Abstract:
:Asthma and COPD are common respiratory diseases that are caused by the interaction of genetic susceptibility with environmental factors. Environmental influences are important in both diseases, and although there are differences in genetic susceptibilities, there are also similarities. Three examples of interest for both asthma and COPD patients are discussed. The first is the results of family studies, which have shown evidence for susceptibility loci for both asthma-related and COPD-related phenotypes in the same chromosomal region. Second, evidence for a gene-environment interaction with passive smoking for asthma patients compared with individual smoking for COPD patients will be covered. The third is an example of one candidate gene (interleukin-13), in which similar results have been observed for both asthma and COPD.
journal_name
Chestjournal_title
Chestauthors
Meyers DA,Larj MJ,Lange Ldoi
10.1378/chest.126.2_suppl_1.105Ssubject
Has Abstractpub_date
2004-08-01 00:00:00pages
105S-110S; discussion 159S-161Sissue
2 Suppleissn
0012-3692issn
1931-3543pii
S0012-3692(15)31479-3journal_volume
126pub_type
杂志文章,评审相关文献
CHEST文献大全abstract::Two cases are presented in which a Dormia ureteral stone dislodger with straight filiform tip was used to retrieve broken central venous pressure catheters from the right side of the heart and vena cavae. It should be emphasized that this particular model is more easily passed into the vascular system and more easily ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.69.3.435
更新日期:1976-03-01 00:00:00
abstract::Indirect evidence from airway pressure recordings in mechanically ventilated patients suggests that the diaphragm exhibits contractile activity beyond that required to trigger a ventilator-assisted breath. We used the diaphragmatic EMG to provide direct evidence of persistent contractile activity and studied the effec...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.96.1.130
更新日期:1989-07-01 00:00:00
abstract:STUDY OBJECTIVE:We analyze the within-subject variation of mouth occlusion pressure (P0.1) response to progressive isocapnic hypoxic stimulation over long time periods in normal subjects. PATIENTS AND INTERVENTIONS:We studied 21 healthy subjects (14 male and 7 female; aged 40+/-12 yrs) (mean+/-SD). Lung volumes, basal...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.114.2.521
更新日期:1998-08-01 00:00:00
abstract::This study describes the extent of agreement in classification of chest radiographs using the International Labor Organization (ILO) classification among six readers from the United States and Canada. A set of 119 radiographs was created and read by three Canadian and three US readers. The two ratings of interest were...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.114.6.1740
更新日期:1998-12-01 00:00:00
abstract::The eosinophil count and concentrations of eosinophil cationic protein (ECP) were measured in bronchoalveolar lavage fluid (BALF) from patients with idiopathic pulmonary fibrosis (IPF), pulmonary fibrosis associated with a collagen vascular disorder (PF-CVD), sarcoidosis, and healthy controls. The patients with IPF an...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.108.1.48
更新日期:1995-07-01 00:00:00
abstract::In 84 consecutive patients with resting T-wave inversion, radionuclide angiography revealed significant new wall motion abnormalities in 13 (28 percent) of the 47 patients with persistent T-wave inversion and in 23 (62 percent) of the 37 patients with T-wave pseudonormalization during exercise (p less than 0.01). The ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.94.3.512
更新日期:1988-09-01 00:00:00
abstract:BACKGROUND:Our laboratory uses pH paper rather than a blood gas analyzer to measure pleural fluid pH to decrease cost and avoid analyzer malfunction due to viscous fluids. METHODS:To compare these two methods of determining pleural fluid pH, 42 patients undergoing diagnostic or therapeutic thoracentesis had two 1-mL a...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.112.5.1291
更新日期:1997-11-05 00:00:00
abstract:OBJECTIVES:To compare the rapid shallow breathing index (RSBI) under different ventilatory support settings prior to extubation trials. DESIGN:Prospective study. SETTING:Cardiac surgery unit at a university hospital. PATIENTS:A total of 33 coronary artery bypass grafting patients ready for extubation. INTERVENTIONS...
journal_title:Chest
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1378/chest.121.2.475
更新日期:2002-02-01 00:00:00
abstract:BACKGROUND:The presence and progression of interstitial lung abnormalities (ILAs) is known to be associated with a decline of lung function and increased risk of mortality. RESEARCH QUESTION:We aimed to elucidate the clinical course according to ILAs in patients with COPD. STUDY DESIGN AND METHODS:A retrospective stu...
journal_title:Chest
pub_type: 杂志文章
doi:10.1016/j.chest.2020.08.017
更新日期:2021-01-01 00:00:00
abstract:STUDY OBJECTIVE:To evaluate the role of microaspiration in gastroesophageal reflux-induced bronchoconstriction. DESIGN:Prospective study blinded to the subject. SETTING:Outpatient laboratory of a 908-bed university hospital. PARTICIPANTS:Thirty nonsmoking adults divided into two groups: asthmatics with reflux (AR), ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.108.5.1220
更新日期:1995-11-01 00:00:00
abstract::To assess the prognostic significance of myocardial contractile reserve in patients with idiopathic dilated cardiomyopathy (DCM) without overt heart failure (New York Heart Association functional class I or II), seventy-one patients underwent exercise radionuclide angiography in addition to clinical, radiographic, hem...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.111.2.344
更新日期:1997-02-01 00:00:00
abstract::Data on pulmonary function, with particular reference to flow-volumes, were obtained in 760 normal healthy Indians in Bombay, who had never smoked and who had no symptom or history of cardiorespiratory disease. Prediction equations were derived for spirometric parameters and for maximal expiratory flows. The maximal e...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.89.6.852
更新日期:1986-06-01 00:00:00
abstract::We studied hypoxic and hypercapnic ventilatory drives in 22 eucapnic obese subjects (14 female and eight male subjects) referred for weight reduction therapy and 23 normal subjects (eight female and 15 male subjects). In the female subjects, both occlusion pressure, currently used as an indicator of ventilatory drive,...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.93.5.968
更新日期:1988-05-01 00:00:00
abstract::This report describes a patient with right lower lung (RLL) pneumonia of a subacute nature. Sputum and bronchial washings both grew N asteroides. Open lung biopsy showed bronchiolitis obliterans. Both the clinical and radiologic picture dramatically improved during three weeks of treatment with trimethoprim and sulfam...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.92.6.1107
更新日期:1987-12-01 00:00:00
abstract:STUDY OBJECTIVE:To describe the clinical characteristics and outcome of patients with severe melioidosis requiring intensive care. DESIGN:Retrospective chart review. SETTING:Two ICUs from a tertiary-care teaching hospital. PATIENTS:Twenty-seven adult ICU patients with microbiologically documented melioidosis. INTER...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.128.5.3674
更新日期:2005-11-01 00:00:00
abstract::OSA is associated with significant adverse outcomes with far-reaching health-care implications. OSA is much more common and severe in patients with Down syndrome (DS) than in the general population, yet there is a striking lack of literature in this area. In this review article, we have summarized the current state of...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.14-0266
更新日期:2015-02-01 00:00:00
abstract::In a 75-year-old patient presenting with a solitary pulmonary mass, a localized form of Wegener's granulomatosis was diagnosed after lobectomy. In the absence of extrapulmonary manifestations and after a benign postoperative course, the patients was discharged without medical treatment. Three months later, diffuse alv...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.104.3.955
更新日期:1993-09-01 00:00:00
abstract::The successful use of streptokinase therapy in a child with chronic thrombosis of a prosthetic valve (Carbomedics) in the tricuspid position is presented. ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.102.5.1599
更新日期:1992-11-01 00:00:00
abstract:BACKGROUND:Tobacco smoke is a major risk factor in the development of COPD. Secondhand smoke (SHS) exposure is a known risk factor in asthma, bronchitis, and coronary artery disease. Elastin is a recognized target for injury in COPD, and the amino acids desmosine and isodesmosine (D/I), which are specific for elastin d...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.10-2298
更新日期:2011-10-01 00:00:00
abstract::Imaging and Doppler echocardiography permits assessment of right ventricular size and systolic function and of pulmonary arterial pressures, and it may facilitate detection of thromboemboli within the heart or pulmonary artery. In patients with acute pulmonary embolism of sufficient severity to appreciably increase ri...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.101.4_supplement.151s
更新日期:1992-04-01 00:00:00
abstract::The relationship between coffee consumption and the prevalence of bronchial asthma has been evaluated using data from the 1983 Italian National Health Survey, based on 72,284 individuals aged over 15 years randomly selected within strata of geographic area, size of the place of residence and of the household in order ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.94.2.386
更新日期:1988-08-01 00:00:00
abstract::Primary pulmonary hypertension (PPH) is a serious pulmonary vascular disease occurring mostly in adult women. Although its occurrence in families was reported within a few years after the original clinical report, PPH was formerly believed rarely to have a genetic basis. Recent progress has not only clarified a basic ...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.122.6_suppl.284s
更新日期:2002-12-01 00:00:00
abstract::The potential for significant interaction between PEEP and the peripheral microcirculations is not as well appreciated as are its central circulatory effects. Therefore, we studied the effects of PEEP, 15 mm Hg, on microvascular fluid flux in the hindlimb of ten mature sheep. Changes in prefemoral lymph flow (QL) and ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.96.5.1142
更新日期:1989-11-01 00:00:00
abstract:OBJECTIVE:To describe the clinical correlates of asthma in a community-based sample of elderly persons. PARTICIPANTS:A community sample of 4,581 persons > or = 65 years old from the Cardiovascular Health Study. MEASUREMENTS:Standardized respiratory, sleep, and quality-of-life (QOL) questions, a medication inventory, ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.116.3.603
更新日期:1999-09-01 00:00:00
abstract:BACKGROUND:Nerve growth factor (NGF) is a neurotrophic cytokine with immunomodulatory activity. NGF contributes to neurogenic inflammation and has been described in asthma and idiopathic pulmonary fibrosis. OBJECTIVES:To identify and quantify NGF in serum and peripheral blood lymphocyte cultures from pigeon fanciers, ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.130.1.37
更新日期:2006-07-01 00:00:00
abstract:OBJECTIVE:Devices that reduce technical difficulty and anastigmatic time when repairing large vessels such as the thoracic aorta would be beneficial. The aim of this study was to determine if titanium vascular closure staples (3 mm) could be safely and quickly applied in the repair of large vessels such as the thoracic...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.118.6.1762
更新日期:2000-12-01 00:00:00
abstract::Benign thymic hyperplasia (BTH) is a known feature of hyperthyroidism, but is infrequently appreciated by clinicians. In most cases thymic enlargement is minimal; however, it may occasionally present as an appreciable anterior mediastinal mass. While surgical resection is a common approach to such a mass, recognition ...
journal_title:Chest
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1378/chest.90.5.691
更新日期:1986-11-01 00:00:00
abstract::The ipsilateral recurrence rate after the first spontaneous pneumothorax treated with tube thoracostomy is reported to be between 23 percent and 52 percent. The incidence of recurrence after the first recurrence is substantially higher. Chemical pleurodesis has been attempted to decrease the recurrence rate. Tetracycl...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.106.4.1162
更新日期:1994-10-01 00:00:00
abstract::COPD is a significant public health challenge, notably set to become the third leading cause of death and fifth leading cause of chronic disability worldwide by the next decade. Skeletal muscle impairment is now recognized as a disabling, extrapulmonary consequence of COPD that is associated with reduced quality of li...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1016/j.chest.2015.11.021
更新日期:2016-05-01 00:00:00
abstract::A V/Q lung scan was obtained in a patient with LLL collapse who was receiving IPPV and PEEP. This revealed absent ventilation and hyperperfusion to the collapsed lobe. After a reduction in PEEP from 12 to 5 cm H2O, a repeat V/Q scan showed a more even distribution of pulmonary perfusion. Arterial hypoxemia improved. ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.99.4.1034
更新日期:1991-04-01 00:00:00