Assessment of bone marrow involvement by magnetic resonance imaging in small cell lung cancer. No significant change of staging.

Abstract:

STUDY OBJECTIVE:This prospective study was performed in an attempt to evaluate (1) the rate of magnetic resonance imaging (MRI) demonstrating bone marrow (BM) abnormalities, (2) the correlation of these abnormalities with a pathologic malignant BM involvement, and (3) the possible modification of patients' usual disease staging in the light of these abnormalities. METHODS:After extensive staging investigations, patients' diseases were classified as limited or extensive. Dorsal and lumbar spine MRI was performed for second staging. RESULTS:Thirty-two patients were eligible for this study. In ten patients (31.2 percent), MRI showed abnormalities; in four of them, the BM sample from the posterior iliac crest was free from malignancy. Three of these four patients had extensive disease. The last patient, because he had limited disease, had biopsy at the site of MRI abnormalities; the biopsy specimen revealed a malignant involvement and therefore this patient, initially classified as having limited disease, was classified in the extensive disease group. In only 1 of 32 patients, BM-MRI data modified initial staging. CONCLUSIONS:The metastases disclosure yield of the MRI in the detection of medullar involvement is higher than BM biopsy but especially in patients with extensive disease. Therefore, MRI should not be considered in routine practice, in particular in patients with extensive disease.

journal_name

Chest

journal_title

Chest

authors

Milleron BJ,Le Breton C,Carette MF,Cadranel JL,Akoun GM

doi

10.1378/chest.106.4.1030

subject

Has Abstract

pub_date

1994-10-01 00:00:00

pages

1030-5

issue

4

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(16)33345-1

journal_volume

106

pub_type

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