Abstract:
BACKGROUND:Fibrotic interstitial lung diseases (ILDs) are highly morbid chronic disorders that frequently occur in working age individuals. The goal of this study was to determine workplace productivity loss, its determinants, and its estimated costs in patients with fibrotic ILD. METHODS:Patients with idiopathic pulmonary fibrosis, chronic hypersensitivity pneumonitis, idiopathic nonspecific interstitial pneumonia, or unclassifiable ILD were identified from the six-center Canadian Registry for Pulmonary Fibrosis (CARE-PF). The Work Productivity and Activity Impairment questionnaire was used to determine health-related productivity loss. Independent predictors of low workplace productivity were identified by using multivariate regression. Patient data were compared with Canadian population census data. The average productivity loss (hours per week) and the individual's hourly wage were used to estimate the costs of productivity loss. RESULTS:Of 650 eligible patients, 148 (23%) were employed. Productivity loss was reported by 55% of employed patients with an average productivity loss of 7.8 ± 0.9 h per week (2.3 ± 0.6 h per week related to absenteeism and 5.5 ± 0.6 h per week related to presenteeism). Employment among patients with ILD aged 25 to 54 years was 23% lower than the age- and sex-matched general Canadian population (60% vs 83%; P < .001). Employment among patients with ILD aged ≥ 55 years was 18% lower than in the age- and sex-matched population (20% vs 38%; P < .001). Dyspnea and cough were independent predictors of workplace productivity loss. Estimated annual costs of productivity loss were 11,610 Canadian dollars per employee with ILD. CONCLUSIONS:Workplace productivity loss is common in fibrotic ILD, strongly correlated with symptom severity, and associated with significant cost.
journal_name
Chestjournal_title
Chestauthors
Algamdi M,Sadatsafavi M,Fisher JH,Morisset J,Johannson KA,Fell CD,Kolb M,Manganas H,Cox G,Gershon AS,Halayko AJ,Hambly N,Khalil N,Shapera S,To T,Wilcox PG,Guler S,Ryerson CJdoi
10.1016/j.chest.2019.04.016subject
Has Abstractpub_date
2019-11-01 00:00:00pages
887-895issue
5eissn
0012-3692issn
1931-3543pii
S0012-3692(19)30885-2journal_volume
156pub_type
杂志文章相关文献
CHEST文献大全abstract:STUDY OBJECTIVES:To ascertain whether inspiratory pressure support (IPS) can be triggered reliably from and targeted at esophageal pressures (Pes), and to compare the work of breathing and time delay to initiation of inspiratory flow between conventional pressure support and esophageal-directed pressure support (EDPS)....
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.115.2.482
更新日期:1999-02-01 00:00:00
abstract::It has been suggested that spirometry should be incorporated into the routine examination of every patient, analogous to obtaining vital signs. To determine the impact of spirometry on the management of outpatients with respiratory disease, spirometry was performed on 150 consecutive patients (123 men and 27 women, me...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.99.3.730
更新日期:1991-03-01 00:00:00
abstract:STUDY OBJECTIVE:To explore the causes of sudden and unexpected death in a young and healthy military population, to examine the various patterns of diseases associated with these tragic events, and to investigate the factors found to be associated with this grave outcome. DESIGN:We retrospectively investigated 151 cas...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.126.2.528
更新日期:2004-08-01 00:00:00
abstract::Fungal endocarditis is a rare complication of permanent pacemaker implantation. In all reports we have identified, this infection has been fatal, diagnosed postmortem. We present a patient in whom early echocardiographic diagnosis resulted in curative surgical and antimicrobial therapy. Fungal endocarditis is an unusu...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.103.1.283
更新日期:1993-01-01 00:00:00
abstract::Simultaneous hemodynamic and blood gas measurements were performed in 26 hypertensive adults, who were cigarette smokers, before and after a 30-minute infusion of saralasin (5 microgram/kg/min) which is a highly specific competitive antagonist of angiotensin II (AII). The arterial pressure fell in nine, rose in seven ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.75.4.492
更新日期:1979-04-01 00:00:00
abstract::Beta-2-integrins belong to a family of leukocyte surface glycoproteins that are essential for immune functions of bronchoalveolar cells. The expression of three alpha chains designed as CD11a, CD11b, CD11c, a common beta chain CD18, and of a ligand for several integrins CD54 (ICAM-1) was studied on alveolar macrophage...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.102.3.882
更新日期:1992-09-01 00:00:00
abstract:STUDY OBJECTIVE:Our objective was to determine if the hemosiderin content of BAL macrophages allows us to draw any differential diagnostic conclusions in a variety of lung diseases. PATIENTS AND STUDY DESIGN:One hundred one patients who underwent BAL for different diagnostic reasons were studied prospectively. MAIN R...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.102.6.1794
更新日期:1992-12-01 00:00:00
abstract:BACKGROUND:The diagnosis of sarcoidosis is made by the combination of clinical features and biopsy results. The clinical features of sarcoidosis can be quite variable. We developed a Sarcoidosis Diagnostic Score (SDS) to summarize the clinical features of patients with possible sarcoidosis. METHODS:Biopsy-confirmed pa...
journal_title:Chest
pub_type: 杂志文章
doi:10.1016/j.chest.2018.05.003
更新日期:2018-11-01 00:00:00
abstract:STUDY OBJECTIVES:The aim was to evaluate demographic, clinical, and laboratory variables in febrile patients, with or without a microbiologically confirmed infection, for prediction of death, in comparison to the systemic inflammatory response syndrome (SIRS) and its criteria, such as abnormal temperature, tachycardia,...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.113.6.1533
更新日期:1998-06-01 00:00:00
abstract::Because of its greater ease and rapidity of insertion, the percutaneous intraaortic balloon in many institutions has become the primary method for implementing counterpulsation. We report the results and complications of 113 attempted procedures in a variety of clinical settings. We had a high (93.8 percent) insertion...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.82.4.422
更新日期:1982-10-01 00:00:00
abstract::The effects of one hour exposures of healthy nonsmoking human volunteers to submicrometer H2SO4 droplets via nasal mask on tracheobronchial mucociliary particle clearance were studied using two different sized monodisperse gamma-tagged Fe2O3 test aerosols. The larger sized Fe2O3 aerosol, 7.5 micrometers AMAD, was depo...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.80.6.873
更新日期:1981-12-01 00:00:00
abstract::Postoperative bronchial stump failure is a life-threatening complication, and several surgical approaches and procedures have been developed to close the stump. In this report, we describe a case of left mainstem bronchial stump diastasis after pneumonectomy for lung cancer, in which the bronchial stump was re-closed ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.117.3.884
更新日期:2000-03-01 00:00:00
abstract::Although the relationship between blood pressure and cardiac performance has been widely recognized, there are few published clinical observations concerning the effect of blood pressure control on cardiac function. We evaluated the effect of prazosin, an antihypertensive agent which also improves hemodynamic measurem...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.80.6.692
更新日期:1981-12-01 00:00:00
abstract::The effects of six weeks of threshold pressure inspiratory muscle training (IMT) on inspiratory muscle performance, breathing pattern and exercise performance were studied in eight patients with severe airflow obstruction. The results indicated that IMT improved inspiratory muscle performance but did not affect exerci...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.95.3.535
更新日期:1989-03-01 00:00:00
abstract::Pulmonary function studies were conducted one to two days prior to, two weeks after, and an average of 116 days after coronary artery revascularization surgery. Preoperation it was found that 11 of 19 patients had mild to moderate obstruction, 8 of 17 had diffusing capacity less than 80 percent of predicted, and 9 of ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.73.3.316
更新日期:1978-03-01 00:00:00
abstract:STUDY OBJECTIVES:This multicenter study was undertaken to characterize the population of ventilator-dependent patients admitted to long-term care hospitals (LTCHs) with weaning programs, and to report treatments, complications, weaning outcome, discharge disposition, and survival in these patients. DESIGN:Observationa...
journal_title:Chest
pub_type: 杂志文章,多中心研究
doi:10.1378/chest.06-1081
更新日期:2007-01-01 00:00:00
abstract::The incidence of congenital heart disease is approximately 8/1,000 live births and appears to be constant around the world. The currently accepted paradigm for the development of pulmonary vascular disease associated with congenital heart disease maintains that increased pulmonary blood flow and pressure trigger unfav...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.09-2861
更新日期:2010-06-01 00:00:00
abstract:INTRODUCTION:Most experimental studies of orthotopic heart and lung graft failure are complicated by an inability to eliminate the rejection-specific inflammatory mediator from the cardiopulmonary bypass. METHODS:The following model was developed in our laboratory to investigate the feasibility of performing an orthot...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.116.5.1360
更新日期:1999-11-01 00:00:00
abstract::The association of complex congenital heart disease with asplenia syndrome and congenital AV block is described in a newborn. Cardiovascular lesions were right atrial isomerism, d-loop, discordant ventriculoarterial connection, pulmonary stenosis, total anomalous pulmonary venous drainage, absent right pulmonary arter...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.85.4.578
更新日期:1984-04-01 00:00:00
abstract:CASE PRESENTATION:A man in his 20s presented to the ED after several months of progressive dyspnea, dry cough, and night sweats. He had no chest pain, fevers, weight loss, or sick contacts. He was previously healthy and took no medications. Social history was notable for 5 pack-years of tobacco use. The patient was sex...
journal_title:Chest
pub_type: 杂志文章
doi:10.1016/j.chest.2019.05.040
更新日期:2019-12-01 00:00:00
abstract::Reliable long-term assessment of cough is necessary in many clinical and scientific settings. A new method for long-term recording and automatic analysis of cough is presented. The method is based on simultaneous recording of two independent signals: high-pass filtered cough sounds and cough-induced fast movements of ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.94.5.970
更新日期:1988-11-01 00:00:00
abstract::Airway pressure release ventilation (APRV), a new ventilatory support technique, was compared with conventional intermittent positive-pressure ventilation plus PEEP (CPPV) in 18 patients with severe acute respiratory failure. Patients were initially stabilized on CPPV and then switched to APRV. The APRV provided effec...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.100.2.460
更新日期:1991-08-01 00:00:00
abstract::Human genetic variation has enormous implications for individual susceptibility to lung disease, as well as for differences in prognosis and response to therapeutic interventions. Single-nucleotide polymorphisms (SNPs) are the most common type of DNA sequence variation. An SNP is the substitution of a single base in t...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.06-2252
更新日期:2007-04-01 00:00:00
abstract::We describe an unusual case of orthodeoxia platypnea syndrome exacerbated by right ventricular inflow obstruction due to iatrogenic steroid-induced adipose deposition in cardiac tissues. A 68-year-old man on long-term prednisone therapy for eosinophilic pneumonia presented with progressive dyspnea worsened by bending ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.10-0874
更新日期:2011-02-01 00:00:00
abstract::Serial hemodynamic alterations were investigated in seven elderly patients with heat stroke. Their mean age was 72 +/- 6 years. The circulatory response to heat stroke was either hyperdynamic of hypodynamic. Two patients had increased cardiac index (4.3 and 4.4 L/min/m2), increased right atrial pressure (10 and 12 mm ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.75.3.362
更新日期:1979-03-01 00:00:00
abstract:BACKGROUND:Endobronchial ultrasound (EBUS)-guided transbronchial needle aspiration (EBUS-TBNA) is performed with a dedicated 22- or 21-gauge needle while suction is applied. Fine-needle sampling without suction (capillary sampling) has been studied for endoscopic ultrasound and for biopsies at various body sites and ha...
journal_title:Chest
pub_type: 杂志文章,随机对照试验
doi:10.1378/chest.11-0692
更新日期:2012-09-01 00:00:00
abstract::The ability of mixed venous oxygen saturation (SvO2) monitoring to reflect changes in cardiac index (CI) with therapy in critically ill patients is unclear. To this end, SvO2 and CI were measured before and during an infusion of enoximone and/or dobutamine in 30 patients with advanced heart failure. A nonlinear relati...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.99.6.1403
更新日期:1991-06-01 00:00:00
abstract::Bronchoscopic examination to diagnose lung metastases has not been as rewarding as in primary lung cancer. Despite a lower expected yield, we believe the procedure has value in certain patients, ie, those with clinical findings of endobronchial disease. To determine better the value of bronchoscopy in this population,...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.88.1.84
更新日期:1985-07-01 00:00:00
abstract::We report three cases of organophosphate (OP) poisoning. One patient was a 19-year-old woman who drank OP compounds in an attempt at suicide. The other two patients became intoxicated on the way to the hospital during mouth-to-mouth breathing. The first patient died in the emergency department, and the other two were ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.122.2.740
更新日期:2002-08-01 00:00:00
abstract:STUDY OBJECTIVES:The purpose of this study was to determine the impact of a multisite implementation of an evidence-based clinical practice guideline for bronchiolitis. DESIGN:Before and after study. SETTING:Eleven Child Health Accountability Initiative (CHAI) study hospitals. PATIENTS:Children < 12 months of age wi...
journal_title:Chest
pub_type: 杂志文章,多中心研究
doi:10.1378/chest.121.6.1789
更新日期:2002-06-01 00:00:00