Airway pressure release ventilation in severe acute respiratory failure.

Abstract:

:Airway pressure release ventilation (APRV), a new ventilatory support technique, was compared with conventional intermittent positive-pressure ventilation plus PEEP (CPPV) in 18 patients with severe acute respiratory failure. Patients were initially stabilized on CPPV and then switched to APRV. The APRV provided effective ventilatory support in 17 of 18 patients; APRV achieved similar levels of alveolar ventilation as CPPV (for APRV, mean PaCO2 = 45.0 +/- 6.2 mm Hg; vs for CPPV, mean PaCO2 = 43.3 +/- 5.7 mm Hg), with significantly lower mean maximum airway pressures (38.9 +/- 10.1 cm H2O vs 64.6 +/- 15.4 cm H2O; p = 0.0001) and mean VT (0.79 +/- 0.11 L vs 1.05 +/- 0.15 L; p = 0.0002). No significant differences in mean airway pressure, end-expiratory pressure, FIO2, ventilator rate, arterial blood gas levels, and hemodynamic function were noted between APRV and CPPV.

journal_name

Chest

journal_title

Chest

authors

Cane RD,Peruzzi WT,Shapiro BA

doi

10.1378/chest.100.2.460

subject

Has Abstract

pub_date

1991-08-01 00:00:00

pages

460-3

issue

2

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(16)37180-X

journal_volume

100

pub_type

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