Effect of continuous positive airway pressure on the rapid shallow breathing index in patients following cardiac surgery.


OBJECTIVES:To compare the rapid shallow breathing index (RSBI) under different ventilatory support settings prior to extubation trials. DESIGN:Prospective study. SETTING:Cardiac surgery unit at a university hospital. PATIENTS:A total of 33 coronary artery bypass grafting patients ready for extubation. INTERVENTIONS:Enrolled patients received a continuous positive airway pressure (CPAP) trial of 5 cm H(2)O and fraction of inspired oxygen (FIO(2)) of 40% (condition 1), a CPAP trial of 5 cmH(2)O and FIO(2) of 21% (condition 2), and a 1-min spontaneously breathing room air trial without ventilatory support (condition 3). These trials were applied in random order. MEASUREMENTS AND MAIN RESULTS:Average values of respiratory frequency and tidal volume were measured under the three experimental conditions in all patients immediately prior to extubation. The RSBIs were determined for each patient under each condition; the average RSBIs under conditions 1, 2, and 3 were compared for significance. The average RSBIs (+/- SD) were significantly smaller under condition 1 (34 +/- 13) and condition 2 (36 +/- 14) compared to condition 3 (71 +/- 24). There was no significant difference in RSBI between conditions 1 and 2. CONCLUSIONS:The administration of 5 cm H(2)O of CPAP can influence the determination of the RSBI. In contrast, changes in FIO(2) have no effect on RSBI determination. We speculate that using the RSBI during CPAP may mislead the clinician into premature discontinuation of mechanical ventilation. Consequently, different threshold values for the RSBI should be derived for different ventilatory support levels.






El-Khatib MF,Jamaleddine GW,Khoury AR,Obeid MY




Has Abstract


2002-02-01 00:00:00
















  • Sleep-disordered breathing in Down syndrome.

    abstract::OSA is associated with significant adverse outcomes with far-reaching health-care implications. OSA is much more common and severe in patients with Down syndrome (DS) than in the general population, yet there is a striking lack of literature in this area. In this review article, we have summarized the current state of...


    pub_type: 杂志文章,评审


    authors: Lal C,White DR,Joseph JE,van Bakergem K,LaRosa A

    更新日期:2015-02-01 00:00:00

  • Clinical correlation with changing radiographic appearance during partial liquid ventilation.

    abstract:STUDY OBJECTIVES:To evaluate the chest radiographic filling pattern associated with partial liquid ventilation (PLV) with the perfluorochemical perflubron (LiquiVent; Alliance Pharmaceutical Corp; San Diego CA) as a function of dose and timing. DESIGN:Post hoc review of chest radiographs by three independent observers...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Schuster DP,Lange NR,Tutuncu A,Wedel M,LiquiVent Study Group.

    更新日期:2001-05-01 00:00:00

  • Formoterol, 24 microg bid, and serious asthma exacerbations: similar rates compared with formoterol, 12 microg bid, with and without extra doses taken on demand, and placebo.

    abstract:STUDY OBJECTIVES:The primary objective was to determine whether high-dose formoterol, 24 mug bid, was associated with more asthma exacerbations compared with lower formoterol doses in patients with stable persistent asthma. Serious asthma exacerbations (life threatening or requiring hospitalization) were the primary en...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Wolfe J,Laforce C,Friedman B,Sokol W,Till D,Della Cioppa G,van As A

    更新日期:2006-01-01 00:00:00

  • Resource-poor settings: response, recovery, and research: care of the critically ill and injured during pandemics and disasters: CHEST consensus statement.

    abstract:BACKGROUND:Planning for mass critical care in resource-poor and constrained settings has been largely ignored, despite large, densely crowded populations who are prone to suffer disproportionately from natural disasters. As a result, disaster response has been suboptimal and in many instances hampered by lack of planni...


    pub_type: 杂志文章,评审


    authors: Geiling J,Burkle FM Jr,West TE,Uyeki TM,Amundson D,Dominguez-Cherit G,Gomersall CD,Lim ML,Luyckx V,Sarani B,Christian MD,Devereaux AV,Dichter JR,Kissoon N,Task Force for Mass Critical Care.,Task Force for Mass Critical Care

    更新日期:2014-10-01 00:00:00

  • Subaortic stenosis caused by two discrete membranes.

    abstract::A case of subaortic stenosis caused by two discrete membranes is presented. Following demonstration of the two distinct sites of obstruction by intraventricular pressure gradients and angiocardiogram, the two membranes were excised through a transaortic approach. The importance of being aware of the occurrence of this...


    pub_type: 杂志文章


    authors: Lemole GM,Tesler UF,Colombi M,Eldredge WJ

    更新日期:1976-01-01 00:00:00

  • Investigating the natural history of lung function: facts, pitfalls, and opportunities.

    abstract::COPD is currently defined as a progressive, preventable, and treatable disease that is characterized by an accelerated decline of lung function. However, contrary to other common chronic conditions like cardiovascular disease or cancer, there are no lifelong population-based studies describing the natural history of l...


    pub_type: 杂志文章,评审


    authors: Kohansal R,Soriano JB,Agusti A

    更新日期:2009-05-01 00:00:00

  • Safety of inferior vena cava filter retrieval in anticoagulated patients.

    abstract:PURPOSES:To evaluate the safety of inferior vena cava (IVC) filter retrieval in therapeutically anticoagulated patients in comparison to prophylactically or not therapeutically anticoagulated patients with respect to retrieval-related hemorrhagic complications. MATERIALS AND METHODS:This was a retrospective study of 1...


    pub_type: 杂志文章


    authors: Hoppe H,Kaufman JA,Barton RE,Petersen BD,Lakin PC,Deloughery TG,Irani Z,Yavuz K,Keller FS

    更新日期:2007-07-01 00:00:00

  • Evaluation of right ventricular performance with a right ventricular ejection fraction thermodilution catheter and MRI in patients with pulmonary hypertension.

    abstract:STUDY OBJECTIVES:We sought to compare catheter studies using a right ventricular ejection fraction (REF) catheter together with echocardiography and MRI in patients with pulmonary hypertension. PATIENTS AND METHODS:We compared hemodynamic findings, echocardiography, and MRI studies in 16 patients with pulmonary hypert...


    pub_type: 杂志文章


    authors: Hoeper MM,Tongers J,Leppert A,Baus S,Maier R,Lotz J

    更新日期:2001-08-01 00:00:00

  • Real-World Effectiveness and the Characteristics of a "Super-Responder" to Mepolizumab in Severe Eosinophilic Asthma.

    abstract:BACKGROUND:Mepolizumab was the first licensed anti-IL5 monoclonal antibody for severe eosinophilic asthma (SEA). To date there are few data to confirm its efficacy in the real-world setting or assessment of baseline characteristics associated with response. RESEARCH QUESTION:How do patients with severe eosinophilic as...


    pub_type: 杂志文章


    authors: Kavanagh JE,d'Ancona G,Elstad M,Green L,Fernandes M,Thomson L,Roxas C,Dhariwal J,Nanzer AM,Kent BD,Jackson DJ

    更新日期:2020-08-01 00:00:00

  • Supplemental oxygen and exercise performance in patients with cystic fibrosis with severe pulmonary disease.

    abstract::Patients with cystic fibrosis (CF) and advanced pulmonary disease have pulmonary limitation of exercise, often associated with arterial oxygen desaturation. Improving oxygenation during exercise by providing supplemental oxygen may improve exercise performance in these patients. To test this, we performed graded exerc...


    pub_type: 杂志文章


    authors: Marcus CL,Bader D,Stabile MW,Wang CI,Osher AB,Keens TG

    更新日期:1992-01-01 00:00:00

  • The effect of regular salbutamol on lung function and bronchial hyperresponsiveness in normal subjects and nonasthmatic atopic subjects with allergic rhinitis.

    abstract:BACKGROUND:The effects of regular inhaled beta-agonist treatment on lung function remain a controversial issue. In an earlier study, the administration of regular inhaled salbutamol resulted in negative changes in FEV1 not only in asthmatics, but also in nonasthmatic atopic subjects. OBJECTIVE:The aim of this study wa...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Boothman-Burrell D,Jones D,Herbison GP,Taylor DR

    更新日期:1997-07-01 00:00:00

  • Occupational risk factors for sarcoidosis in African-American siblings.

    abstract:OBJECTIVES:To determine whether certain occupations and occupationally related exposures were associated with a history of sarcoidosis in African-American siblings. METHODS:We collected occupational data from 921 African Americans in 273 sibships that had been identified through a sarcoidosis case. Among the 648 sibli...


    pub_type: 杂志文章


    authors: Kucera GP,Rybicki BA,Kirkey KL,Coon SW,Major ML,Maliarik MJ,Iannuzzi MC

    更新日期:2003-05-01 00:00:00

  • Successful medical therapy of Rhodococcus equi pneumonia in a patient with HIV infection.

    abstract::A 34-year-old HIV-infected man was successfully treated with antimicrobial therapy alone for Rhodococcus equi pneumonia and has survived longer than six months. In the current literature, only two of seven HIV-infected patients so treated have survived as long as six months. Based on our experience and the available l...


    pub_type: 杂志文章


    authors: Cury JD,Harrington PT,Hosein IK

    更新日期:1992-11-01 00:00:00

  • Computed chest tomography in the evaluation of hemoptysis. Impact on diagnosis and treatment.

    abstract::The results of computed chest tomograms (CT) and chest roentgenograms (CR) were compared in 32 patients who presented with hemoptysis. The CT demonstrated roentgenographic abnormalities more often than CR (p less than 0.01), providing new diagnostic information in 15 patients (46.9 percent), and clarifying CR abnormal...


    pub_type: 杂志文章


    authors: Haponik EF,Britt EJ,Smith PL,Bleecker ER

    更新日期:1987-01-01 00:00:00

  • Left atrial size, chemosensitivity, and central sleep apnea in heart failure.

    abstract:BACKGROUND:Central sleep apnea (CSA) is common among patients with heart failure (HF) and is promoted by elevated CO2 chemosensitivity. Left atrial size is a marker of the hemodynamic severity of HF. The aim of this study was to determine if left atrial size predicts chemosensitivity to CO2 and CSA in patients with HF....


    pub_type: 杂志文章


    authors: Calvin AD,Somers VK,Johnson BD,Scott CG,Olson LJ

    更新日期:2014-07-01 00:00:00

  • Genetics of COPD and emphysema.

    abstract::COPD is a highly prevalent disorder that results from the interplay of genetic susceptibility and environmental exposures. Over the past 2 decades, significant technological advances have been made in genetic investigations of complex diseases, yet limited progress has been made in the identification of additional COP...


    pub_type: 杂志文章,评审


    authors: Wan ES,Silverman EK

    更新日期:2009-09-01 00:00:00

  • Progressive portopulmonary hypertension after liver transplantation treated with epoprostenol.

    abstract::Portopulmonary hypertension (PPHTN) is an uncommon complication of advanced liver disease. Epoprostenol has been effective in the treatment of PPHTN and has been used as a bridge to orthotopic liver transplantation (OLT). The role of OLT in the reversal of PPHTN is unclear. We report a case of severe PPHTN (mean pulmo...


    pub_type: 杂志文章


    authors: Rafanan AL,Maurer J,Mehta AC,Schilz R

    更新日期:2000-11-01 00:00:00

  • Acute left ventricular dysfunction in the critically ill.

    abstract::Acute left ventricular (LV) dysfunction is common in the critical care setting and more frequently affects the elderly and patients with comorbidities. Because of increased mortality and the potential for significant improvement with early revascularization, the practitioner must first consider acute coronary syndrome...


    pub_type: 杂志文章,评审


    authors: Chockalingam A,Mehra A,Dorairajan S,Dellsperger KC

    更新日期:2010-07-01 00:00:00

  • Mucosa-associated lymphoid tissue lymphoma of the lung with cold-reacting autoantibody-mediated hemolytic anemia.

    abstract::Mucosa-associated lymphoid tissue lymphoma (MALT-oma) of the lung is a rare low-grade B cell lymphoma arising from bronchus-associated lymphoid tissue. This report concerns a 39-year-old woman with bilateral diffuse alveolar consolidations and cold-reacting autoantibody-mediated hemolytic anemia. Open-lung biopsy show...


    pub_type: 杂志文章


    authors: Liaw YS,Yang PC,Su IJ,Kuo SH,Wang CH,Luh KT

    更新日期:1994-01-01 00:00:00

  • Measurements of cardiac output in seriously ill patients using a CO2 rebreathing method.

    abstract::A CO2 rebreathing method for the measurement of cardiac output was evaluated by comparison with the direct Fick O2 method in 26 studies performed in 18 patients who were critically ill. The method requires measurement of CO2 output by collection of expired gas, of arterial PCO2, and of mixed venous PCO2 by rebreathing...


    pub_type: 临床试验,杂志文章


    authors: Davis CC,Jones NL,Sealey BJ

    更新日期:1978-02-01 00:00:00

  • Pulmonary function following the adult respiratory distress syndrome.

    abstract::Fifteen patients (range of ages, 18 to 35 years) who survived an acute episole of the adult respiratory distress syndrome caused by mechanical or thermal injuries, sepsis, and shock were studied during 1 to 30 months after recovery. The patients had had no previous pulmonary diseases, and only two had been smokers. Al...


    pub_type: 杂志文章


    authors: Yahav J,Lieberman P,Molho M

    更新日期:1978-09-01 00:00:00

  • Tricuspid valve replacement for Ebstein's anomaly in childhood with a Starr-Edwards caged-ball prosthesis. 21-year follow-up.

    abstract::A 21-year follow-up after tricuspid valve replacement (TVR) with a Starr-Edwards caged-ball prosthesis in a ten-year old boy is described. TVR is performed for Ebstein's anomaly, with strict indications in childhood. Despite the current preference for bioprostheses, good performance can be expected from the Starr-Edwa...


    pub_type: 杂志文章


    authors: Di Lello F,Flemma RJ,Mullen DC,Kleinman LH,Werner PH

    更新日期:1988-11-01 00:00:00

  • Hemodynamics and coronary flow following diltiazem administration in anesthetized dogs and in humans.

    abstract::In this study, the systemic and coronary hemodynamic changes associated with the administration of diltiazem, a recent calcium antagonist, were evaluated in three different situations as follows: following a 200 microgram/kg intravenous bolus of the drug in 12 open-chest anesthetized dogs; following two successive int...


    pub_type: 杂志文章


    authors: Bourassa MG,Cote P,Theroux P,Tubau JF,Genain C,Waters DD

    更新日期:1980-07-01 00:00:00

  • Genetics of asthma and COPD. Similar results for different phenotypes.

    abstract::Asthma and COPD are common respiratory diseases that are caused by the interaction of genetic susceptibility with environmental factors. Environmental influences are important in both diseases, and although there are differences in genetic susceptibilities, there are also similarities. Three examples of interest for b...


    pub_type: 杂志文章,评审


    authors: Meyers DA,Larj MJ,Lange L

    更新日期:2004-08-01 00:00:00

  • Clonidine in the elderly hypertensive. Monotherapy and therapy with a diuretic.

    abstract::Forty-eight elderly patients with uncomplicated mild essential hypertension entered two drug regimens. In group 1, clonidine monotherapy (n = 15), clonidine was titrated to achieve goal blood pressure (less than 90 mm Hg diastolic) in dosages of 0.05 mg twice daily to 0.2 mg three times daily. Blood pressure decreased...


    pub_type: 杂志文章


    authors: Thananopavarn C,Golub MS,Sambhi MP

    更新日期:1983-02-01 00:00:00

  • Prevalence of gastroesophageal reflux disease in patients with nontuberculous mycobacterial lung disease.

    abstract:BACKGROUND:Knowledge of the relationship between respiratory disorders and gastroesophageal reflux disease (GERD) is increasing. However, the association between GERD and pulmonary disease caused by nontuberculous mycobacteria (NTM) has not been studied in detail. We investigated the prevalence of GERD in patients with...


    pub_type: 杂志文章


    authors: Koh WJ,Lee JH,Kwon YS,Lee KS,Suh GY,Chung MP,Kim H,Kwon OJ

    更新日期:2007-06-01 00:00:00

  • Comparison of 24 versus 12 hours of ambulatory ECG monitoring.

    abstract::In order to assess the additional information obtained from 24 hours compared to 12 hours of ambulatory ECG (electrocardiogram) recording, we analyzed 72 ambulatory ECG monitoring tapes in which arrhythmias were present. In all cases the second 12 hours included the entire period of sleep. Only 38 of 233 (16 percent) ...


    pub_type: 杂志文章


    authors: Lopes MG,Runge P,Harrison DC,Schroeder JS

    更新日期:1975-03-01 00:00:00

  • Thoracic outlet syndrome mimicking angina pectoris with elevated creatine phosphokinase values.

    abstract::Four patients with elevated creatine phosphokinase (CPK) values and recurrent chest pain were found to have thoracic outlet syndrome. This association of abnormal CPK levels and chest pain due to thoracic outlet syndrome has not been previously reported. Symptoms and CPK values improved with anti-inflammatory medicati...


    pub_type: 杂志文章


    authors: Godfrey NF,Halter DG,Minna DA,Weiss M,Lorber A

    更新日期:1983-03-01 00:00:00

  • Cardiogenic shock secondary to Tako-tsubo syndrome after debridement of malignant endobronchial obstruction.

    abstract::Transient left ventricular (LV) dysfunction syndrome, or Tako-tsubo syndrome, occurs following intense emotional or physical stress and simulates the clinical presentation of an acute myocardial infarction. We report a case of a 77-year-old man with esophageal adenocarcinoma with local invasion of the central airways ...


    pub_type: 杂志文章


    authors: Guerrero J,Majid A,Ernst A

    更新日期:2009-01-01 00:00:00

  • Dangerous curves. A perspective on exercise, lactate, and the anaerobic threshold.

    abstract::A number of general observations can be made from these recent studies. Lactate is a ubiquitous substance that is produced and removed from the body at all times, even at rest, both with and without the availability of oxygen. It is now recognized that lactate accumulates in the blood for several reasons, not just the...


    pub_type: 杂志文章,评审


    authors: Myers J,Ashley E

    更新日期:1997-03-01 00:00:00