In 20 dogs subjected to acute myocardial ischemia and crushing of the sinus node, standard electrocardiograp...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.71.5.651
更新日期:1977-05-01 00:00:00
abstract::To evaluate whether epithelial damage of airways in asthma could be related to diminished levels of the low molecular weight bronchial leukocyte proteinase inhibitor (BLPI) in airways, we determined BLPI in bronchial washings of 13 asthma patients and 13 healthy subjects, using a sensitive enzyme-linked immunoassay. T...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.93.5.1008
更新日期:1988-05-01 00:00:00
abstract::Caveolae are cell plasma membrane microdomains implicated in organizing and concentrating many signaling molecules. In the lung, caveolae are in endothelium, smooth muscle, fibroblasts, and pneumocytes. Caveolin is the main structural protein of caveolae. Caveolin 1 is down-regulated in transformed cells and may be a ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.129.3.696
更新日期:2006-03-01 00:00:00
abstract::In the past decade and a half, the introduction of new therapeutic agents has revolutionized the management of pulmonary arterial hypertension (PAH). These new treatment options have improved the quality of life and survival in PAH. With an armamentarium of options available, the identification of unique phenotypes ca...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1016/j.chest.2017.08.1159
更新日期:2018-02-01 00:00:00
abstract::During a six-year experience involving 3,089 selective coronary arteriograms (99 percent by the percutaneous transfemoral method), modifications of technique have reduced the incidence of morbid complications. Modifications have involved guidewire technique, systemic heparinization, attention to spontaneous catheter b...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.67.2.221
更新日期:1975-02-01 00:00:00
abstract::We conducted a study of ultrasound (US)-guided pleural biopsy with a Tru-Cut needle and made a comparison with the results of a traditional pleural biopsy with an Abrams needle. A total of 49 patients with unilateral pleural effusion were included in this study. Twenty-four patients underwent a traditional pleural bio...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.100.5.1328
更新日期:1991-11-01 00:00:00
abstract:BACKGROUND:Rhinovirus (RV)-induced pulmonary exacerbations are common in cystic fibrosis (CF) and have been associated with impaired virus clearance by the CF airway epithelium in vitro. Here, we assess in vivo the association of RV prevalence and load with antiviral defense mechanisms, airway inflammation, and lung fu...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.12-0954
更新日期:2013-03-01 00:00:00
abstract:BACKGROUND:Interest in airways inflammatory disease has increasingly focused on innate immunity. We investigated several components of innate immunity in induced sputum of patients with cystic fibrosis (CF), COPD, and asthma, and healthy control subjects. METHODS:Twenty eight patients with mild CF lung disease (age > ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.128.4.2316
更新日期:2005-10-01 00:00:00
abstract::Eosinophilic pulmonary infiltration is an uncommon presentation from cocaine abuse. We present a patient with migratory pulmonary infiltrates and eosinophilia consistent with Löffler's syndrome. Our review uncovered two other similar patients. The importance of early recognition is stressed in our report. Either absti...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.105.5.1599
更新日期:1994-05-01 00:00:00
abstract::The study objective was to assess the widespread applicability of ST/HR slope for the modified Bruce exercise test using a computerized electrocardiogram (ECG); compare the usefulness of the ST/HR slope with standard ECG criteria in detection of coronary artery disease (CAD) and identification of three-vessel or left ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.94.4.737
更新日期:1988-10-01 00:00:00
abstract::We describe a rare case of hydatid cyst in the spleen which communicated to the left pleural cavity. The patient presented with respiratory distress, characterized by nonproductive cough and dyspnea. The difficulties in diagnosis, using standard laboratory and radiologic techniques, were overcome by the use of ultraso...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.72.4.543
更新日期:1977-10-01 00:00:00