Pulmonary hypertension secondary to thrombocytosis in a patient with myeloid metaplasia.

Abstract:

:A 72-year-old physician with myeloid metaplasia developed marked thrombocytosis, pulmonary hypertension, and right heart failure following splenectomy. No cause for the pulmonary hypertension could be found. The pulmonary hypertension and right heart failure returned to normal when hydroxyurea therapy corrected the thrombocythemia. It is concluded that thrombocytosis may cause pulmonary hypertension, mediated by pulmonary capillary obstruction from cellular components, involving platelet aggregation, microthrombosis, and stasis, and possible vasoconstrictor effects.

journal_name

Chest

journal_title

Chest

authors

Marvin KS,Spellberg RD

doi

10.1378/chest.103.2.642

subject

Has Abstract

pub_date

1993-02-01 00:00:00

pages

642-4

issue

2

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(15)41508-9

journal_volume

103

pub_type

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