Reversal of the central hypotensive effect of clonidine by intracisternal curare-like agents.

Abstract:

:Administration of tubocurarine, pancuronium, gallamine, or decamethonium into the cisterna magna of chloralosed dogs induced a rise in blood pressure. Clonidine (3 micrograms/kg) administered into the cisterna magna after tubocurarine, pancuronium, or gallamine significantly increased blood pressure; no significant change was found after decamethonium. The pressor response to clonidine after tubocurarine was antagonized by injection of the alpha 1-adrenoceptor-blocking agents AR-C 239 or prazosin into the cisterna magna at low doses prior to injection of clonidine. Yohimbine, a preferential alpha 2-adrenoceptor-blocking agent was ineffective. It is suggested that the pressor response to intracisternal clonidine after intracisternal tubocurarine is due to stimulation of alpha 1-adrenoceptor stimulation.

journal_name

Chest

journal_title

Chest

authors

Tsoucaris-Kupfer D,Schmitt H

doi

10.1378/chest.83.2_supplement.349

subject

Has Abstract

pub_date

1983-02-01 00:00:00

pages

349-51

issue

2 Suppl

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(15)40031-5

journal_volume

83

pub_type

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