Improvement in arterial oxygenation by saralasin infusion in man.

Abstract:

:Simultaneous hemodynamic and blood gas measurements were performed in 26 hypertensive adults, who were cigarette smokers, before and after a 30-minute infusion of saralasin (5 microgram/kg/min) which is a highly specific competitive antagonist of angiotensin II (AII). The arterial pressure fell in nine, rose in seven and was unchanged in ten patients. The mean cardiac index for the entire group remained unchanged. Pulmonary arterial or wedge pressure, pulmonary vascular resistance, arterial PCO2 and pH did not change. Unrelated to the hemodynamic changes, the mean arterial oxygen pressure (PaO2) increased from 68.6 +/- 2.2 mm Hg to 73.9 +/- 2.1 mm Hg (P less than 0.001). In the absence of a significant increase in alveolar ventilation as indicated by an unchanged mean PCO2 and lacking a hemodynamic explanation, the mechanism for the rise in PaO2 is speculative at this stage. The possibility of an improvement in the distribution of ventilataion by saralasin infusion is under investigation.

journal_name

Chest

journal_title

Chest

authors

Mookherjee S,Obeid AI,Ashutosh K,Warner RA,Smulyan H

doi

10.1378/chest.75.4.492

subject

Has Abstract

pub_date

1979-04-01 00:00:00

pages

492-4

issue

4

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(16)53074-8

journal_volume

75

pub_type

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