The effect of regular salbutamol on lung function and bronchial hyperresponsiveness in normal subjects and nonasthmatic atopic subjects with allergic rhinitis.

Abstract:

BACKGROUND:The effects of regular inhaled beta-agonist treatment on lung function remain a controversial issue. In an earlier study, the administration of regular inhaled salbutamol resulted in negative changes in FEV1 not only in asthmatics, but also in nonasthmatic atopic subjects. OBJECTIVE:The aim of this study was to confirm these findings and also to examine whether regular inhaled salbutamol would increase bronchial hyperresponsiveness in atopic or normal individuals. DESIGN:The study was a randomized, double-blind, placebo-controlled, crossover investigation. PARTICIPANTS:There were two groups: 10 normal healthy subjects (group A) and nine nonasthmatic atopic subjects (group B). INTERVENTIONS:Subjects received inhaled salbutamol or identical placebo for periods of 6 weeks, the dose being increased in stepwise fashion at 2-week intervals. MEASUREMENTS:Changes in lung function were assessed by measuring spirometric values, airways conductance, and changes in complete and partial expiratory flow volume curves. Changes in these parameters following a methacholine challenge were used to assess bronchial hyperresponsiveness. RESULTS:No statistically significant differences in lung function or bronchial hyperresponsiveness were noted to occur as the result of treatment in either group. CONCLUSION:Our results do not support the view that regular inhaled salbutamol in normal or atopic subjects without asthma causes adverse changes in the airways.

journal_name

Chest

journal_title

Chest

authors

Boothman-Burrell D,Jones D,Herbison GP,Taylor DR

doi

10.1378/chest.112.1.12

subject

Has Abstract

pub_date

1997-07-01 00:00:00

pages

12-8

issue

1

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(15)47149-1

journal_volume

112

pub_type

临床试验,杂志文章,随机对照试验

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