Hospitalizations for pulmonary reactions following nitrofurantoin use.


:Acute pulmonary illness compatible with previously described nitrofurantoin toxicity and requiring hospitalization occurred three times among 16,101 first courses of therapy with nitrofurantoin. One case of fatal pulmonary fibrosis was ascribed to long-term use of nitrofurantoin among 742 observed recipients of ten or more prescriptions.






Jick SS,Jick H,Walker AM,Hunter JR




Has Abstract


1989-09-01 00:00:00
















  • Effect of Age on Phenotype and Outcomes in Pulmonary Arterial Hypertension Trials.

    abstract:BACKGROUND:In recent years, the population of patients with pulmonary arterial hypertension (PAH) has changed dramatically, including more advanced age at diagnosis. We hypothesized that older patients have a distinct clinical profile with different disease characteristics and response to intervention. METHODS:All pre...


    pub_type: 杂志文章


    authors: Rose JA,Cleveland JM,Rao Y,Minai OA,Tonelli AR

    更新日期:2016-05-01 00:00:00

  • Surgical transsternal treatment of bronchopleural fistula postpneumonectomy.

    abstract::An original method of treatment for main bronchus fistula occurring after pneumonectomy was described in 1961. The operation is performed via a median sternotomy and the carinal region exposed. The main bronchi can then be divided in an area not involved with infection. We describe ten patients who underwent this proc...


    pub_type: 杂志文章


    authors: Beltrami V

    更新日期:1989-02-01 00:00:00

  • Amoxicillin-clavulanic acid for treating drug-resistant Mycobacterium tuberculosis.

    abstract::This report describes two patients with multidrug resistant tuberculosis who were successfully treated with the addition of amoxicillin-clavulanic acid to second-line drugs. Mycobacterium tuberculosis possesses a beta-lactamase contributing to its resistance to beta-lactam antibiotics. The combination of clavulanic ac...


    pub_type: 杂志文章


    authors: Nadler JP,Berger J,Nord JA,Cofsky R,Saxena M

    更新日期:1991-04-01 00:00:00

  • Battling Intensivist Burnout: A Role for Workload Management.

    abstract::Burnout syndrome is an increasingly common phenomenon that threatens our critical care workforce and the well-being of its members. Burnout syndrome can be conceived of as a workforce manifestation of chronic workload and workforce capacity imbalance. This study explores the role of workload management tools that can ...


    pub_type: 评论,杂志文章,评审


    authors: Lilly CM,Cucchi E,Marshall N,Katz A

    更新日期:2019-11-01 00:00:00

  • The Burden of Community-Acquired Pneumonia Requiring Admission to ICU in the United States.

    abstract:BACKGROUND:A paucity of studies have assessed the epidemiology of community-acquired pneumonia (CAP) that require ICU admission. We conducted a study on this group of patients with the primary objective of defining the incidence, epidemiology, and mortality rate of CAP in the ICUs in Louisville, Kentucky. The secondary...


    pub_type: 杂志文章


    authors: Cavallazzi R,Furmanek S,Arnold FW,Beavin LA,Wunderink RG,Niederman MS,Ramirez JA

    更新日期:2020-09-01 00:00:00

  • Management of malignant air leak in a child with a neonatal high-frequency oscillatory ventilator.

    abstract::A 10-year-old, 36-kg child with a malignant air leak who failed conventional mechanical ventilation and high-frequency jet ventilation was successfully treated with a neonatal high-frequency oscillatory ventilator for 31 days. Since the air leak resolved with minimal hemodynamic compromise, this technique may have app...


    pub_type: 杂志文章


    authors: Mayes TC,Jefferson LS,David Y,Louis PT,Fortenberry JD

    更新日期:1991-07-01 00:00:00

  • Lymphocytic alveolitis after primary HIV infection with CMV coinfection.

    abstract::Herein is a report of an adult case of primary HIV infection with cytomegalovirus coinfection causing cough, fever, and lymphocytic alveolitis. Primary HIV infection has not been previously reported as a cause of lymphocytic alveolitis. ...


    pub_type: 杂志文章


    authors: Jouveshomme S,Couderc LJ,Ferchal F,Vignon D,Autran B,Balloul E,Caubarrere I

    更新日期:1997-10-01 00:00:00

  • Characterization of the clonidine receptor site.

    abstract::At the cardiac sympathetic nerve terminal the alpha 2-adrenoceptor is presynaptic and appears to be located at an extrasynaptic site. This is suggested by (1) absence of evidence of autoinhibitory feedback at physiologic stimulus levels up to about 50 percent of the maximum chronotropic response in the isolated guinea...


    pub_type: 杂志文章


    authors: Korner PI,Angus JA,Lew MJ,Heinzow BG

    更新日期:1983-02-01 00:00:00

  • Low and High Blood Eosinophil Counts as Biomarkers in Hospitalized Acute Exacerbations of COPD.

    abstract:BACKGROUND:Characterizing acute exacerbations of COPD (AECOPD) and individualizing therapy is challenging. Key exacerbation therapies include antibiotics and systemic corticosteroids. Blood eosinophils, when either low or high, may offer a simple, inexpensive distinction to predict beneficial responses to these therapi...


    pub_type: 杂志文章,多中心研究


    authors: MacDonald MI,Osadnik CR,Bulfin L,Hamza K,Leong P,Wong A,King PT,Bardin PG

    更新日期:2019-07-01 00:00:00

  • Varying ejection fractions of both ventricles in paradoxical pulses: demonstration by radionuclide study.

    abstract::A noninvasive radionuclide study of the paradoxical pulse in pericardial effusion is described. The study shows complementary changes of the right and left ventricular ejection fractions in a patient with paradoxical pulse, supporting the theory that the inspiratory reduction of the left ventricular stroke volume is a...


    pub_type: 杂志文章


    authors: Yeh EL

    更新日期:1978-12-01 00:00:00

  • The effect of high-dose inhaled beclomethasone dipropionate in patients with stable COPD.

    abstract:BACKGROUND:The benefits of inhaled corticosteroids in the management of COPD are less apparent than they are in asthma therapy, and the potential for adverse systemic effects of high-dose inhaled corticosteroids has been recognized recently. It is therefore essential to know the maximal obtainable benefits in order to ...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Nishimura K,Koyama H,Ikeda A,Tsukino M,Hajiro T,Mishima M,Izumi T

    更新日期:1999-01-01 00:00:00

  • Pulmonary Nodules: A Small Problem for Many, Severe Distress for Some, and How to Communicate About It.

    abstract::Every year, millions of patients are diagnosed with pulmonary nodules, and as increasing numbers of people undergo lung cancer screening, even more patients will be found to have a nodule. The vast majority of patients cannot benefit from the detection of a pulmonary nodule because most are benign. Accordingly, it is ...


    pub_type: 杂志文章,评审


    authors: Slatore CG,Wiener RS

    更新日期:2018-04-01 00:00:00

  • Percent Emphysema and Daily Motor Activity Levels in the General Population: Multi-Ethnic Study of Atherosclerosis.

    abstract:BACKGROUND:COPD is associated with reduced physical capacity. However, it is unclear whether pulmonary emphysema, which can occur without COPD, is associated with reduced physical activity in daily life, particularly among people without COPD and never smokers. We hypothesized that greater percentage of emphysema-like ...


    pub_type: 杂志文章


    authors: Lo Cascio CM,Quante M,Hoffman EA,Bertoni AG,Aaron CP,Schwartz JE,Avdalovic MV,Fan VS,Lovasi GS,Kawut SM,Austin JHM,Redline S,Barr RG

    更新日期:2017-05-01 00:00:00

  • Subaortic stenosis caused by two discrete membranes.

    abstract::A case of subaortic stenosis caused by two discrete membranes is presented. Following demonstration of the two distinct sites of obstruction by intraventricular pressure gradients and angiocardiogram, the two membranes were excised through a transaortic approach. The importance of being aware of the occurrence of this...


    pub_type: 杂志文章


    authors: Lemole GM,Tesler UF,Colombi M,Eldredge WJ

    更新日期:1976-01-01 00:00:00

  • Refining clinical risk stratification for predicting stroke and thromboembolism in atrial fibrillation using a novel risk factor-based approach: the euro heart survey on atrial fibrillation.

    abstract:BACKGROUND:Contemporary clinical risk stratification schemata for predicting stroke and thromboembolism (TE) in patients with atrial fibrillation (AF) are largely derived from risk factors identified from trial cohorts. Thus, many potential risk factors have not been included. METHODS:We refined the 2006 Birmingham/Na...


    pub_type: 杂志文章,多中心研究


    authors: Lip GY,Nieuwlaat R,Pisters R,Lane DA,Crijns HJ

    更新日期:2010-02-01 00:00:00

  • Smoking cessation counseling: a practice management perspective.

    abstract::Individuals continue to smoke despite its numerous proven adverse health effects. Now viewed as a chronic medical condition, health-care professionals are more involved in cessation efforts. Physicians are often the first line of defense, providing intervention through prescription management and counseling. Some insu...


    pub_type: 杂志文章


    authors: Pohlig C

    更新日期:2006-10-01 00:00:00

  • The effect of cigarette smoke exposure on pulmonary metastatic disease in a murine model of metastatic breast cancer.

    abstract:INTRODUCTION:Women who smoke have a higher rate of fatal breast cancer than nonsmoking women. An association between smoking and pulmonary metastases from breast cancer has been suggested by epidemiologic studies. STUDY OBJECTIVES:To examine the relationship between exposure to cigarette smoke and pulmonary metastasis...


    pub_type: 杂志文章


    authors: Murin S,Pinkerton KE,Hubbard NE,Erickson K

    更新日期:2004-04-01 00:00:00

  • Modification of the effect of fiberoptic bronchoscopy on pulmonary mechanics.

    abstract::Thirty-three patients who were to undergo diagnostic fiberoptic bronchoscopy were studied. Pulmonary function tests were performed before the procedure, after topical lidocaine anesthesia, and immediately and four hours after bronchoscopy. Nine patients received aerosolized isoproterenol (Isuprel) before the topical a...


    pub_type: 杂志文章


    authors: Belen J,Neuhaus A,Markowitz D,Rotman HH

    更新日期:1981-05-01 00:00:00

  • Pleural lipoma. Diagnosis by computed tomography.

    abstract::Until recently, a definitive diagnosis of lipoma in the thorax could only be established by thoracotomy. We undertook this study to determine if chest CT could provide such an answer. Among 4,000 chest CT scans, six patients were found to have lipoma according to the following selected criteria: CT features of a pleur...


    pub_type: 杂志文章


    authors: Epler GR,McLoud TC,Munn CS,Colby TV

    更新日期:1986-08-01 00:00:00

  • A pharmacologic study on CO2 responsiveness of intracranial pressure in rats with chronic hypercapnia.

    abstract:STUDY OBJECTIVES:To investigate intracranial pressure (ICP) changes and their mechanisms in chronic hypercapnia. DESIGN:After 12 male Wistar rats were maintained in CO2-mixed air (mean PaCO2, 71.0 mm Hg) for 21 weeks, their ICP levels were measured during the breathing of 0, 5, 10, 12, and 14% CO2-mixed air before and...


    pub_type: 杂志文章


    authors: Kondo T,Kumagai M,Takei F,Ohta Y

    更新日期:1999-05-01 00:00:00

  • Diagnosis of severe tricuspid regurgitation.

    abstract::Fifty-nine patients were studied who had severe tricuspid regurgitation which was confirmed by right ventriculography and during surgery in order to determine the incidence of clinical, radiologic, and hemodynamic clues of severe tricuspid regurgitation. Eighty-eight percent of patients had Carvallo sign alone or in c...


    pub_type: 杂志文章


    authors: Cha SD,Desai RS,Gooch AS,Maranhao V,Goldberg H

    更新日期:1982-12-01 00:00:00

  • Electrocardiographic findings in brain death; description and presumed mechanism.

    abstract::Electrocardiogram changes and pharmacologic responses were studied in 28 cases of brain death. Cardiac activity in this condition is possibly determined by the dynamic balance between the depressant action of hypothermia and the stimulating action of the sympathetic nervous system (without any vagal or central influen...


    pub_type: 杂志文章


    authors: Drory Y,Ouaknine G,Kosary IZ,Kellermann JJ

    更新日期:1975-04-01 00:00:00

  • Is a raised bicarbonate, without hypercapnia, part of the physiologic spectrum of obesity-related hypoventilation?

    abstract:BACKGROUND:Obesity hypoventilation syndrome (OHS) conventionally includes awake hypercapnia, but an isolated raised bicarbonate, even in the absence of awake hypercapnia, may represent evidence of "early" OHS. We investigated whether such individuals exhibit certain features characteristic of established OHS. METHODS:...


    pub_type: 杂志文章


    authors: Manuel ARG,Hart N,Stradling JR

    更新日期:2015-02-01 00:00:00

  • Patients With Fibrotic Interstitial Lung Disease Hospitalized for Acute Respiratory Worsening: A Large Cohort Analysis.

    abstract:BACKGROUND:Acute respiratory worsening (ARW) requiring hospitalization in patients with fibrotic interstitial lung disease (f-ILD) is common. Little is known about the frequency and implications of ARW in IPF and non-IPF ILD patients hospitalized for acute exacerbation (AE) vs known causes of ARW. METHODS:All consecut...


    pub_type: 杂志文章


    authors: Moua T,Westerly BD,Dulohery MM,Daniels CE,Ryu JH,Lim KG

    更新日期:2016-05-01 00:00:00

  • Relationship between the electrical (electrocardiographic) and mechanical (echocardiographic) events in Wolff-Parkinson-White syndrome.

    abstract::Studies using epicardial mapping on patients with Wolff-Parkinson-White syndrome have demonstrated that the delta vector of the electrocardiogram is a detector of the location of at least one bypass tract. In order to relate the electrical activities (preexcitation) with the mechanical activity (septal and ventricular...


    pub_type: 杂志文章


    authors: Lebovitz JA,Mandel WJ,Laks MM,Kraus R,Weinstein S

    更新日期:1977-04-01 00:00:00

  • Elevated levels of soluble interleukin-2 receptors in tuberculous pleural effusions.

    abstract::The levels of soluble IL-2R were measured in pleural fluid from patients with tuberculosis pleurisy. There were significantly elevated soluble IL-2R values in tuberculous pleural fluid as compared with pleural fluid of nontuberculous etiology including malignant, bacterial and transudative pleural effusions. In patien...


    pub_type: 杂志文章


    authors: Ito M,Kojiro N,Shirasaka T,Moriwaki Y,Tachibana I,Kokubu T

    更新日期:1990-05-01 00:00:00

  • Bronchial thermoplasty: reappraising the evidence (or lack thereof).

    abstract::Bronchial thermoplasty (BT) involves the application of radiofrequency energy to visible proximal airways to selectively ablate airway smooth muscle. BT is the first nonpharmacologic interventional therapy approved by the US Food and Drug Administration (FDA) for severe asthma. This approval was based on the results o...


    pub_type: 杂志文章,评审


    authors: Iyer VN,Lim KG

    更新日期:2014-07-01 00:00:00

  • A Blueprint for Success: Design and Implementation of an Ideal Bronchoscopy Suite.

    abstract::Bronchoscopy is essential to the practice of pulmonary medicine. It is an important diagnostic and therapeutic tool for many disease processes. Bronchoscopy can be performed in a variety of clinical settings, from the bedside to an operating room. Although bronchoscopy has been practiced for more than a century, conse...


    pub_type: 杂志文章,评审


    authors: Mehta AC,Avasarala SK,Jain P,Deshwal H,Gildea TR

    更新日期:2020-03-01 00:00:00

  • Do native and polymeric alpha1-antitrypsin activate human neutrophils in vitro?

    abstract:BACKGROUND:alpha(1)-Antitrypsin (AAT)-Z deficiency is a risk factor for the development of COPD. Compared to wild-type M, AAT-Z has an increased tendency to polymerize, rendering it inactive as a serine proteinase inhibitor. It has been demonstrated that wild-type M- and Z-deficiency AAT polymers are chemotactic for hu...


    pub_type: 杂志文章


    authors: Persson C,Subramaniyam D,Stevens T,Janciauskiene S

    更新日期:2006-06-01 00:00:00

  • Nonsurgical treatment of Histoplasma endocarditis involving a bioprosthetic valve.

    abstract::Endocardial involvement associated with disseminated histoplasmosis has been infrequently documented, especially among patients with prosthetic valves. The therapeutic approach to these patients is also not yet clearly defined. A 54-year-old man with prosthetic valve endocarditis due to histoplasmosis was successfully...


    pub_type: 杂志文章,评审


    authors: Kanawaty DS,Stalker MJ,Munt PW

    更新日期:1991-01-01 00:00:00