The effect of secondhand smoke exposure on markers of elastin degradation.

Abstract:

BACKGROUND:Tobacco smoke is a major risk factor in the development of COPD. Secondhand smoke (SHS) exposure is a known risk factor in asthma, bronchitis, and coronary artery disease. Elastin is a recognized target for injury in COPD, and the amino acids desmosine and isodesmosine (D/I), which are specific for elastin degradation, are elevated in COPD. This study determined whether exposure to SHS affects elastin degradation in asymptomatic individuals. METHODS:Two cohorts of asymptomatic individuals without evidence of respiratory or circulatory disease, exposed to SHS, were studied. Both cohorts comprised normal nonsmokers, active smokers, and those exposed to SHS. D/I were measured in plasma and quantified by high-performance liquid chromatography and tandem mass spectrometry by published methods. Plasma cotinine, a metabolite of nicotine, was also measured. RESULTS:In each cohort, the levels of D/I in plasma were statistically significantly higher in secondhand-smoke-exposed subjects than in the normal nonexposed subjects. Smokers had the highest levels of D/I but their levels were not statistically significantly higher than those of the secondhand-smoke-exposed. Cotinine levels were elevated in secondhand-smoke-exposed subjects and active smokers but not in most nonsmoking control subjects. CONCLUSIONS:Results indicate a tissue matrix effect of degradation of body elastin from SHS exposure and possible lung structure injury, which may result in COPD. Long-term studies of individuals exposed to SHS for the development of COPD are warranted.

journal_name

Chest

journal_title

Chest

authors

Slowik N,Ma S,He J,Lin YY,Soldin OP,Robbins RA,Turino GM

doi

10.1378/chest.10-2298

subject

Has Abstract

pub_date

2011-10-01 00:00:00

pages

946-953

issue

4

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(11)60531-X

journal_volume

140

pub_type

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