Fluid therapy in resuscitated sepsis: less is more.


:Fluid infusion may be lifesaving in patients with severe sepsis, especially in the earliest phases of treatment. Following initial resuscitation, however, fluid boluses often fail to augment perfusion and may be harmful. In this review, we seek to compare and contrast the impact of fluids in early and later sepsis; show that much fluid therapy is clinically ineffective in patients with severe sepsis; explore the detrimental aspects of excessive volume infusion; examine how clinicians assess the intravascular volume state; appraise the potential for dynamic indexes to predict fluid responsiveness; and recommend a clinical approach.






Durairaj L,Schmidt GA




Has Abstract


2008-01-01 00:00:00
















  • Interleukin-2 and soluble interleukin-2 receptor in bronchoalveolar lavage fluid from patients with bronchial asthma.

    abstract::To clarify the interrelation between interleukin-2 (IL-2) and soluble IL-2R receptor (sIL-2R), as products of T-cell activation in the bronchial tree of patients with bronchial asthma, we measured the concentration of IL-2, sIL-2R, and the cellular composition in bronchoalveolar lavage (BAL) fluid. We also measured ph...


    pub_type: 杂志文章


    authors: Park CS,Lee SM,Chung SW,Uh S,Kim HT,Kim YH

    更新日期:1994-08-01 00:00:00

  • Proinflammatory cytokines and fibrinolytic enzymes in tuberculous and malignant pleural effusions.

    abstract:OBJECTIVES:To measure tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) in pleural effusions caused by tuberculosis (TB) and malignancy and their relationship with plasminogen activator inhibitor type I (PAI-1) and tissue type plasminogen activator (tPA), and to compare the differences between tu...


    pub_type: 杂志文章


    authors: Hua CC,Chang LC,Chen YC,Chang SC

    更新日期:1999-11-01 00:00:00

  • The pulmonary response to fiberglass dust. Report of the Committee on Environmental Health. American College of Chest Physicians.

    abstract::Fiberglass inhalation seems to produce a minimal tissue response in the lungs, and the reaction is one of macrophagic mobilization and is characteristic of the pulmonary response to those nonfibrogenic dusts classified as nuisance dusts. In order to merit the designation of a nuisance dust, the pulmonary response must...


    pub_type: 杂志文章,评审



    更新日期:1976-02-01 00:00:00

  • Long-term outcome of pulmonary rehabilitation in patients with COPD.

    abstract:BACKGROUND:This study investigates the long-term benefits of pulmonary rehabilitation in terms of health-related quality of life (HRQL). Such information is of particular importance in developing strategies for aftercare at home which aim to maintain the initial improvements seen after rehabilitation. METHODS:Criteria...


    pub_type: 杂志文章


    authors: Ketelaars CA,Abu-Saad HH,Schlösser MA,Mostert R,Wouters EF

    更新日期:1997-08-01 00:00:00

  • Effect of Statins on COPD: A Meta-Analysis of Randomized Controlled Trials.

    abstract:BACKGROUND:Much controversy persists regarding the place of statin drugs in the treatment of patients with COPD. This systematic review and meta-analysis sought to determine the clinical efficacy of statin therapy in COPD. METHODS:We searched MEDLINE, EMBASE, the Cochrane Database, and PubMed for relevant clinical stu...


    pub_type: 杂志文章,meta分析,评审


    authors: Zhang W,Zhang Y,Li CW,Jones P,Wang C,Fan Y

    更新日期:2017-12-01 00:00:00

  • Multidetector CT scan findings of a right aberrant retroesophageal vertebral artery with an anomalous origin from a cervical aortic arch.

    abstract::Various malformations of the aortic arch and great vessels have been reported in the literature, which reflects the complexity of their embryologic development. Most of them are of incidental finding and remain asymptomatic but can be responsible for respiratory or digestive symptoms and be associated with congenital ...


    pub_type: 杂志文章


    authors: Verin AL,Creuze N,Musset D

    更新日期:2010-08-01 00:00:00

  • Clinical antecedents to in-hospital cardiopulmonary arrest.

    abstract::While the outcome of in-hospital cardiopulmonary arrest has been studied extensively, the clinical antecedents of arrest are less well defined. We studied a group of consecutive general hospital ward patients developing cardiopulmonary arrest. Prospectively determined definitions of underlying pathophysiology, severit...


    pub_type: 杂志文章


    authors: Schein RM,Hazday N,Pena M,Ruben BH,Sprung CL

    更新日期:1990-12-01 00:00:00

  • Mediastinal lymph node enlargement as a result of mitral valve stenosis.

    abstract::Two patients are described with severe MVS, pulmonary venous hypertension and enlarged mediastinal, pulmonary and hilar lymph nodes. These enlargements were diagnosed on a preoperative chest CT. After MV replacement these enlarged lymph nodes nearly all resolved. The lymphadenopathy should be considered to be secondar...


    pub_type: 杂志文章


    authors: Drent M,Gelissen JP,Ascoop CA,Wagenaar SS,van den Bosch JM

    更新日期:1992-10-01 00:00:00

  • Decreased Serum Sirtuin-1 in COPD.

    abstract:BACKGROUND:The protein deacetylase sirtuin-1 (SIRT1) is an antiaging molecule that is decreased in the lung in patients with COPD. Recently, SIRT1 was reported to be detectable in serum, but serum SIRT1 (s120S) levels have not yet been reported in patients with COPD. METHODS:Serum SIRT1 protein of all samples was meas...


    pub_type: 杂志文章


    authors: Yanagisawa S,Papaioannou AI,Papaporfyriou A,Baker JR,Vuppusetty C,Loukides S,Barnes PJ,Ito K

    更新日期:2017-08-01 00:00:00

  • Quadriceps fatigue after cycle exercise in patients with COPD compared with healthy control subjects.

    abstract:STUDY OBJECTIVES:Quadriceps fatigue can occur in patients with COPD after exhaustive cycle exercise. The purpose of this study was to determine whether the degree of fatigue elicited by cycle exercise was greater in patients with COPD compared with matched control subjects. SUBJECTS:Nine male patients with COPD with a...


    pub_type: 临床试验,杂志文章


    authors: Mador MJ,Bozkanat E,Kufel TJ

    更新日期:2003-04-01 00:00:00

  • Ultrastructural and functional studies of cilia from patients with asthma, aspirin intolerance, and nasal polyps.

    abstract::"Triad" asthmatics often have sinus disease, nasal polyps, and obstructive airways disease. This presentation is reminiscent of the symptoms of persons afflicted with various forms of ciliary dyskinesia. Therefore, we examined tissues from seven "triad" asthmatic patients for ciliary structural or functional abnormali...


    pub_type: 杂志文章


    authors: Lewis FH,Beals TF,Carey TE,Baker SR,Mathews KP

    更新日期:1983-03-01 00:00:00

  • The irregularly irregular pattern of respiratory dyskinesia.

    abstract::The respiratory pattern during wakefulness and sleep was characterized in a 70-year-old woman with respiratory dyskinesia. During wakefulness, both respiratory frequency and tidal volume exhibited an irregularly irregular pattern. In addition, wide fluctuations occurred in the position of the rib cage and abdomen at e...


    pub_type: 杂志文章


    authors: Kuna ST,Awan R

    更新日期:1986-11-01 00:00:00

  • Reducing COPD Readmissions: Strategies for the Pulmonologist to Improve Outcomes.

    abstract::Hospitalizations for patients with acute exacerbations of COPD are associated with several adverse patient outcomes as well as with significant health-care costs. Despite many interventions targeted at reducing readmissions following an initial hospitalization, there are few strategies that have been consistently asso...


    pub_type: 杂志文章,评审


    authors: Freedman N

    更新日期:2019-10-01 00:00:00

  • Effects of carbohydrates on carbon dioxide excretion in patients with airway disease.

    abstract::Thirteen patients with stable airway disease were fed a diet high in carbohydrates, and 35 minutes later metabolic and ventilatory effects were observed. The six patients who did not retain carbon dioxide increased their mean respiratory quotient from 0.86 +/- 0.07 to 1.03 +/- 0.04, their mean minute ventilation from ...


    pub_type: 杂志文章


    authors: Gieseke T,Gurushanthaiah G,Glauser FL

    更新日期:1977-01-01 00:00:00

  • Systemic artery-to-pulmonary artery fistula. A new therapeutic approach.

    abstract::A patient with systemic artery-to-pulmonary artery fistulae is described. Historically, all therapy of this type of lesion has been surgical. We describe a new mode of treatment, therapeutic embolization, which obviates surgical intervention and its attendant risks. Embolization is an alternative to surgery that shoul...


    pub_type: 杂志文章


    authors: Wolf DC,Wurtzbacher JJ,Horton J

    更新日期:1982-12-01 00:00:00

  • Effects of additional minocycline pleurodesis after thoracoscopic procedures for primary spontaneous pneumothorax.

    abstract:STUDY OBJECTIVE:To evaluate the safety and efficacy of additional minocycline pleurodesis after thoracoscopic treatment of primary spontaneous pneumothorax. DESIGN:Retrospective comparative study with a historical control. SETTING:Thoracic surgical division of a university-affiliated tertiary medical center. PATIENT...


    pub_type: 杂志文章


    authors: Chen JS,Hsu HH,Kuo SW,Tsai PR,Chen RJ,Lee JM,Lee YC

    更新日期:2004-01-01 00:00:00

  • Silica-induced pleural disease: an unusual case mimicking malignant mesothelioma.

    abstract::A 57-year-old man with a history of exposure to silica for 32 years presented with pleural thickening of the lower lobe of the left lung and a chronic right-sided pleural effusion without any radiographic evidence of parenchymal nodules in either lung. Light microscopic examination of a left visceral pleural biopsy sp...


    pub_type: 杂志文章,评审


    authors: Zeren EH,Colby TV,Roggli VL

    更新日期:1997-11-05 00:00:00

  • Diagnostic utility of ventilation/perfusion lung scans in acute pulmonary embolism is not diminished by pre-existing cardiac or pulmonary disease.

    abstract::The purpose of this study was to assess the impact of prior cardiac or pulmonary disease upon the utility of ventilation/perfusion (V/Q) scans in the diagnosis of acute pulmonary embolism (PE). Ventilation/perfusion scans were evaluated among 365 patients with no prior cardiac or pulmonary disease and compared to V/Q ...


    pub_type: 杂志文章


    authors: Stein PD,Coleman RE,Gottschalk A,Saltzman HA,Terrin ML,Weg JG

    更新日期:1991-09-01 00:00:00

  • Assessment of Intervention Fidelity and Recommendations for Researchers Conducting Studies on the Diagnosis and Treatment of Chronic Cough in the Adult: CHEST Guideline and Expert Panel Report.

    abstract:BACKGROUND:Successful management of chronic cough has varied in the primary research studies in the reported literature. One of the potential reasons relates to a lack of intervention fidelity to the core elements of the diagnostic and/or therapeutic interventions that were meant to be used by the investigators. METHO...


    pub_type: 杂志文章,评审


    authors: French CT,Diekemper RL,Irwin RS,Adams TM,Altman KW,Barker AF,Birring SS,Blackhall F,Bolser DC,Boulet LP,Braman SS,Brightling C,Callahan-Lyon P,Canning BJ,Chang AB,Coeytaux R,Cowley T,Davenport P,Diekemper RL,Ebihara

    更新日期:2015-07-01 00:00:00

  • Double coronary arteriovenous fistula.

    abstract::Coronary arteriovenous fistula is an uncommon, although not rare, congenital cardiac malformation, especially in the adult. Most such reported such cases have involved but a single coronary vessel. This report documents the second case of coronary arteriovenous fistulae involving the right and circumflex coronary vess...


    pub_type: 杂志文章


    authors: Babb JD,Field JM

    更新日期:1977-11-01 00:00:00

  • Bronchial colonization and postoperative respiratory infections in patients undergoing lung cancer surgery.

    abstract:STUDY OBJECTIVES:To evaluate the risk factors associated with postoperative respiratory infection in patients undergoing lung cancer surgery, with special emphasis on the perioperative pattern of airway colonization. DESIGN:Prospective cohort study. SETTING:Department of Pneumology and Thoracic Surgery of a tertiary ...


    pub_type: 杂志文章


    authors: Belda J,Cavalcanti M,Ferrer M,Serra M,Puig de la Bellacasa J,Canalis E,Torres A

    更新日期:2005-09-01 00:00:00

  • Reliability, repeatability, and sensitivity of the modified shuttle test in adult cystic fibrosis.

    abstract:STUDY OBJECTIVES:The purpose of this study was to investigate the test-retest reliability, repeatability, and sensitivity of the modified shuttle test (MST) in adult patients with cystic fibrosis (CF). DESIGN:: Prospective study. SETTING:Adult CF Unit, Belfast City Hospital. PATIENTS:: Adult patients with CF. INTER...


    pub_type: 杂志文章


    authors: Bradley J,Howard J,Wallace E,Elborn S

    更新日期:2000-06-01 00:00:00

  • Left pleural hemorrhagic effusion. A presenting sign of thoracic aortic dissecting aneurysm.

    abstract::Left hemorrhagic pleural effusion was the presenting sign of painless aortic dissecting aneurysm in two elderly hypertensive patients. Computed tomography (CT) of the chest revealed the aneurysmal dilatation of the thoracic aorta and an intimal flap connecting its descending part with the left pleural space. The patie...


    pub_type: 杂志文章


    authors: Gandelman G,Barzilay N,Krupsky M,Resnitzky P

    更新日期:1994-08-01 00:00:00

  • Physiologic evaluation of pressure support ventilation by nasal mask in patients with stable COPD.

    abstract::We evaluated the physiologic effects of pressure support ventilation by nasal route (NPSV) in eight patients with severe stable COPD and chronic hypercapnia who were randomly submitted to 2-h sessions of NPSV both with a portable ventilator (Respironics BIPAP device) and with a standard ventilator (Bird 6400ST device)...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Ambrosino N,Nava S,Bertone P,Fracchia C,Rampulla C

    更新日期:1992-02-01 00:00:00

  • The effects of acetazolamide on the ventilatory response to high altitude hypoxia.

    abstract::Acetazolamide treatment ameliorates the symptoms of AMS; however, the mechanism by which this occurs is unclear. To examine the effects of acetazolamide on oxygenation, CO2 responsiveness and ventilatory pattern during acute exposure to HA, we studied two groups of subjects at SL and following rapid (less than 8 h) tr...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Burki NK,Khan SA,Hameed MA

    更新日期:1992-03-01 00:00:00

  • Maximum cardiac output during incremental exercise by first-pass radionuclide ventriculography.

    abstract:STUDY OBJECTIVE:To validate a noninvasive first-pass radionuclide ventriculographic (FPRV) measurement of maximum cardiac output (Qv) during exercise. DESIGN:Comparison of Qv to that measured by the Fick principle (Qf) at peak exercise. SETTING:Academic cardiopulmonary exercise laboratory. PATIENTS:Seventy-eight con...


    pub_type: 杂志文章


    authors: Maroni JM,Oelberg DA,Pappagianopoulos P,Boucher CA,Systrom DM

    更新日期:1998-08-01 00:00:00

  • Lactic Acidosis in Sepsis: It's Not All Anaerobic: Implications for Diagnosis and Management.

    abstract::Increased blood lactate concentration (hyperlactatemia) and lactic acidosis (hyperlactatemia and serum pH < 7.35) are common in patients with severe sepsis or septic shock and are associated with significant morbidity and mortality. In some patients, most of the lactate that is produced in shock states is due to inade...


    pub_type: 杂志文章,评审


    authors: Suetrong B,Walley KR

    更新日期:2016-01-01 00:00:00

  • Diagnostic value of hemosiderin-containing macrophages in bronchoalveolar lavage.

    abstract:STUDY OBJECTIVE:Our objective was to determine if the hemosiderin content of BAL macrophages allows us to draw any differential diagnostic conclusions in a variety of lung diseases. PATIENTS AND STUDY DESIGN:One hundred one patients who underwent BAL for different diagnostic reasons were studied prospectively. MAIN R...


    pub_type: 杂志文章


    authors: Grebski E,Hess T,Hold G,Speich R,Russi E

    更新日期:1992-12-01 00:00:00

  • Coronary artery bypass performed without the use of cardiopulmonary bypass is associated with reduced cerebral microemboli and improved clinical results.

    abstract:STUDY OBJECTIVES:Strokes and neurocognitive dysfunction have been correlated with cerebral microemboli produced during cardiopulmonary bypass (CPB). The purpose of this study was to determine whether, and to what extent, off-pump coronary artery bypass (OPCAB) reduces the occurrence of cerebral microemboli compared wit...


    pub_type: 杂志文章


    authors: Bowles BJ,Lee JD,Dang CR,Taoka SN,Johnson EW,Lau EM,Nekomoto K

    更新日期:2001-01-01 00:00:00

  • Combined dose ratios of dopamine and dobutamine and right ventricular performance after cardiac surgery.

    abstract::The effect of combined administration of different dose ratios of dobutamine (DB) and dopamine (DA) (DB/DA ratio of 1:1; 1.5:0.5; 2:0; 0.5:1.5; and 0:2), with the added dose kept constant (10 micrograms/kg/min-20 micrograms/kg/min), on right ventricular function (measured by the thermal washout method with the aid of ...


    pub_type: 杂志文章


    authors: Imai T,Saitoh K,Kani H,Fujita T,Murata K

    更新日期:1992-05-01 00:00:00