Fluid therapy in resuscitated sepsis: less is more.

Abstract:

:Fluid infusion may be lifesaving in patients with severe sepsis, especially in the earliest phases of treatment. Following initial resuscitation, however, fluid boluses often fail to augment perfusion and may be harmful. In this review, we seek to compare and contrast the impact of fluids in early and later sepsis; show that much fluid therapy is clinically ineffective in patients with severe sepsis; explore the detrimental aspects of excessive volume infusion; examine how clinicians assess the intravascular volume state; appraise the potential for dynamic indexes to predict fluid responsiveness; and recommend a clinical approach.

journal_name

Chest

journal_title

Chest

authors

Durairaj L,Schmidt GA

doi

10.1378/chest.07-1496

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

252-63

issue

1

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(15)48986-X

journal_volume

133

pub_type

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