Heightened cough sensitivity secondary to latanoprost.

Abstract:

:Chronic cough is a common symptom with significant morbidity. We report a case of a 51-year-old woman who presented with chronic cough. She recently had received a diagnosis of glaucoma and had started receiving therapy with topical latanoprost. The onset of cough coincided with the use of latanoprost. We performed a citric acid cough challenge while the patient was receiving latanoprost and repeated the challenge after therapy with the drug was stopped. The initial cough challenge revealed marked hypersensitivity of the cough reflex. After stopping therapy with latanoprost for 10 days, the cough sensitivity was reduced significantly. Within 3 days of recommending therapy with latanoprost, the cough sensitivity increased to the initial value. This case illustrates that the topical application of latanoprost can markedly increase cough sensitivity, which is reversible on stopping administration of the drug. Moreover, the case reflects the clinical manifestation of the effect of topical latanoprost therapy on cough reflex, which, to our knowledge, has never been reported in the medical literature.

journal_name

Chest

journal_title

Chest

authors

Fahim A,Morice AH

doi

10.1378/chest.09-0070

subject

Has Abstract

pub_date

2009-11-01 00:00:00

pages

1406-1407

issue

5

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(09)60699-1

journal_volume

136

pub_type

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