Genetics and pulmonary hypertension.

Abstract:

:Primary pulmonary hypertension (PPH) is a serious pulmonary vascular disease occurring mostly in adult women. Although its occurrence in families was reported within a few years after the original clinical report, PPH was formerly believed rarely to have a genetic basis. Recent progress has not only clarified a basic molecular mechanism for PPH in families, but has also identified mutations of the same gene in many sporadic PPH patients, suggesting that its basis is commonly genetic. Extensive investigations in many centers are now in progress to provide a complete dissection of all the pathogenetic mechanisms of PPH.

journal_name

Chest

journal_title

Chest

authors

Loyd JE

doi

10.1378/chest.122.6_suppl.284s

subject

Has Abstract

pub_date

2002-12-01 00:00:00

pages

284S-286S

issue

6 Suppl

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(15)32965-2

journal_volume

122

pub_type

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