Abstract:
:Investigators have validated an abbreviated protocol for testing nonspecific bronchial reactivity with methacholine. We performed a similar validation study with histamine, another bronchoprovocative agent known to induce airflow obstruction. Histamine is pharmacologically distinct from methacholine and, under some circumstances, may provide specific clinical and investigative advantages to methacholine. Twenty-four patients with a clinical history of asthma underwent bronchoprovocative testing using the standard histamine airway protocol recommended by the American Academy of Allergy, Committee on Standardization of Bronchoprovocation. In addition, two abbreviated histamine challenge protocols were tested using the same administration and testing equipment. The abbreviated protocols involved fewer dilutions and dosages of histamine than the standard histamine protocol but covered the same range of cumulative doses. The two abbreviated protocols differed only in the intervals for determination of FEV1 between doses of histamine (30 s vs 3 min). The sequence of these three protocols was randomized for each study subject and each airway challenge was separated by one week. The two abbreviated protocols took significantly less time to administer than the standard protocol--18 min vs 30 min vs 44 min. Both the provocative dose to cause a 20 percent decline in the FEV1 (PD20 FEV1) and the slope of the dose-response curve were not significantly different between the standard protocol and either of the two abbreviated protocols. Moreover, a high degree of agreement was observed between the two abbreviated protocols and the standard histamine protocol for both the PD20 FEV1 and the slope of the dose-response curve. These findings indicate that similar estimates of bronchial reactivity are obtained from either of the abbreviated protocols when compared with the standard histamine protocol.
journal_name
Chestjournal_title
Chestauthors
Schmidt LE,Thorne PS,Watt JL,Schwartz DAdoi
10.1378/chest.101.1.141subject
Has Abstractpub_date
1992-01-01 00:00:00pages
141-5issue
1eissn
0012-3692issn
1931-3543pii
S0012-3692(16)33138-5journal_volume
101pub_type
临床试验,杂志文章,随机对照试验相关文献
CHEST文献大全abstract::This study addresses the hypothesis that patients with obstructive sleep apnea, who exhibit recurrent episodes of oxygen desaturation at night, have higher hematocrit levels than nonapneic control subjects. We prospectively studied 624 patients referred to the sleep disorders center at St. Michael's Hospital because o...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.106.3.787
更新日期:1994-09-01 00:00:00
abstract:BACKGROUND:FEV1 may remain stable while high-resolution CT (HRCT) appearances deteriorate in children with cystic fibrosis (CF). However, spirometry results commonly decline in older age groups. OBJECTIVES:To compare the rate of decline in HRCT abnormalities and spirometry results over time in an adult cohort with CF....
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.130.5.1424
更新日期:2006-11-01 00:00:00
abstract::We compared, in a controlled clinical trial, the effect of specific inspiratory muscle training combined with general exercise reconditioning, for six months, with that of general exercise reconditioning alone on inspiratory muscle strength, endurance, and exercise performance in patients with COPD. Thirty-six patient...
journal_title:Chest
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1378/chest.102.5.1351
更新日期:1992-11-01 00:00:00
abstract::Persisting symptoms, consisting of palpitations, dizziness, or syncope, were found in 49 of 570 consecutively followed patients (8.6 percent) with permanent pacemakers (PM). Among 540 patients with ventricular PM, 19 had syncope and 24 dizziness; among 30 patients with dual-chamber PM, five had palpitations and one di...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.85.2.207
更新日期:1984-02-01 00:00:00
abstract:BACKGROUND:The implementation of workplace smoking bans has contributed to a significant reduction in the incidence of acute coronary syndrome admissions, but their influence on adult acute pulmonary disease admissions is unclear. We sought to assess the impact of a national smoking ban on nationwide admissions of indi...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.11-2757
更新日期:2012-09-01 00:00:00
abstract::A 72-year-old physician with myeloid metaplasia developed marked thrombocytosis, pulmonary hypertension, and right heart failure following splenectomy. No cause for the pulmonary hypertension could be found. The pulmonary hypertension and right heart failure returned to normal when hydroxyurea therapy corrected the th...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.103.2.642
更新日期:1993-02-01 00:00:00
abstract::In 283 patients referred for testing in an outpatient pulmonary function laboratory, we studied the single-breath diffusing capacity of the lungs for carbon monoxide (Dco) using the Ogilvie (Og), Jones-Meade (JM), Epidemiological Standardization Project (ESP), and three-phase iterative methods (3PIT, similar to the th...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.105.2.594
更新日期:1994-02-01 00:00:00
abstract:BACKGROUND:Little information exists about the expected time to death after terminal withdrawal of mechanical ventilation. We sought to determine the independent predictors of time to death after withdrawal of mechanical ventilation. METHODS:We conducted a secondary analysis from a cluster randomized trial of an end-o...
journal_title:Chest
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1378/chest.10-0289
更新日期:2010-08-01 00:00:00
abstract:STUDY OBJECTIVES:To determine the usefulness of radioaerosol ventilation scans for the detection and localization of air leaks from the lungs or bronchial tree. DESIGN:Selected patients with suspected air leaks underwent ventilation scans. Retrospective analysis of data was carried out. SETTING AND PATIENTS:Twenty-ei...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.111.2.286
更新日期:1997-02-01 00:00:00
abstract::Four cases of giant cell arteritis causing severe aortic regurgitation secondary to an aneurysm of the ascending aorta are described. In two cases, the nature of the aortic pathology could be suspected considering the past clinical evidence of temporal arteritis and/or polymyalgia rheumatica. In the two other cases, t...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.121.4.1365
更新日期:2002-04-01 00:00:00
abstract::A patient is reported who had Histoplasma capsulatum endocarditis, a rare form of disseminated histoplasmosis. He also had disseminated intravascular coagulopathy and defects in cell-mediated immune responses to Histoplasma antigens. Prompt etiologic diagnosis was made by stain of tissue from a mouth ulcer and confirm...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.78.5.791
更新日期:1980-11-01 00:00:00
abstract::To assess the diagnostic value of telescoping plugged catheters (TPC) in human immunodeficiency virus (HIV)-infected patients with pulmonary infiltrates (PI), we performed a prospective clinical study in 71 episodes of fever and PI in 66 HIV-infected patients (five patients had two different episodes of fever and PI)....
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.102.1.76
更新日期:1992-07-01 00:00:00
abstract::The preponderance of evidence indicates that high airway pressure is not by itself injurious to the lung. Rather, overdistention of the lung appears to be the fundamental mechanism underlying VALI. The physician must bear in mind the factors (ie, flow-resistive pressure losses, respiratory muscle activity, and abnorma...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.105.1.242
更新日期:1994-01-01 00:00:00
abstract::Bronchial epithelial damage and mucus hypersecretion are characteristic features of chronic airway inflammation that can impair mucociliary clearance and can cause recurrent or persistent respiratory infection. In response to chemoattractants produced by damaged or inflamed tissue, neutrophils move through sequential ...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.125.2_suppl.41s
更新日期:2004-02-01 00:00:00
abstract::Simultaneous hemodynamic and blood gas measurements were performed in 26 hypertensive adults, who were cigarette smokers, before and after a 30-minute infusion of saralasin (5 microgram/kg/min) which is a highly specific competitive antagonist of angiotensin II (AII). The arterial pressure fell in nine, rose in seven ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.75.4.492
更新日期:1979-04-01 00:00:00
abstract:BACKGROUND:The coronavirus disease 2019 (COVID-19) pandemic has severely affected ICUs and critical care health-care providers (HCPs) worldwide. RESEARCH QUESTION:How do regional differences and perceived lack of ICU resources affect critical care resource use and the well-being of HCPs? STUDY DESIGN AND METHODS:Betw...
journal_title:Chest
pub_type: 杂志文章
doi:10.1016/j.chest.2020.09.070
更新日期:2020-09-11 00:00:00
abstract::A series of 15 patients with life threatening, massive hemoptysis is reported. Thirteen of these patients underwent immediate operative treatment with only three deaths. One died after bronchoscopic identification of the bleeding site while awaiting elective thoracotomy. The other patient left the hospital against med...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.67.2.152
更新日期:1975-02-01 00:00:00
abstract:BACKGROUND:It is unknown if the radiographic fibrosis score predicts mortality in persistent hypersensitivity pneumonitis (HP) and if survival is similar to that observed in idiopathic pulmonary fibrosis (IPF) when adjusting for the extent of radiographic fibrosis. METHODS:We reviewed records from 177 patients with HP...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.12-2623
更新日期:2013-08-01 00:00:00
abstract::Natural killer-cell activity of fresh interstitial pulmonary cell populations from patients with squamous cell and adenocarcinoma of the lung and carcinoma metastatic to the lung was assessed and compared to that of apparently normal lung. No increase in the percentage of lymphoid cell populations was noted in the int...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.91.1.26
更新日期:1987-01-01 00:00:00
abstract:STUDY OBJECTIVE:To examine the hemodynamic and metabolic short-term effects of hypophosphatemia correction in patients with septic shock receiving catecholamine therapy. DESIGN:Prospective, single cohort study. SETTING:ICU, university hospital. PATIENTS:Ten patients with septic shock and hypophosphatemia below 2 mg/...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.107.6.1698
更新日期:1995-06-01 00:00:00
abstract::Since publication of the seventh American College of Chest Physicians (ACCP) supplement on antithrombotic and thrombolytic therapy, the results of clinical trials have provided important new information on the management of thromboembolic disorders, and the science of developing recommendations has advanced. In the ac...
journal_title:Chest
pub_type: 杂志文章,实务指引
doi:10.1378/chest.08-0652
更新日期:2008-06-01 00:00:00
abstract::The effects of six weeks of threshold pressure inspiratory muscle training (IMT) on inspiratory muscle performance, breathing pattern and exercise performance were studied in eight patients with severe airflow obstruction. The results indicated that IMT improved inspiratory muscle performance but did not affect exerci...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.95.3.535
更新日期:1989-03-01 00:00:00
abstract::Tracheobronchial injury is a rare but a potentially high-impact event with significant morbidity and mortality. Common etiologies include blunt or penetrating trauma and iatrogenic injury that might occur during surgery, endotracheal intubation, or bronchoscopy. Early recognition of clinical signs and symptoms can hel...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1016/j.chest.2018.07.018
更新日期:2019-03-01 00:00:00
abstract::The previously unreported association of chronic persistent cough due to a duplication esophageal cyst is presented. The presence of a long history of atopy, bronchitis, and asthma resulted in a delay in diagnosis. When vigorous bronchodilator therapy was unsuccessful, close observation of the patient and review of he...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.86.1.150
更新日期:1984-07-01 00:00:00
abstract:STUDY OBJECTIVE:To assess whether myocardial contrast echocardiography (MCE) using harmonic power Doppler (HPD) in conjunction with the transvenous contrast agent SHU 563A would be useful in detecting stunned but viable myocardium. DESIGN:Acute coronary occlusion (2 to 3 h) followed by 1 h of reperfusion was created i...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.120.2.567
更新日期:2001-08-01 00:00:00
abstract::We describe the case of a lung transplant patient with primary graft failure and an emphysematous native lung, who displayed different respiratory rates between the transplanted lung and the native lung. Inflation of the native lung delayed the next inspiratory effort relative to inflation of the denervated transplant...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.120.2.678
更新日期:2001-08-01 00:00:00
abstract::A case of subaortic stenosis caused by two discrete membranes is presented. Following demonstration of the two distinct sites of obstruction by intraventricular pressure gradients and angiocardiogram, the two membranes were excised through a transaortic approach. The importance of being aware of the occurrence of this...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.69.1.104
更新日期:1976-01-01 00:00:00
abstract::The utility of the apnea index (number of apneic events per hour of sleep) in diagnosing sleep apnea syndrome is reviewed. Data from currently extant reports indicate that many otherwise normal, aging subjects may be classified as having sleep apnea syndrome based on the current diagnostic threshold of five apneic epi...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.86.4.529
更新日期:1984-10-01 00:00:00
abstract:OBJECTIVE:To evaluate changes in cerebral tissue oxygenation and blood volume during obstructive sleep apnea (OSA). METHODS:We studied eight men with moderate to severe OSA by near-infrared spectroscopy (NIRS) simultaneously with polysomnography during nocturnal sleep (five patients) and daytime naps (three). RESULTS...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.109.4.916
更新日期:1996-04-01 00:00:00
abstract:BACKGROUND:The use of both heroin and cocaine has been associated with asthma exacerbations. However, the magnitude of this effect has not been adequately described. The purpose of this study was to examine the association between cocaine or heroin use and asthma severity. METHODS:We conducted a retrospective chart re...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.128.4.1951
更新日期:2005-10-01 00:00:00