Gastric tonometry in patients with sepsis. Effects of dobutamine infusions and packed red blood cell transfusions.

Abstract:

:We wanted to determine the efficacy of dobutamine infusions and Prbc transfusions on splanchnic tissue oxygen utilization by measuring gastric pHi. Physiologic parameters and pHi measurements via the use of a gastric tonometer were obtained in 21 septic patients before and after the administration of a dobutamine infusion (5 micrograms/kg/min) or the transfusion of two units of Prbc. Subsets of measurements with normal (greater than 7.32) and with low (less than 7.32) pHi were separately analyzed for each intervention. In the dobutamine low pHi group, pHi increased significantly from 7.16 +/- 0.03 to 7.24 +/- 0.03 (n = 9, p less than 0.05). In contrast, pHi failed to increase in the Prbc low pHi subgroup (7.16 +/- 0.05 to 7.17 +/- 0.04 [n = 10, p greater than 0.80]). We conclude that dobutamine rather than Prbc transfusions should be administered to reverse gastric intramucosal acidosis.

journal_name

Chest

journal_title

Chest

authors

Silverman HJ,Tuma P

doi

10.1378/chest.102.1.184

subject

Has Abstract

pub_date

1992-07-01 00:00:00

pages

184-8

issue

1

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(16)35866-4

journal_volume

102

pub_type

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