Respiratory muscle strength in congestive heart failure.

Abstract:

:In experimental animals, conditions which drastically decrease cardiac output may reduce the strength and endurance of respiratory muscles leading to hypercapnic respiratory failure. Because patients with chronic CHF have reduced cardiac output and vital capacity (FVC), we measured PImax and PEmax and maximal handgrip force in 16 patients with CHF and 18 AMNs. The patients with CHF had a mean left ventricular ejection fraction of 26 +/- 7 percent. Maximal respiratory pressures were significantly reduced; group mean values (+/- SD) for PImax at FRC were 41.4 +/- 5.6 cm H2O (CHF) and 102.1 +/- 27.4 cm H2O (AMN) (p less than 0.001), with PImax values in five patients with CHF as low as 20 to 30 cm H2O. In most patients, PEmax was comparably reduced. Handgrip force was less dramatically reduced, suggesting selective respiratory muscle weakness. Possible explanations include reduction in respiratory muscle blood flow or generalized muscular atrophy and weakness related to cardiac cachexia.

journal_name

Chest

journal_title

Chest

authors

Hammond MD,Bauer KA,Sharp JT,Rocha RD

doi

10.1378/chest.98.5.1091

subject

Has Abstract

pub_date

1990-11-01 00:00:00

pages

1091-4

issue

5

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(16)37897-7

journal_volume

98

pub_type

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