Abstract:
:A patient had accelerated attacks of chest pain associated with transient ST elevation or depression in the anterior leads. Coronary angiogram revealed severe multi-vessel disease. Anginal attacks with conspicuous ST depression were induced repeatedly by both oral and sublingual administration of nifedipine. Among various vasodilator drugs tested on this patient, dipyridamole and hydralazine induced anginal attacks. These observations suggest that anginal attacks induced by administration of nifedipine may be related to the augmentation of myocardial oxygen consumption due to increases in cardiac output and heart rate, the coronary steal phenomenon, or an increase in venous return accompanied by the subendocardial underperfusion.
journal_name
Chestjournal_title
Chestauthors
Yokoyama M,Koizumi T,Fujitani K,Mizutani T,Fukuzaki Hdoi
10.1378/chest.81.5.646subject
Has Abstractpub_date
1982-05-01 00:00:00pages
646-8issue
5eissn
0012-3692issn
1931-3543pii
S0012-3692(15)44729-4journal_volume
81pub_type
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