Abstract:
:Simultaneous hemodynamic and blood gas measurements were performed in 26 hypertensive adults, who were cigarette smokers, before and after a 30-minute infusion of saralasin (5 microgram/kg/min) which is a highly specific competitive antagonist of angiotensin II (AII). The arterial pressure fell in nine, rose in seven and was unchanged in ten patients. The mean cardiac index for the entire group remained unchanged. Pulmonary arterial or wedge pressure, pulmonary vascular resistance, arterial PCO2 and pH did not change. Unrelated to the hemodynamic changes, the mean arterial oxygen pressure (PaO2) increased from 68.6 +/- 2.2 mm Hg to 73.9 +/- 2.1 mm Hg (P less than 0.001). In the absence of a significant increase in alveolar ventilation as indicated by an unchanged mean PCO2 and lacking a hemodynamic explanation, the mechanism for the rise in PaO2 is speculative at this stage. The possibility of an improvement in the distribution of ventilataion by saralasin infusion is under investigation.
journal_name
Chestjournal_title
Chestauthors
Mookherjee S,Obeid AI,Ashutosh K,Warner RA,Smulyan Hdoi
10.1378/chest.75.4.492subject
Has Abstractpub_date
1979-04-01 00:00:00pages
492-4issue
4eissn
0012-3692issn
1931-3543pii
S0012-3692(16)53074-8journal_volume
75pub_type
杂志文章相关文献
CHEST文献大全abstract:STUDY OBJECTIVES:To evaluate the risk factors associated with postoperative respiratory infection in patients undergoing lung cancer surgery, with special emphasis on the perioperative pattern of airway colonization. DESIGN:Prospective cohort study. SETTING:Department of Pneumology and Thoracic Surgery of a tertiary ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.128.3.1571
更新日期:2005-09-01 00:00:00
abstract:STUDY OBJECTIVES:This study was conducted to investigate whether intraoperative blood transfusions affect the release of proinflammatory mediators in patients undergoing cardiac surgery. Therefore, we measured plasma levels of bactericidal permeability increasing protein (BPI) as a marker of neutrophil activation, inte...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.116.5.1233
更新日期:1999-11-01 00:00:00
abstract::The significance of dynamic changes of the QS wave magnitude, as demonstrated in the precordial leads, within the natural evolution of acute anterior wall myocardial infarction (AAMI) was assessed in 25 patients within two weeks of their admission to the intensive cardiac care unit. Two sets of tests, including 12-lea...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.94.5.1002
更新日期:1988-11-01 00:00:00
abstract::Continuous measurement of mixed venous oxygen saturation (SvO2) has been suggested as an adjunct in monitoring critically ill patients. We evaluated SvO2 monitoring in 24 patients suffering from complicated myocardial infarctions. Cardiac output and arterial lactate levels were measured when there were persistent 5 pe...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.95.3.607
更新日期:1989-03-01 00:00:00
abstract::Following an outline that details the pathogens causing community-acquired pneumonia (CAP) identified in studies from Europe, this article reviews the guidelines for the management of CAP in four European countries--France, Italy, Spain, and the United Kingdom. The method behind the development of each document is des...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.113.3_supplement.183s
更新日期:1998-03-01 00:00:00
abstract::There are many complementary techniques for mediastinal staging of lung cancer. It is increasingly apparent that the accuracy of mediastinal staging depends not only on which test is used but also on technical factors of how the procedure is performed. This article reviews data regarding such technical factors and pro...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.09-1378
更新日期:2010-02-01 00:00:00
abstract::A 60-pack-year smoker presented with cough, dyspnea and orthopnea of three months' duration. Spirometry revealed severe reduction in maximal expiratory flow; CT of the chest and bronchoscopy demonstrated expiratory collapse of a mid-tracheal segment, and a presumptive diagnosis of tracheomalacia was made. A right late...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.97.4.939
更新日期:1990-04-01 00:00:00
abstract:BACKGROUND:Airway inflammation is important in the development and progression of asthma. Activation of inflammatory cells induces a respiratory burst resulting in the production of reactive oxygen species, such as H(2)O(2). The aim of this study was to measure the concentration of H(2)O(2) in exhaled breath condensate...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.120.4.1136
更新日期:2001-10-01 00:00:00
abstract:OBJECTIVE:To assess the accuracy of dynamic expiratory CT for detecting airway malacia using bronchoscopy as the diagnostic "gold standard." MATERIALS AND METHODS:A computerized hospital information system was used to retrospectively identify all patients with bronchoscopically proven airway malacia referred for CT ai...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.06-2164
更新日期:2007-03-01 00:00:00
abstract:STUDY OBJECTIVE:Our objective was to compare the efficacy of ultrahigh frequency ventilation (UHFV) (frequencies > 3 Hz) with respect to oxygenation, airway pressures, and hemodynamic parameters in patients with adult respiratory distress syndrome (ARDS) who were not responding to conventional ventilation. DESIGN:We u...
journal_title:Chest
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1378/chest.103.5.1413
更新日期:1993-05-01 00:00:00
abstract::The purpose of this phase 1 study was to determine the toxicity and effectiveness of recombinant interleukin-2 (RU 49637 Roussel Uclaf-France) administered by continuous pleural infusion for 5 days to patients with different histologic subtypes of pleural cancer. Incremental doses of rIL-2 from 3 x 10(6) to 24 x 10(6)...
journal_title:Chest
pub_type: 临床试验,杂志文章
doi:10.1378/chest.103.1.209
更新日期:1993-01-01 00:00:00
abstract::Bronchoscopy specimens from 183 known/suspected acquired immunodeficiency syndrome patients were evaluated for pathogens. In each case, transbronchial biopsies were evaluated and bronchoalveolar lavage material was cultured for viruses, fungi and mycobacteria and examined cytologically. A specimen was considered posit...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.98.1.24
更新日期:1990-07-01 00:00:00
abstract::We describe 12 patients with simultaneous bilateral spontaneous pneumothorax (SBSP). They represent 4 percent of patients with spontaneous pneumothorax seen at our hospital from 1971 to 1990. Five of the 12 had no underlying lung disease. In the seven remaining patients, SBSP was secondary to histiocytosis X, lymphang...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.105.4.1142
更新日期:1994-04-01 00:00:00
abstract:OBJECTIVE:To investigate the interrelationship of free radicals (FRs), ischemic preconditioning (IP), and hemodynamic function in coronary artery bypass graft (CABG) patients. DESIGN:Prospective, randomized, and controlled clinical study. PATIENTS:Forty CABG patients were randomized into an IP group (n = 20) and a co...
journal_title:Chest
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1378/chest.119.4.1061
更新日期:2001-04-01 00:00:00
abstract:STUDY OBJECTIVES:To evaluate the differences in the clinical, radiologic, and laboratory features of pulmonary tuberculosis (TB) in older patients, as compared to younger patients. DESIGN:A meta-analysis (the Schmidt-Hunter method) of published works found in MEDLINE and other sources was performed. A total of 12 stud...
journal_title:Chest
pub_type: 杂志文章,meta分析
doi:10.1378/chest.116.4.961
更新日期:1999-10-01 00:00:00
abstract::The goal of this article is to provide an update on recent changes to current procedural terminology codes used for billing physician services for mechanical ventilation in chronic care facilities. In addition to billing information, background data relevant to prolonged mechanical ventilation are reviewed. Topics cov...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.07-0656
更新日期:2008-02-01 00:00:00
abstract:BACKGROUND:Tobacco smoke is a major risk factor in the development of COPD. Secondhand smoke (SHS) exposure is a known risk factor in asthma, bronchitis, and coronary artery disease. Elastin is a recognized target for injury in COPD, and the amino acids desmosine and isodesmosine (D/I), which are specific for elastin d...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.10-2298
更新日期:2011-10-01 00:00:00
abstract::Primary influenza pneumonia is a disease of high mortality. Differentiation between a bacterial and viral etiology for the pulmonary infiltrates frequently presents a diagnostic dilemma. Rapid diagnosis is essential; and once established, the patient requires careful supportive therapy. This report describes two patie...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.68.4.513
更新日期:1975-10-01 00:00:00
abstract:STUDY OBJECTIVE:To define the causes and clinical features of hemoptysis in HIV-infected patients. DESIGN:Retrospective analysis of inpatient medical records for patients with HIV infection and hemoptysis. SETTING:A large New York City teaching hospital and tertiary referral center. PATIENTS:Fifty HIV-infected adult...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.110.3.737
更新日期:1996-09-01 00:00:00
abstract:BACKGROUND:The long-term clinical course of asthma in patients with eosinophilic granulomatosis with polyangiitis (EGPA) remains unclear. We aimed to characterize long-term asthma in EGPA and to identify baseline predictors of long-term asthma severity. METHODS:This retrospective cohort study included patients who ful...
journal_title:Chest
pub_type: 杂志文章
doi:10.1016/j.chest.2019.11.045
更新日期:2020-05-01 00:00:00
abstract:BACKGROUND:The ratio of FVC to slow inspiratory vital capacity (SVC) has been reported to reflect small airways obstruction, but its validity as such is still unclear. The aim of this study was to assess the applicability of the FVC/SVC ratio as a marker of small airways function in patients with bronchiolitis oblitera...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.06-2763
更新日期:2007-10-01 00:00:00
abstract:STUDY OBJECTIVE:To determine the role of craniofacial risk factors in increasing apneic activity between nonobese and obese habitual snorers. DESIGN:Cross-sectional. SETTING:Care-seeking volunteers identified through advertisements, and referral-based volunteers from two sleep centers serving the greater Cleveland ar...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.111.1.154
更新日期:1997-01-01 00:00:00
abstract::Hypothalamic-pituitary-adrenal function in a well-defined, carefully selected group of 25 patients with extrinsic asthma was assessed by measuring plasma levels of adrenocorticotropic hormone (ACTH) and of 11-deoxycorticol after administration of metyrapone and by measuring the level of cortisol following stimulation ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.75.2.161
更新日期:1979-02-01 00:00:00
abstract:STUDY OBJECTIVE:To evaluate the cost effectiveness of the Nd-YAG laser and bronchoscopic electrocautery for palliation in patients with symptomatic tumor obstruction. DESIGN:A retrospective study. SETTING:Bronchoscopy unit of a university hospital. PATIENTS AND INTERVENTION:Thirty-one consecutive patients with inope...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.116.4.1108
更新日期:1999-10-01 00:00:00
abstract:BACKGROUND:To address the major methodological issues of reverse causation and selection bias in epidemiologic studies of antibiotic use in early life and the development of asthma, we undertook a cohort study of this association in a complete population of children. METHODS:Using the health-care and prescription data...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.06-3008
更新日期:2007-06-01 00:00:00
abstract:BACKGROUND:There is a growing use of procalcitonin (PCT) to facilitate the diagnosis and management of severe sepsis. We investigated the impact of one to two PCT determinations on ICU day 1 on health-care utilization and cost in a large research database. METHODS:A retrospective, propensity score-matched multivariabl...
journal_title:Chest
pub_type: 杂志文章
doi:10.1016/j.chest.2016.06.046
更新日期:2017-01-01 00:00:00
abstract::Prior to 1978, the conventional treatment of pneumothorax generally consisted of conservative therapies such as rest, needle puncture, or thoracic cavity drainage; however, when conservative therapies were ineffective or relapse occurred therapeutic approach, 34 percent (11/32) of our patients required a thoracotomy. ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.100.4.953
更新日期:1991-10-01 00:00:00
abstract:STUDY OBJECTIVES:Recent studies combining medical and surgical patients have suggested that mortality is higher for mechanically ventilated women than for men. This study was designed to determine whether there are gender-based differences in outcomes in mechanically ventilated medical ICU (MICU) patients. DESIGN AND ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.116.3.732
更新日期:1999-09-01 00:00:00
abstract:BACKGROUND:Periodic leg movements (PLMs) may appear during nasal CPAP titration, persisting despite the elimination of hypopneas. METHODS:Systematic recordings of expiratory abdominal muscles on the right and left sides with surface electromyographic (EMG) electrodes lateral to navel, and close from the lateral side o...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.11-1563
更新日期:2012-07-01 00:00:00
abstract::Angiotensin-converting enzyme (ACE) was localized in sarcoid lymph nodes by an in vitro autoradiographic technique using a synthetic ACE inhibitor of high affinity, 125I-labelled 351A. The lymph nodes were from seven patients with active sarcoidosis who underwent mediastinoscopy and from six control subjects who had n...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.90.3.315
更新日期:1986-09-01 00:00:00