Abstract:
BACKGROUND:FEV1 may remain stable while high-resolution CT (HRCT) appearances deteriorate in children with cystic fibrosis (CF). However, spirometry results commonly decline in older age groups. OBJECTIVES:To compare the rate of decline in HRCT abnormalities and spirometry results over time in an adult cohort with CF. METHODS:The HRCT scans of 39 consecutive patients (19 males and 20 females; mean age, 22 years; range, 16 to 48 years) with two HRCT scans > 18 months apart were randomly and blindly scored using a modified Bhalla scoring system by two independent chest radiologists. Age, body mass index, spirometry, and sputum cultures were recorded at the time of both HRCTs. Rates of change in clinical parameters and HRCT abnormalities were calculated and compared using repeated-measures analysis of variance. RESULTS:Mean FEV1 declined at a rate of - 2.3% per year, while mean HRCT total score declined at a rate of -2.7% per year. Several individual HRCT abnormalities as well as HRCT total scores declined significantly faster than FEV1 (p < 0.001). Six patients showed stable spirometry results but worsening HRCT scores. Mucus plugging and extent of bronchiectasis deteriorated at a more rapid rate in the group with mildly impaired lung function. Air trapping, collapse/consolidation, peribronchial thickening, severity of bronchiectasis, and generations of bronchial divisions involved deteriorated at a more rapid rate in the group with moderate-to-severely impaired lung function. CONCLUSIONS:Adult CF patients have more rapid rates of decline in HRCT abnormalities than in spirometry results. Individual HRCT abnormalities decline at different rates depending on the degree of lung function impairment.
journal_name
Chestjournal_title
Chestauthors
Judge EP,Dodd JD,Masterson JB,Gallagher CGdoi
10.1378/chest.130.5.1424subject
Has Abstractpub_date
2006-11-01 00:00:00pages
1424-32issue
5eissn
0012-3692issn
1931-3543pii
S0012-3692(15)37319-0journal_volume
130pub_type
杂志文章相关文献
CHEST文献大全abstract::Passive smoking has been shown to adversely affect the health of infants and children. Black children and adults appear to be more susceptible to a variety of tobacco smoke health hazards for unknown reason. The objectives of this study were as follows: (1) to correlate the number of cigarettes reported to have been s...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.109.2.446
更新日期:1996-02-01 00:00:00
abstract::We describe a patient with hemodynamic deterioration and worsening mitral regurgitation related to right ventricular apex pacing. Time-dependent changes in papillary muscle contraction as well as ventricular remodeling by right ventricular apex pacing might be responsible for this rare but serious complication. ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.114.6.1776
更新日期:1998-12-01 00:00:00
abstract:OBJECTIVE:To examine the effect of preoperative smoking behavior on postoperative pulmonary complications. DESIGN:Prospective cohort study. SETTING:The Veterans Administration Medical Center, Syracuse, NY. PARTICIPANTS:Patients scheduled for noncardiac elective surgery (n=410). MEASUREMENTS AND RESULTS:Smoking stat...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.113.4.883
更新日期:1998-04-01 00:00:00
abstract:STUDY OBJECTIVES:(1) To describe a new percutaneous pleural biopsy technique to obtain multiple-site parietal pleural biopsy specimens in patients with pleural effusion (PE), and (2) to evaluate its effectiveness and safety compared to current techniques. DESIGN:Prospective interventional study. SETTING:University te...
journal_title:Chest
pub_type: 临床试验,杂志文章
doi:10.1378/chest.125.5.1776
更新日期:2004-05-01 00:00:00
abstract::The pulmonary status of 178 asymptomatic asthmatic children with normal time-volume spirograms was further evaluated using flow-volume loops, body plethysmographic studies, and blood gas tensions in arterialized capillary blood. Residual volume (RV) was abnormal in 26%, total lung capacity (TLC) in 33%, RV/TLC% in 41%...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.71.3.361
更新日期:1977-03-01 00:00:00
abstract::We wanted to determine the long-term effects of a continuous infusion of PGE1 on DO2 and VO2 in patients with ARDS. Data were obtained from a randomized double-blind multicenter trial, which evaluated the effects of PGE1 on survival in patients with ARDS. Patients were stratified according to treatment and outcome: pl...
journal_title:Chest
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1378/chest.98.2.405
更新日期:1990-08-01 00:00:00
abstract::We report the findings in two patients with sulfasalazine-induced pulmonary disease. The first patient developed pulmonary interstitial fibrosis after more than 4 yr of treatment for Crohn's disease. Pulmonary symptoms and chest roentgenographic and pulmonary function abnormalities gradually reversed after stopping th...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.101.4.1033
更新日期:1992-04-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to identify the CT scan features that predict patient outcome after reexpansion procedures in patients with the fibrotic stage of endobronchial TB. METHODS:We retrospectively enrolled 30 patients (four men, 26 women) aged 32 +/- 11 years who had lobar or whole-lung atelectasis ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.09-1846
更新日期:2010-08-01 00:00:00
abstract:BACKGROUND:Planning for mass critical care in resource-poor and constrained settings has been largely ignored, despite large, densely crowded populations who are prone to suffer disproportionately from natural disasters. As a result, disaster response has been suboptimal and in many instances hampered by lack of planni...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.14-0745
更新日期:2014-10-01 00:00:00
abstract::Most panels that develop clinical practice guidelines are poorly equipped to address resource allocation or cost issues associated with management options. This risks neglect, arbitrariness, lack of transparency, and methodological flaws in consideration of resource allocation. We provide recommendations for guideline...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.129.1.182
更新日期:2006-01-01 00:00:00
abstract::The purpose of this study was to determine the number of procedures necessary to become proficient in flexible fiberoptic bronchoscopic examination. I performed 99 bronchoscopic procedures during a formal training program under the direct supervision of instructors with varying experience. There were no statistical di...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.77.1.65
更新日期:1980-01-01 00:00:00
abstract::Etomidate is commonly used for the facilitation of endotracheal intubation. While etomidate possesses multiple qualities that are beneficial in hemodynamically unstable patients who require a sedative or amnestic, its potential to negatively impact corticosteroid production is well-documented. Given the frequency of r...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.127.3.1031
更新日期:2005-03-01 00:00:00
abstract:STUDY OBJECTIVES:The purpose of this study was to investigate the test-retest reliability, repeatability, and sensitivity of the modified shuttle test (MST) in adult patients with cystic fibrosis (CF). DESIGN:: Prospective study. SETTING:Adult CF Unit, Belfast City Hospital. PATIENTS:: Adult patients with CF. INTER...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.117.6.1666
更新日期:2000-06-01 00:00:00
abstract::In 14 consecutive patients with varying myocardial function, evaluation of the Valsalva maneuver was performed using aortic pulse pressure decay to investigate a possible quantitative relationship between the pattern of response and the degree of myocardial dysfunction. The aortic pulse pressure response during strain...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.95.5.986
更新日期:1989-05-01 00:00:00
abstract::The association between pulmonary impairment and all-cause mortality was investigated among white subjects in a follow-up study of a large national cohort. Pulmonary function was measured during the National Health and Nutrition Examination Survey (NHANESI) (1971 to 1975); subsequent mortality information was obtained...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.103.2.536
更新日期:1993-02-01 00:00:00
abstract::Urticaria with systemic effects occurred in a patient being treated with propranolol and was reproducible upon rechallenge with the drug; Successful beta-adrenergic blocking therapy was achieved using a new agent, tolamolol, with no evidence of any adverse effects. ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.67.4.496
更新日期:1975-04-01 00:00:00
abstract::alpha 1-Antitrypsin (alpha 1-AT) accumulates in the rough endoplasmic reticulum through a mechanism of polymerization. Polymerization is favored by the incorrect tertiary structure of the alpha 1-AT caused by a point mutation at position 342 of the protein. Accumulation of alpha 1-AT in the liver cells (and in hepatoc...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.110.6_supplement.251s
更新日期:1996-12-01 00:00:00
abstract::OSA is a common yet underdiagnosed disorder encountered in everyday practice. The disease is a unique physiologic stressor that contributes to the development or progression of many other disorders, particularly cardiovascular conditions. The pulmonary circulation is specifically affected by the intermittent hypoxic a...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.14-0614
更新日期:2015-03-01 00:00:00
abstract::The aim of the study was to compare (1) the intensity of leg effort and dyspnea during exercise and (2) subjective limitations to performance in normal subjects, patients receiving medication for cardiac disorders, patients with pulmonary impairment, patients with pulmonary impairment who were also receiving cardiac m...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.110.5.1255
更新日期:1996-11-01 00:00:00
abstract::We present a case of adult acute epiglottitis that was successfully managed by endotracheal intubation without the need for subsequent tracheostomy. ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.71.1.93
更新日期:1977-01-01 00:00:00
abstract:BACKGROUND:There are no recommendations on how to measure arm exercise capacity in individuals with COPD. The objectives of this study were (1) to synthesize the literature on measures of arm exercise capacity in individuals with COPD, (2) to describe the psychometric properties and the target construct of each measure...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.11-0475
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Few data are available on the long-term outcome of noninvasive positive pressure ventilation (NPPV) for obesity hypoventilation syndrome (OHS). This study was designed to determine long-term survival, treatment adherence, and prognostic factors in patients with OHS in whom NPPV was initiated in an acute sett...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.09-2472
更新日期:2010-07-01 00:00:00
abstract::The relationships between pulmonary function and sleep-induced respiratory events were studied in 34 consecutive male patients with suspected sleep apnea syndrome. In view of the effects of obstructive airway disease on pulmonary volume and airway resistance (Raw), patients were divided into two groups, those with and...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.87.4.437
更新日期:1985-04-01 00:00:00
abstract::This study evaluated the influence of pregnancy as a relapse factor in pulmonary tuberculosis in 215 patients who recieved adequate chemotherapy. A comparison was made between the evolution of patients who had pregnancies and those who did not. On ending the period of observation (details are lacking with respect to o...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.68.6.800
更新日期:1975-12-01 00:00:00
abstract:STUDY OBJECTIVE:To determine if animals with abnormally low albumin levels are more susceptible to the effects of hypercapnia on BP compared to normal animals. DESIGN:Prospective, controlled laboratory experiment. SETTING:University research laboratory. ANIMALS:Eighteen male Sprague-Dawley rats: 6 rats 10 to 12 week...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.06-2069
更新日期:2007-05-01 00:00:00
abstract::A man with prior AIDS developed acute febrile interstitial pneumonitis, hilar and paratracheal adenopathy, and bronchial polyps. The polyps were histologically typical for bacillary angiomatosis and complete symptomatic and radiographic response to oral clarithromycin was seen. The clinical presentation of bacillary a...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.104.3.973
更新日期:1993-09-01 00:00:00
abstract:STUDY OBJECTIVE:The diagnostic value of tumor markers in pleural fluid is subject to debate. The aim of this study was to evaluate the diagnostic performance of several tumor markers in common use for detecting malignant pleural disease. DESIGN:Blinded comparison of four tumor markers in pleural fluid with a confirmat...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.126.6.1757
更新日期:2004-12-01 00:00:00
abstract:BACKGROUND:Pulmonary aspiration is an important recognized cause of ARDS. Better characterization of patients who aspirate may allow identification of potential risks for aspiration that could be used in future studies to mitigate the occurrence of aspiration and its devastating complications. METHODS:We conducted a s...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.13-3028
更新日期:2014-10-01 00:00:00
abstract::Coronary arteriovenous fistula is an uncommon, although not rare, congenital cardiac malformation, especially in the adult. Most such reported such cases have involved but a single coronary vessel. This report documents the second case of coronary arteriovenous fistulae involving the right and circumflex coronary vess...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.72.5.656
更新日期:1977-11-01 00:00:00
abstract::Point-of-care ultrasonography is a key skill for the critical care clinician and is gaining widespread acceptance by clinicians in all areas of medicine. In addition to mastery of image acquisition, image interpretation, and clinical application, intensivists need to be adept with billing for their scanning activity. ...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1016/j.chest.2019.06.006
更新日期:2019-10-01 00:00:00