Expression of alveolar macrophage adhesion molecules in pulmonary sarcoidosis.

Abstract:

:Beta-2-integrins belong to a family of leukocyte surface glycoproteins that are essential for immune functions of bronchoalveolar cells. The expression of three alpha chains designed as CD11a, CD11b, CD11c, a common beta chain CD18, and of a ligand for several integrins CD54 (ICAM-1) was studied on alveolar macrophages of patients with active and inactive sarcoidosis and in control subjects. The percentage of macrophages expressing CD11b (CR3) was significantly increased in patients with active sarcoidosis compared with patients who had inactive disease and control subjects. The adhesion molecule CD54 (ICAM-1) was detected on a higher percentage of alveolar macrophages in patients with active rather than inactive sarcoidosis and in control subjects. Since integrin-mediated adhesion seems to be important in macrophage-lymphocyte interactions during the immune response, higher expression of both CD11b and CD54 on sarcoid alveolar macrophages may be related to several immune abnormalities reported in pulmonary sarcoidosis.

journal_name

Chest

journal_title

Chest

authors

Striz I,Wang YM,Kalaycioglu O,Costabel U

doi

10.1378/chest.102.3.882

subject

Has Abstract

pub_date

1992-09-01 00:00:00

pages

882-6

issue

3

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(16)39127-9

journal_volume

102

pub_type

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