Abstract:
:A novel technique has been developed for the isolation and lavaging of a central airway segment in humans. The procedure uses a double-balloon airway-sampling catheter that is placed into the airways with fiberoptic bronchoscopic guidance. A protocol using this technique was attempted in 32 subjects (18 normal subjects and 14 subjects with mild asthma), and 27 of the subjects were able to complete all phases of the protocol, including bronchoalveolar lavage and lavage of an isolated airway segment. There was no significant complication in any subject. Cellular composition of the lavages demonstrated differences in cell differential and total cell counts for the two different sampled regions (central airway vs alveolar spaces). We believe that this technique of lavage of an isolated airway segment is safe and has potential usefulness in many areas of pulmonary research.
journal_name
Chestjournal_title
Chestauthors
Eschenbacher WL,Gravelyn TRdoi
10.1378/chest.92.1.105subject
Has Abstractpub_date
1987-07-01 00:00:00pages
105-9issue
1eissn
0012-3692issn
1931-3543pii
S0012-3692(16)37647-4journal_volume
92pub_type
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