Abstract:
:A retrospective study of 34 patients (33 male and one female) was conducted to evaluate a potential correlation between patient survival, propensity to metastasize and specific subtypes of pulmonary adenocarcinomas as determined by ultrastructural examination. Previous electron microscopic studies of pulmonary adenocarcinomas have demonstrated proliferations of three types of cells: mucus, Clara, and alveolar cells. Specific ultrastructural markers of these cell types were assessed in the 34 cases. All cases in this study had a light microscopic diagnosis of adenocarcinoma originating in the pulmonary parenchyma and a follow-up of at least one year. Features such as patient survival time, extent of metastatic involvement, response to therapy, and overall tumor behavior were compared in reference to the cell of origin, in an effort to try to elucidate if such ultrastructural subclassification lent itself to any clinical correlations. Light microscopic growth patterns and special stains were not found to distinguish these neoplasms histogenetically, emphasizing the important role of electron microscopy for an accurate classification.
journal_name
Chestjournal_title
Chestauthors
Herrera GA,Alexander CB,DeMoraes HPdoi
10.1378/chest.84.5.581subject
Has Abstractpub_date
1983-11-01 00:00:00pages
581-6issue
5eissn
0012-3692issn
1931-3543pii
S0012-3692(15)40099-6journal_volume
84pub_type
杂志文章相关文献
CHEST文献大全abstract::This study addresses the hypothesis that patients with obstructive sleep apnea, who exhibit recurrent episodes of oxygen desaturation at night, have higher hematocrit levels than nonapneic control subjects. We prospectively studied 624 patients referred to the sleep disorders center at St. Michael's Hospital because o...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.106.3.787
更新日期:1994-09-01 00:00:00
abstract::Hemodynamic and metabolic effects of methylprednisolone were investigated in a double-blind study of 28 patients with acute myocardial infarction (AMI), confirmed by unequivocal electrocardiographic and enzyme changes. Measurements were performed prior to and at 1.5, 3, 4, 4.5, 12 and 24 hours following infusion of me...
journal_title:Chest
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1378/chest.79.2.186
更新日期:1981-02-01 00:00:00
abstract::The effects of six weeks of threshold pressure inspiratory muscle training (IMT) on inspiratory muscle performance, breathing pattern and exercise performance were studied in eight patients with severe airflow obstruction. The results indicated that IMT improved inspiratory muscle performance but did not affect exerci...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.95.3.535
更新日期:1989-03-01 00:00:00
abstract::The cause of bleeding in a patient with recurrent massive hemoptysis was not apparent after bronchoscopy and gross examination of the lobectomy specimen. Histologic submission of all major bronchi uncovered dilated, tortuous bronchial arteries just below the bronchial mucosa with sites of both current and healing arte...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.99.2.504
更新日期:1991-02-01 00:00:00
abstract:OBJECTIVE:The objective of the present study was to compare antibiotic prescribing practices and survival in the ICU for patients with pneumococcal severe community-acquired pneumonia (SCAP) between 2000 and 2013. METHODS:This was a matched case-control study of two prospectively recorded cohorts in Europe. Eighty pat...
journal_title:Chest
pub_type: 杂志文章,多中心研究
doi:10.1378/chest.13-1531
更新日期:2014-07-01 00:00:00
abstract:STUDY OBJECTIVE:We conducted the first randomized controlled study to assess the effects of short-term 28% and 100% oxygen on PaCO(2) and peak expiratory flow rate (PEFR) in patients with acute severe asthma. PATIENTS AND INTERVENTIONS:Seventy-four patients (mean age, 37.9 +/- 9.7 years [+/- SD]; PEFR, 41.0 +/- 12.1% ...
journal_title:Chest
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1378/chest.124.4.1312
更新日期:2003-10-01 00:00:00
abstract::Among 1,700 primary tumors of the lung, there were 53 cases of bronchial adenoma (3.1 percent); 38 (72 percent) of the 53 were typical carcinoids, and the remaining 15 were of a higher grade of malignant neoplasm. There was a slight predominance of female patients, and the age of greatest incidence was between 30 and ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.77.1.81
更新日期:1980-01-01 00:00:00
abstract:BACKGROUND:Asthma and rhinosinusitis are common medical conditions among adults. Alternative treatments could have important impacts on health status among those individuals with these conditions, but specific prevalence data for these treatments are limited. OBJECTIVE:To estimate the prevalence of specific alternativ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.120.5.1461
更新日期:2001-11-01 00:00:00
abstract::We assessed qualitative and quantitative differences in surfactant lipid composition of bronchoalveolar lavage (BAL) fluid in patients with acquired immune deficiency syndrome (AIDS) and Pneumocystis carinii (PC) pneumonia. Five normal volunteers and 27 patients with human immunodeficiency virus (HIV) infection underw...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.102.6.1730
更新日期:1992-12-01 00:00:00
abstract:STUDY OBJECTIVES:To explore the role of respiratory interactive computer games in teaching spirometry to preschool children, and to examine whether the spirometry data achieved are compatible with acceptable criteria for adults and with published data for healthy preschool children, and whether spirometry at this age c...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.128.3.1146
更新日期:2005-09-01 00:00:00
abstract:BACKGROUND:Recovery of Candida from the respiratory tract of a critically ill patient receiving mechanical ventilation (MV) usually indicates colonization rather than infection of the respiratory tract. However, interactions between Candida and bacteria, particularly Pseudomonas, have been reported. Thus, Candida colon...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.129.1.110
更新日期:2006-01-01 00:00:00
abstract:SETTING:Seven primary health clinics and a pulmonary disease specialty clinic in Rio de Janeiro City, Brazil. OBJECTIVE:To evaluate a commercial immunochromatographic test kit (ICT Tuberculosis; AMRAD-ICT; Sidney, Australia) employing five recombinant Mycobacterium tuberculosis proteins for the detection of pulmonary ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.123.1.107
更新日期:2003-01-01 00:00:00
abstract::The efficacy of continuous positive airway pressure (CPAP) administered with a face mask was compared to oxygen supplementation in 40 patients with acute cardiogenic pulmonary edema. Baseline arterial blood gas values and pH, heart rate, respiratory rate, and blood pressure were recorded after patients breathed 28 per...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.92.3.481
更新日期:1987-09-01 00:00:00
abstract:BACKGROUND:The mid-portion of the maximal expiratory flow-volume (MEFV) curve is often described by values of the mean forced expired flow as lung volume decreases from 75% to 25% of vital capacity (ie, forced expiratory flow, midexpiratory phase [FEF(25-75)]). It is common practice to report also forced expired flow a...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.123.3.731
更新日期:2003-03-01 00:00:00
abstract::The incidence of congenital heart disease is approximately 8/1,000 live births and appears to be constant around the world. The currently accepted paradigm for the development of pulmonary vascular disease associated with congenital heart disease maintains that increased pulmonary blood flow and pressure trigger unfav...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.09-2861
更新日期:2010-06-01 00:00:00
abstract::Tracheal aspirates from four previously healthy infants with acute pulmonary hemorrhage, and small volume bronchial lavages from children undergoing flexible fiberoptic bronchoscopy were examined for pulmonary alveolar macrophages (PAM) containing hemosiderin. Hemosiderin formation was also studied in vitro. Macrophag...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.86.3.409
更新日期:1984-09-01 00:00:00
abstract:STUDY OBJECTIVES:Patients with COPD are at risk of experiencing a deterioration in arterial oxygen saturation (SaO2) during sleep, which is generally most pronounced during rapid eye movement (REM) sleep. Increased cholinergic tone has been suggested as a contributing factor to this decrease in SaO2. Therefore, we inve...
journal_title:Chest
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1378/chest.115.5.1338
更新日期:1999-05-01 00:00:00
abstract:BACKGROUND:FEV1 may remain stable while high-resolution CT (HRCT) appearances deteriorate in children with cystic fibrosis (CF). However, spirometry results commonly decline in older age groups. OBJECTIVES:To compare the rate of decline in HRCT abnormalities and spirometry results over time in an adult cohort with CF....
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.130.5.1424
更新日期:2006-11-01 00:00:00
abstract:STUDY OBJECTIVES:To analyze the influence of a hospital-based home-care program (HCP) on the management of patients with COPD receiving long-term oxygen therapy. DESIGN AND SETTING:Randomized, controlled study in a 1,000-bed university hospital. INTERVENTION:The HCP applied to patients in the intervention group (HCP ...
journal_title:Chest
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1378/chest.119.2.364
更新日期:2001-02-01 00:00:00
abstract:STUDY OBJECTIVES:Cellular growth in the vascular wall, including endothelial and smooth-muscle cell proliferation, is recognized as a component of the obstructive vasculopathy observed in the small vessels of the lungs in pulmonary arterial hypertension (PAH). We hypothesized that angiogenic growth factors may have a r...
journal_title:Chest
pub_type: 杂志文章,多中心研究
doi:10.1378/chest.126.4.1255
更新日期:2004-10-01 00:00:00
abstract::A novel technique has been developed for the isolation and lavaging of a central airway segment in humans. The procedure uses a double-balloon airway-sampling catheter that is placed into the airways with fiberoptic bronchoscopic guidance. A protocol using this technique was attempted in 32 subjects (18 normal subject...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.92.1.105
更新日期:1987-07-01 00:00:00
abstract::Pulmonary infections, which frequently occur during the early and late period following bone marrow transplantation for hematologic malignancies, are associated with significant morbidity and mortality. In this study the incidence, the infectious causes of pneumonia and the mortality related to pneumonia in 130 alloge...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.104.2.371
更新日期:1993-08-01 00:00:00
abstract:BACKGROUND:The risk stratification value of the 6-min walk test (6MWT) to decide the feasibility of surgical resection is not well elucidated in patients with non-small cell lung cancer (NSCLC) and moderately decreased lung function. OBJECTIVE:This study aimed to determine the role of the 6MWT in predicting postoperat...
journal_title:Chest
pub_type: 杂志文章
doi:10.1016/j.chest.2019.12.039
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:Pleural effusions frequently accumulate in patients with left-sided heart failure. However, our recent study in patients with idiopathic and heritable pulmonary arterial hypertension (PAH) demonstrated that pleural effusions frequently occur in patients with isolated right-sided heart failure (RHF). The obje...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.10-0227
更新日期:2011-07-01 00:00:00
abstract:BACKGROUND:A paucity of studies have assessed the epidemiology of community-acquired pneumonia (CAP) that require ICU admission. We conducted a study on this group of patients with the primary objective of defining the incidence, epidemiology, and mortality rate of CAP in the ICUs in Louisville, Kentucky. The secondary...
journal_title:Chest
pub_type: 杂志文章
doi:10.1016/j.chest.2020.03.051
更新日期:2020-09-01 00:00:00
abstract:STUDY OBJECTIVES:Specialty societies have developed practice guidelines for the treatment of community-acquired pneumonia (CAP). To aid in adapting specialty recommendations for a pneumonia practice guideline at Intermountain Health Care, we investigated which physicians care for pneumonia patients in Utah. We wanted t...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.117.2.393
更新日期:2000-02-01 00:00:00
abstract::Chronic cough is a common symptom with significant morbidity. We report a case of a 51-year-old woman who presented with chronic cough. She recently had received a diagnosis of glaucoma and had started receiving therapy with topical latanoprost. The onset of cough coincided with the use of latanoprost. We performed a ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.09-0070
更新日期:2009-11-01 00:00:00
abstract::Of 1,599 patients who underwent surgery for direct myocardial revascularization in 1973 at Cleveland Clinic Hospital, 19 patients (1.2 percent) developed primary ventricular fibrillation or ventricular tachycardia during the immediate postoperative period. Occurrence of postoperative ventricular tachyarrhythmias could...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.72.4.426
更新日期:1977-10-01 00:00:00
abstract::Severe pulmonary reimplantation response after lung transplantation is not very common, although the mortality can be high. We present a patient who developed an extremely severe reperfusion injury after bilateral lung transplantation. Because of severe hypoxia and hemodynamic instability, despite aggressive ventilato...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.118.2.559
更新日期:2000-08-01 00:00:00
abstract::The authors believe this to be the first case report of atrial fibrillation following pulse methylprednisolone therapy in an adult. The literature regarding the complications of pulse methylprednisolone therapy is reviewed, with particular emphasis on the incidence and pathogenesis of arrhythmias. ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.104.2.622
更新日期:1993-08-01 00:00:00