Formoterol suspension aerosol. Comparison with formoterol solution aerosol for 12 weeks in asthmatic patients.

Abstract:

UNLABELLED:Formoterol solution aerosol has proved to be a fast and long-acting beta 2-sympathicomimetic drug in many clinical trials. The physical stability, however, was such that storage needed to be at 4 degrees C to 8 degrees C before first use; afterwards, the aerosol could be used for another three months at room temperature. To improve the stability, new ways have been investigated to formulate ann aerosol with improved shelf life and thus more convenient storage conditions, which was reached with a formoterol suspension aerosol. Equivalent single doses between the two formulations revealed no differences in onset or duration of action. In a double-blind, randomized parallel group multicenter study, organized in the Netherlands, 186 patients with stable asthma and reversible airway obstruction were treated either with one puff of 12 micrograms twice daily of formoterol metered dose inhaler (MDI) supension (SP) or a same dose of solution (SL) aerosol for 12 weeks to study the efficacy and tolerability of both presentations after a longer period of use. The following criteria of effectiveness were used: the FEV1 values on the mornings of the control days at 0, +4, +8, and + 12 weeks, the peak flow values (PEF) in the mornings and in the evenings before, and 1/2 to 1 h after treatment, the number of asthma attacks at night and during the day, the number of extra puffs at night and during day, and the subjective impression of patients and investigator. RESULT:No statistically significant differences between the two formoterol preparations were found. There was no indication of tachyphylaxis. CONCLUSION:The results are consistent with the hypothesis that the biologic effects of formoterol when delivered from MDI containing the two different formulations of the drug are equivalent.

journal_name

Chest

journal_title

Chest

authors

Maesen FP,Nakratzas G,Bantje TA,Prins J,Zweers PG

doi

10.1378/chest.102.5.1544

subject

Has Abstract

pub_date

1992-11-01 00:00:00

pages

1544-9

issue

5

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(16)59089-8

journal_volume

102

pub_type

临床试验,杂志文章,多中心研究,随机对照试验

相关文献

CHEST文献大全
  • Venous thromboembolism, thrombophilia, antithrombotic therapy, and pregnancy: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition).

    abstract::This article discusses the management of venous thromboembolism (VTE) and thrombophilia, as well as the use of antithrombotic agents, during pregnancy and is part of the American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Grade 1 recommendations are strong and indicate that ...

    journal_title:Chest

    pub_type: 杂志文章,实务指引

    doi:10.1378/chest.08-0761

    authors: Bates SM,Greer IA,Pabinger I,Sofaer S,Hirsh J

    更新日期:2008-06-01 00:00:00

  • Use of pulmonary function tests in the management of sarcoidosis.

    abstract::The literature on pulmonary function testing in sarcoidosis is critically reviewed. The results indicate that pulmonary function tests are not a reliable means for detecting the presence of parenchymal sarcoidosis, nor do they provide an accurate estimate of the extent of parenchymal disease. There are at present no k...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.78.4.640

    authors: Winterbauer RH,Hutchinson JF

    更新日期:1980-10-01 00:00:00

  • Endoscopic ultrasound/fine-needle aspiration diagnosis of a malignant subcarinal lymph node in a patient with lung cancer and a negative positron emission tomography scan.

    abstract::Transesophageal, endoscopic ultrasound (EUS)-guided fine-needle aspiration (FNA) and positron emission tomography (PET) scanning are new modalities for staging non-small cell lung cancer (NSCLC), the roles of which are still being defined. A 78-year-old man with a right lower lobe (RLL) mass and mediastinal adenopathy...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.122.3.1091

    authors: Rosenberg JM,Perricone A,Savides TJ

    更新日期:2002-09-01 00:00:00

  • Impact of blood transfusions on inflammatory mediator release in patients undergoing cardiac surgery.

    abstract:STUDY OBJECTIVES:This study was conducted to investigate whether intraoperative blood transfusions affect the release of proinflammatory mediators in patients undergoing cardiac surgery. Therefore, we measured plasma levels of bactericidal permeability increasing protein (BPI) as a marker of neutrophil activation, inte...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.116.5.1233

    authors: Fransen E,Maessen J,Dentener M,Senden N,Buurman W

    更新日期:1999-11-01 00:00:00

  • Treatment of chronic obstructive pulmonary disease with corticosteroids. Comparison of daily vs alternate-day therapy.

    abstract::We compared the efficacy of corticosteroid therapy initiated as an alternate-day regimen to that of a four-times-daily regimen in patients with stable chronic obstructive pulmonary disease. In this double-blind study, 44 patients with moderate to severe COPD (mean FEV1 740 +/- 310 ml) were hospitalized and randomly al...

    journal_title:Chest

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1378/chest.86.4.524

    authors: Blair GP,Light RW

    更新日期:1984-10-01 00:00:00

  • Combined dose ratios of dopamine and dobutamine and right ventricular performance after cardiac surgery.

    abstract::The effect of combined administration of different dose ratios of dobutamine (DB) and dopamine (DA) (DB/DA ratio of 1:1; 1.5:0.5; 2:0; 0.5:1.5; and 0:2), with the added dose kept constant (10 micrograms/kg/min-20 micrograms/kg/min), on right ventricular function (measured by the thermal washout method with the aid of ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.101.5.1197

    authors: Imai T,Saitoh K,Kani H,Fujita T,Murata K

    更新日期:1992-05-01 00:00:00

  • Delivery of albuterol and ipratropium bromide from two nebulizer systems in chronic stable asthma. Efficacy and pulmonary deposition.

    abstract::Bronchodilator responses to both nebulized albuterol (salbutamol) and ipratropium bromide and aerosol delivery to the tracheobronchial tree have been assessed in eight patients with chronic stable asthma (mean baseline FEV1, 50 percent; reversibility greater than 20 percent). Two commercially available nebulizer syste...

    journal_title:Chest

    pub_type: 临床试验,杂志文章

    doi:10.1378/chest.96.1.6

    authors: Johnson MA,Newman SP,Bloom R,Talaee N,Clarke SW

    更新日期:1989-07-01 00:00:00

  • The uncommon case of Jahi McMath.

    abstract::A 13-year-old patient named Jahi McMath was determined to be dead by neurologic criteria following cardiopulmonary arrest and resuscitation at a hospital in Oakland, California. Her family did not agree that she was dead and refused to allow her ventilator to be removed. The family's attorney stated in the media that ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.14-2227

    authors: Luce JM

    更新日期:2015-04-01 00:00:00

  • Assessment of cardiac function in patients with the acquired immunodeficiency syndrome.

    abstract::We have assessed right and left ventricular function by multigated radionuclide ventriculography in 12 consecutive patients with acquired immunodeficiency syndrome (AIDS) grouped according to the CDC classification system for HIV infection. Results were correlated with clinical, electrocardiographic and echocardiograp...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.93.3.592

    authors: Raffanti SP,Chiaramida AJ,Sen P,Wright P,Middleton JR,Chiaramida S

    更新日期:1988-03-01 00:00:00

  • Descriptors of breathlessness in children with persistent asthma.

    abstract:BACKGROUND:In adult patients, the consistent use of language to describe dyspnea enhances patient-provider communication and contributes to diagnostic and therapeutic decisions. The objective of this research was to determine whether pediatric patients similarly display consistency in the language used to describe "unc...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.10-2388

    authors: Harver A,Schwartzstein RM,Kotses H,Humphries CT,Schmaling KB,Mullin ML

    更新日期:2011-04-01 00:00:00

  • Heart rate pattern during sleep in an infant with congenital prolongation of the Q-T interval (Romano-Ward syndrome).

    abstract::Heart rate and the variability of the heart rate, indices of autonomic control, were studied during sleep in an infant with prolonged Q-T interval (Romano-Ward syndrome) and were compared to the heart rate and variability of heart rate in 18 normal infants studied at monthly intervals during the first four months of l...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.84.2.191

    authors: Leistner HL,Haddad GG,Lai TL,Mellins RB

    更新日期:1983-08-01 00:00:00

  • Peripheral arterial embolism due to a left ventricular diverticulum in a young adult.

    abstract::A 32-year-old man was admitted to the emergency department of our hospital after experiencing a peripheral arterial embolism. Investigation of the possible embolic sources in an otherwise asymptomatic patient revealed the existence of a left ventricular diverticulum. The left ventricular diverticulum is a rare congeni...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.127.4.1452

    authors: Parthenakis FI,Kochiadakis GE,Patrianakos AP,Hamilos MI,Mitrouska I,Katsamouris AN,Vardas PE

    更新日期:2005-04-01 00:00:00

  • Effect of the cold pressor test on diffusing capacity. Comparison of normal subjects and those with Raynaud's disease and progressive systemic sclerosis.

    abstract::Single-breath carbon monoxide diffusing capacity (Dsb) was measured before and during immersion of one hand in ice water (cold pressor test) in the following three groups of subjects: (1) normal subjects; (2) patients with isolated Raynaud's disease; and (3) patients with Raynaud's phenomenon and progressive systemic ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.84.3.264

    authors: Miller MJ

    更新日期:1983-09-01 00:00:00

  • Diagnosis of superior vena caval obstruction by transesophageal echocardiography.

    abstract::Superior vena caval (SVC) syndrome may be caused by extravascular compression or intravascular obstruction. Knowing the mechanism of SVC syndrome enables the physician to choose appropriate treatment. Transesophageal echocardiography (TEE) is a safe bedside procedure that is excellent for evaluating the SVC and its su...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.101.3.874

    authors: Ayala K,Chandrasekaran K,Karalis DG,Parris TM,Ross JJ Jr

    更新日期:1992-03-01 00:00:00

  • Single-breath nitrogen washout; effects of alterations of lung volumes and elastic recoil.

    abstract::Strapping of the chest causes decreased lung volumes and increased elastic recoil pressure. Such strapping was used in conjunction with single-breath nitrogen washout to study the effects of changes in these factors on the dynamics of the small airways. Studies consisted of simultaneous measurements of the quasistatic...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.76.1.83

    authors: Al-Bazzaz FJ

    更新日期:1979-07-01 00:00:00

  • Hospitalizations for pulmonary reactions following nitrofurantoin use.

    abstract::Acute pulmonary illness compatible with previously described nitrofurantoin toxicity and requiring hospitalization occurred three times among 16,101 first courses of therapy with nitrofurantoin. One case of fatal pulmonary fibrosis was ascribed to long-term use of nitrofurantoin among 742 observed recipients of ten or...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.96.3.512

    authors: Jick SS,Jick H,Walker AM,Hunter JR

    更新日期:1989-09-01 00:00:00

  • Complete resolution of roentgenographic changes in a patient with pulmonary histiocytosis X.

    abstract::A smoker presented with pleuritic chest pain and was found to have reticulonodular interstitial opacities on chest x-ray film. Open lung biopsy revealed changes consistent with histiocytosis X, a disease seen almost exclusively in smokers. Smoking cessation was recommended, and the patient complied. A chest x-ray film...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.98.3.765

    authors: Von Essen S,West W,Sitorius M,Rennard SI

    更新日期:1990-09-01 00:00:00

  • Central and peripheral airway sites of nitric oxide gas exchange in COPD.

    abstract:BACKGROUND:This study investigated sites of nitric oxide (NO) gas exchange and response to inhaled corticosteroids (ICS) in patients with COPD and varying extents of emphysema. METHODS:This was a prospective, randomized, single-blind, crossover study in treated, stable, ex-smoking patients with COPD who were ICS and l...

    journal_title:Chest

    pub_type: 杂志文章,随机对照试验

    doi:10.1378/chest.09-1522

    authors: Gelb AF,Flynn Taylor C,Krishnan A,Fraser C,Shinar CM,Schein MJ,Osann K

    更新日期:2010-03-01 00:00:00

  • Time-dependent effect of nitrate-rich meals on exhaled nitric oxide in healthy subjects.

    abstract:BACKGROUND:Exhaled nitric oxide (eNO) is a convenient noninvasive marker for airway inflammation in several pulmonary diseases. However, external factors such as nitrate-rich nutrition can affect the levels of eNO and thus compromise its diagnostic value. STUDY OBJECTIVES:The objective of this investigation was to hav...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.128.4.2465

    authors: Vints AM,Oostveen E,Eeckhaut G,Smolders M,De Backer WA

    更新日期:2005-10-01 00:00:00

  • Long-term reproducibility of respiratory gas exchange measurements during exercise in patients with stable cardiac failure.

    abstract::Present-day technology has greatly facilitated the monitoring of respiratory gas exchange in the clinical exercise laboratory. Despite the growing use of these techniques to assess the severity and progression of disease or therapeutic response in patients with heart failure, the long-term reproducibility of oxygen up...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.97.1.12

    authors: Janicki JS,Gupta S,Ferris ST,McElroy PA

    更新日期:1990-01-01 00:00:00

  • Clinical relevance of the interaction of theophylline with diltiazem or nifedipine.

    abstract::The results of previously published studies indicate that calcium channel blockers are capable of competitively inhibiting cytochrome P-450 activity in hepatic microsomes, the pathway of theophylline metabolism. In addition, case reports have suggested that theophylline serum concentrations change when a calcium chann...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.95.2.309

    authors: Christopher MA,Harman E,Hendeles L

    更新日期:1989-02-01 00:00:00

  • Lung health in sawmill workers exposed to pine and spruce.

    abstract::Workers exposed to a variety of wood dusts have been shown to exhibit occupational asthma, lung function deficits, and elevated levels of respiratory symptoms. Despite the popularity of pine and spruce, the health effects of exposures to these woods have not been extensively investigated. A study was undertaken to inv...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.108.3.642

    authors: Hessel PA,Herbert FA,Melenka LS,Yoshida K,Michaelchuk D,Nakaza M

    更新日期:1995-09-01 00:00:00

  • Effect of dobutamine on lung microvascular fluid flux in sheep with "sepsis syndrome".

    abstract::The effect on pulmonary fluid balance of adrenergic receptor agonist agents commonly employed in clinical sepsis has not been well characterized. Therefore, we tested the hypothesis that dobutamine would increase pulmonary microvasular fluid flux in experimental sepsis-induced lung injury. To define the effects of thi...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.93.1.180

    authors: Gnidec AG,Finley RR,Sibbald WJ

    更新日期:1988-01-01 00:00:00

  • Effect of a beta 2-agonist (broxaterol) on respiratory muscle strength and endurance in patients with COPD with irreversible airway obstruction.

    abstract::The effect of broxaterol, a new beta 2-agonist, on respiratory muscle endurance and strength was studied in a double-blind, placebo-controlled, randomized crossover clinical trial in 16 patients with chronic obstructive pulmonary disease (COPD) with irreversible airway obstruction (FEV1 = 57.1 percent of predicted). O...

    journal_title:Chest

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1378/chest.101.1.133

    authors: Nava S,Crotti P,Gurrieri G,Fracchia C,Rampulla C

    更新日期:1992-01-01 00:00:00

  • Interleukin-2 and soluble interleukin-2 receptor in bronchoalveolar lavage fluid from patients with bronchial asthma.

    abstract::To clarify the interrelation between interleukin-2 (IL-2) and soluble IL-2R receptor (sIL-2R), as products of T-cell activation in the bronchial tree of patients with bronchial asthma, we measured the concentration of IL-2, sIL-2R, and the cellular composition in bronchoalveolar lavage (BAL) fluid. We also measured ph...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.106.2.400

    authors: Park CS,Lee SM,Chung SW,Uh S,Kim HT,Kim YH

    更新日期:1994-08-01 00:00:00

  • Effect of preoperative renin-angiotensin system blockade on hypertension following coronary surgery.

    abstract::Renin-angiotensin system activation is suspected of being involved in postcoronary surgery hypertension, but appears to be useful in maintaining blood pressure during anesthesia and cardiopulmonary bypass. To clarify these points, 19 patients were compared: ten as a control group and nine who received captopril during...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.93.6.1156

    authors: Colson P,Grolleau D,Chaptal PA,Ribstein J,Mimran A,Roquefeuil B

    更新日期:1988-06-01 00:00:00

  • Is pulmonary arterial hypertension really a late complication of systemic sclerosis?

    abstract:BACKGROUND:Pulmonary arterial hypertension (PAH) is a frequent cause of morbidity and mortality in patients with systemic sclerosis (SSc). PAH is generally considered to be a late complication of limited cutaneous SSc. This study identified and investigated a subset of SSc patients with early-onset PAH. METHODS:Clinic...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.08-3042

    authors: Hachulla E,Launay D,Mouthon L,Sitbon O,Berezne A,Guillevin L,Hatron PY,Simonneau G,Clerson P,Humbert M,French PAH-SSc Network.

    更新日期:2009-11-01 00:00:00

  • Repeatability of inspiratory capacity during incremental exercise in patients with severe COPD.

    abstract:STUDY OBJECTIVE:Estimating lung volume using inspiratory capacity (IC) maneuvers is a useful way of tracking dynamic hyperinflation. An understanding of the repeatability of the IC in a clinical setting is important when evaluating an individual's response to a therapeutic intervention that might influence lung volume....

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.121.3.708

    authors: Dolmage TE,Goldstein RS

    更新日期:2002-03-01 00:00:00

  • Respiratory muscle performance, pulmonary mechanics, and gas exchange between the BiPAP S/T-D system and the Servo Ventilator 900C with bilevel positive airway pressure ventilation following gradual pressure support weaning.

    abstract:STUDY OBJECTIVE:Our objective was to compare respiratory muscle performance, pulmonary mechanics, and gas exchange between the BiPAP S/T-D ventilation system (Respironics Inc; Murrysville, PA) and the Servo Ventilator 900C (Siemens-Elma AB; Sweden) with similar inspiratory and expiratory airway pressure in patients who...

    journal_title:Chest

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1378/chest.114.5.1390

    authors: Patel RG,Petrini MF

    更新日期:1998-11-01 00:00:00

  • Clinical features of Pseudomonas cepacia pneumonia in an epidemic among immunocompromised patients.

    abstract::Between January 1990 and August 1991, there were 37 patients admitted to our Department of Internal Medicine with hematologic malignancies or solid tumors who showed colonization of the respiratory tract with Pseudomonas cepacia. Extensive surveillance cultures of the environmental surfaces and respiratory equipment o...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.103.6.1706

    authors: Yamagishi Y,Fujita J,Takigawa K,Negayama K,Nakazawa T,Takahara J

    更新日期:1993-06-01 00:00:00