Abstract:
BACKGROUND:Endobronchial ultrasound (EBUS)-guided transbronchial needle aspiration (EBUS-TBNA) is performed with a dedicated 22- or 21-gauge needle while suction is applied. Fine-needle sampling without suction (capillary sampling) has been studied for endoscopic ultrasound and for biopsies at various body sites and has resulted in similar diagnostic yield and fewer traumatic samples. However, the role of EBUS-guided transbronchial needle capillary sampling (EBUS-TBNCS) is still to be determined. METHODS:Adults with suspicious hilar or mediastinal lymph nodes (LNs) were included in a single-blinded, prospective, randomized trial comparing EBUS-TBNA and EBUS-TBNCS. The primary end point was the concordance rate between the two techniques in terms of adequacy and diagnosis of cytologic samples. The secondary end point was the concordance rate between the two techniques in terms of quality of samples. RESULTS:A total of 115 patients and 192 LNs were studied. Concordance between EBUS-TBNA and EBUS-TBNCS was high, with no significant difference in adequacy (88% vs 88%, respectively [P ± .858]; concordance rate, 83.9% [95% CI, 77.9-88.8]); diagnosis (36% vs 34%, respectively [P ± .289]; concordance rate, 95.8% [95% CI, 92-92.8]); diagnosis of malignancy (28% vs 26%, respectively [P ± .125]; concordance rate, 97.9% [95% CI, 94.8-99.4]); or sample quality (concordance rate, 83.3% [95% CI, 73.3-88.3]). Concordance between EBUS-TBNA and EBUS-TBNCS was high irrespective of LN size (≤ 1 cm vs > 1 cm). CONCLUSIONS:Regardless of LN size, no differences in adequacy, diagnosis, or quality were found between samples obtained using EBUS-TBNA and those obtained using EBUS-TBNCS. There is no evidence of any benefit derived from the practice of applying suction to EBUS-guided biopsies. TRIAL REGISTRY:ClinicalTrials.gov; No.: NCT00886847; URL: www.clinicaltrials.gov
journal_name
Chestjournal_title
Chestauthors
Casal RF,Staerkel GA,Ost D,Almeida FA,Uzbeck MH,Eapen GA,Jimenez CA,Nogueras-Gonzalez GM,Sarkiss M,Morice RCdoi
10.1378/chest.11-0692subject
Has Abstractpub_date
2012-09-01 00:00:00pages
568-573issue
3eissn
0012-3692issn
1931-3543pii
S0012-3692(12)60499-1journal_volume
142pub_type
杂志文章,随机对照试验相关文献
CHEST文献大全abstract::Clonidine was given to patients with essential hypertension, renovascular hypertension, and hypertension with parenchymal renal disease. The drug was effective in all groups but was more effective in patients with high plasma renin concentration. Renal function did not deteriorate when the drug was used, and there was...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.83.2_supplement.383
更新日期:1983-02-01 00:00:00
abstract:BACKGROUND:Research on the effects of cigarette smoking on sleep architecture is limited. The objective of this investigation was to examine differences in sleep EEG between smokers and nonsmokers. METHODS:Smokers and nonsmokers who were free of all medical comorbidities were matched on different factors, including ag...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.07-1190
更新日期:2008-02-01 00:00:00
abstract::To predict the postoperative improvement in performance status after bullectomy, preoperative pulmonary function and dyspneic grade were evaluated in 20 patients with giant bulla. The patients were divided into two groups, based on postoperative performance status: group 1 consisted of 15 patients with improved status...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.101.3.668
更新日期:1992-03-01 00:00:00
abstract::Aortic intramural hematoma (IMH) is related to but is pathologically distinct from aortic dissection. In this potentially lethal entity, there is hemorrhage into the aortic media in the absence of an intimal tear. Although intimal disruption is not present, the prognosis is similar to that of classic aortic dissection...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.120.4.1340
更新日期:2001-10-01 00:00:00
abstract:STUDY OBJECTIVES:Inspiratory capacity (IC) has been proposed as a simple method to assess acute changes in functional residual capacity (FRC) with bronchodilation, assuming that total lung capacity (TLC) is unchanged. This assumption is based on studies using body plethysmography, which may not accurately measure TLC i...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.122.6.2009
更新日期:2002-12-01 00:00:00
abstract::We wanted to determine the efficacy of dobutamine infusions and Prbc transfusions on splanchnic tissue oxygen utilization by measuring gastric pHi. Physiologic parameters and pHi measurements via the use of a gastric tonometer were obtained in 21 septic patients before and after the administration of a dobutamine infu...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.102.1.184
更新日期:1992-07-01 00:00:00
abstract:BACKGROUND:Institutional-level disparities in non-small cell lung cancer (NSCLC) survival may be driven by reversible differences in care-delivery processes. We quantified the impact of differences in readily identifiable quality metrics on long-term survival disparities in resected NSCLC. RESEARCH QUESTION:How do rev...
journal_title:Chest
pub_type: 杂志文章
doi:10.1016/j.chest.2020.10.075
更新日期:2020-11-14 00:00:00
abstract:OBJECTIVE:To examine the effect of preoperative smoking behavior on postoperative pulmonary complications. DESIGN:Prospective cohort study. SETTING:The Veterans Administration Medical Center, Syracuse, NY. PARTICIPANTS:Patients scheduled for noncardiac elective surgery (n=410). MEASUREMENTS AND RESULTS:Smoking stat...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.113.4.883
更新日期:1998-04-01 00:00:00
abstract::We developed a Rapid Tuberculosis Screening Program for use in women who have not had prenatal care. All patients who presented for delivery without a documented tuberculin skin test (TBN-ST) were given a symptom questionnaire. Those who had a positive response to any of the questions received a chest roentgenogram to...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.103.2.364
更新日期:1993-02-01 00:00:00
abstract::A 66-year-old woman was cared for at two referral institutions following a witnessed cardiac arrest in a local emergency department. Despite aggressive initial care, she failed to regain consciousness during a 28-day course. Based on an erroneous neurologic diagnosis of anoxic encephalopathy, pessimism regarding likel...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.08-0471
更新日期:2008-05-01 00:00:00
abstract:STUDY OBJECTIVES:To determine whether, in patients with bilateral pleural effusions, the main cellular and biochemical features of the pleural fluid on the right side differ from or correlate with those on the left side. We examined lactate dehydrogenase (LDH), glucose, and total protein (TP) levels, RBC count, nucleat...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.124.1.167
更新日期:2003-07-01 00:00:00
abstract:CASE PRESENTATION:A 34-year-old woman presented for evaluation of several months of a hoarse voice and dyspnea on exertion that progressed over the last 3 years. She had a clinical diagnosis of asthma that had been treated with bronchodilators and inhaled corticosteroids for a few years. She continued to use her inhale...
journal_title:Chest
pub_type: 杂志文章
doi:10.1016/j.chest.2019.01.021
更新日期:2019-06-01 00:00:00
abstract:STUDY OBJECTIVES:Patients with COPD are at risk of experiencing a deterioration in arterial oxygen saturation (SaO2) during sleep, which is generally most pronounced during rapid eye movement (REM) sleep. Increased cholinergic tone has been suggested as a contributing factor to this decrease in SaO2. Therefore, we inve...
journal_title:Chest
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1378/chest.115.5.1338
更新日期:1999-05-01 00:00:00
abstract:STUDY OBJECTIVE:s: To analyze the perception of sexual content (PSC) of tobacco advertisements and its potential impact on the process of smoking in adolescents. DESIGN, PARTICIPANTS, AND SETTING:A questionnaire was administered to 1,186 adolescents at the National Institute of Respiratory Diseases in Mexico City to d...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.121.6.2016
更新日期:2002-06-01 00:00:00
abstract:STUDY OBJECTIVES:To evaluate early and late lung function abnormalities and their predictors in a large sample of children who underwent bone marrow transplantation (BMT) for leukemias in the 1990s, highlighting changes with respect to the 1980s. DESIGNS:Prospective cohort. SETTING:A university department of pediatri...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.120.6.1900
更新日期:2001-12-01 00:00:00
abstract:STUDY OBJECTIVES:Autopsy evaluation of tracheobronchomalacia (TBM) in patients with Duchenne muscular dystrophy (DMD) who were receiving long-term ventilation through uncuffed tracheostomies. DESIGN:Necropsies were performed in seven patients with DMD who had received positive-pressure ventilation through uncuffed tra...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.123.4.1307
更新日期:2003-04-01 00:00:00
abstract:BACKGROUND:In addition to affecting the oxygen supply to the brain, pulmonary function is a marker of multiple insults throughout life (including smoking, illness, and socioeconomic deprivation). In this meta-analysis of existing longitudinal studies, the hypothesis that lower pulmonary function and respiratory illness...
journal_title:Chest
pub_type: 杂志文章
doi:10.1016/j.chest.2019.12.012
更新日期:2020-06-01 00:00:00
abstract::The hypothetic benefit of CPAP on cardiac performance and on a reduction in VO2 was tested in a patient before heart transplantation after acute myocardial infarction using continuous SvO2 monitoring. The CPAP added to inotropic support (enoximone plus dobutamine) and intraaortic balloon pumping dramatically increased...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.99.2.512
更新日期:1991-02-01 00:00:00
abstract::We report a case of pleural dissemination of invasive thymoma, which was successfully treated with intrathoracic chemothermotherapy following panpleuropneumonectomy. Intrathoracic chemothermotherapy in combination with surgery may be a hopeful adjuvant treatment to control pleural disseminated lesions of invasive thym...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.105.6.1884
更新日期:1994-06-01 00:00:00
abstract::The role of lymphocytes in the pathogenesis of amiodarone-induced lung disease is controversial. Increases in the percentages of lymphocytes in bronchoalveolar fluid of both patients and animals with amiodarone pulmonary toxicity have been reported. To assess whether these lymphocytes are functionally activated, we me...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.99.1.230
更新日期:1991-01-01 00:00:00
abstract::Clinical trials have established the superiority of the implantable cardioverter-defibrillator (ICD) over antiarrhythmic drug therapy in survivors of sudden cardiac death and in high-risk patients with coronary artery disease. The ICD has evolved to overcome the limitation of earlier devices that required thoracotomy ...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.119.4.1210
更新日期:2001-04-01 00:00:00
abstract::Urticaria with systemic effects occurred in a patient being treated with propranolol and was reproducible upon rechallenge with the drug; Successful beta-adrenergic blocking therapy was achieved using a new agent, tolamolol, with no evidence of any adverse effects. ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.67.4.496
更新日期:1975-04-01 00:00:00
abstract::Hospitalizations for patients with acute exacerbations of COPD are associated with several adverse patient outcomes as well as with significant health-care costs. Despite many interventions targeted at reducing readmissions following an initial hospitalization, there are few strategies that have been consistently asso...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1016/j.chest.2019.06.005
更新日期:2019-10-01 00:00:00
abstract:BACKGROUND:Inspiratory muscle weakness and abnormalities in breathing pattern and in respiratory drive have been reported in patients with multisystem disorders. In patients with systemic lupus erythematosus (SLE), data on respiratory muscle strength and control of breathing are scarce. METHODS:We studied a subset of ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.108.3.759
更新日期:1995-09-01 00:00:00
abstract::Klippel-Trenaunay syndrome (KTS) is a congenital disorder characterized by a triad of cutaneous vascular nevi, soft tissue or bony hypertrophy, and varicose veins or venous malformations involving one or more extremities. An incidence of venous thromboembolism of up to 22% has been reported in this disorder. Also repo...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.117.5.1520
更新日期:2000-05-01 00:00:00
abstract::The efficacy of bronchoscopy for the diagnosis of tuberculosis in patients infected with human immunodeficiency virus (HIV) has not been systematically evaluated. We therefore compared the diagnostic yield of bronchoscopy in 67 HIV-infected and 45 non-HIV-infected patients with culture-proven pulmonary tuberculosis. I...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.102.4.1040
更新日期:1992-10-01 00:00:00
abstract::Benign thymic hyperplasia (BTH) is a known feature of hyperthyroidism, but is infrequently appreciated by clinicians. In most cases thymic enlargement is minimal; however, it may occasionally present as an appreciable anterior mediastinal mass. While surgical resection is a common approach to such a mass, recognition ...
journal_title:Chest
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1378/chest.90.5.691
更新日期:1986-11-01 00:00:00
abstract::Parasitic infestations affect millions of the world's population. Global immigration and climate change have led to changes in the natural distribution of parasitic diseases far removed from endemic areas. A broad spectrum of helminthic and protozoal parasitic diseases frequently affects the respiratory system. The wi...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.13-2072
更新日期:2014-04-01 00:00:00
abstract::We assessed the importance of Streptococcus pneumoniae and immunologic response to 14-valent pneumococcal vaccine in a randomized (saline placebo or vaccine) double-blind pilot study involving 103 patients with chronic obstructive pulmonary disease (COPD). Antibody titers, the flora of the sputum, respiratory infectio...
journal_title:Chest
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1378/chest.92.2.204
更新日期:1987-08-01 00:00:00
abstract:BACKGROUND:Altitude exposure is associated with mild pulmonary hypertension and decreased exercise capacity. We tested the hypothesis that pulmonary vascular resistance (PVR) contributes to decreased exercise capacity in hypoxic healthy subjects. METHODS:An incremental cycle ergometer cardiopulmonary exercise test and...
journal_title:Chest
pub_type: 杂志文章,随机对照试验
doi:10.1378/chest.08-2222
更新日期:2009-05-01 00:00:00