Heparin added to cardioplegic solution inhibits tumor necrosis factor-alpha production and attenuates myocardial ischemic-reperfusion injury.

Abstract:

OBJECTIVES:Tumor necrosis factor (TNF)-alpha is known to be a proinflammatory cytokine that has a pronounced negative inotropic effect and plays an important role in ischemic-reperfusion injury. METHODS:Twenty isolated rat hearts were randomly divided equally into two groups (heparin and non-heparin) and were perfused with a Krebs-Henseleit solution using a modified Langendorff model. The influence of heparin on the synthesis and release of TNF-alpha by isolated rat hearts after 1 h of global cardioplegic ischemia and on left ventricular (LV) performances during 30 min of postischemic reperfusion was investigated. RESULTS:Significant mean (+/- SEM) amounts of TNF-alpha in myocardial tissue (1,149 +/- 33.7 pg/g) and effluent (951.8 +/- 27.3 pg/mL) from the coronary sinus were detected after global cardioplegic ischemia. The addition of heparin to the cardioplegic solution significantly improved the recovery of LV function in the postischemic heart (p < 0.0001 for all measurements). TNF-alpha protein production in the heparin-treated hearts was below detectable levels despite a postischemic increase of TNF-alpha messenger RNA expression in both heparin-treated hearts and nontreated hearts (0.71 +/- 0.06 and 0.8 +/- 0.12 relative optical density, respectively). CONCLUSION:This study shows, for the first time, that heparin causes the inhibition of TNF-alpha protein synthesis and release from the isolated ischemic rat heart within the posttranscriptional stage, and that it prevents the depression of LV function caused by ischemic-reperfusion injury.

journal_name

Chest

journal_title

Chest

authors

Pevni D,Frolkis I,Shapira I,Schwartz D,Yuhas Y,Schwartz IF,Chernichovski T,Uretzky G

doi

10.1378/chest.128.3.1805

subject

Has Abstract

pub_date

2005-09-01 00:00:00

pages

1805-11

issue

3

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(15)52220-4

journal_volume

128

pub_type

杂志文章

相关文献

CHEST文献大全
  • Prevalence rates of asthma in developing countries and their comparison with those in Europe and North America.

    abstract::Prevalence rates for asthma in various parts of the world are different and this cannot be entirely explained by differences in methodology. Low prevalence rates are found in third world countries, particularly marked for children. The reasons for these differences are obscure but are largely environmental. Some sugge...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.91.6_supplement.97s

    authors: Cookson JB

    更新日期:1987-06-01 00:00:00

  • Low-grade systemic inflammation and the response to exercise training in patients with advanced COPD.

    abstract:STUDY OBJECTIVE:Low-grade systemic inflammation may cause a chronic catabolic state that may affect trainability in patients with COPD as has been seen previously in healthy elderly. Therefore, the aim of the present study was to study the relationship between baseline circulating levels of inflammatory markers and the...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.128.5.3183

    authors: Spruit MA,Gosselink R,Troosters T,Kasran A,Van Vliet M,Decramer M

    更新日期:2005-11-01 00:00:00

  • Hospitalizations for pulmonary reactions following nitrofurantoin use.

    abstract::Acute pulmonary illness compatible with previously described nitrofurantoin toxicity and requiring hospitalization occurred three times among 16,101 first courses of therapy with nitrofurantoin. One case of fatal pulmonary fibrosis was ascribed to long-term use of nitrofurantoin among 742 observed recipients of ten or...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.96.3.512

    authors: Jick SS,Jick H,Walker AM,Hunter JR

    更新日期:1989-09-01 00:00:00

  • Akinesis becoming dyskinesis during dobutamine stress echocardiography. A predictor of poor functional recovery after surgical revascularization.

    abstract:BACKGROUND:Akinesis becoming dyskinesis at high-dose dobutamine stress echocardiography (DSE) has been disregarded as a marker of myocardial ischemia. However, to our knowledge, the relationship between this pattern and myocardial viability has not been assessed. METHODS:We studied 42 patients with myocardial infarcti...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.110.1.155

    authors: Elhendy A,Cornel JH,Roelandt JR,van Domburg RT,Fioretti PM

    更新日期:1996-07-01 00:00:00

  • Hypoxic pulmonary vasoconstriction and gas exchange during exercise in chronic obstructive pulmonary disease.

    abstract::In patients with chronic obstructive pulmonary disease (COPD) studied at rest, nifedipine releases hypoxic pulmonary vasoconstriction (HPV) and worsens gas exchange. During exercise, this drug lowers pulmonary hypertension, but the effects of this lower pulmonary vascular tone on ventilation-perfusion (VA/Q) relations...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.97.2.268

    authors: Agustí AG,Barberá JA,Roca J,Wagner PD,Guitart R,Rodriguez-Roisín R

    更新日期:1990-02-01 00:00:00

  • Right and light ventricular dimensions as determinants of ventricular septal motion.

    abstract::Echocardiographic studies were performed in 86 patients with right ventricular volume overload. In 45 of these 86 patients, 58 echocardiograms were performed at different intervals in the postoperative period. For control purposes, 60 normal subjects and 18 patients with right ventricular pressure overload were also e...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.69.3.388

    authors: Laurenceau JL,Dumesnil JG

    更新日期:1976-03-01 00:00:00

  • Antimyosin scintigraphy for detection of myocarditis. Scintigraphic follow-up.

    abstract::To examine the value of antimyosin-indium 111 imaging in relation to endomyocardial biopsy in patients with suspected myocarditis, as well as the natural evolution of abnormal findings on the antimyosin scan, 12 patients with suspected myocarditis underwent endomyocardial biopsy and antimyosin scan. The heart-to-lung ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.104.5.1427

    authors: Lekakis J,Nanas J,Moustafellou A,Kostamis P,Moulopoulos S

    更新日期:1993-11-01 00:00:00

  • Diagnostic value of pleural fluid adenosine deaminase in tuberculous pleuritis with reference to HIV coinfection and a Bayesian analysis.

    abstract:OBJECTIVES:To evaluate the diagnostic use of pleural fluid adenosine deaminase (ADAPF) levels in tuberculous pleuritis (TBpl), with a special reference to HIV coinfection and a Bayesian analysis. METHODS:We investigated a total of 216 patients with pleural effusion, including 100 with TBpl, 68 with malignant effusion,...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.116.1.97

    authors: Riantawan P,Chaowalit P,Wongsangiem M,Rojanaraweewong P

    更新日期:1999-07-01 00:00:00

  • How should we measure arm exercise capacity in patients with COPD? A systematic review.

    abstract:BACKGROUND:There are no recommendations on how to measure arm exercise capacity in individuals with COPD. The objectives of this study were (1) to synthesize the literature on measures of arm exercise capacity in individuals with COPD, (2) to describe the psychometric properties and the target construct of each measure...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.11-0475

    authors: Janaudis-Ferreira T,Beauchamp MK,Goldstein RS,Brooks D

    更新日期:2012-01-01 00:00:00

  • Graphs.

    abstract::Two rules of good graphs are presented and explicated. ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.130.2.620

    authors: Green J

    更新日期:2006-08-01 00:00:00

  • Therapeutic response patterns to high and cumulative doses of salbutamol in acute severe asthma.

    abstract:STUDY OBJECTIVES:To examine the main therapeutic response patterns to high doses of salbutamol and to determine the factors that contribute to outcome in acute severe asthma. SETTING:The emergency department (ED) of a large, urban hospital with primary and referral care responsibilities. PATIENTS AND DESIGN:One hundr...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.113.3.593

    authors: Rodrigo C,Rodrigo G

    更新日期:1998-03-01 00:00:00

  • Carcinomatous and tuberculous pleural effusions. Comparison of tumor markers.

    abstract::As an aid in the differential diagnosis of exudative pleural effusions, tumor markers were investigated. We measured immunosuppressive acidic protein (IAP), carbohydrate antigen 19-9 (CA 19-9), tissue polypeptide antigen (TPA), carcinoembryonic antigen (CEA), adenosine deaminase (ADA), and alpha 1-acid glycoprotein (A...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.87.3.351

    authors: Niwa Y,Kishimoto H,Shimokata K

    更新日期:1985-03-01 00:00:00

  • Descriptors of breathlessness in children with persistent asthma.

    abstract:BACKGROUND:In adult patients, the consistent use of language to describe dyspnea enhances patient-provider communication and contributes to diagnostic and therapeutic decisions. The objective of this research was to determine whether pediatric patients similarly display consistency in the language used to describe "unc...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.10-2388

    authors: Harver A,Schwartzstein RM,Kotses H,Humphries CT,Schmaling KB,Mullin ML

    更新日期:2011-04-01 00:00:00

  • Left pleural hemorrhagic effusion. A presenting sign of thoracic aortic dissecting aneurysm.

    abstract::Left hemorrhagic pleural effusion was the presenting sign of painless aortic dissecting aneurysm in two elderly hypertensive patients. Computed tomography (CT) of the chest revealed the aneurysmal dilatation of the thoracic aorta and an intimal flap connecting its descending part with the left pleural space. The patie...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.106.2.636

    authors: Gandelman G,Barzilay N,Krupsky M,Resnitzky P

    更新日期:1994-08-01 00:00:00

  • Diaphragmatic dysfunction in siblings with hereditary motor and sensory neuropathy (Charcot-Marie-Tooth disease).

    abstract::Hereditary motor and sensory neuropathy (Charcot-Marie-Tooth disease) is characterized by chronic degeneration of peripheral nerves and roots, resulting in distal muscle atrophy, beginning in the feet and legs and later involving the hands. The association of this disease with diaphragmatic dysfunction has not been re...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.91.4.567

    authors: Chan CK,Mohsenin V,Loke J,Virgulto J,Sipski ML,Ferranti R

    更新日期:1987-04-01 00:00:00

  • A Longitudinal Cohort Study of Aspirin Use and Progression of Emphysema-like Lung Characteristics on CT Imaging: The MESA Lung Study.

    abstract:BACKGROUND:Platelet activation reduces pulmonary microvascular blood flow and contributes to inflammation; these factors have been implicated in the pathogenesis of COPD and emphysema. We hypothesized that regular use of aspirin, a platelet inhibitor, would be associated with a slower progression of emphysema-like lung...

    journal_title:Chest

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.chest.2017.11.031

    authors: Aaron CP,Schwartz JE,Hoffman EA,Angelini E,Austin JHM,Cushman M,Jacobs DR Jr,Kaufman JD,Laine A,Smith LJ,Yang J,Watson KE,Tracy RP,Barr RG

    更新日期:2018-07-01 00:00:00

  • Diffuse tumor microembolism: a rare cause of a high-probability perfusion scan.

    abstract::Pulmonary tumor embolism is a rare but well-documented cause of respiratory failure in patients with cancer. This entity is probably clinically underrecognized and may represent an important cause of morbidity and mortality. A typical pattern of multiple peripheral subsegmental defects on perfusion lung scanning has b...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.111.4.1122

    authors: Moores LK,Burrell LM,Morse RW,Belgrave CH,Balingit AG

    更新日期:1997-04-01 00:00:00

  • Steady antibiotic release from biodegradable beads in the pleural cavity: an in vitro and in vivo study.

    abstract:BACKGROUND:Inadequate localized drug concentrations and systemic adverse effects are among the concerns when regional infections are treated with systemic antibiotics. We designed and fabricated a poly(D,L)-lactide-co-glycolide (PLGA)-based biodegradable drug delivery system and evaluated the release of antibiotics bot...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.11-1254

    authors: Liu KS,Liu SJ,Chen HY,Huang YK,Peng YJ,Wu RC,Ueng SW

    更新日期:2012-05-01 00:00:00

  • New serum indicator of interstitial pneumonitis activity. Sialylated carbohydrate antigen KL-6.

    abstract::Serum levels of a high molecular weight circulating antigen KL-6, detected by means of a sandwich assay using a monoclonal antibody KL-6 against a sialylated carbohydrate antigen, were evaluated for usefulness in monitoring the activity of interstitial pneumonitis. Abnormally high levels of KL-6 antigen were observed ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.96.1.68

    authors: Kohno N,Kyoizumi S,Awaya Y,Fukuhara H,Yamakido M,Akiyama M

    更新日期:1989-07-01 00:00:00

  • Two-dimensional echocardiographic features of bicuspid aortic valve.

    abstract::The two-dimensional cross-sectional echocardiographic diagnosis of bicuspid aortic valves is described and compared with results of M-mode echocardiograms. Aortic valve anatomy was determined in 19 selected patients by angiography, and confirmed in five by direct surgical visualization. Using an eccentricity index (EI...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.75.4.434

    authors: Fowles RE,Martin RP,Abrams JM,Schapira JN,French JW,Popp RL

    更新日期:1979-04-01 00:00:00

  • Efficacy of methylprednisolone in preventing lung injury following pulmonary thromboendarterectomy.

    abstract:BACKGROUND:We sought to determine the efficacy and safety of perioperative treatment with methylprednisolone on the development of lung injury after pulmonary thromboendarterectomy. METHODS:This was a randomized, prospective, double-blind, placebo-controlled study of 98 adult patients with chronic thromboembolic pulmo...

    journal_title:Chest

    pub_type: 杂志文章,随机对照试验

    doi:10.1378/chest.10-2639

    authors: Kerr KM,Auger WR,Marsh JJ,Devendra G,Spragg RG,Kim NH,Channick RN,Jamieson SW,Madani MM,Manecke GR,Roth DM,Shragg GP,Fedullo PF

    更新日期:2012-01-01 00:00:00

  • Relationship of resting lung mechanics and exercise pattern of breathing in patients with chronic obstructive lung disease.

    abstract::To investigate the influence of resting pulmonary mechanics on the pattern of breathing during exercise in chronic obstructive pulmonary disease (COPD), we studied 29 patients with moderate to severe COPD (FEV1 50 +/- 20 percent predicted), and 10 normal subjects. Lung mechanics were studied using esophageal balloon t...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.104.3.705

    authors: Marin JM,Hussain SN,Gibbons WJ,Polverino M,Levy RD,Cosio MG

    更新日期:1993-09-01 00:00:00

  • Effects of long-term aerosol pentamidine for Pneumocystis carinii prophylaxis on pulmonary function.

    abstract:OBJECTIVE:The purpose of the study was to evaluate the long-term effects of aerosolized pentamidine (AP) on the pulmonary function of HIV-positive individuals receiving AP for Pneumocystis carinii pneumonia (PCP) prophylaxis. DESIGN:A retrospective analysis of serial pulmonary function tests (PFTs) performed on a coho...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.114.3.742

    authors: Wei CC,Pack LL,Chan CK

    更新日期:1998-09-01 00:00:00

  • Partially and totally unloading respiratory muscles based on real-time measurements of work of breathing. A clinical approach.

    abstract:OBJECTIVE:To evaluate the clinical feasibility of using real-time measurements of work of breathing obtained at the bedside with a portable, commercially available respiratory monitor as an objective and quantifiable guideline for appropriately setting pressure support ventilation (PSV) to partially and totally unload ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.106.6.1835

    authors: Banner MJ,Kirby RR,Gabrielli A,Blanch PB,Layon AJ

    更新日期:1994-12-01 00:00:00

  • Thrombocytopenia in the intensive care unit.

    abstract:STUDY OBJECTIVE:To determine the prevalence of thrombocytopenia in an ICU and assess which factors were associated with thrombocytopenia. DESIGN:A review of the medical records of patients admitted during 3 separate months during 1 academic year. Patients must have survived at least 12 h in the ICU. SETTING:A medical...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.104.4.1243

    authors: Baughman RP,Lower EE,Flessa HC,Tollerud DJ

    更新日期:1993-10-01 00:00:00

  • Diagnosis of gastric aspiration by fiberoptic bronchoscopy.

    abstract::At the time of bronchoscopic observation, 28 of 31 patients proved to have aspirated gastric contents by the presence of gastric contents in the trachea or by direct observation of gastric aspiration followed by respiratory distress and erythema of subsegmental bronchi. Since gastric aspiration is a difficult diagnosi...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.70.4.458

    authors: Wolfe JE,Bone RC,Ruth WE

    更新日期:1976-10-01 00:00:00

  • Long-Acting Bronchodilator Initiation in COPD and the Risk of Adverse Cardiopulmonary Events: A Population-Based Comparative Safety Study.

    abstract:BACKGROUND:Long-acting bronchodilators, including long-acting beta2-agonists (LABA) and the anticholinergic tiotropium, are recommended as initial maintenance therapy in COPD. Studies to date have been limited in size and reported ambivalent results on the comparative risk of cardiovascular, cerebrovascular, and pulmon...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1016/j.chest.2016.08.001

    authors: Suissa S,Dell'Aniello S,Ernst P

    更新日期:2017-01-01 00:00:00

  • Range in pulmonary artery systolic pressure among highly trained athletes.

    abstract:BACKGROUND:Although the physiologic range of pulmonary artery systolic pressure (PASP) has been reported, data on how it is manifested in athletes are limited. The aim of the present study was to explore the full spectrum of PASP and the long-term training impact in a large population of highly trained athletes. METHO...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.10-1260

    authors: D'Andrea A,Naeije R,D'Alto M,Argiento P,Golia E,Cocchia R,Riegler L,Scarafile R,Limongelli G,Di Salvo G,Citro R,Caso P,Russo MG,Calabrò R,Bossone E

    更新日期:2011-04-01 00:00:00

  • Bronchoprotective effects of single doses of salmeterol combined with montelukast in thermally induced bronchospasm.

    abstract:STUDY OBJECTIVES:Salmeterol (S) and montelukast (M) individually inhibit the obstructive consequences of thermal stimuli such as exercise and hyperventilation (HV), but there is no information on whether these drugs can interact positively. DESIGN:Randomized trial. SETTING:University teaching hospital. PARTICIPANTS:...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.127.5.1572

    authors: Coreno A,Skowronski M,West E,El-Ekiaby A,McFadden ER Jr

    更新日期:2005-05-01 00:00:00

  • The effects of smoking on the signal-averaged electrocardiogram in normal subjects.

    abstract::Tobacco smoking increases the risk of sudden cardiac death, possibly by altering the substrate for propagation or sustainment of ventricular tachyarrhythmias. To test this hypothesis, 15 long-term smokers without known coronary artery disease abstained from tobacco smoking for 12 h, after which they underwent SAECG be...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.99.1.121

    authors: Sperry RE,Vacek JL,Smith GS

    更新日期:1991-01-01 00:00:00